Hongzhe SUN

Full professor

email: hsun@hku.hk
phone: +852 28189743
building: CYM Chemistry Building
room: Rm304

10/1993~ 09/1996: Ph.D., Chemistry, The University of London (Birkbeck College), Great Britain

• 08/2018- : Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, The University of Hong Kong
• 05/2018- : Chair Professor, Department of Chemistry, The University of Hong Kong

Bioinorganic chemistry of bismuth (and arsenic)
Metalloproteomics and systems biology
Medicinal chemistry (metals in medicine)

• UC Berkeley Earl L Muetterties Memorial Lectureship 2017-2018
• WuXi AppTech Life Science & Chemistry Research Award 2016
• Fellow of the Royal Society of Chemistry (FRSC) 2011-
• Croucher Senior Research Fellowship, Croucher Foundation 2010-2011

•Series Editor, Metallobiology (2010-, the Royal Society of Chemistry, UK)
•Editorial Board of Metallomics (the Royal Society of Chemistry; 2008-2014), Journal of Inorganic Biochemistry (Elsevier, 2012-), BioMetals (Springer, 2017-), Chinese Journal of Magnetic Resonance (2007-)
•Editorial Advisory Board of The Journal of Biological Inorganic Chemistry (Springer, 2007-2010; 2015-2018) and The Open Medicinal Chemistry Journal (Bentham Science Publisher)
•Guest editor: Special issue on ‘Metallomics in China’ (July issue of Metallomics, 2013)

(Total citation (Scopus): 9216; H-index: 49; >180 publications including PNAS (3), Nature Commun (1), Angew Chem/JACS (10), JBC (5))
(1) Li H.Y., Wang R.M., Sun H.Z.* (2018) “Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond Helicobacter pylori infection” Accounts of Chemical Research, doi: 10.1021/acs.accounts.8b00439
(2) Han B.J., Xia W., Wang Y.L, Li H.Y., Wang Y.C.*, Sun H.Z.* (2018) “Multi-omics and temporal dynamics profiling reveals disrupted central metabolism in Helicobacter pylori on bismuth treatment” Chemical Science, 9(38), 7488-7497. (Chemical Science 2018 HOT article, highlighted in ChemistryWorld 2018, September issue, 44-45)
(3) Wang R.M., Lai T.P., Gao P., Zhang H.M., Ho P.L, Ma G.X., Woo P.C.Y., Kao Y.T., Li H.Y., Sun H.Z.* (2018) “Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors”, Nature Communications, 9(1), 439. doi: 10.1038/s41467-018-02828-6. (IF: 12)
(4) Yang X.M., Koohi-Moghadam M., Wang R.M., Chang Y.Y., Woo P.C.Y., Wang J.W., Li H.Y.*, Sun H.Z.* (2018) “Metallochaperone UreG serves as a new target for design of urease inhibitor: a novel strategy for development of antimicrobials” PLOS Biology, 16(1), e2003887. (IF: 9)
(5) Hong Y.F., Lai Y.T., Chan G.C.F., Sun H.Z.* (2015) “Glutathione and MRP transporter mediate a self-propelled disposal of bismuth in human cells” Proceedings of the National Academy of Sciences, USA, 112(11), 3211-3216 (highlighted in the issue, PNAS 112(11), 3717 and as a commentary).
(2) Lai Y.Z., Chang Y.Y., Hu L.G., Yang Y., Chao A.L., Du Z.Y., Tanner J.A., Chye M.L., Qian C.M., Ng K.M., Li H.Y., Sun H.Z.* (2015) “Rapid labeling of intracellular His-tagged proteins in living cells” Proceedings of the National Academy of Sciences, USA, 112(10), 2948-2953.
(3) Yang X.M., Li H.Y., Lai T.P., Sun H.Z.* (2015) “Complexation of Helicobacter pylori UreE-UreG facilitates nickel transfer and boosts GTPase activity of UreG” Journal of Biological Chemistry, 290(20), 12474-12485 (Paper of the Week).
(4) Hu L.G., Cheng T.F., He B., Li L., Wang Y.C., Lai Y.T., Jiang G.B., Sun H.Z.* (2013) “Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry” Angewandte Chemie International Edition, 52(18), 4916-4920. (IF: 12)
(5) Tsang C.N., Ho K.S., Sun H.Z.*, Chan W.T.* (2011) “Tracking bismuth drug uptake in single Helicobacter pylori cells” Journal of the American Chemical Society, 133(19), 7355-7357. (IF: 14)
(6) Cun S.J., Sun H.Z.* (2010) “A zinc-binding site by negative selection induces metallodrug susceptibility of an essential chaperonin”, Proceedings of the National Academy of Sciences, USA, 107(11), 4943-4948.

1. “The biological chemistry of arsenic, antimony and bismuth”, John Wiley& Sons, 2011 (380 pp) (as an editor)
2. “Metallomics (in Chinese)”, edited by Li Y.F., Sun H.Z., Chen C.Y. Chai Z.F., Science Press, 2016.

1. Sun H.Z., Lai Y.Z., Yang Y. (2014) “Metal chelation-based fluorescent probes for protein or other biomolecule labeling in cells” (CN appl no: 201580010957.7).
2. Sun H.Z., Chan G.C.F., Chan S., Wag R.M., Li H.Y. (2015) “Bismuth complexes as adjuvants of cisplatin for cancer treatment” Provisional Patent (USPTO 15/210,019; CN appl no: 201680041880.4; EP appl no: 16823909.3).
3. Sun H.Z., Kao Y.T., Wang R.M., Lai L.P., Zhang H.M., Li H.Y. (2016) “Bismuth(III) compounds and methods thereof” (USPTO 15/278,916; PCT appl no: PCT/CN2017/102077)

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