SANTILLI FRANCESCA

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: “Valutazione del potenziale angiogenico di cellule mesenchimali staminali adulte derivate dalla polpa dentaria umana”

Dental pulp has been revealed as an accessible and a rich source of mesenchymal stem cells (MSCs) and its biological potential is currently under intense investigation. MSCs from dental pulp stem cells (DPSC) have been indicated as a heterogeneous population oriented not only in repairing dentine but also in maintaining vascular and nervous homeostasis of the teeth. We sought to verify the phenotype of cells isolated from dental pulp of young donors and to investigate in vitro their role as pericyte-like cells. Specifically, we evaluated how different culture conditions can modulate expression of pericyte markers in DPSC and their capacity to stabilize endothelial tubes in vitro. DPSC cultured in standard conditions expressed MSC markers and demonstrated to contain a population expressing the pericyte marker NG2. These DPSC were associated with low sprouting capacity in extracellular (EC) Matrix and limited ability in retaining tubes formed by endothelial cells in a coculture angiogenesis model. When cultured in endothelial growth medium (EGM-2), DPSC significantly upregulated NG2. The resulting population conserved the stem marker CD73 but was negative for calponin and endothelial markers. EGM-2-conditioned DPSC showed a higher sprouting ability in EC Matrix and efficient association with human umbilical vein endothelial cells allowing the partial retention of endothelial tubes for several days. Among growth factors contained in EGM-2 we identified basic fibroblast growth factor (FGF) as mainly responsible for NG2 upregulation and long-term stabilization of endothelial tubes. According to the in vitro analysis, DPSC represent an effective source of pericytes, and the appropriate culture conditions could result in a population with a promising ability to stabilize vessels and promote vascular maturation.

Produzione scientifica

11573/1690770 - 2023 - The Importance of Stem Cells Isolated from Human Dental Pulp and Exfoliated Deciduous Teeth as Therapeutic Approach in Nervous System Pathologies
Candelise, Niccolò; Santilli, Francesca; Fabrizi, Jessica; Caissutti, Daniela; Spinello, Zaira; Moliterni, Camilla; Lancia, Loreto; Delle Monache, Simona; Mattei, Vincenzo; Misasi, Roberta - 01g Articolo di rassegna (Review)
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 1686- - issn: 2073-4409 - wos: WOS:001028464900001 (2) - scopus: 2-s2.0-85164747667 (4)

11573/1703936 - 2023 - Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)
Santilli, Francesca; Fabrizi, Jessica; Martellucci, Stefano; Santacroce, Costantino; Iorio, Egidio; Elena Pisanu, Maria; Chirico, Mattea; Lancia, Loreto; Pulcini, Fanny; Manganelli, Valeria; Sorice, Maurizio; Delle Monache, Simona; Mattei, Vincenzo - 01a Articolo in rivista
rivista: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:001105070000001 (0) - scopus: 2-s2.0-85177686503 (0)

11573/1621575 - 2022 - Prions and Neurodegenerative Diseases: A Focus on Alzheimer's Disease
Crestini, A.; Santilli, F.; Martellucci, S.; Carbone, E.; Sorice, M.; Piscopo, P.; Mattei, V. - 01d Recensione
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 503-518 - issn: 1387-2877 - wos: WOS:000747048000004 (17) - scopus: 2-s2.0-85123090211 (19)

11573/1648007 - 2022 - Hypoxia induces DPSC differentiation versus a neurogenic phenotype by the paracrine mechanism
Delle Monache, S.; Pulcini, F.; Santilli, F.; Martellucci, S.; Santacroce, C.; Fabrizi, J.; Angelucci, A.; Sorice, M.; Mattei, V. - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. - - issn: 2227-9059 - wos: WOS:000801682700001 (21) - scopus: 2-s2.0-85130009432 (21)

11573/1670846 - 2022 - Gangliosides and their role in multilineage differentiation of mesenchymal stem cells
Santilli, Francesca; Fabrizi, Jessica; Pulcini, Fanny; Santacroce, Costantino; Sorice, Maurizio; Delle Monache, Simona; Mattei, Vincenzo - 01g Articolo di rassegna (Review)
rivista: BIOMEDICINES (Basel : MDPI) pp. - - issn: 2227-9059 - wos: WOS:000900567600001 (8) - scopus: 2-s2.0-85144647671 (8)

