Dottorato in GENETICA E BIOLOGIA MOLECOLARE

email: isabella.saggio@uniroma1.it
telefono: 06.49912870
edificio: Genetics
stanza: 3-08

Isabella Saggio Curriculum Vitae

Part I – General information
Name Isabella Saggio
Place of birth Naples
Citizenship Italian
E-mail Isabella.saggio@uniroma1.it
Spoken languages Italian, English, French, German

Part II - Education
1993 PhD Genetics and Molecular Biology Sapienza University
1988 Laurea full marks cum laude Genetics Sapienza University

Part III – Academic profile and appointments
IIIA – Academic profile

2023 – to date Full Professor of Genetics BIO/18 Sapienza University
2017 National scientific qualification Full Professor of Genetics 05/I1-BIO/18 (passed 3/3)
2017 – 2024 Visiting Professor College of Science Nanyang Technological University of Singapore
2005 – 2023 Associate Professor of Genetics BIO/18 Sapienza University
1996 – 2004 Assistant Professor of Genetics BIO/18 Sapienza University

IIIB – Academic appointments

2025 – 2026 Member of the committee for outreaching as BBCD delegate and as reference person for STAR magazine, SMFNN Faculty Sapienza University
2025 – 2026 Member of the evaluation committee for the of admission to the excellence courses, SMFNN Faculty Sapienza University
2024 – to date Member of the evaluation committee for the “Citizen Science –Guglielmo
Marconi Library” award for CNR.
2024 – to date Board Member of National PhD School in Biodiversity
2024 – 2025 SAPIExcellence evaluation Committee, Sapienza University
2024 – to date Founder and co-director of One Health Master Degree, SSAS, NBFC, Sapienza University
2023 – to date Selected senior fellow of Superior School of Advanced Studies Sapienza University
2023 – to date Nominated coordinator of the Doctoral School in Genetics and Molecular Biology Sapienza University
2022 – 2023 SAPIExcellence evaluation Committee, Sapienza University
2021 – 2023 Selected member Sc MMFFNN Faculty outreaching committee Sapienza University
2021 – to date Selected member Center for preclinical research and animal welfare Sapienza University
2019 – to date Selected member Strategic board Dept. Biology and Biotechnology Sapienza University
2019 – to date Third mission delegate Dept. Biology and Biotechnology Sapienza University
2019-2023 Vice president, delegate for internationalization Degree of Genetics and Molecular Biology Sapienza University
2017– 2023 Founder and co-director of Stem cell and genome editing in memoriam of Paolo Bianco Master Degree Sapienza University
2016 – 2022 Selected junior fellow Superior School of Advanced Studies Sapienza University
2016 – to date Promoter and coordinator Sapienza University/Nanyang Technological University of Singapore agreements (for teacher mobility, student mobility and framework agreement)
2015 – 2016 Selected member Sapienza committee for evaluation of scientific projects
2011 – 2024 Promoter and coordinator Double Degree Sapienza University with Master en Génétique Université de Paris
2008 – to date Board member PhD school in Genetics and Molecular Biology Sapienza University
2005 – to date Founder and Director Master degree of Science Journalism Sapienza University
2005 – to date Erasmus project coordinator Sapienza University/Université de Paris, >100 outgoing and incoming students

IIIC – Research appointments
2020 – to date Associate scientist CNR Institute of molecular biology and pathology
2015 – 2017 Visiting scientist Nanyang Technological University of Singapore
2010 Jan Visiting scientist as CNR fellow Pasteur Institute Paris France
2008 Sept Visiting scientist as CNR fellow Salk Institute La Jolla CA USA
2004 Jan-Feb Visiting scientist as CNR fellow Lyon Laennec University France
2003 – 2018 Associate scientist CNR Institute of molecular biology and pathology
2003 – 2010 Associate scientist and group leader San Raffaele Science Park Rome
1995 – 1996 EU postdoctoral fellow Gustave Roussy Institute Paris France
1991 – 1994 PhD fellow IRBM MSD Research Institute Rome Italy
1989 – 1990 Researcher (in 1990 with permanent position group B) National Institute of Health Rome Italy


