FLAVIA DI FEO

PhD Student

PhD program:: XXXIX
email: flavia.difeo@iss.it
phone: 0649902954
building: 20
room: 11

supervisor: Dott. Pietro Pichierri
advisor: Dott. Pietro Pichierri
co-supervisor: Dott.ssa Annapaola Franchitto

Research: Novel Insights into the Regulation of the PRIMPOL Repriming Pathway and Its Impact on PARPi Sensitivity

Name: Flavia Di Feo
Date and place on birth: 12/06/1998 Roma (RM)
Citizenship: Italian
Work address: Istituto Superiore di Sanità, Viale Regina Elena 299, 0161 – Roma (I)
Email address: flavia.difeo@uniroma1.it

Technical skills and competences:

technique of cell biology,

molecular biology

immunofluorescence

Education and Training:

2024: Enrolment in PhD course in Uman Biology and Medical Genetics (Sapienza University-Rome, Italy)

2024: Master’s Degree in Cellular and Molecular Biology and Biomedical Sciences (Tor Vergata University - Rome, Italy)

2022-2024: Internship during studies at the Genome Stability group of the Section of Mechanisms, Biomarkers and Models (Department of Environment and Health. Istituto Superiore di Sanità)

2020: Bachelor’s Degree in Biological Science (Sapienza University – Rome, Italy)

Workshops and Meetings:

2024: 36° AICC International Meeting 2024, HIJACKING THE <> PATHWAYS: CANCER, IMMUNITY AND THERAPEUTIC APPROACHES. Rome

2025: Fusion Conference: Targeting the DNA Damage Response for Cancer Therapeutics Conference. Lisbon

Publications:

2025: Noto, A., Valenzisi, P., Di Feo, F. et al. Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure. Nat Commun 16, 997 (2025). https://doi.org/10.1038/s41467-025-55958-z

Research products

11573/1756248 - 2026 - CK2 inhibition sensitizes BRCA-proficient cancer cells to PARP inhibitors by modulating PRIMPOL-mediated repriming

Di Feo, Flavia; Franchitto, Annapaola; Pichierri, Pietro - 04f Poster

conference: Targeting the DNA Damage Response for Cancer Therapeutics Conference (Lisbona)

book: in press - ()

11573/1732773 - 2025 - Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

Noto, Alessandro; Valenzisi, Pasquale; Di Feo, Flavia; Fratini, Federica; Kulikowicz, Tomasz; Sommers, Joshua A; Perdichizzi, Benedetta; Semproni, Maurizio; Palermo, Valentina; Crescenzi, Marco; Brosh, Robert M; Franchitto, Annapaola; Pichierri, Pietro - 01a Articolo in rivista

paper: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: (0) - scopus: (0)