FEDERICO TUCCI

Dottore di ricerca

ciclo: XXXV


supervisore: Claudio Babiloni

Titolo della tesi: ABNORMAL REACTIVITY OF RESTING-STATE EEG ALPHA RHYTHMS DURING EYES OPEN IN PATIENTS WITH ALZHEIMER’S AND LEWY BODY DISEASES

Previous studies suggest that resting-state electroencephalographic (rsEEG) rhythms recorded in old patients with dementia due to different neurodegenerative diseases have a significant heuristic and clinical potential in identifying peculiar abnormalities of the ascending activating systems and reciprocal thalamocortical circuits in which oscillatory (de)synchronizing signals dynamically underpin cortical arousal in the regulation of quiet vigilance. In the present PhD program, a new methodological approach based on rsEEG cortical source estimation and individually-based frequency bands was used to test the hypothesis of significant abnormalities in the neurophysiological oscillatory mechanisms underlying the regulation of the quiet vigilance during the transition from an eyes-closed to an eyes-open condition in patients with the most prevalent neurodegenerative dementing disorders such as Alzheimer’s disease and Lewy Body and Parkinson’s diseases and initial abnormalities in the prodrormal stage of ADD, characterized by mild cognitive impairment. Three rsEEG studies were performed for that purpose. In the first study, we tested if the reactivity of posterior rsEEG alpha rhythms from the eye- closed to the eyes-open condition may differ in patients with dementia due to Lewy Bodies (DLB) and Alzheimer’s disease (ADD) as a functional probe of the dominant neural synchronization mechanisms regulating the vigilance in posterior visual systems. We used clinical, demographical, and rsEEG datasets in 28 healthy elderly (Healthy) seniors, 42 DLB, and 48 ADD participants. The eLORETA freeware estimated rsEEG cortical sources at individual delta, theta, and alpha frequencies. Results showed a substantial (> -10%) reduction in the posterior alpha activities during the eyes-open condition in 24 Healthy, 26 ADD, and 22 DLB subjects. There were lower reductions in the posterior alpha activities in the ADD and DLB groups than in the Healthy group. The reduction in the occipital region was lower in the DLB than in the ADD group. These results suggest that DLB patients may suffer a greater alteration in the neural synchronization mechanisms regulating vigilance in occipital cortical systems compared to ADD patients. In the second study, we hypothesized that the vigilance dysregulation seen in PDD patients might be reflected by altered reactivity of posterior rsEEG alpha rhythms during the vigilance transition from an eyes-closed to an eyes-open condition. We used clinical, demographical, and rsEEG datasets in 28 healthy elderly (Healthy), 73 PDD, and 35 ADD participants. We have applied the same methodology used for the first study. Results showed substantial (> -10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the 5 PDD group than in the Healthy and the ADD groups. These results suggest that PDD is characterized by poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. This finding could be an interesting biomarker of impaired vigilance regulation in quiet wakefulness in PDD patients. Indeed, such biomarkers may provide endpoints for pharmacological intervention and brain electromagnetic stimulations to improve the PDD patients’ general ability to regulate vigilance and primary visual consciousness in the activities of daily living. In the third study, we tested the exploratory hypothesis that rsEEG alpha rhythms may predict and be sensitive to mild cognitive impairment due to AD (ADMCI) progression at a 6-month follow-up (a relevant feature for intervention clinical trials). Clinical, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy seniors were used. We applied the same methodology used for the first and the second studies. Results showed a substantial (> -10%) reduction in the posterior alpha source activities during the eyes-open condition in about 90% and 70% of the Healthy and ADMCI participants, respectively. In the younger ADMCI patients (mean age of 64.3±1.1) with “reactive” rsEEG alpha source activities, posterior alpha source activities during the eyes closed condition predicted the global cognitive status at the 6-month follow-up. In all ADMCI participants with “reactive” rsEEG alpha source activities, posterior alpha source activities during the eyes-closed condition reduced in magnitude at that follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. These results suggest that in ADMCI patients, the true (“reactive”) posterior rsEEG alpha rhythms, when present, predict (in relation to younger age) and are quite sensitive to the effects of the disease progression on neurophysiological mechanisms underpinning vigilance regulation. The results of the three studies unveiled the significant extent to which the well-known impairments in the cholinergic and dopaminergic neuromodulatory ascending systems could affect the brain neurophysiological oscillatory mechanisms underpinning the reactivity of rsEEG alpha rhythms during eyes open and, then, the regulation of quiet vigilance in ADD, PDD, and DLB patients, thus enriching the neurophysiological model underlying their known difficulties to remain awake in quiet environmental conditions during daytime.

