Flavia Persechino

Dottoressa di ricerca

ciclo: XXXII



Titolo della tesi: FGFR expression profile, keratinocyte proliferation/differentiation markers and EMT-related genes in AK: a possible predictive factor for AK malignant progression

Actinic Keratosis (AK) is the UV-induced preneoplastic skin lesion which has been clinically classified in keratinocytic intraepithelial neoplasia (KIN) of ‘low’(KIN I), ‘intermediate’ (KIN II) and ‘high’(KIN III) grade. During KIN progression, the downregulation of several keratinocyte differentiation markers has been observed (Lambert et al., 2014), while the epithelial-mesenchymal transition (EMT) phenotype it has been recently described as a typical feature of some aggressive SCCs that directly develop from KIN I through the so-called differentiated pathway. More recently, the presentation of the FGF1 and FGF2 inhibitor (Dobesilate) as a new, effective therapeutic strategy strongly suggested that the deregulation of FGF/FGFR axis could contribute to AK pathogenesis . In this regard, our recent findings underlining that the altered FGFR2 splicing and the consequent aberrant expression of the mesenchymal FGFR2c variant in epithelial context induce impairment of differentiation and EMT induction, strongly encouraged us to investigate if the FGFR2 isoform switch could also take place in AK-keratinocytes possibly contributing the rapid progression of KIN I toward aggressive SCCs. The detailed molecular analysis performed in this work, have first highlighted that the early differentiation markers K1 and DSG1 appeared progressively downregulated during KIN progression, while the downmodulation of the terminal differentiation marker FIL was particularly marked just in some of the KIN I lesions suggesting that FIL could be one of the markers for that KIN I lesions destined to a rapid malignant progression toward SCC. In contrast, a modulation of epithelial/mesenchymal markers and an induction of the transcription factors Snail1 and ZEB1, compatible with pathological EMT, were detectable in all the analyzed AK samples, without significant correlation with KIN progression. Regarding FGFR expression, we found that a modulation of FGFR2b/FGFR2c isoforms, compatible with an FGFR2 isoform switch, as well as the upregulation of FGFR4, are detectable starting from KIN I lesions, encouraging us to suppose that they could be key events detectable starting from the early steps of AK pathogenesis. In contrast, the expression of FGFR3c was detected mainly in KIN II and KIN III lesions, suggesting that the appearance of this receptor could be a late event in AK progression. Finally, the increased expression of FGF2 mRNA in the dermal portion of all KIN lesions further supported the idea that aberrant epidermal/dermal paracrine loops based on FGF2/FGFR axis could contribute to AK pathogenesis. It is worth to note that, particularly in one of the KIN I samples a strong induction of Snail1, as well as an upregulation of FGFR2c, FGFR4, and FGF2 was observed, encouraging us to further assess if these proteins could be specific molecular markers, whose expression profile could in future help to quickly intercept KIN I lesion destined to a rapid, direct progression toward SCC. In the second part of this workwe pointed on the identification pof the specific signaling pathways downstream FGFR2c responsible for its oncogenic outcome in epithelial context. addressing particular attention on PKCe, whose overexpression alone was sufficient to induce an EMT-related phenotype in epithelial cells. Our results showed that aberrant expression and signaling of FGFR2c, but not those of FGFR2b, in human keratinocytes induced a strong phosphorylation/activation of PKCε. The use of siRNA approach showed that PKCε is the hub signaling downstream FGFR2c responsible for the modulation of EMT markers and for the induction of the EMT-related transcription factors STAT3, Snail1 and FRA1, as well as for the acquisition of the invasive behavior. Moreover, the depletion of ESRP1, responsible for FGFR2 splicing in epithelial cells, indicated that the activation of PKCε is the key molecular event triggered by FGFR2 isoform switch and underlying EMT induction. Therefore, the expression/activation of PKCε could represent an additional marker useful to identify that KIN I lesion destined to a rapid progression toward SCC. Our results represent the first step to advance the understanding of the molecular bases of FGFR signaling deregulation occurring in epithelial tissues from the physiological oncosoppressive to the pathological pre-neoplastic and finally oncogenic profiles.