11573/1574433 - 2021 - Exposure profile to traffic related pollution in pediatric age: a biomonitoring study
Antonucci, A.; Protano, C.; Astolfi, M. L.; Mattei, V.; Santilli, F.; Martellucci, S.; Vitali, M. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (Basel: MDPI 2003-) pp. - - issn: 1660-4601 - wos: WOS:000710447200001 (1) - scopus: 2-s2.0-85115678160 (1)

11573/1621879 - 2021 - Profilo di esposizione all’inquinamento da traffico in età pediatrica: uno studio di biomonitoraggio
Antonucci, A; Protano, C; Astolfi, Ml; Mattei, V; Santilli, F; Martellucci, S; Vitali, M; Serva, D; Fabrizi, J - 04d Abstract in atti di convegno
congresso: 54° Congresso Nazionale Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI) (Lecce 03-06 novembre 2021)
libro: atti del 54° Congresso Nazionale Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI) Lecce 03-06 novembre 2021 - ()

11573/1548393 - 2021 - Regenerative potential of DPSCs and revascularization. direct, paracrine or autocrine effect?
Mattei, V.; Martellucci, S.; Pulcini, F.; Santilli, F.; Sorice, M.; Delle Monache, S. - 01a Articolo in rivista
rivista: STEM CELL REVIEWS AND REPORTS (New York NY: Springer; New York NY: Humana Press) pp. - - issn: 2629-3277 - wos: WOS:000637664000001 (46) - scopus: 2-s2.0-85103899688 (48)

11573/1579992 - 2021 - The importance of tumor stem cells in glioblastoma resistance to therapy
Mattei, V.; Santilli, F.; Martellucci, S.; Monache, S. D.; Fabrizi, J.; Colapietro, A.; Angelucci, A.; Festuccia, C. - 01g Articolo di rassegna (Review)
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-18 - issn: 1661-6596 - wos: WOS:000644333700001 (27) - scopus: 2-s2.0-85103860416 (34)

11573/1547478 - 2020 - Prion protein in stem cells: a lipid raft component involved in the cellular differentiation process
Martellucci, S.; Santacroce, C.; Santilli, F.; Manganelli, V.; Sorice, M.; Mattei, V. - 01g Articolo di rassegna (Review)
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-12 - issn: 1661-6596 - wos: WOS:000543400300430 (12) - scopus: 2-s2.0-85086359777 (15)

11573/1389050 - 2020 - Neuritogenic signal pathway of tPA mediated by the multimolecular complex containing PrPC and LRP1 is dependent on lipid rafts
Martellucci, Stefano; Manganelli, Valeria; Santilli, Francesca; Mei, Cecilia; Ferri, Alberto; Mantuano, Elisabetta; Garofalo, Tina; Sorice, Maurizio; Misasi, Roberta; Mattei, Vincenzo - 01h Abstract in rivista
rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. - - issn: 0892-6638 - wos: WOS:000546023102514 (0) - scopus: (0)

11573/1547483 - 2020 - The Big Killers. II Edizione. Studio della mortalità per patologia oncologica nei residenti in provincia di Rieti Anno 1982-2011
Santilli, F; Martellucci, S; Di Pasquale, J; Mei, C; Vitali, M; Protano, C; Liberati, F; Sorice, M; Mattei, V. - 03a Saggio, Trattato Scientifico

11573/1306577 - 2019 - In vitro conditioning determines the capacity of dental pulp stem cells to function as pericyte-like cells
Delle Monache, Simona; Martellucci, Stefano; Clementi, Letizia; Pulcini, Fanny; Santilli, Francesca; Mei, Cecilia; Piccoli, Luca; Angelucci, Adriano; Mattei, Vincenzo - 01a Articolo in rivista
rivista: STEM CELLS AND DEVELOPMENT (MARY ANN LIEBERT INC, 2 MADISON AVENUE, LARCHMONT, USA, NY, 10538) pp. 695-706 - issn: 1547-3287 - wos: WOS:000465491200001 (33) - scopus: 2-s2.0-85065998485 (37)

11573/1412574 - 2019 - Lipid rafts and Prion Protein are involved in neuronal differentiation process of mesenchymal stem cells
Martellucci, S; Santacroce, C; Santilli, F; Mei, C; Manganelli, V; Piccoli, L; Delle Monache, S; Angelucci, A; Mattei, V; Misasi, R; Sorice, M - 04d Abstract in atti di convegno
congresso: SIPMeT Young Meeting (Florence; Italy)
libro: Pathobiology: from molecular disease to clinical application - ()

