FARID HAJAREH HAGHIGHI

Dottore di ricerca

ciclo: XXXVI


supervisore: Prof.ssa Ilaria Fratoddi

Titolo della tesi: Synthesis and characterizations of TiO2 and γ-Fe2O3 nanohybrids and their biological and environmental applications

This Ph.D. thesis focused on the synthesis and characterization of TiO2 and γ-Fe2O3 nanoparticles (NPs) for their potential antibacterial and environmental applications. For the TiO2NPs, a commercial TiO2 nanopowder was employed and functionalized with organic and alkoxysilane molecules. For the antibacterial and gas sensing applications, the TiO2 nanopowder was functionalized with a bifunctional silane linker, (3-mercaptopropyl)trimethoxysilane (MPTMS), bearing –O and –SH moieties in its opposing sites, to mediate the covalent attachment of TiO2- to AgNPs and enhance their colloidal stability as well. The synthesis was carried out by the two main steps: i) the commercially available TiO2NPs were functionalized with MPTMS through the formation of surface Ti–O–Si covalent bonds (TiO2NPs-MPTMS), and ii) the nanohybrid was prepared by decoration of AgNPs, modified with 3MPS (3-mercapto-1-propanesulfonate) i.e. AgNPs-3MPS, on the surface of TiO2NPs-MPTMS, to form TiO2NPs-MPTMS-AgNPs-3MPS, abbreviated as TiO2-Ag_2.5, TiO2-Ag_1, and TiO2-Ag_4. The silanization reaction was tested in different conditions in terms of solvent, time, use of ammonia (as catalyst), and the precursor ratios. The stability, size, morphology, and chemical composition of these nanoparticles were studied by extensive characterizations including FTIR-ATR (and far-IR), FESEM-EDS, TEM, ICP, DLS, ζ-potential, 1H-NMR, UV-Vis, and XPS. The colloidal stabilities of TiO2NPs-MPTMS and the nanohybrids were studied in both water and biological culture media. The results demonstrated both successful chemical silanization of the pristine TiO2NPs and the subsequent AgNPs decoration. Thanks to a multidisciplinary approach, antibacterial activities of these nanohybrids were investigated on multidrug resistance Gram-positive and Gram-negative bacteria and the results showed a synergic antibacterial effect of TiO2- and AgNPs in the nanohybrid, compared to the pristine TiO2NPs and control groups. Also, the nanohybrids have been employed for designing a solid-state chemoresistive sensor with the aim to detect H2S toxic gas. Deposition of the nanohybrids on the interdigitated electrodes could enhance the sensitivity of resistive sensor with high response. Also, direct loading of an anticancer prodrug, 5-aminolevolinic acid (ALA), onto the surface of the TiO2 nanopowder was studied, because of importance of this nanocomposite in photodynamic cancer therapy. Regarding the γ-Fe2O3 nanohybrid, a novel peptide-based magnetogel was synthesized through the encapsulation of γ-Fe2O3-polyacrylic acid (PAA) nanoparticles (γ-Fe2O3NPs) into a hydrogel matrix, used for enhancing the ability of the hydrogel to remove Cr(III), Co(II), and Ni(II) pollutants from water. Fmoc-Phe (fluorenylmethoxycarbonyl-phenylalanine) and diphenylalanine (Phe2) were used as starting reagents for the hydrogelator (Fmoc-Phe3) synthesis via an enzymatic method. The PAA-coated magnetic nanoparticles were synthesized in a separate step, using the co-precipitation method, and encapsulated into the peptide-based hydrogel. The resulting organic/inorganic hybrid system (γ-Fe2O3NPs-peptide) was characterized with different techniques, including FT-IR, Raman, UV-Vis, DLS, ζ-potential, XPS, FESEM-EDS, swelling ability tests, and rheology. Considering the application in heavy metals removal from water, the adsorption of this magnetogel was compared to its precursors and the effect of an external magnetic field was assessed. Four different systems were selected for this study including: 1) γ-Fe2O3NPs stabilized with PAA, (γ-Fe2O3NPs); 2) Fmoc-Phe3 hydrogel (HG); 3) γ-Fe2O3NPs embedded in peptide magnetogel (γ-Fe2O3NPs@HG); and 4) γ-Fe2O3NPs@HG in the presence of an external magnetic field. To quantify the removal efficiency of these four model systems, UV-Vis technique was employed as a fast, cheap, and versatile method. The results demonstrated that both Fmoc-Phe3 hydrogel and γ-Fe2O3NPs peptide magnetogel can efficiently remove all the tested pollutants from water. Interestingly, due to the presence of magnetic γ-Fe2O3NPs inside the hydrogel, the removal efficiency can be enhanced by applying the external magnetic field. The proposed magnetogel represents a smart multifunctional nanosystem with improved absorption efficiency and synergic effect upon applying the external magnetic field.

