Current Positions:
- Associate Professor, Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA (since 2024)
- Honorary Assistant Professor Adjunct, Department of Dermatology, Yale School of Medicine, New Haven, CT, USA
- Faculty Member, Graduate School of Biomedical Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
- Faculty Member, Graduate School of Pharmacological Sciences, University of Padova, Padova, Italy
- Faculty Member, Graduate School of Network Oncology and Precision Medicine, University of Rome "La Sapienza", Rome, Italy
Education and Training
- 2005-2008: PhD, University Paris Sud, Le Kremlin-Bicêtre, France
- 2009-2011: Post-doctoral training, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Professional Background:
- 2024-present: Associate Professor, Fox Chase Cancer Center, Philadelphia, PA, USA
- 2017-2024: Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA
- 2012-2016: Junior Scientist, Research Team "Apoptosis, Cancer and Immunity", Cordeliers Research Center, Paris, France
- 2009-2011: Post-doctoral Researcher, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Institutional Roles:
- Associate Director, European Academy for Tumor Immunology (EATI)
- Founding Member, European Research Institute for Integrated Cellular Pathology (ERI-ICP)
Scientific Skills:
- Cell death mechanisms (apoptosis, necrosis, ferroptosis, immunogenic cell death)
- Autophagy and adaptive stress responses in cancer cells
- Tumor metabolism and metabolic reprogramming
- Tumor immunology and anticancer immune response
- Mechanisms of immune response activation in the context of chemotherapy and radiotherapy
- Integration between cellular stress and antitumor immunity
Methodological Expertise:
- Cellular and molecular biology of cancer
- Preclinical models of immunotherapy
- Study of cell death pathways
- Analysis of cellular and tumor metabolism
- Translational approaches in oncology
Scientific Leadership:
- Associate Director, European Academy for Tumor Immunology (EATI)
- Founding Member, European Research Institute for Integrated Cellular Pathology (ERI-ICP)
- Co-founder of international scientific journals (OncoImmunology, Molecular and Cellular Oncology)
Research Activities
Main Scientific Contributions:
Lorenzo Galluzzi is recognized for fundamental experimental and conceptual contributions in:
1. Cell Death Research:
- Molecular mechanisms of immunogenic cell death (ICD)
- Regulation of apoptosis and regulated necrosis
- Ferroptosis and other forms of cell death
2. Autophagy:
- Role of autophagy in cancer cell survival and death
- Integration between autophagy and immune response
- Autophagy as mechanism of therapeutic resistance
3. Tumor Metabolism:
- Metabolic reprogramming in cancer cells
- Links between metabolism and immune response
- Metabolic targeting in oncology
4. Tumor Immunology:
- Activation of clinically relevant anticancer immune response
- Immunogenicity of chemotherapy and radiotherapy
- Mechanisms of immunosuppression in tumor microenvironment
Fundamental Insights:
- Links between adaptive stress responses in cancer cells and activation of immune response in the context of chemotherapy and radiotherapy
- Definition of immunogenic cell death (ICD) and its molecular mechanisms
- Integration between autophagy, metabolism and tumor immunity
International Experiences:
- 2005-2008: PhD, University Paris Sud, France
- 2009-2011: Post-doc, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
- 2012-2016: Junior Scientist, Cordeliers Research Center, Paris, France
- 2017-2024: Assistant Professor, Weill Cornell Medical College, New York, USA
- 2024-present: Associate Professor, Fox Chase Cancer Center, Philadelphia, USA
Multiple Academic Affiliations:
- Yale School of Medicine, New Haven, CT, USA (Honorary Assistant Professor Adjunct)
- University of Ferrara, Ferrara, Italy (Faculty Member)
- University of Padova, Padova, Italy (Faculty Member)
- Sapienza University of Rome, Rome, Italy (Faculty Member)
International Roles:
- Associate Director, European Academy for Tumor Immunology (EATI)
- Founding Member, European Research Institute for Integrated Cellular Pathology (ERI-ICP)
Translational Contributions:
- Preclinical studies that informed clinical trials on immunogenic cell death
- Identification of biomarkers of immunogenicity of cancer therapies
- Development of strategies to enhance immunogenicity of chemotherapy and radiotherapy
Exceptional Scientific Output:
- Over 600 scientific articles published in international peer-reviewed journals
Scientific Recognition:
- Highly Cited Researcher nominated by Clarivate Analytics (formerly Thomson Reuters):
- 2016: Biology & Biochemistry
- 2018: Cross-Fields
- 2019: Immunology and Molecular Biology & Genetics
- 2020: Immunology and Molecular Biology & Genetics
- 2021: Immunology, Molecular Biology & Genetics and Pharmacology/Toxicity (one of only 22 scientists worldwide, all disciplines)
- 2022: Immunology, Molecular Biology & Genetics and Pharmacology/Toxicity (one of only 31 scientists worldwide)
- 2023: Immunology and Molecular Biology & Genetics
- 2024: Immunology and Molecular Biology & Genetics
- Lab Times Survey (2007-2013)
- 6th among the 30 most cited European cell biologists
- The youngest in the ranking
Editorial Activities (Editor-in-Chief):
- OncoImmunology (co-founded in 2011)
- International Review of Cell and Molecular Biology
- Methods in Cell Biology
- Molecular and Cellular Oncology (co-founded in 2013)
Other Editorial Roles:
- Cell Death and Disease
- iScience
- Pharmacological Research
- Cell Communication and Signaling
- Microbial Cell
- Cell Stress
- Aging
Impact:
- Contributions that changed understanding of immunogenic cell death mechanisms
- Definition of fundamental concepts at the interface between oncology and immunology
- Influence on development of new therapeutic strategies in immuno-oncology