Giacomo Frati was born on 1974. He obtained his MD diploma magna cum laude at the University of Rome in 1999 with a thesis on "Heart xenotransplantation: experimental models and clinical perspectives". He pursued specialist training in cardiovascular surgery, obtaining his Cardiac Surgery diploma magna cum laude in 2004 with a thesis on "Heart regeneration and Stem cells". He completed his fellowship at Thomas Jefferson University (Pa,USA,Prof.C.Croce), in the National Heart & Lung Institute (London,UK,Prof. M. Yacoub) and at Hopital Européen George Pompidou-Laboratoire de valvules et de protheses cardiac (Paris,France,Prof.A.Carpentier,Prof.J.C.Chachques). Research associate in 2002, Associate professor in 2005, Full professor in 2011, professor Frati's research interests concern surgical techniques, technological/biotechnological procedures applied to medicine, molecular medicine and regenerative medicine applied to cardiovascular disease leading professor Frati to be inventor and owner of 5 international patents exploited in 4 clinical trials. Since 2014, investigator in Phase I trial of endocavitary injection of bone-marrow-derived cd133+ cells in ischemic refractory cardiomyopathy (RECARDIO Trial). He has coauthored 278 articles published on international journals and indexed in PubMed, he won 27 national-international research projects-grants as Principal Investigator, he is author of several national and international book chapters. His international leadership in clinical research is testified by the high total impact factor (1295) and by the high h index (hi-47, 9350 citations) as well as by international awards and scientific societies' memberships. Last, he is Academic Editor of 10 international biomedical journals and reviewer of 28 international journals. Since 2010 he is the director of the GMP Facility (Cell-Factory) and of the Regenerative Research Program of Sapienza University, Department of Medico-Surgical Sciences and Biotechnologies