Produzione scientifica

11573/1708998 - 2024 - Liposome–Hydrogel Composites for Controlled Drug Delivery Applications
Binaymotlagh, Roya; Hajareh Haghighi, Farid; Chronopoulou, Laura; Palocci, Cleofe - 01g Articolo di rassegna (Review)
rivista: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: (0) - scopus: (0)

11573/1709109 - 2024 - Preparation of Peptide-Based Magnetogels for Removing Organic Dyes from Water
Hajareh Haghighi, Farid; Binaymotlagh, Roya; Pintilei, Paula Stefana; Chronopoulou, Laura; Palocci, Cleofe - 01a Articolo in rivista
rivista: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: (0) - scopus: (0)

11573/1692832 - 2023 - Biosynthesis of Peptide Hydrogel–Titania Nanoparticle Composites with Antibacterial Properties
Binaymotlagh, Roya; Hajareh Haghighi, Farid; Di Domenico, Enea Gino; Sivori, Francesca; Truglio, Mauro; Del Giudice, Alessandra; Fratoddi, Ilaria; Chronopoulou, Laura; Palocci, Cleofe - 01a Articolo in rivista
rivista: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: (0) - scopus: (0)

11573/1685635 - 2023 - Acrylates-based hydrophilic co-polymeric nanobeads as nanocarriers for imaging agents
Cerra, S.; Dini, V.; Salamone, T. A.; Hajareh Haghighi, F.; Mercurio, M.; Cartoni, A.; Del Giudice, A.; Marsotto, M.; Venditti, I.; Battocchio, C.; Scaramuzzo, F. A.; Matassa, R.; Nottola, S.; Faccini, R.; Mirabelli, R.; Fratoddi, I. - 01a Articolo in rivista
rivista: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0927-7757 - wos: WOS:001057756500001 (2) - scopus: 2-s2.0-85162129612 (2)

11573/1685772 - 2023 - Noble metal nanoparticles networks stabilized by rod-like organometallic bifunctional thiols
Cerra, S; Carlini, L; Salamone, Ta; Hajareh Haghighi, F; Mercurio, M; Pennacchi, B; Sappino, C; Battocchio, C; Nottola, S; Matassa, R; Fratoddi, I - 01a Articolo in rivista
rivista: CHEMISTRYSELECT (John Wiley & Sons, Inc) pp. 1-8 - issn: 2365-6549 - wos: WOS:000961818300001 (1) - scopus: 2-s2.0-85152082957 (1)

11573/1666235 - 2023 - Thiol-functionalized palladium nanoparticles networks. Synthesis, characterization, and room temperature (toxic) vapor detection
Cerra, Sara; Salamone, Tommaso A.; Bearzotti, Andrea; Hajareh Haghighi, Farid; Mercurio, Martina; Marsotto, Martina; Battocchio, Chiara; Fioravanti, Raoul; Diociaiuti, Marco; Fratoddi, Ilaria - 01a Articolo in rivista
rivista: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. - - issn: 0934-0866 - wos: WOS:000917983000001 (2) - scopus: 2-s2.0-85147009737 (2)

11573/1673950 - 2023 - Preparation of hydrogel composites using a sustainable approach for In situ Silver nanoparticles formation
Chronopoulou, Laura; Binaymotlagh, Roya; Cerra, Sara; Hajareh Haghighi, Farid; Di Domenico, Enea Gino; Sivori, Francesca; Fratoddi, Ilaria; Mignardi, Silvano; Palocci, Cleofe - 01a Articolo in rivista
rivista: MATERIALS (Basel: Molecular Diversity Preservation International-MDPI) pp. - - issn: 1996-1944 - wos: WOS:000959711000001 (5) - scopus: 2-s2.0-85151916494 (4)