11573/1306575 - 2019 - Isolation, propagation, and prion protein expression during neuronal differentiation of human dental pulp stem cells
Martellucci, Stefano; Santacroce, Costantino; Manganelli, Valeria; Santilli, Francesca; Piccoli, Luca; Cassetta, Michele; Misasi, Roberta; Sorice, Maurizio; Mattei, Vincenzo - 01a Articolo in rivista
rivista: JOURNAL OF VISUALIZED EXPERIMENTS ([Boston, Mass. : MYJoVE Corp., 2006]-) pp. 1-7 - issn: 1940-087X - wos: WOS:000462909500103 (20) - scopus: 2-s2.0-85063988869 (23)

11573/1268017 - 2019 - Cellular and molecular mechanisms mediated by recPrP C involved in the neuronal differentiation process of mesenchymal stem cells
Martellucci, Stefano; Santacroce, Costantino; Santilli, Francesca; Piccoli, Luca; Monache, Simona Delle; Angelucci, Adriano; Misasi, Roberta; Sorice, Maurizio; Mattei, Vincenzo - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-12 - issn: 1422-0067 - wos: WOS:000459746500113 (27) - scopus: 2-s2.0-85060163840 (28)

11573/1413519 - 2019 - In vitro conditioning determines the capacity of dental pulp stem cells to stabilise endothelial tubes
Mei, C; Delle Monache, S; Martellucci, S; Clementi, L; Pulcini, F; Santilli, F; Piccoli, L; Santacroce, C; Angelucci, A; Mattei, V - 04d Abstract in atti di convegno
congresso: X meeting Stem Cell Research Italy (Naples; Italy)
libro: X meeting Stem Cell Research Italy - ()

11573/1373801 - 2019 - Further insights on predictors of environmental tobacco smoke exposure during the pediatric age
Protano, C.; Cammalleri, V.; Antonucci, A.; Ungureanu, A. S.; Santilli, F.; Martellucci, S.; Mattei, V.; Vitali, M. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (Basel: MDPI 2003-) pp. 1-11 - issn: 1660-4601 - wos: WOS:000498842000008 (8) - scopus: 2-s2.0-85074137762 (9)

11573/1264457 - 2019 - Cancer mortality trend in central Italy. focus on a “low rate of land use” area from 1982 to 2011
Santilli, Francesca; Martellucci, Stefano; Di Pasquale, Jennifer; Mei, Cecilia; Liberati, Fabrizio; Protano, Carmela; Vitali, Matteo; Sorice, Maurizio; Mattei, Vincenzo - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (Basel: MDPI 2003-) pp. 628- - issn: 1660-4601 - wos: WOS:000460804900107 (2) - scopus: 2-s2.0-85062024128 (3)

11573/1412552 - 2018 - In vitro model for the evaluation of angiogenic potential of MSCs derived from dental pulp
Delle Monache, S; Passadoro, V; Santilli, F; Martellucci, S; Marchioni, C; Mattei, V; Angelucci, A - 04d Abstract in atti di convegno
congresso: IX meeting Stem Cell Research Italy (Milano)
libro: IX meeting Stem Cell Research Italy - ()

11573/1114564 - 2018 - Role of Prion protein-EGFR multimolecular complex during neuronal differentiation of human dental pulp-derived stem cells
Martellucci, Stefano; Manganelli, Valeria; Santacroce, Costantino; Santilli, Francesca; Piccoli, Luca; Sorice, Maurizio; Mattei, Vincenzo - 01a Articolo in rivista
rivista: PRION (Austin, Tex. : Landes Bioscience, 2007-) pp. 117-126 - issn: 1933-6896 - wos: WOS:000434447700006 (28) - scopus: 2-s2.0-85046425455 (29)

11573/1412543 - 2018 - PrPC and EGFR: a multimolecular complex involved during neuronal differentiation of human dental pulp-derived stem cells
Martellucci, Stefano; Manganelli, Valeria; Santilli, Francesca; Santacroce, Costantino; Piccoli, Luca; Sorice, Maurizio; Mattei, Vincenzo - 04d Abstract in atti di convegno
congresso: Prion 2018 (Santiago De Compostela; Spain)
libro: Prion 2018 - ()

11573/1373730 - 2018 - Divieto di fumo negli ambienti domestici quando ci sono bambini? Una fotografia della popolazione nella provincia di Rieti
Protano, C; Mattei, V; Martellucci, S; Santilli, F; Antonucci, A; Marconi, E; Astolfi, Ml; Canepari, S; Valeriani, F; Romano Spica, V; Vitali, M - 04d Abstract in atti di convegno
congresso: 51° Congresso Nazionale della Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (Riva del Garda, Italy)
libro: Atti del 51° Congresso Nazionale della Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica - ()

11573/1412532 - 2017 - Angiogenic profile of hASCs and hDPSCs and theirs role on vascular stabilization
Delle Monache, Simona; Santilli, Francesca; Martellucci, Stefano; Gentile Warschauer, Emilio; Mattei, Vincenzo; Angelucci, Adriano - 04d Abstract in atti di convegno
congresso: VIII Meeting Stem Cell Research Italy (Chieti)
libro: VIII Meeting Stem Cell Research Italy - ()

11573/1412522 - 2017 - Morphine withdrawal modifies PrP expression in rat hippocampus
Martellucci, Stefano; Santilli, Francesca; Manganelli, Valeria; Garofalo, Tina; Candelise, Niccolò; Caruso, Alessandra Sebastiana Maria; Sorice, Maurizio; Scaccianoce, Sergio; Misasi, Roberta; Mattei, Vincenzo - 04d Abstract in atti di convegno
congresso: Prion 2017 (Edinburgh)
libro: Deciphering neurodegenerative disorders - ()

11573/1547481 - 2017 - The Big Killers - Studio della mortalità per patologia oncologica nei residenti in provincia di Rieti. Anno 2006-2010
Mattei, V; Santilli, F; Martellucci, S; Di Pasquale, J; Capparella, V; Vitali, M; Protano, C; Liberati, F; Santarelli, M; Sorice, M. - 03a Saggio, Trattato Scientifico

11573/953749 - 2017 - Cancer mortality in Rieti province (Latium Region, Italy) for the years 2006-2010: evaluation of temporal and spatial trends and comparison with the other Latium provinces
Mattei, Vincenzo; Santilli, F; Martellucci, S; Di Pasquale, J; Liberati, F; Protano, Carmela; Vitali, Matteo; Sorice, Maurizio - 01a Articolo in rivista
rivista: ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ (Rome Italy: Societa Editrice Universo Srl) pp. 161-170 - issn: 1120-9135 - wos: WOS:000417836700008 (1) - scopus: 2-s2.0-85030178557 (1)

11573/797474 - 2015 - Epidemiological profile of cancer mortality in a province of central Italy for the years 2008 and 2009: preliminary analysis
Mattei, V; Tasciotti, V; Santilli, F; Martellucci, S; Liberati, F; Protano, Carmela; Vitali, Matteo; Sorice, Maurizio - 01a Articolo in rivista
rivista: ANNALI DI IGIENE MEDICINA PREVENTIVA E DI COMUNITÀ (Rome Italy: Societa Editrice Universo Srl) pp. 613-622 - issn: 1120-9135 - wos: WOS:000378215200002 (2) - scopus: 2-s2.0-84953739635 (2)

11573/844179 - 2015 - Role of lipid rafts in neuronal differentiation of dental pulp-derived stem cells
Mattei, Vincenzo; Santacroce, Costantino; Tasciotti, Vincenzo; Martellucci, Stefano; Santilli, Francesca; Manganelli, Valeria; Piccoli, Luca; Misasi, Roberta; Sorice, Maurizio; Garofalo, Tina - 01a Articolo in rivista
rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 231-240 - issn: 0014-4827 - wos: WOS:000366618700007 (31) - scopus: 2-s2.0-84947741239 (32)

11573/769788 - 2014 - LRP1 activates ERK1/2 in lipid rafts in neuron-like cells
Mantuano, Elisabetta; Vincenzo, Mattei; Tasciotti, Vincenzo; Manganelli, Valeria; Martellucci, Stefano; Santilli, Francesca; Garofalo, Tina; Sorice, Maurizio; Gonias, Steven L.; Misasi, Roberta - 04d Abstract in atti di convegno
congresso: Neuroscience 2014 (Washington DC)
libro: Neuroscience 2014 - ()

11573/1412624 - 2014 - Cellular prion protein associates with a multimolecular complex including LRP1 and glycosphingolipids within lipid rafts
Mantuano, Elisabetta; Vincenzotasciotti, ; Garofalo, Tina; Martellucci, Stefano; Santilli, Francesca; Sorice, Maurizio; Misasi, Roberta; Mattei, Vincenzo - 04f Poster
congresso: Experimental Biology 2014 (San Diego, California, USA)
libro: Experimental Biology - ()

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma