GIULIA SERRA

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: Suicidal behavior in juvenile major depressive and bipolar disorder: a systematic review and meta-analysis

Objective: The primary aim of this study is to assess risk, rates, and lethality of suicidal behavior among juveniles diagnosed with a major depressive disorder (MDD) or a bipolar disorder (BD). Secondarily we aim to compare rates of suicide attempts in children or adolescents diagnosed with BD versus MDD. Methods: We systematically searched for studies of suicidal behavior among juveniles (age ≤18 years), and pooled data on risk (% of subjects) and rates (%/exposure-years), followed by random-effects meta-analysis and multivariable linear regression modeling. The protocol for this review was registered on PROSPERO (CRD42019159676). Results: We included 38 reports (1995–2018) from 14 countries involving 105,874 juveniles (103,772 with MDD, 2,102 with bipolar disorder BD), with exposures ranging 1.00–12.5 years. Suicide attempter-rates averaged 6.55%/year [95%CI: 6.04–7.10] with BD and 2.59%/year [2.55–2.63] with MDD (rate-ratio = 2.53 [2.32–2.75]; p<0.0001), or 2.79%/year overall. Meta-analysis of 6 studies with both diagnostic groups further supported greater risk of attempts with BD (OR=1.71 [CI = 1.33–2.20], p<0.0001). Multivariate regression indicated more suicidal risk with older subjects and shorter exposure-time. Estimated from six studies, suicide rate averaged 125 [56.9–236]/100,000 person-exposure years (100k PEY)—more than 30-times greater than in the general juvenile population. The ratio of attempts/suicides (A/S) was 22.3, indicating more than 11-times greater lethality than estimates of A/S in the juvenile general population. Conclusions: Rates of suicide attempts in juveniles with a major mood disorder averaged 2790/100k PEY, were greater in BD than MDD, among older adolescents and in the first years after assessment. Lethality was greater than the juvenile general population. These results should inform patients, caregivers, and clinicians.

Produzione scientifica

11573/1350713 - 2019 - Early clinical predictors of long-term morbidity in major depressive disorder
Serra, G.; Koukopoulos, A.; De Chiara, L.; Koukopoulos, A. E.; Sani, G.; Tondo, L.; Girardi, P.; Reginaldi, D.; Baldessarini, R. J. - 01a Articolo in rivista
rivista: EARLY INTERVENTION IN PSYCHIATRY (Blackwell Publishing) pp. 999-1002 - issn: 1751-7885 - wos: WOS:000474493100040 (3) - scopus: 2-s2.0-85057964668 (3)

11573/1292289 - 2018 - Predicting suicide in adolescence: Mood disorders, personality pathology and narcissistic functioning
Williams, Riccardo; Maria Pia Casini, ; Serra, Giulia; Frattini, Camilla; Stefano, Vicari; Ronningstam, Elsa Frideborg - 04d Abstract in atti di convegno
congresso: 5th International congress on borderline personality disorder and allied disorders rethinking borderline personality disorder. improving treatment and training (Barcelona)
libro: 5th International congress on borderline personality disorder and allied disorders rethinking borderline personality disorder. improving treatment and training - ()

11573/1350576 - 2017 - Pediatric mania. The controversy between euphoria and irritability
Serra, G.; Uchida, M.; Battaglia, C.; Casini, M. P.; De Chiara, L.; Biederman, J.; Vicari, S.; Wozniak, J. - 01a Articolo in rivista
rivista: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. 386-393 - issn: 1570-159X - wos: WOS:000395930600008 (16) - scopus: 2-s2.0-85010698137 (15)

11573/961707 - 2017 - Early clinical predictors and correlates of long-term morbidity in bipolar disorder
Serra, Giulia; Koukopoulos, Alexia; De Chiara, Lavinia; Koukopoulos, A. E.; Sani, Gabriele; Tondo, L.; Girardi, Paolo; Reginaldi, D.; Baldessarini, R. J. - 01a Articolo in rivista
rivista: EUROPEAN PSYCHIATRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 35-43 - issn: 0924-9338 - wos: WOS:000406391700006 (13) - scopus: 2-s2.0-85016508650 (14)

