FRANCESCO GIOSUÈ IRACE

PhD Graduate

PhD program:: XXXIV



Thesis title: OXIDATIVE STRESS AND AUTOPHAGY IN THORACIC AORTIC ANEURYSMS

Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. In this study, we investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displayed higher oxidative stress and endothelial dysfunction then control patients. Autophagy in the TAA group was reduced. The association of oxidative stress and autophagy with aortic disease supports the role of these processes in TAA. We demonstrate a putative role of Nox2 and autophagy dysregulation in human TAA. These findings could pinpoint novel treatment targets to prevent or limit TAA progression.

Research products

11573/1704209 - 2024 - Extended septal myectomy for obstructive hypertrophic cardiomyopathy and its impact on mitral valve function
Lio, Antonio; D’Ovidio, Mariangela; Chirichilli, Ilaria; Saitto, Guglielmo; Nicolò, Francesca; Russo, Marco; Irace, Francesco; Ranocchi, Federico; Davoli, Marina; Musumeci, Francesco - 01a Articolo in rivista
paper: JOURNAL OF CARDIOVASCULAR MEDICINE (Lippincott Williams & Wilkins) pp. 210-217 - issn: 1558-2027 - wos: WOS:001158283700003 (1) - scopus: 2-s2.0-85184290788 (1)

11573/1704210 - 2024 - Systematic adjustment of root dimensions to cusp size in aortic valve repair: a computer simulation
Marom, Gil; Weltert, Luca Paolo; Raanani, Ehud; Chirirchilli, Ilaria; Giebels, Christian; Irace, Francesco Giosue; De Paulis, Ruggero; Schäfers, Hans-Joachim - 01a Articolo in rivista
paper: INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY (Oxford: Oxford University Press) pp. - - issn: 2753-670X - wos: (0) - scopus: (0)

11573/1698186 - 2023 - Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine
Bergonzini, Marcello; Loreni, Francesco; Lio, Antonio; Russo, Marco; Saitto, Guglielmo; Cammardella, Antonio; Irace, Francesco; Tramontin, Corrado; Chello, Massimo; Lusini, Mario; Nenna, Antonio; Ferrisi, Chiara; Ranocchi, Federico; Musumeci, Francesco - 01a Articolo in rivista
paper: BIOMEDICINES (Basel: MDPI) pp. - - issn: 2227-9059 - wos: WOS:001094150700001 (2) - scopus: 2-s2.0-85175470261 (2)

11573/1698185 - 2023 - Aortic Annuloplasty: Focus on the Use of an External Teflon Ring
Chirichilli, Iilaria; Ricci, Alessandro; Weltert, Luca; Torre, Mario; Irace, Francesco; Scaffa, Raffaele; Folino, Giulio; Salica, Andrea; D'aleo, Salvatore; Wolf, Lorenzo Guerrieri; Fusca, Samuel; Bellisario, Alessandro; Marra, Giulia; Andreis, Marco; Ciani, Camilla; Forcina, Sara; De Paulis, Ruggero - 01a Articolo in rivista
paper: SURGICAL TECHNOLOGY INTERNATIONAL ([Oklahoma City] : Century Press, c1991-) pp. - - issn: 1090-3941 - wos: WOS:001163719800002 (0) - scopus: (0)

11573/1687788 - 2023 - Reply: Leave well enough alone
Irace, Francesco Giosuè; Chirichilli, Ilaria; De Paulis, Ruggero - 01a Articolo in rivista
paper: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (New York: Elsevier Orlando, FL: Mosby Year Book) pp. - - issn: 0022-5223 - wos: WOS:001103026000001 (0) - scopus: 2-s2.0-85173479593 (0)

11573/1698187 - 2023 - Aortic Valve Replacement: Understanding Predictors for the Optimal Ministernotomy Approach
Irace, Francesco Giosuè; Chirichilli, Ilaria; Russo, Marco; Ranocchi, Federico; Bergonzini, Marcello; Lio, Antonio; Nicolò, Francesca; Musumeci, Francesco - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:001103316400001 (1) - scopus: 2-s2.0-85176576839 (1)