Produzione scientifica

11573/1704232 - 2024 - Resting - state EEG rhytms are abnormal in post covid - 19 patients with brain fog whithout cognitive and affective disorders
Babiloni, Claudio; Gentilini Cacciola, Elio; Tucci, Federico; Vassalini, Paolo; Chilovi, Agnese; Jakhar, Dharmendra; Maria Musat, Andreea; Salvatore, Marco; Soricelli, Andrea; Stocchi, Fabrizio; Vacca, Laura; Ferri, Raffaele; Catania, Valentina; Mastroianni, Claudio; D'ettorre, Gabriella; Noce, Giuseppe - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 159-172 - issn: 1388-2457 - wos: (0) - scopus: 2-s2.0-85188018494 (0)

11573/1702734 - 2024 - Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer’s disease mild cognitive impairment progression at a 6-month follow-up
Babiloni, Claudio; Jakhar, Dharmendra; Tucci, Federico; Del Percio, Claudio; Lopez, Susanna; Soricelli, Andrea; Salvatore, Marco; Ferri, Raffaele; Catania, Valentina; Massa, Federico; Arnaldi, Dario; Famà, Francesco; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; Giubilei, Franco; Yıldırım, Ebru; Hanoğlu, Lutfu; Hünerli, Duygu; Frisoni, Giovanni B.; Noce, Giuseppe - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 19-37 - issn: 0197-4580 - wos: (0) - scopus: 2-s2.0-85185782393 (1)

11573/1700119 - 2023 - Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease
Babiloni, Claudio; Noce, Giuseppe; Tucci, Federico; Jakhar, Dharmendra; Ferri, Raffaele; Panerai, Simonetta; Catania, Valentina; Soricelli, Andrea; Salvatore, Marco; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Radicati, Fabiana; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Parnetti, Lucilla; Marizzoni, Moira; D'antonio, Fabrizia; Bruno, Giuseppe; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Hünerli, Duygu; Taylor, John-Paul; Schumacher, Julia; Mckeith, Ian; Frisoni, Giovanni B; Antonini, Angelo; Ferreri, Florinda; Bonanni, Laura; De Pandis, Maria Francesca; Del Percio, Claudio - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING ([New York, NY] : Elsevier, 1980-) pp. 1-14 - issn: 1558-1497 - wos: (0) - scopus: 2-s2.0-85180581915 (0)

11573/1672760 - 2023 - What a Single Electroencephalographic (EEG) Channel Can Tell us About Alzheimer's Disease Patients With Mild Cognitive Impairment
Del Percio, Claudio; Lopez, Susanna; Noce, Giuseppe; Lizio, Roberta; Tucci, Federico; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Marizzoni, Moira; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B; Babiloni, Claudio - 01a Articolo in rivista
rivista: CLINICAL EEG AND NEUROSCIENCE (Wheaton, IL : EEG and Clinical Neuroscience Society, c2004-) pp. 21-35 - issn: 1550-0594 - wos: WOS:000890567400004 (5) - scopus: 2-s2.0-85142918552 (5)

11573/1658125 - 2022 - Alzheimer's Disease with Epileptiform EEG Activity: Abnormal Cortical Sources of Resting State Delta Rhythms in Patients with Amnesic Mild Cognitive Impairment
Babiloni, C; Noce, G; Di Bonaventura, C; Lizio, R; Eldellaa, A; Tucci, F; Salamone, Em; Ferri, R; Soricelli, A; Nobili, F; Famà, F; Arnaldi, D; Palma, E; Del Percio, C - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Amsterdam : IOS Press) pp. 903-931 - issn: 1875-8908 - wos: WOS:000837090900007 (4) - scopus: 2-s2.0-85135599632 (4)

11573/1634350 - 2022 - Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases.
Babiloni, Claudio; Lorenzo, Ivan; Lizio, Roberta; Lopez, Susanna; Tucci, Federico; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Marizzoni, Moira; D'antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Hünerli Gündüz, Duygu; Paul Taylor, John; Schumacher, Julia; Mckeith, Ian; B Frisoni, Giovanni; Francesca De Pandis, Maria; Bonanni, Laura; Del Percio, Claudio; Noce, Giuseppe - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 88-108 - issn: 0197-4580 - wos: WOS:000800025900003 (11) - scopus: 2-s2.0-85129683296 (12)

11573/1672742 - 2022 - Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study
Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lutfu; Yener, Görsev; Gündüz, Duygu Hünerli; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B; Del Percio, Claudio - 01a Articolo in rivista
rivista: CEREBRAL CORTEX (New York, NY : Oxford University Press, c1991-) pp. 2197-2215 - issn: 1047-3211 - wos: WOS:000789377200001 (9) - scopus: 2-s2.0-85128377064 (9)

11573/1571160 - 2022 - Microglia modulates hippocampal synaptic transmission and sleep duration along the light/dark cycle
Corsi, G.; Picard, K.; Di Castro, M. A.; Garofalo, S.; Tucci, F.; Chece, G.; Del Percio, C.; Golia, M. T.; Raspa, M.; Scavizzi, F.; Decoeur, F.; Lauro, C.; Rigamonti, M.; Iannello, F.; Ragozzino, D. A.; Russo, E.; Bernardini, G.; Nadjar, A.; Tremblay, M. E.; Babiloni, C.; Maggi, L.; Limatola, C. - 01a Articolo in rivista
rivista: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-17 - issn: 0894-1491 - wos: WOS:000692843300001 (33) - scopus: 2-s2.0-85114388167 (34)

11573/1672758 - 2022 - What a single electroencephalographic (EEG) channel can tell us about patients with dementia due to Alzheimer's disease
Del Percio, Claudio; Noce, Giuseppe; Lopez, Susanna; Tucci, Federico; Carlin, Graziano; Lizio, Roberta; Musat, Andreea M; Soricelli, Andrea; Salvatore, Marco; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Marizzoni, Moira; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B; Babiloni, Claudio - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 169-181 - issn: 0167-8760 - wos: WOS:000882404200007 (2) - scopus: 2-s2.0-85140882971 (2)

11573/1540792 - 2021 - EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel
Babiloni, C.; Arakaki, X.; Bonanni, L.; Bujan, A.; Carrillo, M. C.; Del Percio, C.; Edelmayer, R. M.; Egan, G.; Elahh, F. M.; Evans, A.; Ferri, R.; Frisoni, G. B.; Guntekin, B.; Hainsworth, A.; Hampel, H.; Jelic, V.; Jeong, J.; Kim, D. K.; Kramberger, M.; Kumar, S.; Lizio, R.; Nobili, F.; Noce, G.; Puce, A.; Ritter, P.; Smit, D. J. A.; Soricelli, A.; Teipel, S.; Tucci, F.; Sachdev, P.; Valdes-Sosa, M.; Valdes-Sosa, P.; Vergallo, A.; Yener, G. - 01g Articolo di rassegna (Review)
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 78-97 - issn: 0197-4580 - wos: WOS:000656835500009 (10) - scopus: 2-s2.0-85103754690 (13)

11573/1571343 - 2021 - Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
Babiloni, C.; Ferri, R.; Noce, G.; Lizio, R.; Lopez, S.; Lorenzo, I.; Tucci, F.; Soricelli, A.; Nobili, F.; Arnaldi, D.; Fama, F.; Orzi, F.; Buttinelli, C.; Giubilei, F.; Cipollini, V.; Marizzoni, M.; Guntekin, B.; Akturk, T.; Hanoglu, L.; Yener, G.; Ozbek, Y.; Stocchi, F.; Vacca, L.; Frisoni, G. B.; Del Percio, C. - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 1085-1114 - issn: 1387-2877 - wos: WOS:000683026700019 (7) - scopus: 2-s2.0-85112072065 (8)

11573/1504607 - 2021 - Measures of Resting State EEG Rhythms for Clinical Trials in Alzheimer’s Disease: Recommendations of an Expert Panel
Babiloni, Claudio; Arakaki, Xianghong; Azami, Hamed; Bennys, Karim; Blinowska, Katarzyna; Bonanni, Laura; Bujan, Ana; Carrillo, Maria C.; Cichocki, Andrzej; De Frutos-Lucas, Jaisalmer; Del Percio, Claudio; Dubois, Bruno; Edelmayer, Rebecca; Egan, Gary; Epelbaum, Stephane; Escudero, Javier; Evans, Alan; Farina, Francesca; Fargo, Keith; Fernández, Alberto; Ferri, Raffaele; Frisoni, Giovanni; Hampel, Harald; Harrington, Michael G.; Jelic, Vesna; Jeong, Jaeseung; Jiang, Yang; Kaminski, Maciej; Kavcic, Voyko; Kilborn, Kerry; Kumar, Sanjeev; Lam, Alice; Lim, Lew; Lizio, Roberta; Lopez, David; Lopez, Susanna; Lucey, Brendan; Maestú, Fernando; Mcgeown, William J.; Mckeith, Ian; Vito Moretti, Davide; Nobili, Flavio; Noce, Giuseppe; Olichney, John; Onofrj, Marco; Osorio, Ricardo; Parra-Rodriguez, Mario; Rajji, Tarek; Ritter, Petra; Soricelli, Andrea; Stocchi, Fabrizio; Tarnanas, Ioannis; Paul Taylor, John; Teipel, Stefan; Tucci, Federico; Valdes-Sosa, Mitchell; Valdes-Sosa, Pedro; Weiergräber, Marco; Yener, Gorsev; Guntekin, Bahar - 01a Articolo in rivista
rivista: ALZHEIMER'S & DEMENTIA (New York : Elsevier, c2005-) pp. - - issn: 1552-5279 - wos: WOS:000641180200001 (67) - scopus: 2-s2.0-85104694674 (80)

11573/1466180 - 2020 - Abnormalities of cortical sources of resting state delta electroencephalographic rhythms are related to epileptiform activity in patients with amnesic mild cognitive impairment not due to Alzheimer's disease
Babiloni, C.; Noce, G.; Di Bonaventura, C.; Lizio, R.; Pascarelli, M. T.; Tucci, F.; Soricelli, A.; Ferri, R.; Nobili, F.; Fama, F.; Palma, E.; Cifelli, P.; Marizzoni, M.; Stocchi, F.; Frisoni, G. B.; Del Percio, C. - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2295 - wos: WOS:000585924500001 (7) - scopus: 2-s2.0-85095601099 (8)

11573/1504603 - 2020 - ONGOING ELECTROENCEPHALOGRAPHIC RHYTHMS RELATED TO EXPLORATORY MOVEMENTS IN TRANSGENIC TASTPM MICE
Tucci, Federico; Del Percio, Claudio; (Pim) Drinkenburg, Wilhelmus; Lopez, Susanna; Pascarelli, Maria Teresa; Lizio, Roberta; Noce, Giuseppe; Soricelli, Andrea; Ferri, Raffaele; Bastlund, Jesper F.; Clausen, Bettina; Forloni, Gianluigi; Frasca, Angelisa; Francesco Fabene, Paolo; Bertini, Giuseppe; Colavito, Valeria; Kelley, Jonathan; Dix, Sophie; Richardson, Jill; Babiloni, Claudio - 04d Abstract in atti di convegno
congresso: AAIC2020 (Virtual Event)
libro: Alzheimer's & Dementia - ()

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