FIORENZA SANTAMARIA

PhD Student

PhD program:: XXXVIII
email: fiorenza.santamaria@uniroma1.it

supervisor: Prof. Andrea Botticelli

Research:

WORK EXPERIENCE

01/11/2022 - nowadays
University of Rome “La Sapienza”
PhD in "Network Oncology and Precision Medicine” (Prof.ssa E. Ferretti, Prof. A. Botticelli)

01/07/2024 - nowadays
Oncologist
Casa di cura Villa Del Rosario, Roma

03/05/2021 - nowadays
OMCEO, Oncologic Commission, Onco-geriatric sub commission in collaboration with GOGI – Onlus (Italian Group of Geriatric Oncology)

11/2017 - 12/2022
University of Rome “La Sapienza”
Doctor in specialist training in Medical Oncology. 70/70 cum laude

EDUCATION AND TRAINING

03/2016 Medical register in Rome, position number: OMCEO Roma M62285

10/2009 – 09/2015
University of Rome “La Sapienza”
Degree in Medicine and Surgery. Vote 110/110 cum laude

2013-2015 Percorso di eccellenza. Department of Translational Medicine at University of Rome “La Sapienza”, Faculty Of Medicine and Psychology. Research project “Personalized Medicine in patients with Multiple Chemical Sensibility”

Twelve national congress as scientific coordinator and more than fifteen national congress as speaker in the last five years.

EXPERTISE
Excellent skills in the utilization of Office Pack, MedCalc and SPSS, and good skills in using R.
Excellent capacity in clinical application of Personalized Medicine, with complex pharmacological treatment optimization integrating genomic and molecular information, clinical and pathological phenotype, anamnestic and demographic data and single patient need.
Excellent clinical management of gastrointestinal and genitourinay cancers and oncogeriatric population.

OTHER CERTIFICATE ACTIVITIES

Coordinator of “PERCORSO MULTIDISCIPLINARE DIAGNOSTICO-TERAPEUTICO (PDTA) IN ONCOLOGIA GERIATRICA” at the AOU Policlinico Umberto I, Roma (Agenas n. 535- 426203, 40 ECM- from 31/07/2024 to 16/12/2024, for 2 hours/week).

Winner of type 1B financing among “Bando di Ateneo 2023 per avvio alla ricercar” with the project “EVALUTATION OF CLINICAL IMPACT OF DRUG-DRUG INTERACTIONS IN METASTATIC COLORECTAL CANCER PATIENTS DURING 5FU-BASED CHEMOTHERAPY USING DRUG-PIN SOFTWARE: A pooled post-hoc analysis of TRIBE and TRIBE2 studies” approved by S.A. 263/2023 on 10.10.2023.

05/07/2022 P.D.T.A of onco-geriatric patient produced by Oncologic Commission, Onco-geriatric sub commission and validated by Directive board of OMCEO of Rome

12/12/2021 GOOD CLINICAL PRACTICE (GCP) CERTIFICATE realized by Nida clinical trials Network

Research products

11573/1713708 - 2024 - Efficacy of regorafenib and trifluridine/tipiracil according to extended RAS evaluation in advanced metastatic colorectal cancer patients: a multicenter retrospective analysis

Basso, Michele; Signorelli, Carlo; Calegari, Maria Alessandra; Lucchetti, Jessica; Zurlo, Ina Valeria; Dell'aquila, Emanuela; Arrivi, Giulia; Zoratto, Federica; Santamaria, Fiorenza; Saltarelli, Rosa; Trovato, Giovanni; Caira, Giulia; Angotti, Lorenzo; Schirripa, Marta; Anghelone, Annunziato; Schietroma, Francesco; Chilelli, Mario Giovanni; Salvatore, Lisa; Pozzo, Carmelo; Tortora, Giampaolo - 01a Articolo in rivista

paper: TARGETED ONCOLOGY (Paris : Springer Verlag France 2006-) pp. 371-382 - issn: 1776-2596 - wos: WOS:001202026000003 (0) - scopus: 2-s2.0-85190088684 (0)

11573/1719761 - 2024 - Immunotherapy-Based Combinations in First-Line Urothelial Cancer: A Systematic Review and Individual Patient Data (IPD) Meta-Analysis