Produzione scientifica

11573/507163 - 9999 - A NEW THERAPEUTIC OPTION with natural cellulose powder FOR THE TREATMENT OF SEASONAL ALLERGIC RHINITIS
Tammaro, Antonella; Abruzzese, C.; Narcisi, Alessandra; Cortesi, G.; Persechino, F.; Parisella, F. R.; Persechino, Severino - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (- London : SAGE Publications Ltd - Chieti : Biomedical Research Press, 1988-) pp. - - issn: 0394-6320 - wos: (0) - scopus: (0)

11573/434569 - 9999 - CONTACT ALLERGY TO LIMONENE FROM A HOME-MADE COSMETIC
Tammaro, Antonella; Narcisi, Alessandra; Di Russo, P. P.; Abruzzese, C.; De Marco, Gabriella; Persechino, F.; Parisella, F. R.; Persechino, S. - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF INFLAMMATION (Biolife, Silvi Marina) pp. - - issn: 1721-727X - wos: (0) - scopus: (0)

11573/1677970 - 2023 - FGFR2c Upregulation Contributes to Cancer-Associated Fibroblast Program Activation and to Enhanced Autophagy in Actinic Keratosis-Derived Dermal Fibroblasts. A Possible Role in Precancerous Cell/Stromal Cell Crosstalk
Guttieri, Luisa; Raffa, Salvatore; Salerno, Gerardo; Bigi, Rachele; Persechino, Flavia; Visco, Vincenzo; Torrisi, Maria Rosaria; Ranieri, Danilo; Belleudi, Francesca - 01a Articolo in rivista
rivista: BIOLOGY (Basel : MDPI) pp. 1-20 - issn: 2079-7737 - wos: WOS:000957177800001 (1) - scopus: 2-s2.0-85152406980 (3)

11573/1652316 - 2022 - An update on ophthalmological perspectives in oculodermal melanocytosis (Nevus of Ota)
Abdolrahimzadeh, Solmaz; Pugi, Damiano Maria; Manni, Priscilla; Iodice, Clemente Maria; Di Tizio, Federico; Persechino, Flavia; Scuderi, Gianluca - 01d Recensione
rivista: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (Heidelberg ; Berlin : Springer) pp. - - issn: 1435-702X - wos: WOS:000826832400001 (1) - scopus: 2-s2.0-85134497460 (1)

11573/1656523 - 2022 - Biosimilar versus originator etanercept: a real-life clinical study
Giordano, Domenico; Capalbo, Alessandro; Gagliostro, Nazareno; Fedele, Giusy; Balampanos, Charalampos G; Persechino, Flavia; Bushati, Vilma; Ulisse, Salvatore; Persechino, Severino; Pellacani, Giovanni - 01l Trial clinico
rivista: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY (Torino: Minerva medica) pp. 318-324 - issn: 2784-8671 - wos: WOS:000842982600001 (1) - scopus: 2-s2.0-85135420808 (2)

11573/1657122 - 2022 - The FGFR2c/PKCε axis controls MCL-1-Mediated invasion in pancreatic ductal adenocarcinoma cells: perspectives for innovative target therapies
Ranieri, Danilo; French, Deborah; Persechino, Flavia; Guttieri, Luisa; Torrisi, Maria Rosaria; Belleudi, Francesca - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 1-14 - issn: 2227-9059 - wos: WOS:000831972900001 (0) - scopus: 2-s2.0-85137306141 (0)

11573/1560791 - 2021 - Alopecia areata in a COVID-19 patient. A case report
Capalbo, A.; Giordano, D.; Gagliostro, N.; Balampanos, C. G.; Persechino, F.; Orru, F.; Persechino, S. - 01f Lettera, Nota
rivista: DERMATOLOGIC THERAPY (Malden, MA: Blackwell Science Incorporated Copenhagen: Munksgaard) pp. 1-2 - issn: 1396-0296 - wos: WOS:000607064200001 (16) - scopus: 2-s2.0-85099294072 (21)

11573/1333844 - 2021 - Enlarging melanocytic lesions with peripheral globular pattern: a dermoscopy and confocal microscopy study
Carbone, Anna; Persechino, Flavia; Paolino, Giovanni; Cota, Carlo; Piemonte, Paolo; Franceschini, Chiara; Eibenschutz, Laura; Ferrari, Angela; Buccini, Pierluigi; Frascione, Pasquale; Calvieri, Stefano; Ardigò, Marco - 01a Articolo in rivista
rivista: ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY (Torino: Minerva medica) pp. 467-472 - issn: 2784-8671 - wos: WOS:000704757200009 (3) - scopus: 2-s2.0-85116799933 (3)

11573/1560796 - 2021 - Vitiligo with Progressive Repigmentation during Secukinumab Treatment in a Patient with Psoriatic Arthritis. A Case Report
Giordano, D.; Magri, F.; Persechino, F.; Lepore, A.; Verde, R.; Capalbo, A.; Persechino, S. - 01i Case report
rivista: CASE REPORTS IN DERMATOLOGY (Basel: S. Karger, cop. 2009-) pp. 209-215 - issn: 1662-6567 - wos: WOS:000647600500034 (6) - scopus: 2-s2.0-85105604010 (6)