Part IV – Funding information
IVA – Grants as PI -principal Investigator or I-investigator
2022-2026 National spoke coordinator and Sapienza spoke coordinator PNRR Campione Nazionale CN5-National Biodiversity Future Center. PI 4100000€
2022-2024 Italian Ministry of Health, Fighting doping No doping. PI 85000€
2023- 2024 Ministry of Health Singapore, National Innovation Challenge (NIC) on Active and Confident Ageing Nanoscale, Nuclear Patterning to Detect Nuclear Envelope Remodeling During Skin Cell Aging I 69600SG$
2022-2023 Pasteur Cenci Bolognetti 2020 Nuclear Envelope and Cancer, PI 40000€
2021 – 2026 AIRC IG Nuclear Envelope and telomere stability in lymphomagenesis PI 432000€
2017 – 2020 Progeria Research Foundation USA Progerias PI 150000$
2016 Telethon EG project AKTIP and progerias PI 45404€
2015 – 2018 AIRC IG Telomeric genes I 446000€
2013 – 2016 EU FP7 Marie Curie Industry-Academia IAPP Brainvectors - Gene therapy PI 38776€
2007 – 2012 EU FP7 BrainCAV -Gene therapy PI and work-package leader 227376€
2006 – 2018 Sponsoring MSD, Pfizer, Abbott, Novartis, Roche to Science communication initiatives PI avg5000€/year
2006 – 2007 MIUR PRIN Modeling and correcting organogenetic and pathogenetic skeletal processes using stem cells I 25000€
2004 – 2009 Telethon IG Stem cell disease fibrous dysplasia I 320000€
2004 MIUR 6-2000 Science communication PI 20000€
2004 – 2021 MIUR Sapienza internal annual funding PI avg 4000€/year
2002 MIUR 6-2000 Openlab PI 20milioni lire
2001 – 2002 Inter-University Biotechnology Consortium Phage vectors for gene transfer PI 200milioni lire
2000 – 2001 Pasteur Cenci Bolognetti Phage technology for the study of Adenovirus-receptor interaction PI 20milioni lire
2000 – 2001 SIGMA TAU Adenoviral vectors for gene therapy PI 400milioni lire
2000 CNR Structure-function analysis of Adenovirus penton base PI 30milioni lire

IVB – Grants to I. Saggio lab members (selection)
2023 - 2026 PNRR funded 2xRTDA positions SSD Genetics BIO/18 300000€
2021 Be for ERC When Borders Lose integrity: study of the impact of Nuclear Envelope and telomere fragility in lymphomagenesis (BLiNET) 50000€
2019 Buzzati Traverso Foundation 2019 Nuclear envelope organization and genome instability in cancer diffusion 20000€
2019 Veronesi Foundation 2019 Nuclear envelope organization and genome instability in cancer diffusion 15000€
2019 FIRC Nuclear envelope organization and genome instability in cancer diffusion 25000€
2012 Pasteur Cenci Bolognetti Telomeric genes 18600€
2012 Inter-University Biotechnology Consortium Comparative investigation of the toxicogenomic signature of adenovirus vectors 10000€
2010 Sapienza AST Gene therapy of neurodegenerative disorders 19000€

IVC - Revision of projects (selection)
2023 Poland National Science center
2020 USA-Israel Binational Science Foundation
2019 Dutch Research council
2019 Medical Research Council UK
2019 – to date Transnational research projects to accelerate diagnosis and/or explore disease progression and mechanisms of rare diseases
2017 Leonardo da Vinci EU programme
2015 – 2016 Italian Ministry of University and Research MIUR
2014 INSERM-CNRS ATIP Avenir, France
2008 – to date Association Nationale Recherche (ANR) France
2008 Université de Montpellier
2007 – 2009 Unity Through Knowledge Fund

Part V – Society memberships
2019 – 2023 Elected counselor in the board of the Italian Association of Genetics (AGI)
2000 – 2014 Member European Association of Gene and Cell Therapy (ESGCT), American Society of Gene Therapy (ASGT), American Society of Bone and Mineral Research (ASBMR)
2000 – to date Member Italian Association of Genetics (AGI), Italian Federation of Life Sciences (FISV)

Part VI - Teaching experience
VIA - National teaching – degree BIO/18-BIOS/14A

2024 – to date Science communication, Mathematics for Artificial Intelligence, Sapienza University (3CFU BIO/18)
2021 – to date Communication processes in science and medicine, Sapienza University (9CFU BIO/18)
2013 – to date Gene therapy and Neuroscience, Sapienza University (6CFU BIO/18)
2001 – 2023 Gene Therapy, Sapienza University (in English) (6CFU BIO/18)
2001 – 2013 Genetics, Sapienza University (5 to 9 CFU BIO/18)
2001 – 2005 Genetics, University of Urbino (5 to 9 CFU BIO/18)

VIB - National teaching – upskilling BIO/18

2025 Director of GLASS - Gender & Leadership in Academia - Advanced training course Sapienza University (2 CFU; 1CFU BIO/18)
2023
Director and teacher of Genome integrity and genome organization in physiology and pathology, International Winter School Sapienza University (5CFU; 2CFU BIO/18)
2023 Director and teacher of Nature and politics Advanced training course Sapienza University (2 CFU; 1CFU BIO/18)
2023
Director and teacher of Public Science and Empowerment Advanced training course Sapienza University (1CFU BIO/18)

2023 Director and teacher of Writers' week – science and literature Advanced training course Sapienza University (1CFU BIO/18)
2022 Director and teacher of Rare Diseases: Genetics, biomedicine and political challenges, International Winter School Sapienza University (5CFU; 1CFU BIO/18)
2022 Director and teacher of Science, Knowledge, Democracy and decisional processes Advanced training course Sapienza University (2CFU; 1CFU BIO/18)
2022 Director and teacher of OneHealth and Biodiversity - Governance and Geopolitical challenges Advanced training course (2CFU; 1CFU BIO/18) Sapienza University
2021 Director and teacher of Communication in science Advanced training course, Sapienza University (1CFU BIO/18)
2021
Director and teacher of Science and Democracy Advanced training course (3CFU; 2CFU BIO/18)
2021 Director and teacher of Stem Cell and Molecular Medicine, International Winter School Sapienza University (5CFU; 1CFU BIO/18)
2021 Director and teacher of Creating a journal, Advanced training course Sapienza University (3CFU; 2CFU BIO/18)
2021 Director and teacher of Public speaking Advanced training course Sapienza University (BIO/18 1CFU)
2020 Director and teacher of Molecular Medicine International Winter School Sapienza University (5CFU; 1CFU BIO/18)
2018 – to date Organizer Public speaking course PhD School Genetics and Molecular Biology Sapienza University (2CFU)
2019 Director and teacher of Molecular Medicine International Winter School Sapienza University (5CFU; 2 CFU BIO/18)
2018 – to date Genetic medicine Superior School of Advanced studies Sapienza University (3CFU BIO/18)
2017 – 2018 Models in biology Superior School of Advanced studies Sapienza University (3CFU)
2017 – 2021 The biology of stem cells and their applications Sapienza University (3CFU BIO/18)
2017– 2022 Founder, co-director and teacher of Stem cell and genome editing in memoriam of Paolo Bianco Master degree (in English) Sapienza University (60CFU; 10 CFU BIO/18)
2005 – to date Founder, director and teacher of Science Journalism Master degree Sapienza University (60CFU; 21 CFU BIO/18)

VIC- International teaching experience
2021 Lecture 3D structured illumination microscopy for studies on nuclear integrity and cancer invasion CIVIS - Project for a European Civic University
2017 – to date Mentoring and seminar activity as visiting professor Nanyang Technological University of Singapore College of Science
2011 – to date Gene Therapy Université de Paris France (1CFU BIO/18 per year)
2011 – to date Stage and thesis tutoring of >20 foreign students
2011 – to date Member of thesis committees at Master Génétique Université de Paris France

VID- Mentoring experience
2024 – to date SSAS thesis tutor
2001 – to date Thesis tutoring > 30 graduate students, >20 PhD students and >100 Master students
2001 – to date Young researcher mentoring (selection - name and current position) Y Martina Vice president Grünenthal Group London UK, G Cherubini Permanent position Achilles Therapeutics London UK, R Burla CNR permanent position Rome Italy, E Di Matteo permanent position Nuscom Rome Italy, S Del Giudice fellow CNR Naples Italy, L Astrologo Research associate University of Bern Switzerland, P Caruso Research associate University of Cambridge UK. Romina Burla, CNR scientist permanent position. Mattia la Torre, Sapienza research type A.


Part VII – Third Mission
VIIA – Science communication, outreaching and public engagement
In parallel to her scientific work, I. Saggio dedicates energy to promote the idea of keeping science an open field for the society at large. Among different initiatives, it Is to note that she founded, and directs since 2006, a Master degree of Science Journalism (www.mastersgp.it), which brings together science stakeholders including scientists, journalists, patients, and students. In 2022, in agreement with the Rector of Sapienza, Antonella Polimeni, I. Saggio registered as journalist, designed and, since then, directs the Magazine for scientific culture of Sapienza University.

2025 Saggio I, organizer and chair, Disparità di genere in accademia Symposium – SSAS, Sapienza, University of Rome
2024 Saggio I, Invited speaker for “Dialoghi di mezza estate”, “L’età, se esiste. Saremo tutti immortali?” Accademia Olimipica – Vicenza (Italy)
2024 Saggio I, curator exhibition for PNRR-NBFC “Elogio della Diversità”, Palaexpo, Rome
2024 Saggio I, chair of the session Citizen Science, Forum Nazionale della Biodiversità- PNRR-NBFC- Palermo (Italy)
2024 Saggio I, chair “Biodiversità tra ricerca e impatto”, Scuola Superiore Sant’Anna-Pisa, PNRR-NBFC (Italy)
2024 Saggio I, chair of SSAS event Le violenze di genere, Sapienza
2023
2023
2022 – to date Saggio I, scientific expert, interview for Progetto Scienza, RAI TV
Invited seminar PCTO Sapienza Fare Scienza “Aging and immortality”
Founder and director Sapienza STAR Magazine ISSN 2785-5058
2022 Invited speaker Economics Festival Trento (Italy)
2022 Invited speaker at Association for Cultural Reinascence “Aging and immmortality”, Italy
2022
Member of the scientific committee in charge of the organization of SapienzAmbiente event
2022 Invited speaker Science Festival Genova (Italy): “Forever young”
2022 Saggio I, Le parole per dirlo, RAI TV
2022 Saggio I, A cena coi telomeri RaiRadio3 Scienza; Saggio I
2021 – to date Registered journalist at the national association
2021 Saggio I. Genetics in the history of science RAI TV
2016 – to date Organizer of >30 meetings for >800 journalists, recognized as educational CFPs by the National association of journalism (ODG)
2015 – to date Founder and Director online journal Stoccolmaaroma (40,000 visitors/year)
2006 – to date Promoter and coordinator of student training agreements between Sapienza Job soul and (selection) CNR, RAI, IFO, INFN, Telethon, APRE, IGMM CNRS (Montpellier), Institut Pasteur (Paris), IFOM Cogentech (Milan), IEO (Milan), NIH (Bethesda, US)

VIIB – Articles in the press
2025 Articles related to the exhibition Elogio della diversità (2025) n>15
2024 La Repubblica Salute:
Saggio I, Arriva il Master sulla salute globale, nasce l'One health analyst
2022-to date Sapienza STARMagazine ISSN 2785-5058:
Saggio I. Editoriale Pop STARs (2024); #12; Saggio I. la scienza non veste Prada #allebasi (2024); #12;
Saggio I. Editoriale Pop STARs (2024); #11; Saggio I. la scienza non veste Prada #allebasi (2024); #11; Saggio I. ReligiosaMente starPinioni (2023); #11;
Saggio I. Editoriale Pop STARs (2023); #10; Saggio I. la scienza non veste Prada #allebasi (2023); #10;
Saggio I. Editoriale Pop STARs (2023); #9; Saggio I. la scienza non veste Prada #allebasi (2023); #9;
Saggio I. Editoriale Pop STARs (2023); #8; Saggio I. la scienza non veste Prada #allebasi (2023); #8; Saggio I. Chi giudica la scienza?Movimenti e contromovimenti starPinioni (2023); #8; Saggio I. Il CD146 di Paolo Bianco-Star System(2023); #8; Saggio I. La confusione è precisa in amore-Per saperne di più (2023); #8;
Saggio I. Editoriale Pop STARs (2023); #7; Saggio I. la scienza non veste Prada #allebasi (2023); #7; Saggio I. sui gener* starPinioni (2023); #7;
Saggio I. Editoriale Pop STARs (2022); #6;
Saggio I. Editoriale Pop STARs (2022); #4-5; Saggio I. no beach no party? starPinioni (2022); #4-5;
Saggio I. Editoriale Pop STARs (2022); #3;
Saggio I. Editoriale Pop STARs (2022); #2;
Saggio I. Editoriale Pop STARs (2021); #1
2012 Saggio I, Ce l’ho nel Dna La Stampa
2012 - 2016 Longitude Italian Monthly on World Affairs:
Saggio I. Intimations of immortality (2016); #63; Saggio I. Ebola: What is to be done? (2014); #43; Saggio I. Keeping resistance at bay. (2013); #27; Saggio I. Deadly friends. (2012) #06

VIIC – Transfer of technology, patents
Saggio I, Di Giovine M, Salone B, Martina Y. Chimeric vectors and their use for gene transfer. Granted Italian and international patent (2002; WO 02/24934)
Laufer R, Saggio I, Gloaguen I, Di Marco A, Demartis A. Variants of human ciliary neurotrophic factor (hCNTF) with improved receptor-selectivity, and methodology for their selection. Granted Italian and international patent. (1998; WO 98/41625)
Ciliberto G, Saggio I, Savino R, Perricaudet M. Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity over hIL-6. Pharmaceutical compositions there with and their uses. Granted Italian and international patent. (1998; WO 98/13383)
Laufer R, Saggio I. Variants of human ciliary neurotrophic factor (hCNTF) with improved receptor binding affinity. Granted Italian patent. (1994; n. 012878094)
Laufer R, Saggio I. Method for production of Filamentous phages displaying on the surface of the capsids peptides capable of binding biotin, and Filamentous phages and peptides thus obtained. Granted Italian patent. (1993; n. 1261693)

PART VIII – Scientific activities

VIIIA – Research activity
Gene and stem cell therapy During the association with the laboratories of San Raffaele Science Park, I. Saggio has been involved in the study of stem cells and contributed to unravel the characterization of stem cell progenitors as organizers of the hematopoietic microenvironment (Sacchetti et al Cell 2007; Sacchetti et al Stem cell reports 2016). In addition, I. Saggio laboratory has experience in vectors for gene and cell therapies, including lentiviral, adenoviral and humanized phages (patented WO 02/24934). I. Saggio developed growth factor antagonists and expressed them with adenoviral vectors as proof of principle studies of disease customized gene therapy (Saggio et al Gene therapy 1997; Di Marco et al PNAS 1996; and patent on viral vectors WO 98/13383).

Telomeres and mechanogenetics
I. Saggio identified the first human telomere-associated factor linked with the nuclear envelope. Telomere dysfunction causes genome instability and is a driver of cancer and premature aging (Burla et al Plos Genetics 2015; Cenci et al Plos Genetics 2015; Burla et al Open Biology 2016; La Torre et al Aging Cell 2018, Chen et al. Cell Reports 2019). More recently, building on the link between telomeres and the nuclear envelope, I. Saggio developed new research focusing on the implication of nuclear integrity in aging and cancer. The model systems used by I. Saggio are primarily mammalian cells and mice. In addition, comparative studies were performed in D. melanogaster. Research by I. Saggio and the work of her group have been recognized internationally and she has been funded, as PI, based on open competition and peer reviewing, by national and international agencies, including, in the last 5 years, Telethon, the Progeria Research Foundation USA and AIRC. In a trans-kingdom perspective, our most recent program focuses on a comparative study in plants and mammals to identify common and possibly transplantable telomere-associated genes controlling aging and life-span.

VIIIB – Papers (IF publication year)


1.Mitra A, Cutiongco MFA, Burla R , Zeng Y, Qin N , Kong M, Vinod B, Nai MHB, Hübner B, Ludwig A, Lim CT, Shivashankar GV, Saggio I, Zhao W (2025). Acute chromatin decompaction stiffens the nucleus as revealed by nanopillar-induced nuclear deformation in cells. PNAS (accepted for publication).

2.Di Pietro E, La Torre M, Burla R, Dello Ioio R, Saggio I: Telomers: an organized string linking plants and mammals (2024). Biology Direct. 19(1), 119. IF 5.7.

3.La Torre M, Burla R, Saggio I: Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery. (2024). Cells. 13(15), 1307. IF 5.1.

4.Biodiversity and Planetary Health: A Call for Integrated Action. (2024) Cena H, Labra M, et al. and Saggio I. The Lancet. 403(10440): 1985-1986. IF 168.9

5.La Torre M; Centofante E; Nicoletti C; Burla R; Giampietro A; Cannistrà F; Schirone L; Valenti V; Sciarretta S; Musarò A; Saggio I (2023). Impact of diffused vs vasculature trageted DNA damage on the heart of mice depleted for telomeric factor Ft1. Aging Cell 22(12): e14022. IF 11.05

6.La Torre M; Merigliano C; Maccaroni K; Chojnowski A; Goh WI; Giubettini M; Vernì F; Capanni C; Rhodes D; Wright G; Burke B; Soddu S; Burla R; Saggio I (2022). Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP. Journal of Experimental & Clinical Cancer Research. IF 12.658

7.Zeng Y, Zhuang Y, Vinod B, Guo X, Mitra A, Chen P, Saggio I, Shivashankar GV, Gao W, and Zhao W (2022). Guiding Irregular Nuclear Morphology on Nanopillar Arrays for Malignancy Differentiation in Tumor Cells. Nanoletters, https://doi.org/10.1021/acs.nanolett.2c01849. IF 11.38

8.Maccaroni K, La Torre M, Burla R and Saggio I (2022). Phase Separation in the Nucleus and at the Nuclear Periphery during Post‐Mitotic Nuclear Envelope Reformation. Cells, 11, 1749. IF 6.6

9.Riminucci M, Palmisano B, Labella R, Donsante S, Remoli C, Spica E, Coletta I, Farinacci G, Dello Spedale Venti M, Saggio I, Serafini M, Robey P, and Corsi A. (2022) GsαR201C and estrogen reveal different subsets of bone marrow adiponectin expressing osteogenic cells. Bone Research. IF: 13.567

10.Merigliano C, Burla R, La Torre M, Del Giudice S, Teo Hsiang L, Chong Wai L, Chojnowski A, Goh WI, Olmos Y, Maccaroni K, Giubettini M, Chiolo I, Carlton J, Raimondo D, Verni F, Stewart CL, Rhodes D, Wright G, Burke B and Saggio I (2021) Human AKTIP interacts with ESCRT proteins and functions at the midbody in cytokinesis. Plos Genetics. 17(8):e1009757. IF: 5.917

11.Burla R, La Torre M, Maccaroni K, Verni F, Giunta S and Saggio I (2020). Interplay of the nuclear envelope with chromatin in physiology and pathology. Nucleus. Dec11(1):205-218. IF:2.792

12.Chen L, Roakel CM, Galati A, Bavasso F, Saggio I, Schoeftner S, Cacchione S, Gatti M, Artandi SE, Raffa GD (2020) Loss of human TGS1 hypermethylase promotes increased telomerase RNA and telomere elongation. Cell Reports. 30(5):1358-1372. IF: 8.109

13.Raimondo D, Remoli C, Astrologo L, Burla R, La Torre M, Vernì F, Tagliafico E, Corsi A, Del Giudice S, Persichetti A, Giannicola G, Robey PG, Riminucci R and Saggio I (2020) Changes in gene expression in human skeletal stem cells transduced with constitutively active Gsα correlates with hallmark histopathological changes seen in fibrous dysplastic bone. Plos One. 15(1):e0227279. IF:2.74

14.Sechi S, Frappaolo A, Karimpour-Ghahnavieh A, Gottardo M, Burla R, Di Francesco L, Szafer-Glusman E, Schininà E, Fuller M T, Saggio I, Riparbelli M G, Callaini G, and Giansanti M G (2019) Drosophila Doublefault protein coordinates multiple events during male meiosis by controlling mRNA translation. Development. 146(22). IF: 5.611

15.Mascolo E, Barile A, Stufera Mecarelli L, Amoroso N, Merigliano C, Massimi A, Saggio I Hansen T, Tramonti A, Di Salvo ML, Barbetti F, Contestabile R and Vernì F (2019) The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity. Scientific Reports. 9(1):14188. IF: 3.998

16.Mascolo E, Amoroso N, Saggio I, Merigliano C, Vernì F (2019) Pyridoxine/pyridoxamine 5’-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila. J. Cell. Physiology. 235(1):504-512. IF: 5.546
17.Merigliano C, Mascolo E, Cesta A, Saggio I, Vernì F (2019) A new role for Drosophila Aurora-A in maintaining chromosome integrity. Chromosoma, 128(1):41-52. IF: 3.442

18.del Rio D, Beucher B, Lavigne M, Wehbi A, Saggio I & Kremer EJ (2019) CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems. Frontiers in molecular neuroscience, 12:71. IF: 4.057

19.Saggio I (2019) Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia. Stem cells translational medicine 8(2):110-111. IF: 6.429
20.Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F and Saggio I (2018) p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics 9:581. IF: 3.517

21.Merigliano C, Mascolo E, Burla R, Saggio I and Vernì F (2018) The relationship between Vitamin B6, diabetes and cancer. Frontiers in Genetics 9(SEP):388. IF: 3.517

22.Merigliano C, Mascolo E, La Torre M, Saggio I and Vernì F (2018) Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes. Scientific Reports 8(1):11432. IF: 4.011

23.Burla R, La Torre M, Merigliano C, Verni F and Saggio I (2018). Genomic instability and DNA replication defects in progeroid syndromes. Nucleus 9(1):368-379. IF: 2.157

24.La Torre M, Burla R, Merigliano C et al. (2018). Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits. Aging cell 17(4):e12730. IF: 7.346

25.Mestre-Francés N, Serratrice N, Gennetier A, Devau G, Cobo S, Trouche S, Fontes P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet FKJD, Dusonchet J,
Schneider B, Saggio I, Kalatzis V, Luquin-Piudo MRJ, Verdier M, and Kremer 
EJ (2018) Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate. JCI Insight 3(14):98202. IF: 6.014

26.Burla R, La Torre M, Saggio I (2016) Mammalian telomeres and their partnership with lamins. Nucleus 7(2):187-202. IF: 2.387

27.Burla R, Carcuro MT, La Torre M, Fratini F, Crescenzi M, D’Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio AM, Gatti M, Saggio I (2016) The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open Biology 6(8):160103. IF: 3.481

28.Sacchetti B, Funari A, Remoli C, Giannicola G, Robey PG, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E, Saggio I, Riminucci M, Bianco P. (2016) No identical "mesenchymal stem cells" at different times and sites: Human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels. Stem cell reports 6(6):897-913. IF: 7.338

29.Simão D, Pinto C, Fernandes P, Peddie CJ, Piersanti S, Collinson LM, Salinas S, Saggio I, Schiavo G, Kremer EJ, Brito C, Alves PM. (2016) Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model. Gene therapy 23(1):86–94. IF: 3.11

30.Cenci G, Ciapponi L, Marzullo M, Raffa GD, Morciano P, Raimondo D, Burla R, Saggio I and Gatti M (2015) The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres. Plos Genetics 11(6):e1005260. IF: 6.661

31.Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, la Torre M, Micheli M, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M and Saggio I (2015) AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance. Plos Genetics 11(6):e1005167. IF: 6.661

32.Piersanti S, Burla R, Licursi V, Brito C, la Torre, M, Alves P, Simao D, Mottini C, Salinas S, Negri R, Tagliafico E, Kremer EJ and Saggio I (2015) Transcriptional response of human neurospheres to helper-dependent CAV-2 vectors: activation of DNA damage response, modulation of microtubule motors and centromeric proteins. Plos One 10(7):e0133607. IF: 3.057

33.Remoli C, Michienzi S, Sacchetti B, Di Consiglio A, Cersosimo S, Spica S, Robey PG, Holmbeck K, Cumano A, Boyde A, Davis G, Saggio I, Riminucci M, and Bianco P (2015) Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse. Journal of Bone and Mineral Research 30(6):1030-1043.

