LUCIA ILARIA SGARAMELLA

Dottoressa di ricerca

ciclo: XXXV


supervisore: Prof. Vito D'Andrea

Titolo della tesi: Utilizzo della risonanza magnetica e della mammografia nelle pazienti candidate a mastectomia nipple o skin sparing. Valutazione degli Outcomes chirurgici precoci

Ischemic complications in patients submitted to nipple or skin sparing mastectomy can be severe surgical sequelae that negatively impact the reconstruction causing temporary flap complication up to total loss of the implant. The risk factors for ischemic complications include patient and surgical risk factors. Among these the importance of flap thickness and the role of superficial vascularization in the subcutaneous tissue and in the dermal matrix remain poorly studied. The aim of the study is to evaluate the incidence of skin flap thickness in predicting ischemic complications and how these can be avoided with a correct preoperative study given by the integration of MRI and mammography data. A prospectively maintained institutional database from January 2018 to August 2022 was retrospectively reviewed. All patients with preoperative MRI availability who underwent skin or nipple sparing mastectomy were included in the study. For each patient, an external reviewer blindly calculated the thickness of the flaps from skin to gland on preoperative MRI and breast volume by mammography examination using PACS software. Demographics and outcomes were stratified by those with and without ischemic complications. Of 568 patients submitted to breast surgery, 28 surgical interventions were analyzed of which 20 for unilateral mastectomy and 8 interventions for bilateral mastectomy the latter equal to 16 glands operated with reconstruction, for a total of 36 operated glands. Three cases (8,33%) of ischemic complications were reported: 2 cases (66,67%) of nipple necrosis and 1 case (33,33%) of flap necrosis. All risk factors were analyzed and assessed in relation to ischemic complications. At univariable analysis a correlation with ischemic complications and a history of heart disease (p * 0.008) and with a preoperative thickness on MRI< 8 mm (p * 0.045) were identified. At multivariable analysis the preoperative thickness > 8 mm was an independent predictor inversely correlated with generic ischemic complications (p * 0.037) with strength of association equal to an 18-fold higher frequency of ischemic events (OR 18.1) in patients with flap thickness less than 8 mm. Thickness is a key predictor for assessing the risk of general ischemic complications in patients who are candidates for skin or nipple sparing mastectomy with one- or two-stage reconstructions. The presence of additional factors including heart disease, previous breast surgery or previous chest radiotherapy are certainly worthy of further study and should be the subject of further studies.

Produzione scientifica

11573/1668481 - 2023 - Mastectomy with one-stage or two-stage reconstruction in breast cancer: analysis of early outcomes and patient's satisfaction
Gurrado, Angela; Pasculli, Alessandro; Toma, Alessia; Maruccia, Michele; Elia, Rossella; Moschetta, Marco; Telegrafo, Michele; De Luca, Giuseppe Massimiliano; Lavermicocca, Walter; Poli, Elisabetta; Prete, Francesco Paolo; Sgaramella, Lucia Ilaria; Giudice, Giuseppe; Testini, Mario - 01a Articolo in rivista
rivista: UPDATES IN SURGERY (Milano : Springer-Verlag Italia) pp. 235-243 - issn: 2038-3312 - wos: WOS:000885422200001 (1) - scopus: 2-s2.0-85142152379 (0)

11573/1668484 - 2022 - Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis
Polistena, Andrea; Prete, Francesco Paolo; Avenia, Stefano; Cavallaro, Giuseppe; Di Meo, Giovanna; Pasculli, Alessandro; Rondelli, Fabio; Sanguinetti, Alessandro; Sgaramella, Lucia Ilaria; Avenia, Nicola; Testini, Mario; Gurrado, Angela - 01a Articolo in rivista
rivista: ANTIBIOTICS (Basel : MDPI) pp. 290- - issn: 2079-6382 - wos: WOS:000775372100001 (0) - scopus: 2-s2.0-85125453094 (5)