11573/1553792 - 2021 - Expression profile of fibroblast growth factor receptors, keratinocyte differentiation markers, and epithelial mesenchymal transition-related genes in actinic keratosis. A possible predictive factor for malignant progression?
Persechino, F.; Ranieri, D.; Guttieri, L.; Nanni, M.; Torrisi, M. R.; Belleudi, F. - 01a Articolo in rivista
rivista: BIOLOGY (Basel : MDPI) pp. 1-16 - issn: 2079-7737 - wos: WOS:000642738700001 (5) - scopus: 2-s2.0-85104967295 (6)

11573/1360950 - 2020 - ACANTHOSIS NIGRICANS: THE TELLTALE SIGN OF A GASTRIC CANCER RECURRENCE
Crovetto, Anna; Antolino, Laura; Moschetta, Giovanni; Persechino, Flavia; Persechino, Severino; Nigri, Giuseppe; Valabrega, Stefano; Aurello, Paolo; D'angelo, Francesco; Ramacciato, Giovanni - 01h Abstract in rivista
rivista: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY (Oxford: Elsevier Ltd. London; Orlando: Academic Press, c1985- United Kingdom: Harcourt Publishers Limited) pp. - - issn: 0748-7983 - wos: (0) - scopus: (0)

11573/1338276 - 2020 - Dermoscopy and confocal microscopy for different chemotherapy-induced alopecia (CIA) phases characterization: preliminary study
Franceschini, C.; Garelli, V.; Persechino, F.; Sperduti, I.; Caro, G.; Rossi, A.; Ardigo, M. - 01a Articolo in rivista
rivista: SKIN RESEARCH AND TECHNOLOGY (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. 269-276 - issn: 0909-752X - wos: WOS:000487751400001 (4) - scopus: 2-s2.0-85073997982 (4)

11573/1462399 - 2020 - Clinical management of very small pigmented lesions. Improved clinical outcome through dermoscopy and reflectance confocal microscopy combination
Persechino, Flavia; 2, Chiara Franceschini; 3, Alessandra Iorio; 3, Anna Carbone; 3, Angela Ferrari; 3, Pierluigi Buccini; 3, Paolo Piemonte; 3, Laura Eibenschutz; 4, Isabella Sperduti; 5, Carlo Cota; 3, Pasquale Frascione; 2, Marco Ardigo - 01a Articolo in rivista
rivista: Clinical management of very small pigmented lesions: Improved clinical outcome through dermoscopy and reflectance confocal microscopy combination (Skin Res Technol . ) pp. 718-726 - issn: - wos: WOS:000564555000001 (2) - scopus: 2-s2.0-85082108522 (2)

11573/1396073 - 2020 - Remission of Kimura disease with carotid hypervascularization after cyclosporine treatment
Persechino, Severino; Bartolazzi, Armando; Persechino, Flavia; Tammaro, Antonella; Valente, Sabatino; Raffa, Salvatore; Visco, Vincenzo; Torrisi, Maria Rosaria - 01a Articolo in rivista
rivista: DERMATOLOGY PRACTICAL & CONCEPTUAL (New York: Derm101.com) pp. - - issn: 2160-9381 - wos: WOS:000580876400003 (1) - scopus: (0)

11573/1402684 - 2020 - Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch
Ranieri, D.; Nanni, M.; Persechino, F.; Torrisi, M. R.; Belleudi, F. - 01a Articolo in rivista
rivista: CELL COMMUNICATION AND SIGNALING (BioMed Central, London) pp. 76-88 - issn: 1478-811X - wos: WOS:000536672700002 (8) - scopus: 2-s2.0-85084964867 (10)

11573/1346208 - 2019 - Reed syndrome: A case report and dermatoscopic features
Chello, Camilla; Magri, Francesca; Giordano, Domenico; Persechino, Flavia; Tammaro, Antonella; Persechino, Severino - 01i Case report
rivista: JOURNAL OF COSMETIC DERMATOLOGY (Blackwell Science.) pp. - - issn: 1473-2130 - wos: WOS:000504094700001 (0) - scopus: 2-s2.0-85076887304 (0)

11573/1307854 - 2019 - The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy
Nanni, Monica; Ranieri, Danilo; Persechino, Flavia; Torrisi, Maria Rosaria; Belleudi, Francesca - 01a Articolo in rivista
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 653- - issn: 2073-4409 - wos: WOS:000478902000049 (4) - scopus: 2-s2.0-85085607526 (4)

11573/1139294 - 2019 - A new high-throughput method to make a quality control on tattoo inks
Persechino, S.; Toniolo, C.; Ciccola, A.; Serafini, I.; Tammaro, A.; Postorino, P.; Persechino, F.; Serafini, M. - 01a Articolo in rivista
rivista: SPECTROCHIMICA ACTA. PART A, MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 547-551 - issn: 1386-1425 - wos: WOS:000447570700070 (10) - scopus: 2-s2.0-85054090497 (13)

