Dottoressa di ricerca

ciclo: XXXVI

Titolo della tesi: Audiometria vocale adattiva, abilità linguistiche e funzioni cognitive nei giovani adulti impiantati in età infantile

During the three years of the PhD program, I focused on the field of auditory perception, in particular on cochlear implant patients. Auditory perception is critical for human communication and interaction. Cochlear implants have been crucial in the treatment of severe or profound deafness, but individual patient variables influence their success. These variables include subjective aspects such as motivation and cognitive variables such as attention and memory. Hearing loss in the elderly has a significant impact on quality of life, contributing to social isolation, anxiety, and depression. The treatment approach should be multidisciplinary, considering audiological, cognitive, and psychological aspects. The literature reported a potential link between presbycusis (age-related hearing loss) and cognitive decline. The prevalence of hearing loss in childhood is about 1.5 cases per 1000 live births. About 30% of deaf children also have a history of additional disability, frequently cognitive retardation. Congenital hearing loss can have significant effects on the development of language, communication, cognition, and education, with potential long-term consequences. Several studies have shown that early detection and early intervention are important for the proper language and cognitive development of children with hearing loss. Age at implantation is a critical factor in achieving optimal results in children with cochlear implants. Early intervention harnesses brain plasticity and improves the chances of a good auditory and language experience. BACKGROUND: The primary aim of the study was to assess the long-term speech perception outcomes (in quiet and noise) and language skills in a sample of prelingually deaf young adults who received their cochlear implant (CI) during childhood. The secondary aim was to determine if and to what extent speech perception in adulthood was related to the age at implantation and morphosyntactic comprehension skills. In addiction, the study evaluated fluid intelligence and executive functions, particularly working memory (WM) of long-term CI users and the relationship with speech perception in noise and language skills. MATERIALS AND METHODS: A prospective cohort study of 60 young adult CI users, 34 unilateral and 26 bilateral (mean age at surgery 57.7 ± 47.49 months; mean age at the last follow-up assessment 22.64 ± 3.8 years, and mean follow-up 21 ± 19.72 years). The Shapiro-Wilk test was used to assess normal data distribution (p-value ≤ 0.05). Kruskall Wallis and Mann-Whitney tests were used to compare listening modes, demographic variables, audiologic variables, linguistic variables, and cognitive variables. Bivariate analysis was performed to investigate the relationship between It-Matrix and TROG-2 and Peabody with perceptive and cognitive audiologic variables. Multivariate analysis was performed to quantify the relationship between a dependent variable (TROG-2, Peabody, and It-Matrix) and a set of explanatory variables (age at cochlear implant, speech perception in quiet and noise, language skills, cognitive functions) using a hierarchical stepwise linear regression. RESULTS: Bivariate analysis showed that It-Matrix was positively correlated with age at implantation (age CI r=0.38 p: 0.004) and auditory attention (r= 0.49 e p: 0.006). Audiologic results in noise and in quiet were strongly correlated with It-Matrix test results (p < 0.01), and PCA sentences were strongly correlated with TROG-2 and Peabody (p < 0.01). Morphosyntax (TROG-2) was negatively correlated with It-Matrix test results (TROG-2 r = - 0.5; p <0,001). Linguistic variables (TROG-2 and Peabody) were strongly correlated with the Listening Span Test and SPM with a p-value of < 0.01. CONCLUSIONS: These long-term data help us increase our understanding of the effects of variables such as the age at cochlear implantation or bilateral implantation on the outcomes of auditory rehabilitation with cochlear implants. The study also provides information on how language perception and language development are mutually related and, most importantly, further confirms that language perception in noise is influenced not only by several years of experience with the cochlear implant and the achieved language but also by other factors like higher cognitive functions.

Produzione scientifica

11573/1699151 - 2023 - Low-Frequency Pitch Coding: Relationships with Speech-in-Noise and Music Perception by Pediatric Populations with Typical Hearing and Cochlear Implants
Dincer D'alessandro, Hilal; Nicastri, Maria; Portanova, Ginevra; Giallini, Ilaria; Russo, Francesca Yoshie; Magliulo, Giuseppe; Greco, Antonio; Mancini, Patrizia - 01a Articolo in rivista
rivista: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (Berlin; Heidelberg: Springer) pp. 1-8 - issn: 0937-4477 - wos: WOS:001138668900001 (0) - scopus: 2-s2.0-85182216543 (4)