11573/1668482 - 2022 - Risk factors for difficult thyroidectomy and postoperative morbidity do not match: retrospective study from an endocrine surgery academic referral centre
Prete, F P; Panzera, P C; Di Meo, G; Pasculli, A; Sgaramella, L I; Calculli, G; Dimonte, R; Ferrarese, F; Testini, M; Gurrado, A - 01a Articolo in rivista
rivista: UPDATES IN SURGERY (Milano : Springer-Verlag Italia) pp. 1943-1951 - issn: 2038-3312 - wos: WOS:000849985400001 (0) - scopus: 2-s2.0-85137454816 (0)

11573/1668483 - 2022 - Intraabdominal sporadic desmoid tumors and inflammation: an updated literature review and presentation and insights on pathogenesis of synchronous sporadic mesenteric desmoid tumors occurring after surgery for necrotizing pancreatitis
Prete, Francesco; Rotelli, Mariateresa; Stella, Alessandro; Calculli, Giovanna; Sgaramella, Lucia Ilaria; Amati, Antonio; Resta, Nicoletta; Testini, Mario; Gurrado, Angela - 01a Articolo in rivista
rivista: CLINICAL AND EXPERIMENTAL MEDICINE (Milano : Springer-Verlag Italia) pp. - - issn: 1591-9528 - wos: WOS:000834754000001 (2) - scopus: 2-s2.0-85135271932 (2)

11573/1619648 - 2021 - The value of intraoperative ultrasound in selective lateral cervical neck lymphadenectomy for papillary thyroid cancer: a prospective pilot study
Di Meo, Giovanna; Paolo Prete, Francesco; Massimiliano De Luca, Giuseppe; Pasculli, Alessandro; Sgaramella, Lucia Ilaria; Minerva, Francesco; Antonio Logoluso, Francesco; Calculli, Giovanna; Gurrado, Angela; Testini, Mario - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000659608600001 (6) - scopus: 2-s2.0-85106700447 (7)

11573/1561222 - 2021 - The THYCOVIT (Thyroid Surgery during COVID-19 pandemic in Italy) study: results from a nationwide, multicentric, case-controlled study
Medas, F.; Ansaldo, G. L.; Avenia, N.; Basili, G.; Boniardi, M.; Bononi, M.; Bove, A.; Carcoforo, P.; Casaril, A.; Cavallaro, G.; Chiofalo, M. G.; Conzo, G.; De Pasquale, L.; Del Rio, P.; Dionigi, G.; Dobrinja, C.; Docimo, G.; Graceffa, G.; Iacobone, M.; Innaro, N.; Lombardi, C. P.; Palestini, N.; Pedicini, F.; Perigli, G.; Pezzolla, A.; Scerrino, G.; Spiezia, S.; Testini, M.; Calo, P. G.; Anedda, G.; Antonelli, G.; Arrigoni, G.; Badii, B.; Bonati, E.; Bulfamante, A. M.; Candalise, V.; Cangiano, A.; Canu, G. L.; Cappellacci, F.; Caracciolo, A.; Caruso, E.; Annamaria, D. A.; Ide, E. C.; Chiappini, A.; Cipolla, C.; Costigliola, L.; Cozzani, F.; Crocco, A.; Crocetti, D.; Demanzini, N.; Digioia, A.; Diresta, V.; Eramo, R.; Erdas, E.; Ferriolo, S.; Filardo, M.; Filograna Pignatelli, M.; Gervasi, R.; Giudici, F.; Gordini, L.; Gurrado, A.; Impellizzeri, H.; Inama, M.; Koleva Radica, M.; Laforgia, R.; Lattarulo, S.; Loderer, T.; Lucchini, R.; Mascioli, F.; Marcellinaro, R.; Menditto, R.; Melfa, G.; Minuto, M.; Misso, C.; Offi, C.; Orlando, G.; Ossola, P.; Pagetta, C.; Pasculli, A.; Patrone, R.; Pauna, I.; Pennetti Pennella, F.; Pietrasanta, D.; Pino, A.; Pinto, V. L.; Piras, S.; Polistena, A.; Portinari, M.; Reina, S.; Rotolo, G.; Russo, G.; Scalise, E.; Sgaramella, L. I.; Sibilla, M. G.; Spinelli, S.; Spoletini, D.; Curto, L. S.; Tascone, M.; Torresan, F.; Varaldo, E.; Viviani, E.; Zucca, A. - 01a Articolo in rivista
rivista: UPDATES IN SURGERY (Milano : Springer-Verlag Italia) pp. - - issn: 2038-131X - wos: WOS:000640730800003 (20) - scopus: 2-s2.0-85105006531 (21)