11573/1338251 - 2019 - Treatment of refractory conjunctivitis associated to dupilumab with topical pimecrolimus applied to the eyelid skin
Sernicola, A.; Gattazzo, I.; Di Staso, F.; Giordano, D.; Capalbo, A.; Persechino, F.; Scuderi, G.; Persechino, S. - 01a Articolo in rivista
rivista: DERMATOLOGIC THERAPY (Malden, MA: Blackwell Science Incorporated Copenhagen: Munksgaard) pp. 1-3 - issn: 1396-0296 - wos: WOS:000494263900001 (7) - scopus: 2-s2.0-85074860734 (8)

11573/1191253 - 2018 - Identifying the factors that influence surgeon's compliance with excisional margins of non-melanoma skin cancer
Cautela, Jennifer Marchetti; Mannocci, Alice; Reggiani, Camilla; Persechino, Flavia; Ferrari, Federica; Rossi, Elena; Passini, Erika; Bellini, Pierantonio; Meleti, Marco; Rowan, Sara Wertzberger; Magnoni, Cristina - 01a Articolo in rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e0204330- - issn: 1932-6203 - wos: WOS:000445907400037 (1) - scopus: 2-s2.0-85054050966 (3)

11573/1191251 - 2018 - Resurfacing with Ablation of Periorbital Skin Technique: Indications, Efficacy, Safety, and 3D Assessment from a Pilot Study
Guida, Stefania; Nisticò, Steven Paul; Farnetani, Francesca; Del Duca, Ester; De Carvalho, Nathalie; Persechino, Flavia; Verdina, Tommaso; Giannetti, Luca; D'alessandro, Martina; Urtis, Giacomo Giovanni; Pellacani, Giovanni; D'alessandro, Giovanni - 01a Articolo in rivista
rivista: PHOTOMEDICINE AND LASER SURGERY (Larchmont, NY : Mary Ann Liebert, Inc., 2004-) pp. 541-547 - issn: 1549-5418 - wos: WOS:000445085800001 (8) - scopus: 2-s2.0-85054773662 (10)

11573/1482902 - 2018 - Skin above the knees: treatments for a difficult area
Guida, Stefania; Persechino, Flavia; Mandel, Victor Desmond; Pellacani, Giovanni; Urtis, Giacomo Giovanni; Farnetani, Francesca - 04b Atto di convegno in volume
congresso: 39th SIME National Congress (Roma)
libro: 39th SIME (Italian Society of Aesthetic Medicine) National Congress - ()

11573/1191263 - 2018 - Improving mandibular contour: A pilot study for indication of PPLA traction thread use
Guida, Stefania; Persechino, Flavia; Rubino, Giuseppe; Pellacani, Giovanni; Farnetani, Francesca; Urtis, Giacomo Giovanni - 01a Articolo in rivista
rivista: JOURNAL OF COSMETIC AND LASER THERAPY (-INFORMA HEALTHCARE-SWEDEN -Basingstoke : Taylor & Francis -London : Martin Dunitz, 2001-) pp. 1-5 - issn: 1476-4172 - wos: WOS:000455939700019 (7) - scopus: 2-s2.0-85042229050 (8)

11573/1191271 - 2018 - Dermoscopy of syringocystadenoma papilliferum
Lombardi, Mara; Piana, Simonetta; Longo, Caterina; Borsari, Stefania; Persechino, Flavia; Argenziano, Giuseppe; Moscarella, Elvira - 01i Case report
rivista: AUSTRALASIAN JOURNAL OF DERMATOLOGY (Blackwell Science Asia Party Limited:550 Swanston Street, Carlton VIC 3053 Australia:011 61 3 83591011, EMAIL: info@blackwell-science-asia.com, INTERNET: http://www.blackwell-science.com, Fax: 011 61 3 83591120) pp. e59-e61 - issn: 0004-8380 - wos: WOS:000423999900011 (6) - scopus: 2-s2.0-85022227903 (7)

11573/1191247 - 2018 - Treatment of chronic infected post-oncological wounds with a dermal matrix: Two case studies
Mandel, Victor Desmond; Persechino, Flavia; Fiorentini, Null; Passini, Erica; Magnoni, Cristina - 01i Case report
rivista: JOURNAL OF WOUND CARE (-London : Macmillan Magazines, 1992- -London : MA Healthcare) pp. 558-562 - issn: 0969-0700 - wos: WOS:000444349700004 (1) - scopus: 2-s2.0-85053285501 (2)

11573/1191267 - 2018 - Folliculotropism in pigmented facial macules: Differential diagnosis with reflectance confocal microscopy
Persechino, Flavia; De Carvalho, Nathalie; Ciardo, Silvana; De Pace, Barbara; Casari, Alice; Chester, Johanna; Kaleci, Shaniko; Stanganelli, Ignazio; Longo, Caterina; Farnetani, Francesca; Pellacani, Giovanni - 01a Articolo in rivista
rivista: EXPERIMENTAL DERMATOLOGY (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. 227-232 - issn: 0906-6705 - wos: WOS:000427009500222 (19) - scopus: 2-s2.0-85043323672 (19)