Di Civita, M. A.; Torchia, A.; Santini, D.; Marinelli, D.; Magro, V.; Cerro, M.; Pappalardo, L.; Maltese, G.; Santamaria, F.; Zacco, L.; Buccilli, D.; Dehghanpour, A.; Speranza, I.; Sciarra, A.; Panebianco, V.; Roberto, M. - 01g Articolo di rassegna (Review)

paper: CURRENT ONCOLOGY (Basel, Switzerland: MDPI dal Volume 28 Issue 1-2021 Milton ON Canada: Multimed, [2005]-) pp. 4713-4727 - issn: 1718-7729 - wos: WOS:001305503700001 (0) - scopus: 2-s2.0-85202627603 (0)

11573/1713710 - 2024 - Treatment of patients with BRAF-mutated metastatic colorectal cancer after progression to encorafenib and cetuximab: data from a real-world nationwide dataset

Germani, M. M.; Vetere, G.; Santamaria, F.; Intini, R.; Ghelardi, F.; Bensi, M.; Boccaccino, A.; Minelli, A.; Carullo, M.; Ciracì, P.; Passardi, A.; Santucci, S.; Giampieri, R.; Persano, M.; Fenocchio, E.; Puccini, A.; Lonardi, S.; Pietrantonio, F.; Salvatore, L.; Cremolini, C. - 01a Articolo in rivista

paper: ESMO OPEN (London: BMJ) pp. - - issn: 2059-7029 - wos: WOS:001235957000001 (3) - scopus: 2-s2.0-85190154354 (4)

11573/1713713 - 2024 - Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments

Santamaria, Fiorenza; Roberto, Michela; Buccilli, Dorelsa; Di Civita, Mattia Alberto; Giancontieri, Paola; Maltese, Giulia; Nicolella, Francesco; Torchia, Andrea; Scagnoli, Simone; Pisegna, Simona; Barchiesi, Giacomo; Speranza, Iolanda; Botticelli, Andrea; Santini, Daniele - 01a Articolo in rivista

paper: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (-NEW YORK, USA, NY: ELSEVIER SCIENCE INC -Boca Raton, Fla.: CRC Press.) pp. - - issn: 1040-8428 - wos: (0) - scopus: 2-s2.0-85196171896 (0)

11573/1726130 - 2024 - 529P Evaluating metastatic disease sites as a prognostic marker in patients receiving sequential treatment with regorafenib and trifluridine/tipiracil for refractory colorectal cancer: Survival outcomes from the multicenter retrospective “ReTrITA” study

Signorelli, C.; Calegari, M. A.; Anghelone, A.; Basso, M.; Passardi, A.; Frassineti, G. L.; Zurlo, I. V.; Angotti, L.; Chilelli, M. G.; Morelli, C.; Dell'aquila, E.; Gemma, D.; Corsi, D. C.; Mazzuca, F.; Zoratto, F.; Morandi, M. G.; Santamaria, F.; Saltarelli, R.; Dettori, M.; Ruggeri, E. M. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: (0) - scopus: (0)

11573/1726133 - 2024 - 73P Efficacy outcomes in ≥70-year-old or younger patients receiving regorafenib-to-trifluridine/tipiracil sequence or vice versa for refractory metastatic colorectal cancer: Findings from the multicenter retrospective “ReTrITA” study

Signorelli, C.; Calegari, M. A.; Basso, M.; Passardi, A.; Lucchetti, J.; Zurlo, I. V.; Morelli, C.; Dell'aquila, E.; Gemma, D.; Emiliani, A.; Arrivi, G.; Zoratto, F.; Chilelli, M. G.; Morandi, M. G.; Santamaria, F.; Dettori, M.; Cosimati, A.; Saltarelli, R.; Minelli, A.; Ruggeri, E. M. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: WOS:001299993900073 (1) - scopus: (0)

11573/1730498 - 2024 - Survival Outcomes with Regorafenib and/or Trifluridine/Tipiracil Sequencing to Rechallenge with Third-Line Regimens in Metastatic Colorectal Cancer: A Multicenter Retrospective Real-World Subgroup Comparison from the ReTrITA Study