11573/1688006 - 2023 - Self-Assembling Peptide-Based Magnetogels for the Removal of Heavy Metals from Water
Hajareh Haghighi, Farid; Binaymotlagh, Roya; Chronopoulou, Laura; Cerra, Sara; Marrani, Andrea Giacomo; Amato, Francesco; Palocci, Cleofe; Fratoddi, Ilaria - 01a Articolo in rivista
rivista: GELS (Basel : MDPI) pp. 621- - issn: 2310-2861 - wos: WOS:001056940000001 (2) - scopus: 2-s2.0-85169141034 (2)

11573/1693240 - 2023 - Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery
Hajareh Haghighi, Farid; Binaymotlagh, Roya; Fratoddi, Ilaria; Chronopoulou, Laura; Palocci, Cleofe - 01g Articolo di rassegna (Review)
rivista: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: (0) - scopus: (0)

11573/1689111 - 2023 - Surface modification of TiO2 nanoparticles with organic molecules and their biological applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso Alberto; Binaymotlagh, Roya; Palocci, Cleofe; Romano Spica, Vincenzo; Fratoddi, Ilaria - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MATERIALS CHEMISTRY. B (Cambridge : RSC Publishing, 2012-) pp. 2334-2366 - issn: 2050-7518 - wos: WOS:000939746800001 (17) - scopus: 2-s2.0-85149257759 (20)

11573/1652979 - 2022 - Peptide-based hydrogels: new materials for biosensing and biomedical applications
Binaymotlagh, Roya; Chronopoulou, Laura; Hajareh Haghighi, Farid; Fratoddi, Ilaria; Palocci, Cleofe - 01g Articolo di rassegna (Review)
rivista: MATERIALS (Basel: Molecular Diversity Preservation International-MDPI) pp. - - issn: 1996-1944 - wos: WOS:000851994400001 (36) - scopus: 2-s2.0-85137860860 (35)

11573/1654984 - 2022 - Synthesis of a novel biocompatible peptide hydrogel impregnated with titanium oxide nanoparticles; investigation of its biological applications
Binaymotlagh, Roya; Hajareh Haghighi, Farid; Chronopoulou, Laura; Fratoddi, Ilaria; Palocci, Cleofe - 04d Abstract in atti di convegno
congresso: YoungInnovation 2022 The State of Research communicated by Young Researchers (University of sapienza, Rome)
libro: conference, oral presentation - ()

11573/1654482 - 2022 - Synthesis and characterizations of highly stable magnetite-silver (Fe3O4-Ag) nanohybrid for recyclable antibacterial materials
Hajareh Haghighi, Farid; Cerra, Sara; Salamone, Tommaso A.; Mercurio, Martina; Fratoddi, Ilaria - 04f Poster
congresso: NanoInnovation2022 (Faculty of Civil and Industrial Engineering, Sapienza University of Rome)
libro: NanoInnovation2022 conference and exhibition - ()

11573/1650120 - 2022 - Chemical conjugation of highly stable Ag nanoparticles with silane-functionalized TiO2 nanoparticles for potential dual antibacterial effect
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04f Poster
congresso: The workshop "Novel frontiers in nanocarriers preparation and characterization" (Rome, Italy)
libro: The workshop "Novel frontiers in nanocarriers preparation and characterization" - ()

11573/1650266 - 2022 - Silane-functionalized metal oxide nanoparticles link silver nanoparticles: a new platform for antibacterial applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Matassa, Roberto; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: The First Symposium for Young Chemists: Innovation and Sustainability (Sync2022) (Rome, Italy)
libro: The First Symposium for Young Chemists: Innovation and Sustainability (Sync2022) - ()

11573/1651531 - 2022 - Silver nanoparticles as stimulating agents for arbuscular mycorrhizal fungi growth: a new perspective for agri-food
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) (Sapienza University of Rome)
libro: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) - ()

11573/1651535 - 2022 - Silver nanoparticles as efficient tool in agrifood applications
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: YoungInnovation - The State of Research communicated by Young Researchers (Faculty of Civil and Industrial Engineering, Sapienza University of Rome)
libro: YoungInnovation - The State of Research communicated by Young Researchers - ()

11573/1651539 - 2022 - Nanotechnology in agriculture: the role of silver nanoparticles in mycorrhization process
Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Pagliarani, Sofia; Morales-Rodriguez, Carmen; Kuzminsky, Elena; Vannini, Andrea; Fratoddi, Ilaria - 04f Poster
congresso: XLVIII Italian Conference of Inorganic Chemistry (Polo Didattico San Rossore 1938)
libro: XLVIII Italian Conference of Inorganic Chemistry - ()

11573/1650125 - 2022 - Loading of phototherapeutic drug 5-aminolevulinic acid on TiO2 nanoparticles: a new approach for potential dual phototherapeutic effects
Placitelli, Francesca Ilaria; Hajareh Haghighi, Farid; Mercurio, Martina; Fratoddi, Ilaria - 04f Poster
congresso: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) (Rome, Italy)
libro: The First Symposium for YouNg Chemists: Innovation and Sustainability (SYNC2022) - ()

11573/1579484 - 2021 - Methylmethacrylate-based polymeric nanoparticles as platform for multimodal imaging
Cerra, Sara; Dini, Valentina; Salamone, Tommaso Alberto; Hajareh Haghighi, Farid; Scaramuzzo, Francesca Anna; Matassa, Roberto; Marsotto, Martina; Battocchio, Chiara; Cartoni, Antonella; Fratoddi, Ilaria - 04f Poster
congresso: XXVII CONGRESSO NAZIONALE DELLA SOCIETÀ CHIMICA ITALIANA (Virtual)
libro: Book of abstract - ()

11573/1616211 - 2021 - Functionalized gold nanoparticles in colorimetric and chemoresistive sensors: synthesis, sensing mechanism and interface properties
Cerra, Sara; Salamone, Tommaso A.; Hajareh Haghighi, Farid; Matassa, Roberto; Maria Beltrán, Ana; Scaramuzzo, Francesca A.; Marsotto, Martina; Battocchio, Chiara; Li Voti, Roberto; Sibilia, Concetta; Bearzotti, Andrea; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: NanoInnovation 2021 (Virtual (Università degli Studi di Roma “La Sapienza” Facoltà di Ingegneria Civile e Industriale, Roma))
libro: Book of abstracts - ()

11573/1615942 - 2021 - Truffle farming and nanomaterials: a new technology for the optimization of the mycorrhization process and release of "helper" microorganisms
Fratoddi, I.; Bodo, E.; Cerra, S.; Salamone, T. A.; Hajareh Haghighi, F.; Bovi, M.; Bonaconsa, M.; Kuzminsky, E.; Morales-Rodriguez, C.; Pagliarani, S.; Vannini, A. - 04f Poster
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: in book of abstract - ()

11573/1616223 - 2021 - Silane-functionalized TiO2 nanoparticles decorated with Ag nanoparticles for dual antimicrobial effects
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Fratoddi, Ilaria - 04d Abstract in atti di convegno
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: Book of abstracts - ()

11573/1615694 - 2021 - In situ conjugation of silver nanoparticles with silane-functionalized TiO2 nanoparticles for antibacterial applications
Hajareh Haghighi, Farid; Mercurio, Martina; Cerra, Sara; Salamone, Tommaso A.; Marsotto, Martina; Battocchio, Chiara; Fratoddi, Ilaria - 04f Poster
congresso: NanoInnovation 2021 (Virtual (Università degli Studi di Roma “La Sapienza” Facoltà di Ingegneria Civile e Industriale, Roma))
libro: In situ conjugation of silver nanoparticles with silane-functionalized TiO2 nanoparticles for antibacterial applications - ()

11573/1616520 - 2021 - Functionalised gold nanoparticles loaded with methotrexate for the treatment of neuroblastoma: synthesis, characterisation, and in vitro study
Salamone, Tommaso A.; Rutigliano, Lavinia; Cerra, Sara; Hajareh Haghighi, Farid; Mongillo, Marzia; Fratoddi, Ilaria; Agostinelli, Enzo - 04f Poster
congresso: XXVII Congresso Nazionale della Società Chimica Italiana (Virtual)
libro: Book of abstracts - ()

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma