ACADEMIC QUALIFICATIONS
10/1993~ 09/1996: Ph.D., Chemistry, The University of London (Birkbeck College), Great Britain
PROFESSIONAL EXPERIENCE
• 08/2018- : Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, The University of Hong Kong
• 05/2018- : Chair Professor, Department of Chemistry, The University of Hong Kong
RESEARCH INTERESTS
Bioinorganic chemistry of bismuth (and arsenic)
Metalloproteomics and systems biology
Medicinal chemistry (metals in medicine)
AWARDS AND HONORS
• UC Berkeley Earl L Muetterties Memorial Lectureship 2017-2018
• WuXi AppTech Life Science & Chemistry Research Award 2016
• Fellow of the Royal Society of Chemistry (FRSC) 2011-
• Croucher Senior Research Fellowship, Croucher Foundation 2010-2011
EDITORSHIP
•Series Editor, Metallobiology (2010-, the Royal Society of Chemistry, UK)
•Editorial Board of Metallomics (the Royal Society of Chemistry; 2008-2014), Journal of Inorganic Biochemistry (Elsevier, 2012-), BioMetals (Springer, 2017-), Chinese Journal of Magnetic Resonance (2007-)
•Editorial Advisory Board of The Journal of Biological Inorganic Chemistry (Springer, 2007-2010; 2015-2018) and The Open Medicinal Chemistry Journal (Bentham Science Publisher)
•Guest editor: Special issue on ‘Metallomics in China’ (July issue of Metallomics, 2013)
REPRESENTATIVE PUBLICATIONS
(Total citation (Scopus): 9216; H-index: 49; >180 publications including PNAS (3), Nature Commun (1), Angew Chem/JACS (10), JBC (5))
(1) Li H.Y., Wang R.M., Sun H.Z.* (2018) “Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond Helicobacter pylori infection” Accounts of Chemical Research, doi: 10.1021/acs.accounts.8b00439
(2) Han B.J., Xia W., Wang Y.L, Li H.Y., Wang Y.C.*, Sun H.Z.* (2018) “Multi-omics and temporal dynamics profiling reveals disrupted central metabolism in Helicobacter pylori on bismuth treatment” Chemical Science, 9(38), 7488-7497. (Chemical Science 2018 HOT article, highlighted in ChemistryWorld 2018, September issue, 44-45)
(3) Wang R.M., Lai T.P., Gao P., Zhang H.M., Ho P.L, Ma G.X., Woo P.C.Y., Kao Y.T., Li H.Y., Sun H.Z.* (2018) “Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors”, Nature Communications, 9(1), 439. doi: 10.1038/s41467-018-02828-6. (IF: 12)
(4) Yang X.M., Koohi-Moghadam M., Wang R.M., Chang Y.Y., Woo P.C.Y., Wang J.W., Li H.Y.*, Sun H.Z.* (2018) “Metallochaperone UreG serves as a new target for design of urease inhibitor: a novel strategy for development of antimicrobials” PLOS Biology, 16(1), e2003887. (IF: 9)
(5) Hong Y.F., Lai Y.T., Chan G.C.F., Sun H.Z.* (2015) “Glutathione and MRP transporter mediate a self-propelled disposal of bismuth in human cells” Proceedings of the National Academy of Sciences, USA, 112(11), 3211-3216 (highlighted in the issue, PNAS 112(11), 3717 and as a commentary).
(2) Lai Y.Z., Chang Y.Y., Hu L.G., Yang Y., Chao A.L., Du Z.Y., Tanner J.A., Chye M.L., Qian C.M., Ng K.M., Li H.Y., Sun H.Z.* (2015) “Rapid labeling of intracellular His-tagged proteins in living cells” Proceedings of the National Academy of Sciences, USA, 112(10), 2948-2953.
(3) Yang X.M., Li H.Y., Lai T.P., Sun H.Z.* (2015) “Complexation of Helicobacter pylori UreE-UreG facilitates nickel transfer and boosts GTPase activity of UreG” Journal of Biological Chemistry, 290(20), 12474-12485 (Paper of the Week).
(4) Hu L.G., Cheng T.F., He B., Li L., Wang Y.C., Lai Y.T., Jiang G.B., Sun H.Z.* (2013) “Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometry” Angewandte Chemie International Edition, 52(18), 4916-4920. (IF: 12)
(5) Tsang C.N., Ho K.S., Sun H.Z.*, Chan W.T.* (2011) “Tracking bismuth drug uptake in single Helicobacter pylori cells” Journal of the American Chemical Society, 133(19), 7355-7357. (IF: 14)
(6) Cun S.J., Sun H.Z.* (2010) “A zinc-binding site by negative selection induces metallodrug susceptibility of an essential chaperonin”, Proceedings of the National Academy of Sciences, USA, 107(11), 4943-4948.
Books:
1. “The biological chemistry of arsenic, antimony and bismuth”, John Wiley& Sons, 2011 (380 pp) (as an editor)
2. “Metallomics (in Chinese)”, edited by Li Y.F., Sun H.Z., Chen C.Y. Chai Z.F., Science Press, 2016.
PATENTS:
1. Sun H.Z., Lai Y.Z., Yang Y. (2014) “Metal chelation-based fluorescent probes for protein or other biomolecule labeling in cells” (CN appl no: 201580010957.7).
2. Sun H.Z., Chan G.C.F., Chan S., Wag R.M., Li H.Y. (2015) “Bismuth complexes as adjuvants of cisplatin for cancer treatment” Provisional Patent (USPTO 15/210,019; CN appl no: 201680041880.4; EP appl no: 16823909.3).
3. Sun H.Z., Kao Y.T., Wang R.M., Lai L.P., Zhang H.M., Li H.Y. (2016) “Bismuth(III) compounds and methods thereof” (USPTO 15/278,916; PCT appl no: PCT/CN2017/102077)