Signorelli, Carlo; Calegari, Maria Alessandra; Anghelone, Annunziato; Passardi, Alessandro; Frassineti, Giovanni Luca; Bittoni, Alessandro; Lucchetti, Jessica; Angotti, Lorenzo; Di Giacomo, Emanuela; Zurlo, Ina Valeria; Morelli, Cristina; Dell'aquila, Emanuela; Artemi, Adele; Gemma, Donatello; Corsi, Domenico Cristiano; Emiliani, Alessandra; Ribelli, Marta; Mazzuca, Federica; Arrivi, Giulia; Zoratto, Federica; Chilelli, Mario Giovanni; Schirripa, Marta; Morandi, Maria Grazia; Santamaria, Fiorenza; Dettori, Manuela; Cosimati, Antonella; Saltarelli, Rosa; Minelli, Alessandro; Lucci-Cordisco, Emanuela; Basso, Michele - 01a Articolo in rivista

paper: CURRENT ONCOLOGY (Basel, Switzerland: MDPI dal Volume 28 Issue 1-2021 Milton ON Canada: Multimed, [2005]-) pp. 7793-7808 - issn: 1718-7729 - wos: (0) - scopus: 2-s2.0-85213436635 (0)

11573/1726134 - 2024 - Survival benefit with regorafenib and/or trifluridine/tipiracil sequencing to rechallenge with anti-EGFR-based third-line regimens in metastatic colorectal cancer: A multicenter retrospective real-world subgroups comparison

Signorelli, Carlo; Chilelli, Mario Giovanni; Basso, Michele; Calegari, Maria Alessandra; Anghelone, Annunziato; Lucchetti, Jessica; Minelli, Alessandro; Angotti, Lorenzo; Zurlo, Ina Valeria; Schirripa, Marta; Morelli, Cristina; Dell'aquila, Emanuela; Gemma, Donatello; Corsi, Domenico Cristiano; Arrivi, Giulia; Zoratto, Federica; Morandi, Maria Grazia; Santamaria, Fiorenza; Saltarelli, Rosa; Ruggeri, Enzo Maria - 01h Abstract in rivista

paper: JOURNAL OF CLINICAL ONCOLOGY (editori attuale: -American Society of Clinical Oncology. , 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, USA, VA, 22314 precedente: -W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. - - issn: 0732-183X - wos: (0) - scopus: (0)

11573/1705598 - 2023 - P-368 Efficacacy of trifluridine/tipiracil according to extended RAS evaluation: A multicenter retrospective analysis

Caira, G.; Calegari, M.; Anghelone, A.; Lucchetti, J.; Dell’Aquila, E.; Signorelli, C.; Spring, A.; Saltarelli, R.; Cosimati, A.; Zurlo, I.; Angotti, L.; Schietroma, F.; Pozzo, C.; Chiofalo, L.; Santamaria, F.; Morelli, C.; Zoratto, F.; Schirripa, M.; Salvatore, L.; Basso, M.; Tortora, G. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: WOS:001037960400369 (0) - scopus: (0)

11573/1705596 - 2023 - P-195 Influence of age on disease control rate of patients treated with regorafenib and trifluridine/tipiracil in refractory metastatic colorectal cancer: A multicenter retrospective real-world study

Signorelli, C.; Calegari, M.; Basso, M.; Anghelone, A.; Lucchetti, J.; Minelli, A.; Angotti, L.; Zurlo, I.; Schirripa, M.; Chilelli, M.; Morelli, C.; Dell’Aquila, E.; Cosimati, A.; Gemma, D.; Ribelli, M.; Corsi, D.; Arrivi, G.; Zoratto, F.; Morandi, M.; Santamaria, F.; Saltarelli, R.; Ruggeri, E. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: WOS:001037960400196 (0) - scopus: (0)

11573/1683365 - 2023 - Treatment settings and outcomes with Regorafenib and Trifluridine/Tipiracil at third-line treatment and beyond in metastatic colorectal cancer: a real-world multicenter retrospective study

Signorelli, Carlo; Calegari, Maria Alessandra; Basso, Michele; Anghelone, Annunziato; Lucchetti, Jessica; Minelli, Alessandro; Angotti, Lorenzo; Zurlo, Ina Valeria; Schirripa, Marta; Chilelli, Mario Giovanni; Morelli, Cristina; Dell’Aquila, Emanuela; Cosimati, Antonella; Gemma, Donatello; Ribelli, Marta; Emiliani, Alessandra; Corsi, Domenico Cristiano; Arrivi, Giulia; Mazzuca, Federica; Zoratto, Federica; Morandi, Maria Grazia; Santamaria, Fiorenza; Saltarelli, Rosa; Ruggeri, Enzo Maria - 01a Articolo in rivista

paper: CURRENT ONCOLOGY (Basel, Switzerland: MDPI dal Volume 28 Issue 1-2021 Milton ON Canada: Multimed, [2005]-) pp. 5456-5469 - issn: 1718-7729 - wos: WOS:001014209900001 (4) - scopus: 2-s2.0-85163725552 (4)