11573/1561231 - 2021 - Impact of the COVID-19 pandemic on surgery for thyroid cancer in Italy: nationwide retrospective study
Medas, F.; Ansaldo, G. L.; Avenia, N.; Basili, G.; Bononi, M.; Bove, A.; Carcoforo, P.; Casaril, A.; Cavallaro, G.; Conzo, G.; De Pasquale, L.; Del Rio, P.; Dionigi, G.; Dobrinja, C.; Docimo, G.; Graceffa, G.; Iacobone, M.; Innaro, N.; Lombardi, C. P.; Novelli, G.; Palestini, N.; Pedicini, F.; Perigli, G.; Pezzolla, A.; Pezzullo, L.; Scerrino, G.; Spiezia, S.; Testini, M.; Calo, P. G.; Anedda, G.; Antonelli, G.; Arrigoni, G.; Badii, B.; Bonati, E.; Boniardi, M.; Bulfamante, A. M.; Candalise, V.; Cangiano, A.; Canu, G. L.; Cappellacci, F.; Caracciolo, A.; Caruso, E.; Casal Ide, E.; Chiappini, A.; Chiofalo, M. G.; Cipolla, C.; Costigliola, L.; Cozzani, F.; Crocco, A.; Crocetti, D.; De Manzini, N.; Di Gioia, A.; Di Resta, V.; Eramo, R.; Erdas, E.; Ferriolo, S.; Filardo, M.; Filograna Pignatelli, M.; Gervasi, R.; Giudici, F.; Gordini, L.; Gurrado, A.; Impellizzeri, H.; Inama, M.; Koleva Radica, M.; Laforgia, R.; Lattarulo, S.; Loderer, T.; Lucchini, R.; Mascioli, F.; Marcellinaro, R.; Menditto, R.; Melfa, G.; Minuto, M.; Misso, C.; Offi, C.; Orlando, G.; Ossola, P.; Pagetta, C.; Pasculli, A.; Patrone, R.; Pauna, I.; Pennetti Pennella, F.; Pietrasanta, D.; Pino, A.; Pinto, V. L.; Piras, S.; Polistena, A.; Portinari, M.; Reina, S.; Rotolo, G.; Russo, G.; Scalise, E.; Sgaramella, L. I.; Sibilla, M. G.; Spinelli, S.; Spoletini, D.; Curto, L. S.; Tascone, M.; Torresan, F.; Varaldo, E.; Viviani, E.; Zucca, A. - 01f Lettera, Nota
rivista: BRITISH JOURNAL OF SURGERY (Oxford: John Wiley & Sons Oxford: Oxford University Press Bristol: John Wright, 1913-) pp. E166-E167 - issn: 0007-1323 - wos: WOS:000652409700011 (14) - scopus: 2-s2.0-85106069722 (17)

11573/1619652 - 2021 - Prognostic and therapeutic role of angiogenic microenvironment in thyroid cancer
Melaccio, Assunta; Sgaramella, Lucia Ilaria; Pasculli, Alessandro; Di Meo, Giovanna; Gurrado, Angela; Paolo Prete, Francesco; Vacca, Angelo; Ria, Roberto; Testini, Mario - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000659602100001 (9) - scopus: 2-s2.0-85107162196 (9)