11573/1350568 - 2017 - Age at menarche predicts age at onset of major affective and anxiety disorders
Tondo, L.; Pinna, M.; Serra, G.; De Chiara, L.; Baldessarini, R. J. - 01a Articolo in rivista
rivista: EUROPEAN PSYCHIATRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 80-85 - issn: 0924-9338 - wos: WOS:000393535600011 (13) - scopus: 2-s2.0-85006488896 (11)

11573/961724 - 2016 - Child and adolescent clinical features preceding adult suicide attempts
Serra, Giulia; Koukopoulos, Athanasios; De Chiara, Lavinia; Napoletano, Flavia; Koukopoulos, Alexia; Sani, Gabriele; Faedda, Gianni L.; Girardi, Paolo; Reginaldi, Daniela; Baldessarini, Ross J. - 01a Articolo in rivista
rivista: ARCHIVES OF SUICIDE RESEARCH (-United Kingdom: Taylor & Francis Limited -Dordrecht; Boston; London: Kluwer Academic Publishers. -Wurzburg: International Academy for Suicide Research.) pp. 1-17 - issn: 1381-1118 - wos: WOS:000409999700011 (1) - scopus: 2-s2.0-84989907538 (2)

11573/961732 - 2015 - Precursors of bipolar disorders. A systematic literature review of prospective studies
Faedda, Gianni L.; Marangoni, Ciro; Serra, Giulia; Salvatore, Paola; Sani, Gabriele; Vázquez, Gustavo H.; Tondo, Leonardo; Girardi, Paolo; Baldessarini, Ross J.; Koukopoulos, Athanasios - 01a Articolo in rivista
rivista: JOURNAL OF CLINICAL PSYCHIATRY (Physicians Postgraduate Press:3175 Lenox Park Boulevard, Suite 409:Memphis, TN 38115:(901)273-2748, EMAIL: kponder@psychiatrist.com, INTERNET: http://www.psychiatrist.com, Fax: (901)273-2747) pp. 614-624 - issn: 0160-6689 - wos: WOS:000355935300026 (59) - scopus: 2-s2.0-84932125692 (70)

11573/751019 - 2015 - Features preceding diagnosis of bipolar versus major depressive disorders
Serra, Giulia; A., Koukopoulos; De Chiara, Lavinia; F., Napoletano; Koukopoulos, Alexia; Curto, Martina; G., Manfredi; G., Faedda; Girardi, Paolo; R. J., Baldessarini - 01a Articolo in rivista
rivista: JOURNAL OF AFFECTIVE DISORDERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 134-142 - issn: 0165-0327 - wos: WOS:000346643500020 (30) - scopus: 2-s2.0-84914101555 (33)

11573/1350589 - 2015 - The role of neuroinflammation in juvenile bipolar disorder
Serra, Giulia; De Chiara, Lavinia; Marangoni, Ciro; Faedda, Giannil - 01g Articolo di rassegna (Review)
rivista: NEUROIMMUNOLOGY AND NEUROINFLAMMATION (Hong Kong : Hongkong Partner Publishing Co. Limited Mumbai: Medknow Publications & Media Pvt. Ltd.) pp. 244-251 - issn: 2349-6142 - wos: (0) - scopus: (0)

11573/996917 - 2015 - Three-year, naturalistic, mirror-image assessment of adding memantine to the treatment of 30 treatment-resistant patients with bipolar disorder
Serra, Giulia; Koukopoulos, Alexia; De Chiara, Lavinia; Koukopoulos, Alexia E.; Tondo, Leonardo; Girardi, Paolo; Baldessarini, Ross J.; Serra, Gino - 01a Articolo in rivista
rivista: JOURNAL OF CLINICAL PSYCHIATRY (Physicians Postgraduate Press:3175 Lenox Park Boulevard, Suite 409:Memphis, TN 38115:(901)273-2748, EMAIL: kponder@psychiatrist.com, INTERNET: http://www.psychiatrist.com, Fax: (901)273-2747) pp. e91-e97 - issn: 0160-6689 - wos: WOS:000350973400004 (16) - scopus: 2-s2.0-84925372786 (19)