11573/1705594 - 2023 - Retrospective Correlation between First Drug Treatment Duration and Survival Outcomes in Sequential Treatment with Regorafenib and Trifluridine/Tipiracil in Refractory Metastatic Colorectal Cancer: A Real-World Subgroup Analysis

Signorelli, Carlo; Chilelli, Mario; Giannarelli, Diana; Basso, Michele; Calegari, Maria; Anghelone, Annunziato; Lucchetti, Jessica; Minelli, Alessandro; Angotti, Lorenzo; Zurlo, Ina; Schirripa, Marta; Morelli, Cristina; Dell’Aquila, Emanuela; Cosimati, Antonella; Gemma, Donatello; Ribelli, Marta; Emiliani, Alessandra; Corsi, Domenico; Arrivi, Giulia; Mazzuca, Federica; Zoratto, Federica; Morandi, Maria; Santamaria, Fiorenza; Saltarelli, Rosa; Ruggeri, Enzo - 01a Articolo in rivista

paper: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:001132629600001 (0) - scopus: 2-s2.0-85180704882 (0)

11573/1667585 - 2023 - Sequential treatment with regorafenib and trifluridine/tipiracil in later-line refractory metastatic colorectal cancer: A real-world multicenter retrospective study

Signorelli, Carlo; Schirripa, Marta; Chilelli, Mario Giovanni; Calegari, Maria Alessandra; Basso, Michele; Anghelone, Annunziato; Lucchetti, Jessica; Minelli, Alessandro; Angotti, Lorenzo; Gemma, Donatello; Dell'aquila, Emanuela; Cosimati, Antonella; Arrivi, Giulia; Morelli, Cristina; Corsi, Domenico Cristiano; Saltarelli, Rosa; Morandi, Maria Grazia; Zoratto, Federica; Santamaria, Fiorenza; Ruggeri, Enzo Maria - 01h Abstract in rivista

11573/1705597 - 2023 - P-360 Efficacy of regorafenib according to extended RAS evaluation: A multicenter retrospective analysis

Trovato, G.; Valente, G.; Calegari, M.; Dell’Aquila, E.; Anghelone, A.; Lucchetti, J.; Schietroma, F.; Zurlo, I.; Signorelli, C.; Morelli, C.; Zoratto, F.; Caira, G.; Spring, A.; Saltarelli, R.; Cosimati, A.; Schirripa, M.; Santamaria, F.; Angotti, L.; Salvatore, L.; Pozzo, C.; Basso, M.; Tortora, G. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: WOS:001037960400361 (0) - scopus: (0)

11573/1667584 - 2022 - 398P Effectiveness and safety of regorafenib and trifluridine/tipiracil in refractory metastatic colorectal cancer: A real-world multicenter retrospective study with focus on sequential treatment

Signorelli, C.; Schirripa, M.; Chilelli, M. G.; Calegari, M. A.; Basso, M.; Anghelone, A.; Lucchetti, J.; Minelli, A.; Angotti, L.; Morelli, C.; Dell'aquila, E.; Cosimati, A.; Gemma, D.; Ribelli, M.; Corsi, D. C.; Arrivi, G.; Zoratto, F.; Morandi, M. G.; Santamaria, F.; Saltarelli, R.; Ruggeri, E. M. - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. S719- - issn: 0923-7534 - wos: WOS:000866211600392 (0) - scopus: (0)

11573/1667582 - 2022 - Comparative Analysis of Regorafenib and Trifluridine/Tipiracil in Later-Line Refractory Metastatic Colorectal Cancer: A Real-Life Multicenter Retrospective Study

Signorelli, Carlo; Schirripa, Marta; Giovanni Chilelli, Mario; Alessandra Calegari, Maria; Basso, Michele; Anghelone, Annunziato; Lucchetti, Jessica; Minelli, Alessandro; Angotti, Lorenzo; Morelli, Cristina; Dell'aquila, Emanuela; Cosimati, Antonella; Gemma, Donatello; Emiliani, Alessandra; Corsi, Domenico; Mazzuca, Federica; Zoratto, Federica; Grazia Morandi, Maria; Santamaria, Fiorenza; Saltarelli, Rosa; Maria Ruggeri, Enzo - 01h Abstract in rivista

paper: TUMORI (-Roma: Il Pensiero Scientifico Editore srl -Milano: Istituto nazionale per to studio e la cura dei tumori -Milan Italy: Casa Editrice Ambrosiana) pp. - - issn: 0300-8916 - wos: (0) - scopus: (0)