Education
2003 – 2005 Post Doctoral Fellowship, Ottawa Health Research Institute, Supervisor: Dr. Michael Rudnicki, Area of Specialization: Stem Cell Biology
2000 - 2003 Doctor of Philosophy, McMaster University, Supervisor: Dr. Mark A. Tarnopolsky, Area of Specialization: Aging Skeletal Muscle
1997– 1999 Master of Science, McMaster University, Supervisor: Dr. Mark A. Tarnopolsky, Area of Specialization: Creatine and Skeletal Muscle Metabolism
1993 - 1997 Bachelor of Kinesiology, McMaster University, Area of Specialization: Exercise Physiology
CURRENT STATUS AT MCMASTER
Professor
Department of Kinesiology
MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS
McMaster Institute for Research on Aging
Canadian Society for Exercise Physiology
American Physiological Society
American Society of Hematology
ACADEMIC EMPLOYMENT HISTORY
2016 - present Professor, Department of Kinesiology
2010 -present Associate Professor, Department of Kinesiology, Department of Medical Physics & Applied Radiation Sciences
2011 -present Associate Dean (Research and External Relations), Faculty of Science
2005 - 2009 Assistant Professor, Department of Kinesiology, Department of Medical Physics & Applied Radiation Sciences
RESEARCH FUNDING
04/2016 Parise, G (Principle Investigator). “Human muscle stem cell physiology: Characterization, regulation and function. Natural Sciences and Engineering Research Council Discovery Grant, $160,000. April 1, 2016. YR1 - $32,000, YR2 - $32,000, YR3 - $32,000, YR4 - $32,000, YR5 - $32,000.
10/2012 Parise, G (Principle Investigator). “Optimizing Mobility and Aging through Exercise and Nutrition.” Labarge Optimal Aging Initiative. $430,000 over 3 years.
04/2011 Parise, G (Principle Investigator). “Exercise as a Therapeutic Strategy for bone Marrow transplantation.” Ontario Ministry of Research and Innovation – Early Researcher Award. $150,000 over 5 years.
05/2011 Parise, G (Principle Investigator). “Muscle Stem Cell Regulation in Humans.” Natural Sciences and Engineering Research Council Discovery Grant, $207, 500. April 1, 2011 – March 31, 2016. YR1 - $41,500, YR2 - $41,500, YR3 - $41,500, YR4 - $41,500, YR5 - $41,500.
05/2011 Parise, G (Principle Investigator). “Is Myostatin Blockade an Appropriate Pharmaceutical Strategy for the Maintenance of Muscle Mass in Older Adults: Lessons from Exercise and the Muscle” Canadian Institutes of Health Research, $50,000. March 2011 – march 2012.
05/2009 Parise, G (Co-applicant), Levinson, A (Co-applicant), Tarnopolsky, MA (Principle Investigator). “Optimization of exercise training programs
based on in vivo molecular outcomes” Canadian Institutes of Health Research/Natural Science and Engineering Research Council - Collaborative Health Research Project, $486,250. April 1, 2009 - March 31, 2012. YR1 - $173,358, YR2 - $ $172,164, YR3 - $148,724.
01/2009 Parise, G (Principle Investigator). “Protective effect of exercise on hematopoietic stem cells: Implications for bone marrow transplants” Canadian Institutes of Health Research, $100,000. January 1, 2009 – March 31, 2009.
09/2008 Parise, G. (Principle Investigator), Tarnopolsky, MA (Co-applicant) “Enumeration and regulation of muscle stem cells following muscle damage in older adults using fluorescence activated cell sorting.”
Canadian Institutes of Health Research, $46,850. September 1, 2008 – August 31, 2009.
03/2008 Parise, G (Principle Investigator), Tarnopolsky, MA (Co-applicant). “The response of signaling factors, in blood and muscle, for the mobilization of muscle stem cells following exercise-induced muscle damage and repair in old and young adults.” Canadian Institutes of Health Research, $76, 850. March 1, 2008 – March 31, 2009.
03/2006 Parise, G (Principle Investigator). “Muscle Stem Cell Function in Advanced Age.” Natural Sciences and Engineering Research Council Discovery Grant, $137, 500. April 1, 2006 – March 31, 2011. YR1 - $27,500, YR2 - $27,500, YR3 - $27,500, YR4 - $27,500, YR5 - $27,500.
03/2006 Parise, G (Principle Investigator). “The Function and Regulation of Myogenic Progenitors During Aging and Exercise, Canadian Foundation for Innovation – Leadership Opportunity Fund. $344, 883. October 1, 2006 – March 1, 2008.
Research interests
Generally, my interests involve understanding the mechanisms of skeletal muscle adaptation and repair to exercise and injury. We focus primarily on skeletal muscle progenitor cells and their role in remodelling of tissue. Additionally, we focus on how muscle progenitor cells fails in aging and examine strategies to rejuvenate the muscle progenitor response to injury and exercise in older adults.