11573/1677406 - 2023 - Neuropsychological functions and audiological findings in elderly cochlear implant users: the role of attention in postoperative performance
Giallini, Ilaria; Inguscio, Bianca Maria Serena; Nicastri, Maria; Portanova, Ginevra; Ciofalo, Andrea; Pace, Annalisa; Greco, Antonio; Dincer D'alessandro, Hilal; Mancini, Patrizia - 01a Articolo in rivista
rivista: AUDIOLOGY RESEARCH (Pavia : PagePress Publications) pp. 236-253 - issn: 2039-4349 - wos: WOS:000977522900001 (4) - scopus: 2-s2.0-85153746291 (2)

11573/1674524 - 2023 - Long-term speech perception and morphosyntactic outcomes in adolescents and young adults implanted in childhood
Mancini, Patrizia; Nicastri, Maria; Giallini, Ilaria; Odabaşi, Yilmaz; Greco, Antonio; Dincer D'alessandro, Hilal; Portanova, Ginevra; Mariani, Laura - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (Limerick Ireland: Elsevier Science Ireland Limited) pp. - - issn: 0165-5876 - wos: WOS:000959544400001 (2) - scopus: 2-s2.0-85150345694 (2)

11573/1690083 - 2023 - Cochlear implant and tinnitus: a narrative literature review and evidence for clinical use
Mariani, Laura; Fabiano, Enrica; Portanova, Ginevra; Giallini, Ilaria; Nicastri, Maria; Musacchio, Angela; Altissimi, Giancarlo; Dincer D'alessandro, Hilal; Mancini, Patrizia - 01g Articolo di rassegna (Review)
rivista: OTORHINOLARYNGOLOGY (Torino: Minerva Medica) pp. 69-82 - issn: 2724-6760 - wos: (0) - scopus: 2-s2.0-85176219798 (0)

11573/1635708 - 2023 - The influence of auditory selective attention on linguistic outcomes in deaf and hard of hearing children with cochlear implants
Nicastri, Maria; Giallini, Ilaria; Inguscio, Bianca Maria Serena; Turchetta, Rosaria; Guerzoni, Letizia; Cuda, Domenico; Portanova, Ginevra; Ruoppolo, Giovanni; Dincer D'alessandro, Hilal; Mancini, Patrizia - 01a Articolo in rivista
rivista: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (Berlin; Heidelberg: Springer) pp. 115-124 - issn: 0937-4477 - wos: WOS:000824284900001 (5) - scopus: 2-s2.0-85134302260 (4)

11573/1680581 - 2023 - Vocal singing skills by cochlear implanted children without formal musical training: familiar versus unfamiliar songs
Nicastri, Maria; Lo Castro, Fabio; Giallini, Ilaria; Inguscio, Bianca Maria Serena; Mariani, Laura; Portanova, Ginevra; Ruoppolo, Giovanni; Orlando, Maria Patrizia; Dincer D'alessandro, Hilal; Mancini, Patrizia - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY ([S.l.] : Elsevier Science) pp. 1-10 - issn: 1872-8464 - wos: WOS:001008185100001 (1) - scopus: 2-s2.0-85160107869 (1)

11573/1590397 - 2022 - Cochlear implant in immune mediated inner ear diseases: impedance variations and clinical outcomes
Atturo, Francesca; Portanova, Ginevra; Russo, Francesca Yoshie; De Seta, Daniele; Mariani, Laura; Borel, Stephanie; Greco, Antonio; Mosnier, Isabelle; Mancini, Patrizia - 01a Articolo in rivista
rivista: COCHLEAR IMPLANTS INTERNATIONAL (London : Whurr Publishers for the British Cochlear Implant Group, c2000- Latest Publisher: Chichester, UK : John Wiley & Sons 2003-(?)) pp. 70-79 - issn: 1467-0100 - wos: WOS:000724068000001 (2) - scopus: 2-s2.0-85120322511 (2)

11573/1565117 - 2022 - Temporal coding and music perception in bimodal listeners
Dincer D'alessandro, Hilal; Ballantyne, Deborah; Portanova, Ginevra; Greco, Antonio; Mancini, Patrizia - 01a Articolo in rivista
rivista: AURIS, NASUS, LARYNX (-OXFORD:ELSEVIER SCI LTD. -Tokyo: SOciety for Promotion of International Otorhinolaryngology.) pp. 202-208 - issn: 0385-8146 - wos: WOS:000779967000006 (2) - scopus: 2-s2.0-85111051371 (4)

11573/1580465 - 2022 - Music perception and speech intelligibility in noise performance by italian-speaking cochlear implant users
Dincer D'alessandro, Hilal; Boyle, Patrick J.; Portanova, Ginevra; Mancini, Patrizia - 01a Articolo in rivista
rivista: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY AND HEAD & NECK (Berlin; Heidelberg: Springer.) pp. 3821-3829 - issn: 1434-4726 - wos: WOS:000702606600001 (2) - scopus: 2-s2.0-85116248605 (5)

11573/1630853 - 2022 - Effects of the “Active Communication Education” program on hearing-related quality of life in a group of Italian cochlear implant elderly users
Giallini, Ilaria; Nicastri, Maria; Inguscio, Bianca Maria Serena; Portanova, Ginevra; Magliulo, Giuseppe; Greco, Antonio; Mancini, Patrizia - 01a Articolo in rivista
rivista: FRONTIERS IN PSYCHOLOGY (Lausanne: Frontiers Editorial) pp. 1-15 - issn: 1664-1078 - wos: WOS:000806047900001 (1) - scopus: 2-s2.0-85131757339 (1)

11573/1649998 - 2022 - Audiometria vocale adattiva e abilità linguistiche ricettive in bambini con impianto cocleare: risultati a lungo termine.
Mariani, Laura; Portanova, Ginevra; Nicastri, Maria; Giallini, Ilaria; Fabiano, Enrica; Turchetta, Rosaria; Mancini, Patrizia - 04d Abstract in atti di convegno
congresso: Congresso Società Italiana di Otorinolaringoiatria 2022 (Roma)
libro: Congresso SIO 2022 - ()

Simoncelli, E; Gattamelata, A; Giardina, F; Villa, M; Colafrancesco, F; Mastromanno, L; Izzo, R; Mancini, P; Portanova, G; Mariani, L; Atturo, F; Conti, F; Priori, R - 01h Abstract in rivista
rivista: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (Pisa: Clinical and Experimental Rheumatology.) pp. 79-79 - issn: 1593-098X - wos: WOS:000900129900142 (0) - scopus: (0)

11573/1457349 - 2021 - Bimodal cochlear implantation in elderly patients
Mancini, Patrizia; Dincer D'alessandro, Hilal; Portanova, Ginevra; Atturo, Francesca; Russo, Francesca Yoshie; Greco, Antonio; De Vincentiis, Marco; Giallini, Ilaria; De Seta, Daniele - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF AUDIOLOGY (First or current publisher Hamilton, Ont. : BC Decker, [2005]- Intervening publisher London : Taylor & Francis Group Current or last publisher [S.l.] : Informa Healthcare) pp. 469-478 - issn: 1708-8186 - wos: WOS:000588514300001 (7) - scopus: 2-s2.0-85096110368 (9)

11573/1124765 - 2018 - Transcutaneous bone conductive implants in patients with conductive/mixed hearing loss: audiological outcomes in noise condition
Magliulo, Giuseppe; Iannella, Giannicola; De Vincentiis, Marco; Turchetta, Rosaria; Portanova, Ginevra; Angeletti, Diletta; Mancini, Patrizia - 01a Articolo in rivista
rivista: ACTA OTO-LARYNGOLOGICA (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL:,, INTERNET:, Fax: 011 44 1256 330245) pp. 822-829 - issn: 0001-6489 - wos: WOS:000443836800010 (2) - scopus: 2-s2.0-85049070514 (3)

11573/1033279 - 2018 - Hearing loss in autoimmune disorders: prevalence and therapeutic options
Mancini, P; Atturo, F; Di Mario, A; Portanova, G; Ralli, M; De Virgilio, A; De Vincentiis, M; Greco, A. - 01g Articolo di rassegna (Review)
rivista: AUTOIMMUNITY REVIEWS (Amsterdam; London; New York; Oxford; Paris; Shannon; Tokyo: Elsevier Oxford: Elsevier Science) pp. 644-652 - issn: 1568-9972 - wos: WOS:000438322500002 (32) - scopus: 2-s2.0-85047369123 (44)

11573/1126098 - 2018 - Bimodal hearing in asymmetrical hearing loss: prospective study in patients with same CI and HA devices
Mancini, Patrizia; Atturo, F; Portanova, G; Nicastri, M; Chantera, M; De Vincentiis, M; De Seta, E - 01h Abstract in rivista
rivista: JOURNAL OF HEARING SCIENCE (Kajetany : Institute of Sensory Organs) pp. 206-206 - issn: 2083-389X - wos: (0) - scopus: (0)

11573/1048669 - 2017 - Validazione dello STARR-IT in relazione a reattivi verbali alternativi in ambito audiologico: dati normativi e risultati in pazienti adulti portatori di impianto cocleare
Mancini, Patrizia; Ballantyne, Deborah; De Seta, Elio; Nicastri, Maria; Portanova, Ginevra; Boyle, Patrick; Di Mario, Alessia; Riccardi, Pasquale; Dincer D'alessandro, Hilal - 01a Articolo in rivista
rivista: AUDIOLOGIA & FONIATRIA (Roma: CIC edizioni internazionali) pp. 355-358 - issn: 2531-7008 - wos: (0) - scopus: (0)

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