11573/1620340 - 2021 - Introducing routine intraoperative nerve monitoring in a high-volume endocrine surgery centre: a health technology assessment
Paolo Prete, Francesco; Sgaramella, Lucia Ilaria; Di Meo, Giovanna; Pasculli, Alessandro; Calculli, Giovanna; Protopapa, Gianluigi; Gurrado, Angela; Testini, Mario - 01a Articolo in rivista
rivista: UPDATES IN SURGERY (Milano : Springer-Verlag Italia) pp. - - issn: 2038-3312 - wos: WOS:000668826000001 (7) - scopus: 2-s2.0-85115086335 (7)

11573/1496162 - 2021 - Effect of thyroidectomy on circulating angiogenic cytokines in papillary thyroid carcinoma and benign goiter: Potential for new biomarkers?
Ria, R.; Prete, F.; Melaccio, A.; Di Meo, G.; Saltarella, I.; Solimando, A. G.; Gurrado, A.; Ferraro, V.; Pasculli, A.; Sgaramella, L. I.; Racanelli, V.; Vacca, A.; Testini, M. - 01a Articolo in rivista
rivista: SURGERY (New York: Elsevier. Orlando, FL: Mosby Year Book Incorporated) pp. 27-33 - issn: 0039-6060 - wos: WOS:000600403200006 (5) - scopus: 2-s2.0-85085601579 (5)

11573/1619661 - 2021 - Rare gastrointestinal metastases from primary lung cancer. Two case reports of patients managed with emergency surgery
Sgaramella, Lucia Ilaria; Gurrado, Angela; Fischetti, Enrico; Massimiliano De Luca, Giuseppe; Pasculli, Alessandro; Brascia, Debora; Cazzato, Gerardo; Trabucco, Senia; Testini, Mario - 01a Articolo in rivista
rivista: ANNALI ITALIANI DI CHIRURGIA (-Roma : Luigi Pozzi, 2005- -Bologna : Cappelli Licinio) pp. - - issn: 2239-253X - wos: WOS:000722027300009 (1) - scopus: 2-s2.0-85106965179 (1)

11573/1496164 - 2020 - A combined open and laparoscopic technique for the treatment of umbilical hernia. Retrospective review of a consecutive series of patients
Prete, Fp; Gurrado, A; Pasculli, A; Sgaramella, Li; Catalano, G; Sallustio, Pnm; Carbotta, G; Ialongo, P; Cavallaro, G; Testini, M - 01g Articolo di rassegna (Review)
rivista: SURGICAL TECHNOLOGY INTERNATIONAL ([Oklahoma City] : Century Press, c1991-) pp. 124-130 - issn: 1090-3941 - wos: WOS:000587503100040 (0) - scopus: 2-s2.0-85085630180 (1)

11573/1495908 - 2020 - The critical view of safety during laparoscopic cholecystectomy: Strasberg Yes or No? An Italian Multicentre study
Sgaramella, L. I.; Gurrado, A.; Pasculli, A.; De Angelis, N.; Memeo, R.; Prete, F. P.; Berti, S.; Ceccarelli, G.; Rigamonti, M.; Badessi, F. G. A.; Solari, N.; Milone, M.; Catena, F.; Scabini, S.; Vittore, F.; Perrone, G.; De Werra, C.; Cafiero, F.; Testini, M.; Baiocchi, G. L.; Baldazzi, G.; Battocletti, M.; Bertoglio, S.; Bianco, P.; Bugiantella, W.; Ciaccio, G.; Cobianchi, L.; Conzo, G.; Crespi, M.; De Rosa, M.; Di Meo, G.; Docimo, L.; Fabris, L.; Feleppa, C.; Ferraro, V.; Fontana, T.; Gambardella, C.; Gennai, A.; Guida, F.; Invernizzi, L.; Massobrio, A.; Medas, F.; Monaco, L.; Muntoni, G.; Musella, M.; Palombo, D.; Perinotti, R.; Pertile, D.; Pezzolla, A.; Piccirillo, G.; Polastri, R.; Ruggiero, R.; Scatizzi, M.; Somaglino, C.; Tolone, S.; Traverso, E.; Tutino, R.; Valduga, C.; Zuolo, M. - 01a Articolo in rivista
rivista: SURGICAL ENDOSCOPY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. - - issn: 0930-2794 - wos: WOS:000559630200004 (29) - scopus: 2-s2.0-85089247013 (31)

11573/1495910 - 2020 - Open necrosectomy is feasible as a last resort in selected cases with infected pancreatic necrosis: a case series and systematic literature review
Sgaramella, L. I.; Gurrado, A.; Pasculli, A.; Prete, F. P.; Catena, F.; Testini, M. - 01g Articolo di rassegna (Review)
rivista: WORLD JOURNAL OF EMERGENCY SURGERY (London,BioMed Central Ltd) pp. - - issn: 1749-7922 - wos: WOS:000557561200001 (6) - scopus: 2-s2.0-85088851672 (8)

11573/1495903 - 2020 - Severe anemia in a patient with vulvar melanoma
Tucci, M; Pasculli, A; Sgaramella, Li; Cazzato, G; Macorano, E; Piscitelli, D; Gurrado, A; Testini, M - 01m Editorial/Introduzione in rivista
rivista: SURGERY (New York: Elsevier. Orlando, FL: Mosby Year Book Incorporated) pp. e21-e22 - issn: 0039-6060 - wos: WOS:000580560500004 (2) - scopus: (0)

11573/1350065 - 2019 - Current concepts in parathyroid carcinoma. A single Centre experience
Ferraro, V.; Sgaramella, L. I.; Di Meo, G.; Prete, F. P.; Logoluso, F.; Minerva, F.; Noviello, M.; Renzulli, G.; Gurrado, A.; Testini, M. - 01a Articolo in rivista
rivista: BMC ENDOCRINE DISORDERS (London: BioMed Central.) pp. 46- - issn: 1472-6823 - wos: WOS:000469457000002 (52) - scopus: 2-s2.0-85066935876 (53)

11573/1346526 - 2019 - A Novel Technique of Digestive Anastomosis Reinforcement Using Bovine Pericardium Patch
Gurrado, Angela; D'ambra, Luigi; Sgaramella, Lucia Ilaria; Prete, Francesco Paolo; Fragassi, Francesco; De Luca, Giuseppe Massimiliano; Cavallaro, Giuseppe; Berti, Stefano; Falco, Emilio; Simone, Michele; Ceccarelli, Graziano; Pezzolla, Angela; Testini, Mario - 01a Articolo in rivista
rivista: THE AMERICAN SURGEON (Cummings GA: Southeastern Surgical Congress Philadelphia: Lippincott) pp. e79-e82- - issn: 1555-9823 - wos: WOS:000460116200005 (1) - scopus: 2-s2.0-85062436966 (1)

11573/1349721 - 2018 - Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: case report and systematic literature review
Di Meo, G.; Sgaramella, L. I.; Ferraro, V.; Prete, F. P.; Gurrado, A.; Testini, M. - 01g Articolo di rassegna (Review)
rivista: CLINICAL AND EXPERIMENTAL MEDICINE (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 585-593 - issn: 1591-8890 - wos: WOS:000451750300016 (16) - scopus: 2-s2.0-85048805813 (18)

11573/1496772 - 2017 - Patologia litiasica della colecisti e delle vie biliari. Testo di “Chirurgia Generale” a cura di Minni F. Edizioni CEA. Zanichelli 2019.
Gurrado, A; Sgaramella, Li; Di Meo, G; Catalano, G; Ferraro, V; Testini, M. - 02a Capitolo o Articolo
libro: Chirurgia Generale - ()

11573/1496768 - 2017 - Management of Mirizzi syndrome in emergency
Testini, M.; Sgaramella, L. I.; De Luca, G. M.; Pasculli, A.; Gurrado, A.; Biondi, A.; Piccinni, G. - 01a Articolo in rivista
rivista: JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 28-32 - issn: 1092-6429 - wos: WOS:000391849600006 (14) - scopus: 2-s2.0-85009273487 (14)

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