Publications in the last 5 years
1. Allison DJ, Nederveen JP, Snijders T, Bell KE, Kumbhare D, Phillips SM, Parise G, Heisz J. Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway. Am J Physiol Cell Physiol. 2019 Jan 16. doi: 10.1152/ajpcell.00448.2018.
2. Mayhew AJ, Amog K, Phillips S, Parise G, McNicholas PD, de Souza RJ, Thabane L, Raina P. The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: a systematic review and meta-analyses. Age Ageing. 2019, 1;48(1):48-56.
3. Snijders T, Nederveen JP, Bell KE, Lau SW, Mazara N, Kumbhare DA, Phillips SM, Parise G. Prolonged exercise training improves the acute type II muscle fibre satellite cell response in healthy older men. J Physiol. 2019;597(1):105-119.
4. Oikawa SY, McGlory C, D'Souza LK, Morgan AK, Saddler NI, Baker SK, Parise G, Phillips SM. A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons. Am J Clin Nutr. 2018, 1;108(5):1060-1068.
5. Moore DR, McKay BR, Tarnopolsky MA, Parise G. Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. Eur J Appl Physiol. 2018;118(10):2225-2231.
6. Snijders T, Bell KE, Nederveen JP, Saddler NI, Mazara N, Kumbhare DA, Phillips SM, Parise G. Ingestion of a Multi-Ingredient Supplement Does Not Alter Exercise-Induced Satellite Cell Responses in Older Men. J Nutr. 2018; 1;148(6):891-899.
7.Moore DR, Kelly RP, Devries MC, Churchward-Venne TA, Phillips SM, Parise G, Johnston AP. Low-load resistance exercise during inactivity is associated with greater fibre area and satellite cell expression in older skeletal muscle. J Cachexia Sarcopenia Muscle. 2018;9(4):747-754.
8. Joanisse S, Snijders T, Nederveen JP, Parise G. The Impact of Aerobic Exercise on the Muscle Stem Cell Response. Exerc Sport Sci Rev. 2018;46(3):180-187.
9. Tan R, Nederveen JP, Gillen JB, Joanisse S, Parise G, Tarnopolsky MA, Gibala MJ. Skeletal muscle fiber-type-specific changes in markers of capillary and mitochondrial content after low-volume interval training in overweight women. Physiol Rep. 2018;6(5).
10. Damas F, Libardi CA, Ugrinowitsch C, Vechin FC, Lixandrão ME, Snijders T, Nederveen JP, Bacurau AV, Brum P, Tricoli V, Roschel H, Parise G, Phillips SM. Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men. PLoS One. 2018;11;13(1).
11. Nederveen JP, Joanisse S, Snijders T, Thomas ACQ, Kumbhare D, Parise G. The influence of capillarization on satellite cell pool expansion and activation following exercise-induced muscle damage in healthy young men. J Physiol. 2018; 15;596(6):1063-1078.
12. Baker J, Nederveen JP, Ibrahim G, Ivankovic V, Joanisse S, Parise G. Exercise training differentially alters axial and appendicular marrow cellularity in old mice. Appl Physiol Nutr Metab. 2018 May;43(5):523-527.
13. Bell KE, Snijders T, Zulyniak MA, Kumbhare D, Parise G, Chabowski A, Phillips SM. A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men. Appl Physiol Nutr Metab. 2018;43(3):299-302.
14. Baker J, Nederveen JP, Ibrahim G, Ivankovic V, Joanisse S, Parise G. Exercise training differentially alters axial and appendicular marrow cellularity in old mice. Appl Physiol Nutr Metab. 2018;43(5):523-527.
15. Bell KE, Snijders T, Zulyniak MA, Kumbhare D, Parise G, Chabowski A, Phillips SM. A multi-ingredient nutritional supplement enhances exercise training-related reductions in markers of systemic inflammation in healthy older men. Appl Physiol Nutr Metab. 2018;43(3):299-302.
16. Bell KE, Snijders T, Zulyniak M, Kumbhare D, Parise G, Chabowski A, Phillips SM. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLoS One. 2017; 18;12(7)
17. Chorghade S, Seimetz J, Emmons R, Yang J, Bresson SM, Lisio M, Parise G, Conrad NK, Kalsotra A. Poly(A) tail length regulates PABPC1 expression to tune translation in the heart. Elife. 2017; 27;6. pii: e24139.
18. Snijders T, Nederveen JP, Verdijk LB, Houben AJHM, Goossens GH, Parise G, van Loon LJC. Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiol Rep. 2017;5(10). pii: e13278.
19. Snijders T, Parise G. Role of muscle stem cells in sarcopenia. Curr Opin Clin Nutr Metab Care. 2017;20(3):186-190.
20. Snijders T, Nederveen JP, Verdijk LB, Houben AJHM, Goossens GH, Parise G, van Loon LJC. Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiol Rep. 2017;5(10).
