ISABEL BEATRICE MARC

Dottoressa di ricerca

ciclo: XXXVI


supervisore: Emiliano Brunamonti

Titolo della tesi: Cognitive Control Dynamics: A complex interplay of cognitive variables in actions.

In the present study, we focused on response inhibition as a fundamental aspect of cognitive control, emphasizing its significance in dynamic environments and ensuring goal-directed behaviors. The "Stop Signal Task" (SST) is introduced as a behavioral paradigm for investigating inhibitory control, with a detailed description of its execution and outcomes. Subsequently, the "horse race" model is presented, offering a conceptual framework to understand SST paradigm results. The model highlights the dynamic competition between response initiation and response inhibition, underscoring the temporal independence of these processes, crucial for accurately estimating the "Stop Signal Reaction Time" (SSRT). In the first experiment, we explored motor control in a context requiring the selective inhibition of an effector which movement started paired with a second effector. In this experiment, we modeled a situation where acting a motor decision corresponding to stopping or continuing a prepared movement could be linked to the foreknowledge of the effector involved to be recruited in the movement. The distinction between non-selective and selective stopping contexts emphasized the complexity of selective inhibitory responses in a multi-component context. The motor stage of this decision process underscores how selective inhibitory responses involve the specific suppression of components of a multi-component action. In a second study, we investigated the selective control of movements by manipulating the degree of difficulty in interpreting a perceptual stimulus as informative for executing or canceling prepared actions. In our manipulation, the degree of difficulty was manipulated by cognitive variables involving engaging a numerical comparison, rather than the comparison between perceptual characteristics of the stimuli as in previous experiments. The results of this study show the influence of cognitive variables on motor decision processes. By behavioral neurophysiology experiment, we further analyzed the neuronal correlates of this form of decision-making. In this third study, attention was focused on the activity of the dorsal premotor cortex, a brain area supporting motor decision both by selecting the appropriate motor action depending on contextual demands and which activity has been observed to be modulated by cognitive variables. In this study, we focused on the modulation of different frequency bands of neural activity in response to varying task difficulty, modulated by cognitive operations, within a computational framework focused on processing incoming information for decision-making. Overall, here we explored a framework for understanding cognitive control, examining both motor and cognitive aspects through behavioral paradigms and neural studies. It contributes to the understanding of the underlying dynamics of cognitive control and inhibitory responses.

Produzione scientifica

11573/1667826 - 2024 - Response preparation affects cognitive motor control
Andujar, Marta; Marc, Isabel Beatrice; Giuffrida, Valentina; Ferraina, Stefano; Brunamonti, Emiliano; Pani, Pierpaolo - 01a Articolo in rivista
rivista: HUMAN FACTORS (SAGE PUBLICATIONS INC, 2455 TELLER RD, THOUSAND OAKS, USA, CA, 91320 - HUMAN FACTORS SOC, BOX 1369, SANTA MONICA, USA, CA, 90406. - Pergamon Press. Luogo pubbl. New York .) pp. 975-986 - issn: 0018-7208 - wos: WOS:000867348400001 (2) - scopus: 2-s2.0-85139822743 (2)

11573/1714588 - 2024 - The role of COMT Val158Met Polymorphism impacts the performance in solving transitive inference problems
Paul, Ann; Marc, Isabel Beatrice; Canterini, Sonia; Fiorenza, Maria Teresa; Ferraina, Stefano; Pani, Pierpaolo; Brunamonti, Emiliano - 04f Poster
congresso: FENS Forum 2024 (Vienna, Austria)
libro: FENS Forum 2024 (Vienna, Austria) - ()

11573/1727438 - 2024 - Force monitoring reveals single trial dynamics of motor control in a stop signal task
Ramawat, Surabhi; Marc, Isabel B.; Di Bello, Fabio; Bardella, Giampiero; Ferraina, Stefano; Pani, Pierpaolo; Brunamonti, Emiliano - 01a Articolo in rivista
rivista: PHYSIOLOGICAL REPORTS () pp. - - issn: 2051-817X - wos: (0) - scopus: 2-s2.0-85210010501 (0)