34.Simão D, Pinto C, Piersanti S, Weston A, Peddie CJ, Bastos AEP, Licursi V, Schwarz SC, Collinson LM, Salinas S, Serra M, Teixeira AP, Saggio I, Lima PA, Kremer EJ, Schiavo G, Brito C, Alves PM (2015) Modeling human neural functionality in vitro: 3D culture for dopaminergic differentiation. Tissue Engineering-Part A 21(3-4):654-668. IF: 3.892

35.Saggio I, Remoli C, Spica E, Cersosimo S, Sacchetti B, Robey PJ, Holmbeck K, Cumano A, Boyde A, Bianco P, Riminucci M (2014) Constitutive Expression of GsαR201C in Mice Produces a Heritable, Direct Replica of Human Fibrous Dysplasia Bone Pathology and Demonstrates Its Natural History. Journal of Bone and Mineral Research 29(11S1):2357-2368. IF: 6.832

36.Piersanti S, Tagliafico E, Saggio I (2014) DNA microarray to analyze Adenovirus-host interactions. Methods in Molecular Biology Humana Press 1089:89-104. IF: n/a

37.Cossetti C, Lugini L, Astrologo L, Saggio I, Fais S and Spadafora C (2014) Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes. Plos One 9(7):e101629. IF: 3.234

38.Piersanti S, Astrologo L, Licursi V, Costa R, Roncaglia E, Gennetier A, Ibanes S, Chillon M, Negri R, Tagliafico, Kremer EJ, Saggio I (2013) Differentiated neuroprogenitor cells incubated with human or canine adenovirus, or lentiviral vectors have distinct transcriptome profiles. Plos One 8(7):e69808. IF: 3.534

39.Soldati C, Cacci E, Biagioni S, Carucci N, Lupo G, Perrone-Capano C, Saggio I, Augusti-Tocco G (2012) Restriction of neural precursor ability to respond to Nurr1 by early regional specification. Plos One 7(12):e51798. IF: 3.73

40.Khalaj-Kondori M, Sadeghizadeh M, Behmanesh M, Saggio I, Monaci P (2011) Chemical coupling as a potent strategy for preparation of targeted bacteriophage-derived gene nanocarriers into eukaryotic cells. Journal of Gene Medicine 13(11):622-631. IF: 2.483

41.Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, et al. (2011) The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Research 39(13):5459-5473. IF:8.026

42.Riminucci M, Robey PG, Saggio I, Bianco P (2010) Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells. Journal of Molecular Endocrinology 45(6):355-364. IF: 3.628

43.Piersanti S, Remoli C, Saggio I, Funari A, Michienzi S, et al. (2010) Transfer, Analysis, and Reversion of the Fibrous Dysplasia Cellular Phenotype in Human Skeletal Progenitors. Journal of Bone and Mineral Research 25(5):1103-1116 IF: 7.059

44.Bianco P, Robey PG, Saggio I, Riminucci M (2010) "Mesenchymal'' Stem Cells in Human Bone Marrow (Skeletal Stem Cells): A Critical Discussion of Their Nature, Identity, and Significance in Incurable Skeletal Disease. Human Gene Therapy 21(9):1057-1066. IF: 4.829

45.Caruso P, Burla R, Piersanti S, Cherubini G, Remoli C, et al. (2009) Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells. Virology 385(2):343-350 IF: 3.042

46.Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, et al. (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131(2):324-336. IF: 29.887

47.Martina Y, Avitabile D, Piersanti S, Cherubini G, Saggio I (2007) Different modulation of cellular transcription by adenovirus 5, Delta E1/E3 adenovirus and helper-dependent vectors. Virus Research 130(1-2):71-84. IF: 2.81

48.Benihoud K, Esselin S, Descamps D, Jullienne B, Salone B, et al. (2007) Respective roles of TNF-alpha and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice. Gene Therapy 14(16):533-544. IF: 4.812

49.Riminucci M, Saggio I, Robey PG, Bianco P (2006) Fibrous dysplasia as a stem cell disease. Journal of Bone and Mineral Research 22(SUPPL.2): 125-131. IF: 6.635

50.Piersanti S, Sacchetti B, Funari A, Di Cesare S, Bonci D, et al. (2006) Lentiviral transduction of human postnatal skeletal (stromal, mesenchymal) stem cells: In vivo transplantation and gene silencing. Calcified Tissue International 78(6):372-384. IF: 2.483

51.Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, et al. (2006) E1B55K-deleted adenovirus (ONYX-015) overrides G(1)/S and G(2)/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells. Cell Cycle 5(19):2244-2252. IF: 3.214

52.Campo S, Serlupi-Crescenzi O, Arseni B, Rossi S, Saggio I, et al. (2005) Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma. Cytokine 31(5):368-374. IF: 2.012

53.Piersanti S, Martina Y, Cherubini G, Avitabile D, Saggio I (2004) Use of DNA microarrays to monitor host response to virus and virus-derived gene therapy vectors. Am J Pharmacogenomics 4(6):345-356. IF: n/a

54.Piersanti S, Cherubini G, Martina Y, Salone B, Avitabile D, et al. (2004) Mammalian cell transduction and internalization properties of lambda phages displaying the full-length adenoviral penton base or its central domain. Journal of Molecular Medicine 82(7):467-476. IF: 4.256

55.Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, et al. (2003) Integrin alpha 3 beta 1 is an alternative cellular receptor for adenovirus serotype 5. Journal of Virology 77(24):13448-13454. IF: 5.225

56.Di Giovine M, Salone B, Martina Y, Amati V, Zambruno G, et al. (2001) Binding properties, cell delivery, and gene transfer of adenoviral penton base displaying bacteriophage. Virology 282(1):102-112. IF: 3.27

57.Benihoud K, Salone B, Esselin S, Opolon P, Poli V, et al. (2000) The role of IL-6 in the inflammatory and humoral response to adenoviral vectors. Journal of Gene Medicine 2(3):194-203. IF: 3.103

58.Benihoud K, Saggio I, Opolon P, Salone B, Amiot F, et al. (1998) Efficient, repeated adenovirus-mediated gene transfer in mice lacking both tumor necrosis factor alpha and lymphotoxin alpha. Journal of Virology 72(12):9514-9525. IF: 5.828

59.Saggio I, Ciapponi L, Savino R, Ciliberto G, Perricaudet M (1997) Adenovirus-mediated gene transfer of a human IL-6 antagonist. Gene Therapy 4(8):839-845. IF: 5.996

60.Di Marco A, Gloaguen I, Demartis A, Saggio I, Graziani R, et al. (1997) Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor. Journal of Biological Chemistry 272(37):23069-23075. IF: 6.963

61.Di Marco A, Gloaguen I, Graziani R, Paonessa G, Saggio I, et al. (1996) Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. Proc Natl Acad Sci U S A 97(17):9247-9252. IF: 10.244

62.Saggio I, Gloaguen I, Poiana G, Laufer R (1995) CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction. Embo Journal 14(13):3045-3054. IF: 13.505

63.Saggio I, Gloaguen I, Laufer R (1995) Functional phage display of ciliary neurotrophic factor. Gene 152(1):35-39. IF: 2.16

64.Saggio I, Paonessa G, Gloaguen I, Graziani R, Deserio A, et al. (1994) Nonradioactive receptor binding assay for ciliary neurotrophic factor. Analytical Biochemistry 221(2):387-391. IF: 2.313

65.Saggio I, Laufer R (1993) Biotin binders selected from a random peptide library expressed on phage. Biochemical Journal 293(3):613-616. IF: 3.579

66.Saggio I, Laufer R (1993) Detection of biotinylated molecules in solid-phase assays using a recombinant biotin-binding bacteriophage. Analytical Biochemistry 214(1):352-355. IF: 2.313


VIIIC - Books and book chapters
Saggio I e Lingiardi V. One Health – Pensare le emergenze del pianeta. (2025). Editor il Saggiatore (Mi). ISBN 978-88-4283-565-3
Saggio I. Rufo F. Elogio della diversità (In Praise of Diversity). (2024) Editor Sillabe (Li) ISBN 978-88-3340-495-0, SBN RMB0826510
Saggio I. Longevità (Longevity). (2024) Editor RCS Media Group (Mi) ISSN 1827-97080
Saggio I. L'eta' se esiste (Aging. If it exists). (2022) Editor Il Mulino ISBN 9788815259637
Saggio I. In Genetica, Terapia genica (2014) Casa Editrice Ambrosiana Rozzano (Mi) 550-559
Saggio I. Terapia genica. I virus usati per curare (2008) Enciclopedia medica 52-58.
Saggio I. Targeting bacteriophage vectors. (2002) In Vector targeting for therapeutic gene delivery. Edited by Curiel DT and Douglas JT Published by Wiley, New York. 20: 429-456.

VIIID - Board of editors/ reviewer in scientific journals
2020 – to date Cells, editor
2018 – to date PLOS One, editor
2018 – to date Nucleus, reviewer
2018 Stem cell translational medicine, reviewer
2017 Molecular therapy, reviewer
2016 – to date BMC Medical Genomics, reviewer
2014 – to date Stem Cell Research, reviewer
2009 Experimental Cell Research, reviewer

VIIE – Speaker at conferences and invited seminars (selection)
2024 Talk Embo meeting Nuclear Mechano/genomics
2023 Invited talk National Biodiversity Future Center meeting, Rome It
2023 Invited talk National AIOL meeting University Federico II Naples It
2022 Invited talk Sapienza BBCD site visit, Rome It
2019 Talk Science communication TIGEM Naples It
2019 Talk Laminopathy meeting London UK
2019 Seminar Mechanobiology Institute NUS Singapore
2019 Seminar Nanyang Technological University College of Science Singapore
2018 Talk Progeria research Foundation Boston USA
2018 Talk Italian laminopathy meeting Bologna It
2018 Talk Telomere Embo meeting Singapore
2018 Seminar Nanyang Technological University College of Science Singapore
2017 Talk Telomere CSH Cold Spring Harbor NY USA
2017 Talk FISV Rome It
2017 Talk Italian laminopathy meeting Bologna It
2017 Talk p53 international meeting Singapore
2016 Talk Nuclear organization and function CSH Cold Spring Harbor NY USA
2016 Talk Telethon Skelethon convention Rome It


Part IX – Bibliometrics
Total scientific articles 65 (Scopus)
Total citations 4049 (Scopus)
Total H index 27 (Scopus)