21. Chorghade S, Seimetz J, Emmons R, Yang J, Bresson SM, Lisio M, Parise G, Conrad NK, Kalsotra A. Poly(A) tail length regulates PABPC1 expression to tune translation in the heart. Elife. 2017; 27;6.
22. Bell KE, Snijders T, Zulyniak M, Kumbhare D, Parise G, Chabowski A, Phillips SM. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLoS One. 2017; 18;12(7):e0181387.
23. Baker JM, Nederveen JP, Parise G. Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner. J Appl Physiol (1985). 2017;122(1):182-190.
24. Snijders T, Nederveen JP, Joanisse S, Leenders M, Verdijk LB, van Loon LJ, Parise G. Muscle fibre capillarization is a critical factor in muscle fibre
hypertrophy during resistance exercise training in older men. J Cachexia Sarcopenia Muscle. 2016 Aug 4.
25. Nederveen JP, Joanisse S, Snijders T, Thomas AC, Kumbhare D, Parise G. The influence of capillarization on satellite cell pool expansion and activation following exercise-induced muscle damage in healthy young men. J Physiol. 2018 Jan 6.
26. Damas F, Libardi CA, Ugrinowitsch C, Vechin FC, Lixandrão ME, Snijders T, Nederveen JP, Bacurau AV, Brum P, Tricoli V, Roschel H, Parise G, Phillips SM. Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men. PLoS One. 2018 Jan 11;13(1):e0191039.
27. Joanisse S, Nederveen JP, Snijders T, McKay BR, Parise G. Skeletal Muscle Regeneration, Repair and Remodelling in Aging: The Importance of Muscle Stem Cells and Vascularization. Gerontology. 2016 Oct 20.
28. Snijders T, Nederveen JP, Parise G. Are satellite cells lost during short-term disuse-induced muscle fiber atrophy? J Appl Physiol (1985). 2016 Jun
15;120(12):1490.
29. Nederveen JP, Joanisse S, Séguin CM, Bell KE, Baker SK, Phillips SM, Parise G. The effect of exercise mode on the acute response of satellite cells in old men. Acta Physiol (Oxf). 2015 Sep 14.
30. Nederveen JP, Snijders T, Joanisse S, Wavell CG, Mitchell CJ, Johnston LM, Baker SK, Phillips SM, Parise G. Altered muscle satellite cell activation following 16 wk of resistance training in young men. Am J Physiol Regul Integr Comp Physiol. 2017;312(1):R85-R92.
31. Joanisse S, Nederveen JP, Baker JM, Snijders T, Iacono C, Parise G.Exercise conditioning in old mice improves skeletal muscle regeneration. FASEB J. 2016;30(9):3256-68.
32. Nederveen JP, Joanisse S, Snijders T, Ivankovic V, Baker SK, Phillips SM, Parise G. Skeletal muscle satellite cells are located at a closer proximity to capillaries in healthy young compared with older men. J Cachexia Sarcopenia Muscle. 2016;7(5):547-554.
33. Damas F, Phillips SM, Libardi CA, Vechin FC, Lixandrão ME, Jannig PR, Costa LA, Bacurau AV, Snijders T, Parise G, Tricoli V, Roschel H, Ugrinowitsch C. Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage. J Physiol. 2016;594(18):5209-22.
34. Joanisse S, Parise G. Cytokine Mediated Control of Muscle Stem Cell Function. Adv Exp Med Biol. 2016;900:27-44.
35.Baker JM, Parise G. Skeletal Muscle Erythropoietin Expression Is Responsive to Hypoxia and Exercise. Med Sci Sports Exerc. 2016;48(7):1294-301.
36.Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA. Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Skelet Muscle. 2016; 31;6:7.
37. Snijders T, Nederveen JP, McKay BR, Joanisse S, Verdijk LB, van Loon LJ, Parise G. Satellite cells in human skeletal muscle plasticity. Front Physiol. 2015;6:283
38. Parise G, Snijders T. Myostatin inhibition for treatment of sarcopenia. Lancet Diabetes Endocrinol. 2015;3(12):917-8.
39. Joanisse S, McKay BR, Nederveen JP, Scribbans TD, Gurd BJ, Gillen JB, Gibala MJ, Tarnopolsky M, Parise G. Satellite cell activity, without expansion, after nonhypertrophic stimuli. Am J Physiol Regul Integr Comp Physiol. 2015;309(9):R1101-11.
40.Ogborn DI., McKay BR., Crane JD., Safdar A., Akhtar M., Parise G., Tarnopolsky MA. Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men. Am J Physiol Regul Integr Comp Physiol. 308(8);R734-31. 2015.
41. Bell KE., Séguin C., Parise G., Baker SK., Phillips SM. Day-to-day Changes in Muscle Protein Synthesis in Recovery From Resistance, Aerobic, and High-Intensity Interval Exercise in Older Men. J Gerontol A Biol Sci Med Sci. 2015.