11573/1692650 - 2023 - Inhibitory cortical control in healthy subjects: modulation of beta and gamma oscillations in frontal cortical areas
Falletti, Marco; Marc, Isabel Beatrice; D’Onofrio, Valentina; Asci, Francesco; Ferraina, Stefano; Suppa, Antonio - 04f Poster
congresso: 67° Congresso Nazionale Società Italiana di Neurofisiologia Clinica (Bergamo)
libro: 67 SINC abstracts - ()

11573/1679366 - 2023 - Reward prospect affects strategic adjustments in stop signal task
Giuffrida, V.; Marc, I. B.; Ramawat, S.; Fontana, R.; Fiori, L.; Bardella, G.; Fagioli, S.; Ferraina, S.; Brunamonti, E.; Pani, P. - 01a Articolo in rivista
rivista: FRONTIERS IN PSYCHOLOGY (Lausanne: Frontiers Editorial) pp. 1125066- - issn: 1664-1078 - wos: WOS:000961217800001 (2) - scopus: 2-s2.0-85152585440 (2)

11573/1682600 - 2023 - Functional network complexity reflects diverse reward contexts in macaque premotor cortex
Giuffrida, Valentina; Bardella, Giampiero; Ramawat, Surabhi; Marc, Isabel Beatrice; Fontana, Roberto; Brunamonti, Emiliano; Pani, Pierpaolo; Ferraina, Stefano - 04f Poster
congresso: Human Brain Project - Summit 2023 (Marisiglia - Francia)
libro: Human Brain Project - Summit 2023 - ()

11573/1692658 - 2023 - Neuronal population dynamics and network organizations reflect motivational context in monkey premotor cortex during movement execution and inhibition
Giuffrida, Valentina; Marc, Isabel Beatrice; Bardella, Giampiero; Ramawat, Surabhi; Fontana, Roberto; Brunamonti, Emiliano; Pani, Pierpaolo; Ferraina, Stefano - 04f Poster
congresso: NEUROSCIENCE ANNUAL MEETING 2023 (Washington, DC)
libro: Neuroscience 2023 abstracts - ()

11573/1692645 - 2023 - Local field potentials in macaque dorsal premotor cortex are modulated by the manipulation of acquired ordinal information in a transitive inference task
Marc, I. B.; Giuffrida, V.; Ramawat, S.; Andujar, M.; Bardella, G.; Pani, P.; Ferraina, S.; Brunamonti, E. - 04f Poster
congresso: NEUROSCIENCE ANNUAL MEETING 2023 (Washington, DC)
libro: Neuroscience 2023 abstracts - ()

11573/1692647 - 2023 - Motor decision is influenced by the difficulty of solving a numerical comparison in a selective stop signal task
Marc, I.; Segreti, M.; Giuffrida, V.; Ramawat, S.; Paul, Ann; Bardella, G.; Pani, P.; Ferraina, S.; Brunamonti, E. - 04f Poster
congresso: NEUROSCIENCE ANNUAL MEETING 2023 (Washington, DC)
libro: Neuroscience 2023 abstracts - ()

11573/1682738 - 2023 - The premises of a transitive inference task modulate the synchrony of local field potentials in macaque dorsal premoto rcortex
Marc, Isabel Beatrice; Bardella, Giampiero; Giuffrida, Valentina; Ramawat, Surabhi; Pani, Pierpaolo; Ferraina, Stefano; Brunamonti, Emiliano - 04f Poster
congresso: 13th Primate Neurobiology Meeting 2023 (Goettingen; Germany)
libro: The premises of a transitive inference task modulate the synchrony of local field potentials in macaque dorsal premotor cortex - ()

11573/1669953 - 2023 - Restart errors reaction time of a two-step inhibition process account for the violation of the race model’s independence in multi-effector selective stop signal task
Marc, Isabel Beatrice; Giuffrida, Valentina; Ramawat, Surabhi; Fiori, Lorenzo; Fontana, Roberto; Bardella, Giampiero; Fagioli, Sabrina; Ferraina, Stefano; Pani, Pierpaolo; Brunamonti, Emiliano - 01a Articolo in rivista
rivista: FRONTIERS IN HUMAN NEUROSCIENCE (Lausanne : Frontiers Research Foundation) pp. - - issn: 1662-5161 - wos: WOS:000937342100001 (2) - scopus: 2-s2.0-85148654336 (2)

