GIUSEPPE PASCULLI

PhD Graduate

PhD program:: XXXV


supervisor: Prof Serena Arima
co-supervisor: Prof Francesco Pesce

Thesis title: A Bayesian nonparametric approach to correct for underreporting in count data

In this research thesis we deal with the issue of underreporting, often affecting administrative data particularly in developing countries or more deprived areas within a country or region, with particular focus on its effects on the estimation of the prevalence of a phenomenon. When health or vital statistics are concerned, underreporting may severely affect estimates, impacting on government intervention policies and resource allocation. We propose a nonparametric compound Poisson model that introduces a latent clustering structure for the reporting probabilities and estimates them jointly with the model’s parameters exploiting an auxiliary variable associated with the reporting process. The proposed model is then used to estimate the prevalence of Chronic Kidney Disease (CKD) in Apulia, Italy, from unpublished administrative data coming from a retrospective study conducted between the 1st of January 2011 and the 31st of December 2013. Whereas accurate estimation of the prevalence is necessary for monitoring, surveillance and management purposes, counts are expected to be considerably underreported, especially in some areas of Apulia, which is one of the most deprived and heterogeneous regions in Italy. Our results agree with previous findings and experts’ expectations and highlight interesting geographical patterns of the disease. We compare our model to existing approaches in the literature using simulated as well as real data described in previous literature, namely early neonatal mortality risk in Minas Gerais, Brazil. In comparison with alternative models, the proposed approach proves to be accurate and particularly suitable when prior information about data quality is not completely accurate.

Research products

  • 11573/1613145 - 2022 - A Bayesian non parametric approach for bias correction for underreported data. (02a Capitolo o Articolo)
    ARIMA, SERENA; PASCULLI, GIUSEPPE; POLETTINI, SILVIA
  • 11573/1650880 - 2022 - Network Proximity-Based Drug Repurposing Strategy for Early and Late Stages of Primary Biliary Cholangitis (01a Articolo in rivista)
    PASCULLI, GIUSEPPE; MASTROPIETRO, ANDREA; STOLFI, PAOLA; VERGNI, DAVIDE
  • 11573/1645170 - 2022 - “The Disease Awareness Innovation Network” for chronic kidney disease identification in general practice (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1661039 - 2022 - Protocol to explain graph neural network predictions using an edge-centric Shapley value-based approach (01a Articolo in rivista)
    MASTROPIETRO, ANDREA; PASCULLI, GIUSEPPE
  • 11573/1652545 - 2022 - EdgeSHAPer: Bond-Centric Shapley Value-Based Explanation Method for Graph Neural Networks (01a Articolo in rivista)
    MASTROPIETRO, ANDREA; PASCULLI, GIUSEPPE
  • 11573/1648128 - 2022 - Role of plasma phosphorylated neurofilament heavy chain (pNfH) in amyotrophic lateral sclerosis (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1660804 - 2022 - Economic impact of industry-sponsored clinical trials in inflammatory bowel diseases: Results from the national institute of gastroenterology “Saverio de Bellis” (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1685553 - 2023 - GALAD score outperforms aMAP and ALBI scores in the 5- and 10-year prediction of hepatocellular carcinoma (HCC) development in patients with compensated advanced chronic liver disease (cACLD): a 12-year prospective study (01h Abstract in rivista)
    PASCULLI, GIUSEPPE; VILLA, ERICA
  • 11573/1565282 - 2021 - Adaptive Positive-Unlabelled Learning via Markov Diffusion (02a Capitolo o Articolo)
    MASTROPIETRO, ANDREA; PASCULLI, GIUSEPPE
  • 11573/1626863 - 2022 - Early versus delayed antiretroviral therapy based on genotypic resistance test: Results from a large retrospective cohort study (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1668281 - 2023 - NIAPU: Network-Informed Adaptive Positive-Unlabeled learning for disease gene identification (01a Articolo in rivista)
    STOLFI, PAOLA; MASTROPIETRO, ANDREA; PASCULLI, GIUSEPPE; VERGNI, DAVIDE
  • 11573/1581532 - 2021 - Diagnostic and prognostic role of plasma phosphorylated neurofilament heavy chain (pNf-H) in amyotrophic lateral sclerosis (01h Abstract in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1395087 - 2020 - A Non-Stationary Markov Model for Economic Evaluation of Grass Pollen Allergoid Immunotherapy (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1444280 - 2020 - FOUR-CLASS RESISTANCE IS RARE IN TREATMENT-EXPERIENCED PATIENTS ACROSS EUROPE (04f Poster)
    PASCULLI, GIUSEPPE
  • 11573/1566463 - 2021 - The Role of Age on Beta-Amyloid1–42 Plasma Levels in Healthy Subjects (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1566121 - 2021 - Bias correction for underreported data in small area mapping. (04b Atto di convegno in volume)
    PASCULLI, GIUSEPPE; POLETTINI, SILVIA
  • 11573/1604075 - 2022 - Identification of glomerulosclerosis using IBM Watson and shallow neural networks (01a Articolo in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1631757 - 2022 - MO492: ‘The Disease Awareness Innovation Network’ (DANTE) Framework for Chronic Kidney Disease Diagnosis (01h Abstract in rivista)
    PASCULLI, GIUSEPPE
  • 11573/1631720 - 2022 - NETWORK PROXIMITY-BASED DRUG REPURPOSING STRATEGY FOR PRIMARY BILIARY CHOLANGITIS (01h Abstract in rivista)
    PASCULLI, GIUSEPPE; MASTROPIETRO, ANDREA; STOLFI, PAOLA; VERGNI, DAVIDE
  • 11573/1599942 - 2021 - Predictors of virological failure among people living with HIV switching from an effective first-line antiretroviral regimen. (01a Articolo in rivista)
    PASCULLI, GIUSEPPE

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