11573/1692413 - 2023 - Temporary intravascular shunts and limb salvage in civilian vascular trauma
Martinelli, Ombretta; Miceli, Francesca; Cuozzo, Simone; Irace, Francesco Giosuè; Avenia, Stefano; Iannone, Immacolata; Clementi, Ilaria; Sapienza, Paolo; Bellini, Maria Irene - 01a Articolo in rivista
paper: FRONTIERS IN SURGERY (Lausanne : Frontiers Media S.A., 2014-) pp. - - issn: 2296-875X - wos: WOS:001119819300001 (0) - scopus: (0)

11573/1664303 - 2022 - Twenty-year experience of aortic valve reimplantation using the Valsalva graft
Chirichilli, Ilaria; Scaffa, Raffaele; Irace, Francesco Giosuè; Salica, Andrea; Weltert, Luca Paolo; D'aleo, Salvatore; Chiariello, Luigi; De Paulis, Ruggero - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (Oxford: Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery Amsterdam: Elsevier Science Berlin: Springer, 1987-) pp. - - issn: 1010-7940 - wos: WOS:000943585200001 (8) - scopus: 2-s2.0-85149999029 (1)

11573/1616782 - 2022 - The black root: Aortic valve sparing in alkaptonuria
Folino, G.; Scaffa, R.; Salica, A.; Weltert, L.; D'aleo, S.; Guerrieri, L.; Irace, F.; Coscioni, E.; Gerosa, G.; De Paulis, R. - 01a Articolo in rivista
paper: JOURNAL OF CARDIAC SURGERY (Mount Kisco, N.Y. : Futura Pub. Co., c1986-) pp. - - issn: 0886-0440 - wos: WOS:000754389800001 (1) - scopus: 2-s2.0-85124510055 (1)

11573/1663397 - 2022 - Mitral repair of myxomatous valves with simple annuloplasty: a follow-up up to 12 years
Folino, Giulio; Salica, Andrea; Scaffa, Raffaele; Irace, Francesco Giosuè; Weltert, Luca Paolo; Bellisario, Alessandro; Gerosa, Gino; De Paulis, Ruggero - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (Oxford: Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery Amsterdam: Elsevier Science Berlin: Springer, 1987-) pp. - - issn: 1010-7940 - wos: WOS:000910891400005 (2) - scopus: 2-s2.0-85145955417 (3)

11573/1655284 - 2022 - Reimplantation versus aortic ring annuloplasty in bicuspid valve with borderline aortic root ectasia
Irace, F. G.; Chirichilli, I.; Folino, G.; Salica, A.; Guerrieri Wolf, L.; Scaffa, R.; D'aleo, S.; Weltert, L. P.; De Paulis, R. - 01a Articolo in rivista
paper: JTCVS TECHNIQUES (New York: Elsevier Inc) pp. - - issn: 2666-2507 - wos: WOS:000873983200007 (1) - scopus: 2-s2.0-85135956230 (0)

11573/1655282 - 2021 - Root Reimplantation and Aortic Annuloplasty With External Ring in Bicuspid Aortic Valve: An Anatomical Comparison
Chirichilli, Ilaria; Irace, Francesco; Salica, Andrea; D'aleo, Salvatore; Guerrieri Wolf, Lorenzo; Garufi, Luigi; De Paulis, Ruggero - 01a Articolo in rivista
paper: SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 844-851 - issn: 1043-0679 - wos: WOS:000863679800012 (2) - scopus: 2-s2.0-85111551659 (2)

11573/1616819 - 2021 - Aortic root anatomy after aortic valve reimplantation
Irace, F. G.; Chirichilli, I.; Salica, A.; D'aleo, S.; Guerrieri Wolf, L.; Garufi, L.; De Paulis, R. - 01a Articolo in rivista
paper: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (New York: Elsevier Orlando, FL: Mosby Year Book) pp. - - issn: 0022-5223 - wos: WOS:000955238200001 (7) - scopus: 2-s2.0-85105345030 (7)

11573/1571385 - 2021 - Role of oxidative stress and autophagy in thoracic aortic aneurysms
Irace, Francesco G.; Cammisotto, Vittoria; Valenti, Valentina; Maurizio, Forte; Schirone, Leonardo; Bartimoccia, Simona; Alessandra, Iaccarino; Peruzzi, Mariangela; Schiavon, Sonia; Morelli, Andrea; Marullo, Antonino G. M.; Miraldi, Fabio; Nocella, Cristina; Ruggero De Paulis, ; Umberto, Benedetto; Greco, Ernesto; Biondi Zoccai, Giuseppe; Sciarretta, Sebastiano; Carnevale, Roberto; Frati, Giacomo - 01a Articolo in rivista
paper: JACC. BASIC TO TRANSLATIONAL SCIENCE (New York: Elsevier B.V.) pp. 719-730 - issn: 2452-302X - wos: WOS:000711000100001 (13) - scopus: 2-s2.0-85122627701 (14)

11573/1546918 - 2021 - Optimized use of the "skirt" of the Valsalva graft for the completion Bentall
Scaffa, Raffaele; Salica, Andrea; Weltert, Luca; Irace, Francesco Giosuè; Wolf, Lorenzo Guerrieri; D'aleo, Salvo; Bellisario, Alessandro; De Paulis, Ruggero - 01a Articolo in rivista
paper: ANNALS OF THORACIC SURGERY ([Boston etc.]: [Little Brown & Co. etc.]) pp. - - issn: 0003-4975 - wos: WOS:000697696500014 (3) - scopus: 2-s2.0-85115034376 (3)

11573/1667787 - 2020 - Semeiotica dell'apparato Cardiovascolare
Amoroso, Antonio; Basili, Stefania; Biffoni, Marco; Catania, Antonio; Casella, Giovanni; Caronna, Roberto; Chirletti, Piero; D'orazio, Valerio; Gentile, Vincenzo; Irace, Luigi; Mascagni, Domenico; Mezzetti, Giuseppe; Mongardini, Massimo; Monti, Massimo; Angelo Rendina, Erano; Urcioli Collaboratori Capitolo 5: Alessia Alunno, Paolo; Belli, Cristina; Benhamida, Jamila; Castiglione, Anna; Di Girolamo, Alessia; Dorelli, Barbara; Faccenna, Federico; Gattuso, Roberto; Gigante, Antonietta; Giosuè Irace, Francesco; Jabbout, Jihad; Malaj, Alban; Marino, Mario; Martinelli, Ombretta; Maruca, Debora; Proietti, Camilla - 03c Manuale Didattico

11573/1386538 - 2020 - Long-term follow-up of Bentall procedure using the Perimount bioprosthesis and the Valsalva graft
Chirichilli, Ilaria; Irace, Francesco Giosuè; D'aleo, Salvatore; Folino, Giulio; Weltert, Luca Paolo; Scaffa, Raffaele; Nardella, Saverio; De Paulis, Ruggero - 01a Articolo in rivista
paper: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (-[S.l.] : European Association for Cardio-thoracic Surgery -Oxford : Elsevier Science) pp. - - issn: 1569-9285 - wos: WOS:000537398800004 (4) - scopus: 2-s2.0-85084101588 (4)

11573/1361388 - 2020 - A direct correlation between commissural orientation and annular shape in bicuspid aortic valves: a new anatomical and computed tomography classification
Chirichilli, Ilaria; Irace, Francesco Giosue'; Weltert, Luca Paolo; Salica, Andrea; Guerrieri Wolf, Lorenzo; Fusca, Samuel; Ricci, Alessandro; De Paulis, Ruggero - 01a Articolo in rivista
paper: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (-[S.l.] : European Association for Cardio-thoracic Surgery -Oxford : Elsevier Science) pp. - - issn: 1569-9285 - wos: WOS:000537398800002 (4) - scopus: 2-s2.0-85084103619 (3)

11573/1361374 - 2020 - Ascending aorta disruption after thoracic blunt trauma
Irace, F.; Rico, V.; Ciuffetta, D.; Miraldi, F. - 01i Case report
paper: CHINESE JOURNAL OF TRAUMATOLOGY (Chongqing : Editorial Board of Chinese Journal of Traumatology) pp. 32-33 - issn: 1008-1275 - wos: WOS:000518215500008 (0) - scopus: 2-s2.0-85078257240 (0)

11573/1698188 - 2020 - Procedure cardiovascolari - Protesi valvolari cardiache
Miraldi, Fabio; Chourda, Emmanouela; Marullo, Antonino G. M.; Irace, Francesco Giosue - 02a Capitolo o Articolo
book: Malattie cardiovascolari Approccio clinico e scientifico - (9788855320665)

11573/1386533 - 2020 - External stents for vein grafts in coronary artery bypass grafting: targeting intimal hyperplasia
Weltert, Luca Paolo; Wolf, Lorenzo Guerrieri; Garufi, Luigi; Scaffa, Raffaele; Salica, Andrea; Ricci, Alessandro; Irace, Francesco Giosuè; Fusca, Samuel; D'aleo, Salvatore; Chirichilli, Ilaria; Bellisario, Alessandro; De Paulis, Ruggero - 01a Articolo in rivista
paper: SURGICAL TECHNOLOGY INTERNATIONAL ([Oklahoma City] : Century Press, c1991-) pp. 197-201 - issn: 1090-3941 - wos: WOS:000587503100028 (0) - scopus: 2-s2.0-85085630186 (2)

11573/1252879 - 2019 - Morphological modification of the aortic annulus in tricuspid and bicuspid valves after aortic valve reimplantation: an electrocardiography-gated computed tomography study
Chirichilli, Ilaria; Irace, Francesco; Weltert, Luca; Tsuda, Kazumasa; Scaffa, Raffaele; Salica, Andrea; Galea, Nicola; De Paulis, Ruggero - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (Oxford: Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery Amsterdam: Elsevier Science Berlin: Springer, 1987-) pp. - - issn: 1010-7940 - wos: WOS:000491248300019 (9) - scopus: 2-s2.0-85067362661 (10)

11573/1321744 - 2019 - Latest Advances in Annuloplasty Protheses for Valvular Reconstructive Surgery
Weltert, Luca; Licitra, Rosaria; Salica, Andrea; Irace, Francesco; De Paulis, Ruggero - 01a Articolo in rivista
paper: SURGICAL TECHNOLOGY INTERNATIONAL ([Oklahoma City] : Century Press, c1991-) pp. - - issn: 1090-3941 - wos: WOS:000567363300002 (0) - scopus: 2-s2.0-85074744191 (2)

11573/1178862 - 2018 - One-year outcomes after ruptured abdominal aortic aneurysms repair: is endovascular aortic repair the best choice? A single-center experience
Martinelli, Ombretta; Fenelli, Cecilia; Ben-Hamida, Jamila Ben; Fresilli, Mauro; Irace, Francesco Giosuè; Picone, Veronica; Malaj, Alban; Gossetti, Bruno; Irace, Luigi - 01a Articolo in rivista
paper: ANNALS OF VASCULAR SURGERY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 63-69 - issn: 0890-5096 - wos: WOS:000446674300005 (8) - scopus: 2-s2.0-85049298564 (8)

11573/1061014 - 2017 - Open and endovascular treatment by covered and multilayer stents in the therapy of renal artery aneurysms. Mid and long term outcomes in a single center experience
Irace, L.; Ben Hamida, Jamila; Martinelli, O.; Stumpo, R.; Irace, F. G.; Venosi, S.; Gattuso, R.; Berloco, P. B.; Gossetti, B. - 01a Articolo in rivista
paper: IL GIORNALE DI CHIRURGIA (CIC Edizioni Internazionali:Corso Trieste N 42, I 00198 Rome Italy:011 39 06 8412673, EMAIL: abbonamenti@gruppocic.it, INTERNET: http://www.gruppocic.it, Fax: 011 39 06 8412688) pp. 219-224 - issn: 0391-9005 - wos: WOS:000426956100002 (8) - scopus: 2-s2.0-85039798775 (10)

11573/927666 - 2017 - Therapeutical options in the management of carotid dissection
Martinelli, Ombretta; Venosi, Salvatore; Ben Hamida, Jamila; Malaj, Alban; Belli, Cristina; Irace, Francesco Giosue'; Gattuso, Roberto; Frati, Giacomo; Gossetti, Bruno; Irace, Luigi - 01a Articolo in rivista
paper: ANNALS OF VASCULAR SURGERY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 69-76 - issn: 0890-5096 - wos: WOS:000402642100024 (14) - scopus: 2-s2.0-85009192456 (20)

11573/924218 - 2016 - Optimizing the exposure in minimally invasive mitral surgery. a new left atrial retractor system
Greco, Ernesto; Rose, David; Irace, Francesco Giosue'; Frati, Giacomo - 01a Articolo in rivista
paper: JOURNAL OF THORACIC DISEASE (Hong Kong : Pioneer Bioscience Publishing Company) pp. 3728-3732 - issn: 2072-1439 - wos: WOS:000391175400096 (6) - scopus: 2-s2.0-85010295341 (6)

11573/1089336 - 2015 - Video assistance in mitral surgery. reaching the thru port access
Irace, Francesco G; Rose, David; D'ascoli, Riccardo; Caldaroni, Federica; Andriani, Ines; Piscioneri, Fernando; Vitulli, Piergiusto; Piattoli, Matteo; Tritapepe, Luigi; Greco, Ernesto - 01a Articolo in rivista
paper: JOURNAL OF VISUALIZED SURGERY (香港 : AME Publishing Company Xiānggǎng : AME Publishing Company) pp. - - issn: 2221-2965 - wos: (0) - scopus: (0)

11573/899078 - 2015 - Recent developments in minimally invasive cardiac surgery. evolution or revolution
Marullo, Antonino G. M; Irace, Francesco G.; Vitulli, Piergiusto; Peruzzi, Mariangela; Rose, David; D'ascoli, Riccardo; Iaccarino, Alessandra; Pisani, Angelo; De Carlo, Carlotta; Mazzesi, Giuseppe; Barretta, Antonio; Greco, Ernesto - 01a Articolo in rivista
paper: BIOMED RESEARCH INTERNATIONAL ([London]: [Hindawi] Cairo: Hindawi Publishing Corporation) pp. - - issn: 2314-6133 - wos: WOS:000363135100001 (18) - scopus: 2-s2.0-84945548679 (26)

11573/558069 - 2013 - Extra-anatomical bypass: a surgical option for recurrent aortic coarctation.
Malaj, A; Martinelli, Ombretta; Irace, Fg; Jabbour, J; Gossetti, Bruno; Mazzesi, Giuseppe - 01a Articolo in rivista
paper: CASE REPORTS IN VASCULAR MEDICINE (Cairo: Hindawi Publishing Corporation) pp. - - issn: 2090-6986 - wos: (0) - scopus: (0)

11573/444524 - 2012 - Mid- and long-term results of endovascular treatment in thoracic aorta blunt trauma
Irace, Luigi; Laurito, Antonella; Venosi, Salvatore; Irace, Francesco Giosue'; Alban, Malay; Gossetti, Bruno; Gattuso, Roberto; Martinelli, Ombretta - 01a Articolo in rivista
paper: THE SCIENTIFIC WORLD JOURNAL (-NEW YORK, USA: -Newbury : TheScientificWorld. -Boynton Beach, Fla. : Scientific World.) pp. 1-4 - issn: 1537-744X - wos: WOS:000307064900001 (11) - scopus: 2-s2.0-84862329716 (13)

11573/408036 - 2009 - Trattamento chirurgico degli aneurismi dell'aorta addominale in urgenza: risultati del trattamento chirurgico classico e propettive dell'esclusione endovascolare.
Martinelli, Ombretta; Felli, Mmg; Alunno, A; Castiglione, A; Mansour, W; Irace, Fg; Malaj, A; De Marchi, F; Irace, Luigi - 01a Articolo in rivista
paper: MINERVA CARDIOANGIOLOGICA (Edizioni Minerva Medica:Corso Bramante 83-85, 10126 Turin Italy:011 39 011 678282318, EMAIL: journals.dept@minervamedica.it, INTERNET: http://www.minervamedica.it, Fax: 011 39 011 674502) pp. - - issn: 0026-4725 - wos: (0) - scopus: (0)

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