11573/1681947 - 2023 - The transitive inference task to study the neuronal correlates of memory-driven decision making: a monkey neurophysiology perspective
Ramawat, Surabhi; Marc, Isabel Beatrice; Ceccarelli, Francesco; Ferrucci, Lorenzo; Bardella, Giampiero; Ferraina, Stefano; Pani, Pierpaolo; Brunamonti, Emiliano - 01a Articolo in rivista
rivista: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 105258- - issn: 0149-7634 - wos: WOS:001019059200001 (2) - scopus: 2-s2.0-85161351209 (2)

11573/1682673 - 2022 - Motor inhibition parameters are reflected in the kinetic and kinematic of gait initiation in a step version of the Stop Signal Task
Fiori, L.; Marc, I. B.; Ramawat, S.; Tatarelli, A.; Varrecchia, T.; Chini, G.; Ranavolo, A.; Draicchio, F.; Pani, P.; Ferraina, S.; Brunamonti, E. - 01h Abstract in rivista
rivista: GAIT & POSTURE (editore attuale: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. 9- - issn: 0966-6362 - wos: (0) - scopus: (0)

11573/1621825 - 2021 - Stable and dynamic response population coding in prefrontal cortex
Ceccarelli, Francesco; Londei, F.; Dibello, F.; Ramawat, S.; Marc, I. B.; Brunamonti, E.; Genovesio, A. - 04d Abstract in atti di convegno
congresso: 71st SIF National Congress The Italian Society of Physiology (Milan (Online))
libro: 71st SIF National Congress - ()

11573/1621821 - 2021 - Forcing the winning horse: how the amount of force on a push button affects the inhibition of finger release in a stop signal task
Colangeli, S.; Ramawat, S.; Marc, I. B.; Pani, P.; Ferraina, S.; Brunamonti, E - 04d Abstract in atti di convegno
congresso: Neuroscience 2021 50th Annual Meeting (Chicago(Online))
libro: Neuroscience 2021 50th Annual Meeting - ()

11573/1621826 - 2021 - Formation of cell assemblies in the prefrontal cortex of macaque monkeys during a distance and a temporal discrimination task
Londei, Fabrizio; Ceccarelli, F.; Ferrucci, L.; Ramawat, S.; Marc, I. B.; Russo, E.; Genovesio, A. - 04d Abstract in atti di convegno
congresso: 71st SIF National Congress (Milano (Online))
libro: 71st SIF National Congress - ()

11573/1621811 - 2021 - Failure of the race model accounting for inhibition in a stop signal selective task of upper and lower limb
Marc, I. B.; Romano, V.; Ramawat, S.; Fiori, L.; Andujar, M.; Londei, F.; Ceccarelli, F.; Ferraina, S.; Brunamonti, E. - 04f Poster
congresso: 71st SIF National Congress (Milano (Online))
libro: 71st SIF National Congress - ()

11573/1621813 - 2021 - Differences in task-difficulty encoding during logical decision-making in prefrontal and premotor cortical activity from non-human primates
Ramawat, S.; Marc, I. B.; Andujar, M.; Ceccarelli, F.; Londei, F.; Pani, P.; Genovesio, A.; Ferraina, S.; Brunamonti, E. - 04f Poster
congresso: 71st SIF National Congress The Italian Society of Physiology (Milan (Online))
libro: 71st SIF National Congress - ()

11573/1551925 - 2021 - Mental representation of autobiographical memories along the sagittal mental timeline: evidence from spatiotemporal interference
Teghil, A.; Marc, I. B.; Boccia, M. - 01a Articolo in rivista
rivista: PSYCHONOMIC BULLETIN & REVIEW (Psychonomic Society Publications:1710 Fortview Road:Austin, TX 78704:(512)462-2442, INTERNET: http://www.psychonomic.org, Fax: (512)462-1101) pp. 1327-1335 - issn: 1069-9384 - wos: WOS:000634637100001 (12) - scopus: 2-s2.0-85103432057 (13)

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