11573/1482891 - 2018 - Improving the aging of the neck: combined treatments
Persechino, Flavia; Farnetani, Francesca; Mandel, Victor Desmond; Pellacani, Giovanni; Urtis, Giacomo Giovanni; Guida, Stefania - 04b Atto di convegno in volume
congresso: 39th SIME National Congress (Roma)
libro: 39th SIME (Italian Society of Aesthetic Medicine) National Congress - ()

11573/1191194 - 2018 - A new single red nodule on the abdomen of a woman with history of endometrial carcinoma: Noninvasive evaluation and histologic correlation
Persechino, Flavia; Franceschini, Chiara; Cota, Carlo; Frascione, Pasquale; Ardigò, Marco - 01i Case report
rivista: ‫JAAD CASE REPORTS ([New York] : Elsevier) pp. 941-943 - issn: 2352-5126 - wos: (0) - scopus: 2-s2.0-85054466050 (1)

11573/1191258 - 2018 - Melanoma and hemangioma: An atypical presentation
Persechino, Severino; Pigliacelli, Flavia; Persechino, Flavia; Demarco, Gabriella; Tammaro, Antonella - 01i Case report
rivista: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA (Torino: Minerva medica) pp. 593-595 - issn: 0392-0488 - wos: WOS:000441207500031 (0) - scopus: 2-s2.0-85048244889 (0)

11573/1080574 - 2018 - Seborrheic keratoses mimicking melanoma unveiled by in vivo reflectance confocal microscopy
Pezzini, C.; Mandel, V. D.; Persechino, F.; Ciardo, S.; Kaleci, S.; Chester, J.; Teixeira De Carvalho, Nathalie; Persechino, S.; Pellacani, G.; Farnetani, F. - 01a Articolo in rivista
rivista: SKIN RESEARCH AND TECHNOLOGY (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. 1-9 - issn: 0909-752X - wos: WOS:000430185900017 (8) - scopus: 2-s2.0-85040971455 (10)

11573/1482859 - 2018 - Presentazione dermoscopica atipica di lesioni non melanocitarie benigne: quale aiuto dal confocale?
Pezzini, Claudia; Mandel, Victor Desmond; Persechino, Flavia; Ciardo, Silvana; Kaleci, Shaniko; Chester, Johanna; De Carvalho, Nathalie; Persechino, Severino; Pellacani, Giovanni; Farnetani, Francesca - 04f Poster
congresso: Congresso Annuale AIDNID 2018 (Catania)
libro: Congresso Annuale AIDNID (Associazione Italiana Diagnostica non Invasiva in Dermatologia) 2018 - ()

11573/1483171 - 2017 - Reflectance confocal microscopy features of regression in congenital naevus: case report
Persechino, Flavia; De Pace, Barbara; Cesinaro, A. M.; Pellacani, G.; Farnetani, F. - 01a Articolo in rivista
rivista: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. e243-e245 - issn: 0926-9959 - wos: WOS:000400188900012 (0) - scopus: 2-s2.0-85006414878 (0)

11573/1191284 - 2017 - Acral melanoma
Persechino, Flavia; Longo, Caterina; Benati, Elisa; Borsari, Stefania; Lombardi, Mara; Piana, Simonetta; Argenziano, Giuseppe; Moscarella, Elvira - 01i Case report
rivista: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (Mosby Year Book Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)654-2452, (407)345-4000, EMAIL: hhspcs@harcourt.com, INTERNET: http://www.mosby.com, Fax: (407)363-9661, (314)432-1380) pp. S34-S36 - issn: 0190-9622 - wos: WOS:000396911400013 (1) - scopus: 2-s2.0-85009101188 (1)

11573/987085 - 2017 - Successful of subcutaneous and oral hyposensitizing therapy in 30 patients
Tammaro, Antonella; Romano, I; Parisella, Fr; De Marco, Gabriella; Persechino, Flavia; Trimarchi, I; Persechino, Severino - 01a Articolo in rivista
rivista: EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (Paris : Meditions Carline 2003-200u -Fidenza (PR) : Mattioli 1885, 2008-) pp. - - issn: 1764-1489 - wos: WOS:000407852600007 (0) - scopus: 2-s2.0-85018373728 (0)

11573/987087 - 2017 - Plasticity of immune system vs. memory therapy IST
Tammaro, Antonella; Romano, Irene; Persechino, Flavia; Parisella, Fr; Trimarchi, I; Persechino, Severino - 01a Articolo in rivista
rivista: ALLERGOLOGIA ET IMMUNOPATHOLOGIA (Editorial Garsi SA:Ronda General Mitre 149-151, 08022 Barcelona Spain:011 34 3 2530517, Fax: 011 34 3 2530515) pp. - - issn: 0301-0546 - wos: WOS:000411656400011 (0) - scopus: 2-s2.0-85019559264 (0)