11573/600382 - 2014 - Clinical risk factors for bipolar disorders: A systematic review of prospective studies
Gianni L., Faedda; Serra, Giulia; Ciro, Marangoni; Paola, Salvatore; Sani, Gabriele; Gustavo H., Vazquez; Leonardo, Tondo; Girardi, Paolo; Ross J., Baldessarini; Athanasios, Koukopoulos - 01a Articolo in rivista
rivista: JOURNAL OF AFFECTIVE DISORDERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 314-321 - issn: 0165-0327 - wos: WOS:000341483100042 (72) - scopus: 2-s2.0-84905379424 (73)

11573/1350654 - 2014 - Memantine in the treatment and prophylaxis of bipolar II disorder and comorbid fibromyalgia. A case report
Serra, G.; De Chiara, L.; Koukopoulos, A. E.; Koukopoulos, A.; Serra, G.; Kahn, D. A. - 01i Case report
rivista: JOURNAL OF PSYCHIATRIC PRACTICE (Philadelphia, PA : Lippincott Williams & Wilkins, c2000-) pp. 232-236 - issn: 1527-4160 - wos: WOS:000336808200010 (9) - scopus: 2-s2.0-84901487779 (8)

11573/600388 - 2014 - Memantine in the management of affective recurrences of bipolar disorders after the discontinuation of long-term lithium treatment. three case histories
Serra, Giulia; De Chiara, Lavinia; Giovanni, Manfredi; Koukopoulos, Alexia; Sani, Gabriele; Girardi, Paolo; A., Koukopoulos; G., Serra - 01a Articolo in rivista
rivista: THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (London : SAGE, 2011-) pp. 53-55 - issn: 2045-1253 - wos: (0) - scopus: 2-s2.0-84998133492 (11)

11573/1350644 - 2014 - Memantine. New prospective in bipolar disorder treatment
Serra, Giulia; Demontis, Francesca; Serra, Francesca; De Chiara, Lavinia; Spoto, Andrea; Girardi, Paolo; Vidotto, Giulio; Serra, Gino - 01g Articolo di rassegna (Review)
rivista: WORLD JOURNAL OF PSYCHIATRY (Hong Kong : Baishideng Publishing Group Co., Limited) pp. 80-90 - issn: 2220-3206 - wos: (0) - scopus: (0)

11573/522384 - 2013 - Olanzapine in manic/mixed patients with or without substance abuse
Sani, Gabriele; Simonetti, Alessio; Serra, Giulia; Solfanelli, A.; Girardi, Nicoletta; Janiri, D.; Danese, E.; Rapinesi, Chiara; Tatarelli, Roberto; Girardi, Paolo - 01a Articolo in rivista
rivista: RIVISTA DI PSICHIATRIA (Roma : Il Pensiero Scientifico) pp. 140-145 - issn: 2038-2502 - wos: WOS:000339136200009 (3) - scopus: 2-s2.0-84878397796 (3)

11573/1350651 - 2013 - Antimanic and Long-Lasting Mood Stabilizing Effect of Memantine in Bipolar I Mood Disorder Two Case Reports
Serra, G; De Chiara, L; Koukopoulos, A; Serra, G - 01i Case report
rivista: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 715-717 - issn: 0271-0749 - wos: WOS:000330345700024 (11) - scopus: 2-s2.0-84883783192 (14)

11573/495410 - 2012 - The Wnt Pathway in Mood Disorders
Sani, Gabriele; Napoletano, Flavia; Forte, Alberto; Kotzalidis, Giorgio; Panaccione, Isabella; G. M., Porfiri; Simonetti, Alessio; Matteo, Caloro; Girardi, Nicoletta; C. L., Telesforo; Serra, Giulia; Silvia, Romano; Giovanni, Manfredi; Valeria, Savoja; S. M., Tamorri; Koukopoulos, Alexia; Daniele, Serata; Rapinesi, Chiara; Del Casale, Antonio; Nicoletti, Ferdinando; Girardi, Paolo - 01a Articolo in rivista
rivista: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. 239-253 - issn: 1570-159X - wos: WOS:000309491600006 (42) - scopus: 2-s2.0-84867564968 (46)

11573/961741 - 2012 - The role of memantine in the treatment of psychiatric disorders other than the dementias: A review of current preclinical and clinical evidence
Sani, Gabriele; Serra, Giulia; Kotzalidis, Giorgio D.; Romano, Silvia; Tamorri, Stefano Maria; Manfredi, Giovanni; Caloro, Matteo; Telesforo, C. Ludovica; Caltagirone, Saverio Simone; Panaccione, Isabella; Simonetti, Alessio; Demontis, Francesca; Serra, Gino; Girardi, Paolo - 01a Articolo in rivista
rivista: CNS DRUGS (Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766) pp. 663-690 - issn: 1172-7047 - wos: WOS:000307039800003 (92) - scopus: 2-s2.0-84863685351 (103)

11573/358169 - 2011 - The functional neuro-anatomy of the human response to fear: A brief review
Del Casale, Antonio; Ferracuti, Stefano; Kotzalidis, Giorgio; Rapinesi, Chiara; Serata, Daniele; Ambrosi, Elisa; Simonetti, Alessio; Serra, Giulia; Savoja, Valeria; Pompili, Maurizio; Angeletti, Gloria; Tatarelli, Roberto; Girardi, Paolo - 01a Articolo in rivista
rivista: SAJP (Pinelands : SA Medical Association ; Medical Publishing Group) pp. 3-8 - issn: 1608-9685 - wos: WOS:000290129000001 (1) - scopus: 2-s2.0-80051608257 (1)

11573/139672 - 2010 - Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder
Athanasios, Koukopoulos; Daniela, Reginaldi; Serra, Giulia; Koukopoulos, Alexia; Sani, Gabriele; Gino, Serra - 01a Articolo in rivista
rivista: BIPOLAR DISORDERS () pp. 348-349 - issn: 1398-5647 - wos: WOS:000277522200016 (33) - scopus: 2-s2.0-77953932377 (37)

11573/138700 - 2010 - Patient outcome in migraine prophylaxis: the role of psychopharmacological agents.
Pompili, Maurizio; Serafini, Gianluca; M., Innamorati; Serra, Giulia; Dominici, Giovanni; J., Fortes Lindau; M., Pastina; Telesforo, Carla Ludovica; D., Lester; Girardi, Paolo; Tatarelli, Roberto; Martelletti, Paolo - 01a Articolo in rivista
rivista: PATIENT RELATED OUTCOME MEASURES (Dove Medical Press) pp. 107-118 - issn: 1179-271X - wos: WOS:000208791900304 (0) - scopus: (0)

11573/143251 - 2010 - White matter hyperintensities, suicide risk and late-onset affective disorders: an overview of the current literature.
Pompili, Maurizio; Serafini, Gianluca; M., Innamorati; Serra, Giulia; Forte, Alberto; D., Lester; G., Ducci; Girardi, Paolo; Tatarelli, Roberto - 01a Articolo in rivista
rivista: LA CLINICA TERAPEUTICA (Societa Editrice Universo Srl:Via GB Morgagni 1, 00161 Rome Italy:011 39 06 4402053, EMAIL: seuroma@seuroma.com, INTERNET: http://www.seuroma.com, Fax: 011 39 06 4402033) pp. 555-563 - issn: 0009-9074 - wos: WOS:000286779400011 (14) - scopus: 2-s2.0-79953781381 (16)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma