Dottore di ricerca

ciclo: XXXIV

Titolo della tesi: Environmental enrichment modifies gut microbiome and metabolome

The intestinal microbiota composed of both microorganisms and their products influences both behavior and brain functions; however, the improvement of synaptic plasticity and cognitive functions have been demonstrated with an accommodation in an enriched environment with sensory, motor and social stimuli. To study gut-brain communication and provide missing parts of the effects of the environment on the host, we hypothesized that environmental enrichment could modulate both microbial and metabolomic composition. Metagenomic and metabolomic analyses of mice housed in standard or enriched environment, highlight environment-specific microbial community, and metabolic profiles. We observed that mice housed in an enriched environment showed a reduction of gut microbial richness and diversity indexes and were characterized by a metabolomic fingerprint with the increase of two short chain fatty acids (SCFA) formate and acetate and the decrease of bile salts. Furthermore, we have shown that animals treated with a mix of format and acetate improved hippocampal neurogenesis, the expression of neurotrophins, as well as the cognitive response. These data showed us that SCFAs could be molecular effectors of enriched environment in the brain.

Produzione scientifica

11573/1682506 - 2022 - Microglial cells: Sensors for neuronal activity and microbiota-derived molecules
D'alessandro, Giuseppina; Marrocco, Francesco; Limatola, Cristina - 01a Articolo in rivista
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 1011129- - issn: 1664-3224 - wos: WOS:000890606200001 (5) - scopus: 2-s2.0-85142291763 (7)

11573/1638245 - 2022 - Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice
Marrocco, Francesco; Delli Carpini, Mary; Garofalo, Stefano; Giampaoli, Ottavia; De Felice, Eleonora; Di Castro, Maria Amalia; Maggi, Laura; Scavizzi, Ferdinando; Raspa, Marcello; Marini, Federico; Tomassini, Alberta; Nicolosi, Roberta; Cason, Carolina; Trettel, Flavia; Miccheli, Alfredo; Iebba, Valerio; D’Alessandro, Giuseppina; Limatola, Cristina - 01a Articolo in rivista
rivista: COMMUNICATIONS BIOLOGY ([London]: Springer Nature) pp. 1-13 - issn: 2399-3642 - wos: WOS:000803887600003 (18) - scopus: 2-s2.0-85130993774 (20)

11573/1366948 - 2020 - Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice
D'alessandro, Giuseppina; Antonangeli, Fabrizio; Marrocco, Francesco; Porzia, Alessandra; Lauro, Clotilde; Santoni, Angela; Limatola, Cristina - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF IMMUNOLOGY (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL:, INTERNET:, Fax: 011 49 6201 606328) pp. - - issn: 0014-2980 - wos: WOS:000517137700001 (57) - scopus: 2-s2.0-85081412203 (62)

11573/1409583 - 2020 - Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers
Scopa, C.; Marrocco, F.; Latina, V.; Ruggeri, F.; Corvaglia, V.; La Regina, F.; Ammassari-Teule, M.; Middei, S.; Amadoro, G.; Meli, G.; Scardigli, R.; Cattaneo, A. - 01a Articolo in rivista
rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL:, INTERNET:, Fax: 011 44 20 78434640) pp. 934-948 - issn: 1350-9047 - wos: WOS:000524400500009 (81) - scopus: 2-s2.0-85076587534 (88)

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