11573/1483552 - 2016 - Un caso di forma eruttiva di nevi di Spitz
Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ciardo, Silvana; Pellacani, Giovanni; Farnetani, Francesca - 04f Poster
congresso: 91° Congresso nazionale Sidemast (Genova)
libro: 91° Congresso Nazionale SIDeMaST (Società Italiana di Dermatologia medica, chirurgica, estetica e delle Malattie Sessualmente Trasmesse) - ()

11573/1483639 - 2016 - Congenital glioblastoma multiforme and eruptive disseminated spitz nevi
Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca - 01i Case report
rivista: THE ITALIAN JOURNAL OF PEDIATRICS (London: BioMed Central Ltd. 2008- -Pacini Editore) pp. 1-5 - issn: 1720-8424 - wos: WOS:000377515400001 (9) - scopus: 2-s2.0-84969165010 (8)

11573/1483593 - 2016 - Caractéristiques dermoscopiques et en microscopie confocale par réflectance dgune kératose séborrhéique clonale [Dermoscopic and reflectance confocal microscopic features of clonal seborrhoeic keratosis]
Persechino, Flavia; Longo, Caterina; Cesinaro, A. M.; Cinotti, E; Ciardo, Silvia; Pellacani, Giovanni; Bassoli, S. - 01a Articolo in rivista
rivista: ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE (Masson Editeur:21 rue Camille Desmoulins, 92786 Issy Cedex 9 France:011 33 1 73281634, EMAIL: infos@masson.fr, INTERNET: http://www.masson.fr, Fax: 011 33 1 73281649) pp. 164-166 - issn: 0151-9638 - wos: WOS:000372592700013 (0) - scopus: 2-s2.0-84960401168 (0)

11573/883969 - 2016 - Heavy metal and tattoo: an allergy and legislative problem.
Tammaro, Antonella; Cortesi, Giorgia; Pigliacelli, Flavia; Parisella, Fr; Persechino, Flavia; De Marco, Gabriella; Persechino, Severino - 01a Articolo in rivista
rivista: EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY (Paris : Meditions Carline 2003-200u -Fidenza (PR) : Mattioli 1885, 2008-) pp. - - issn: 1764-1489 - wos: WOS:000387486300008 (2) - scopus: 2-s2.0-84995767488 (2)

11573/883973 - 2016 - Sea Anemone: A Rare Case of Contact Dermatitis in Italy.
Tammaro, Antonella; Pigliacelli, Flavia; D'arino, Andrea; Persechino, Flavia; Parisella, Fr; Persechino, Severino - 01a Articolo in rivista
rivista: DERMATITIS (B C DECKER INC, 50 KING STREET EAST, 2ND FLOOR, PO BOX 620, L C D 1, HAMILTON, CANADA, ONTARIO, L8N 3K7) pp. - - issn: 1710-3568 - wos: WOS:000372450400007 (1) - scopus: 2-s2.0-84961784553 (1)

11573/883968 - 2016 - Effects of TIO NICKEL in patients with ACD and SNAS: experience on 700 patients in Italy.
Tammaro, Antonella; Romano, Irene; De Marco, Gabriella; Parisella, Fr; Pigliacelli, Flavia; D'arino, Andrea; Persechino, Flavia; Gaspari, Aa; Persechino, Severino - 01a Articolo in rivista
rivista: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (Oxford : Blackwell Publishing) pp. - - issn: 1468-3083 - wos: WOS:000399765300008 (1) - scopus: 2-s2.0-84998953434 (1)

11573/883970 - 2016 - A case of Koebner phenomenon in a patient with tattoo to lips.
Tammaro, Antonella; Romano, Irene; Parisella, F; Persechino, Flavia; Persechino, Severino - 01a Articolo in rivista
rivista: JOURNAL OF COSMETIC AND LASER THERAPY (-INFORMA HEALTHCARE-SWEDEN -Basingstoke : Taylor & Francis -London : Martin Dunitz, 2001-) pp. - - issn: 1476-4172 - wos: (0) - scopus: (0)

11573/1483547 - 2015 - BRAFV600E mutated and wild type melanomas: dermoscopy and reflectance confocal microscopy characterization
Manfredini, Marco; Ponti, Giovanni; Mandel, Victor Desmond; Persechino, Flavia; Ruini, Cristel; Maccaferri, Monia; Pellacani, Giovanni - 04f Poster
congresso: 4th World Congress of Dermoscopy and Skin Imaging (Vienna)
libro: 4th World Congress of Dermoscopy and Skin Imaging - ()

11573/596632 - 2014 - Chemotherapic outcomes in a child with neurofibromatosis type 1 and optic pathway glioma.
Giustini, Sandra; Visconti, Bianca; Miraglia, Emanuele; Persechino, F; Calvieri, Stefano - 01a Articolo in rivista
rivista: DERMATOLOGIA CLINICA (CIC Edizioni Internazionali:Corso Trieste N 42, I 00198 Rome Italy:011 39 06 8412673, EMAIL: abbonamenti@gruppocic.it, INTERNET: http://www.gruppocic.it, Fax: 011 39 06 8412688) pp. 162-164 - issn: 0392-1395 - wos: (0) - scopus: (0)

11573/565341 - 2014 - A rare association between neurofibromatosis type 1 and vulvar sarcoma.
Miraglia, Emanuele; Pecorella, Irene; Persechino, F.; Visconti, Bianca; Calvieri, Stefano; Giustini, Sandra - 01a Articolo in rivista
rivista: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA (Torino: Minerva medica) pp. 374-376 - issn: 0392-0488 - wos: WOS:000340012200015 (11) - scopus: 2-s2.0-84907602167 (14)

11573/764380 - 2014 - Condyloma acuminata and mollusca contagiosa: a giant manifestation in a patient with lupus.
Persechino, Severino; Abruzzese, Claudia; Caperchi, C; Persechino, F; Tammaro, Antonella - 01a Articolo in rivista
rivista: SKINMED (Darien, Conn. : Le Jacq Communications) pp. - - issn: 1540-9740 - wos: (0) - scopus: 2-s2.0-84924449766 (1)

11573/637476 - 2014 - Decreased expression of KGF/FGF7 and its receptor in pathological hypopigmentation.
Purpura, V; Persechino, F; Belleudi, Francesca; Scrofani, Cristina; Raffa, Salvatore; Persechino, Severino; Torrisi, Maria Rosaria - 01a Articolo in rivista
rivista: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (Bucharest : University Press "Carol Davila" Bucharest: Foundation for Cellular and Molecular Medicine, 2000-) pp. 2553-2557 - issn: 1582-4934 - wos: WOS:000345513400023 (10) - scopus: 2-s2.0-84911986489 (11)

11573/511670 - 2013 - KYRLE'S DISEASE: TREATMENT WITH MINOCYCLINE AND TOPIC TACALCITOL
Caperchi, C.; Cortesi, Giorgia; Persechino, F.; Tammaro, Antonella; Persechino, Severino - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF INFLAMMATION (Biolife, Silvi Marina) pp. 245-246 - issn: 1721-727X - wos: WOS:000318128100024 (2) - scopus: 2-s2.0-84879966752 (2)

11573/517375 - 2013 - SUN: FRIEND OR ENEMY?
Miraglia, Emanuele; Persechino, F; Visconti, B; Iacovino, C; Calvieri, Stefano; Giustini, Sandra - 01a Articolo in rivista
rivista: PREVENTION & RESEARCH (Roma : Francesco Tomei) pp. 152-162 - issn: 2240-2594 - wos: (0) - scopus: (0)

11573/506781 - 2012 - xeroderma pigmentosum: the star’s sons. case report and review of the literature.
Miraglia, Emanuele; Curatolo, Pietro; Rotunno, R; Visconti, B; Persechino, F; Calvieri, Stefano; Giustini, Sandra - 01a Articolo in rivista
rivista: PREVENTION & RESEARCH (Roma : Francesco Tomei) pp. 388-393 - issn: 2240-2594 - wos: (0) - scopus: (0)

11573/488313 - 2012 - Magnesium stearate: an underestimated allergen
Tammaro, Antonella; Abruzzese, C.; Narcisi, A.; Cortesi, G.; Persechino, F.; Parisella, F. R.; Persechino, Severino - 01a Articolo in rivista
rivista: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS (Wichtig Editore:Via Friuli 72 74, I 20135 Milan Italy:011 39 02 5455122, 011 39 2 55195443, EMAIL: info@wichtig-publisher.com, INTERNET: http://www.wichtig-publisher.com, Fax: 011 39 2 55195971) pp. 783-784 - issn: 0393-974X - wos: WOS:000313603200022 (5) - scopus: 2-s2.0-84876480691 (6)

11573/482222 - 2012 - Disperse yellow dye: An emerging professional sensitizer in contact allergy dermatitis
Tammaro, Antonella; Abruzzese, Claudia; Narcisi, Alessandra; Cortesi, Giorgia; Grippaudo, Francesca Romana; Persechino, F.; Parisella, F. R.; Persechino, Severino - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF INFLAMMATION (Biolife, Silvi Marina) pp. 525-526 - issn: 1721-727X - wos: WOS:000313668100028 (2) - scopus: 2-s2.0-84873476664 (1)

11573/461343 - 2012 - TWO CASES OF CERCARIAL DERMATITIS IN AN ITALIAN LAKE
Tammaro, Antonella; Narcisi, Alessandra; Abruzzese, C.; Cortesi, G.; Persechino, F.; Parisella, F. R.; Caperchi, C.; Persechino, Severino - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF INFLAMMATION (Biolife, Silvi Marina) pp. 139-141 - issn: 1721-727X - wos: WOS:000304233700018 (1) - scopus: 2-s2.0-84861660833 (1)

11573/434581 - 2012 - EFFECTS OF ORAL HYPOSENSITIZATION THERAPY WITH NICKEL ON HAEMOGLOBIN AND HAEMATOCRIT VALUES IN SENSITIZED PATIENTS
Tammaro, Antonella; Narcisi, Alessandra; Di Russo, P. P.; Abruzzese, Claudia; Caperchi, C.; Persechino, F.; Parisella, F. R.; Persechino, Severino - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (- London : SAGE Publications Ltd - Chieti : Biomedical Research Press, 1988-) pp. 519-521 - issn: 0394-6320 - wos: WOS:000305879500023 (1) - scopus: 2-s2.0-84863668590 (1)

11573/29418 - 2011 - Expression and signaling of the tyrosine kinase FGFR2b/KGFR regulates phagocytosis and melanosome uptake in human keratinocytes
Belleudi, Francesca; Purpura, Valeria; Scrofani, Cristina; Persechino, F.; Leone, Laura; Torrisi, Maria Rosaria - 01a Articolo in rivista
rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 170-181 - issn: 0892-6638 - wos: WOS:000285869500016 (28) - scopus: 2-s2.0-79251591302 (30)

11573/456472 - 2011 - Giant basal cell carcinoma: An old but effective therapy with 5FU
Persechino, Severino; C., Caperchi; A., Alhadeff; G., Fatuzzo; F., Persechino; Tammaro, Antonella - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF DERMATOLOGY (Montrouge: John Libbey eurotext) pp. 287-287 - issn: 1167-1122 - wos: WOS:000291024000050 (1) - scopus: 2-s2.0-79960832706 (1)

11573/438549 - 2011 - ANETODERMA: EVIDENCE OF THE RELATIONSHIP WITH AUTOIMMUNE DISEASE AND A POSSIBLE ROLE OF MACROPHAGES IN THE ETIOPATHOGENESIS
Persechino, Severino; Caperchi, C.; Cortesi, G.; Persechino, F.; Raffa, Salvatore; Pucci, E.; Tammaro, Antonella; Torrisi, Maria Rosaria - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (- London : SAGE Publications Ltd - Chieti : Biomedical Research Press, 1988-) pp. 1075-1077 - issn: 0394-6320 - wos: WOS:000299757500025 (4) - scopus: 2-s2.0-84856578850 (6)

11573/380950 - 2011 - Erythema dyschromicum perstans in phototype II women: three unusual clinical cases studied with electron microscopy
Persechino, Severino; Caperchi, C.; Cortesi, G.; Persechino, F.; Raffa, Salvatore; Pulcini, F.; Tammaro, Antonella; Torrisi, Maria Rosaria - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF DERMATOLOGY (Montrouge: John Libbey eurotext) pp. 261-262 - issn: 1167-1122 - wos: WOS:000291024000027 (2) - scopus: 2-s2.0-79960768231 (3)

11573/227832 - 2009 - Carcinoma en cuirasse of the breast
Carlesimo, Marta; Rossi, Alfredo; De Marco, Gabriella; Narcisi, Alessandra; C., Cacchi; E., Mari; F., Persechino; G., Camplone - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF DERMATOLOGY (Montrouge: John Libbey eurotext) pp. 289-290 - issn: 1167-1122 - wos: WOS:000265752400042 (9) - scopus: 2-s2.0-66449083842 (14)

11573/1654762 - 1991 - Incidental prostate carcinoma: 4-year follow-up folowing treatment with cyproterone acetate,IL CARCINOMA PROSTATICO INCIDENTALE: QUATTRO ANNI DI FOLLOW-UP DOPO TERAPIA CON CIPROTERONE ACETATO
Di Silverio, F.; D(')Eramo, G.; Caponera, M.; Persechino, F.; Sciarra, A.; Oke, E. - 01a Articolo in rivista
rivista: ACTA UROLOGICA ITALICA (Acta medica. Edizioni e Congressi. Societa Italian Urologia:DIP URO Barcci, Un Sapienza Policlin, Umberto 1, 00161 Rome Italy:011 39 6 490853) pp. 303-306 - issn: 0394-2511 - wos: (0) - scopus: 2-s2.0-0026356286 (0)

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