FEDERICO FRUSONE

Dottore di ricerca

ciclo: XXXV



Titolo della tesi: Ricostruzione mammaria immediata con protesi e copertura parziale o totale con membrane biologiche: valutazione di sicurezza, tollerabilità ed efficacia

Background Breast prosthetic reconstruction plays an important role for quality of life and satisfaction of patients subjected to “conservative” mastectomies (nipple-sparing, skin-sparing or skin-reducing), and the research of new surgical techniques, materials and medical devices is currently increasing. In particular, the advent of acellular dermal (ADM) and pericardial (APM) biological meshes has made immediate breast reconstruction possible in more cases, avoiding the use of tissue expanders, improving the quality of reconstruction, and lowering the ratio of critical complications, mainly capsule contracture. On the other hand, the use of APM is still debated, due to some specific side effects related to residual immunogenic biologic material and the productive process itself; for this reason, it is necessary to increase knowledge on tissue inflammation, integration and remodeling mechanisms. Current researches led to the development of new APMs able to reduce complication rates and prosthesis-induced adverse effects as well as maintaining their benefits for breast reconstruction. Preclinical data showed good integration of a new developed mesh (Exashape®) with low complication rates, but clinical data are still missing. The aim of the study is to assess safety, tolerability and efficacy of this new APM in comparison to another biological mesh and delayed breast reconstruction. Materials and methods We performed a prospective observational study using Exashape® for the reconstruction surgery of patients subjected to mastectomy in both dual-plane and prepectoral setting, comparing it with a cohort of patients subjected to breast reconstruction using a different type of ADM with higher biologic mass (Braxon®) and with a group of patients subjected to delayed breast reconstruction with tissue expander and definitive prosthesis. The primary objective of the stydt was to evaluate the APM’s safety, comparing major and minor complication rates of the four study groups (Exashape® prepectoral, group A1, Exashape® dual plane, group A2, Braxon® prepectoral, group B, and delayed breast reconstruction, group C). Secondary objectives were evaluation of tolerability (assessed by total sierosity, operative times, drainage maintaining times) and efficacy (APM “in vivo” integration, assessed by breast ultrasound at 1, 3, 6 and 12 months after surgery, evaluating vascularization, APM width and viscoelastic properties via elastosonography). Results We performed 26 mastectomies followed by reconstruction between 2020 and 2022, for a total of 32 breast implants and 21 meshes (14 Exashape® and 7 Braxon®). With a mean follow-up of 13,7 months, we observed no major complications and only 2 minor complications in groups A1 and A2; 2 major and 2 minor complications in group B (without any cases of capsule contracture) and 3 major complications (with 2 cases of capsule contracture) and 3 minor complications in group C. Operative times were significantly lower in A1 and A2 groups compared to group B and C, as well as amount of drained fluids and time until drain removal. Finally, in our in vivo ultrasound integration study showed good and predictable integration process in a 12-month period with progressive neovascularization and balancing of viscoelastic properties with superficial tissues, without the development of excessive fibrosis (periprosthetic capsule). Conclusion Despite the limited number of patients, our data suggested that breast prosthetic reconstruction with Exashape® APM is a valuable and safe alternative in selected patients, both in the dual plane and the prepectoral settings. Moreover, our clinical and ultrasonographic data could be the base for future studies, leading to a better understanding of biological mesh remodeling and integration process, since the balance of degradation and rebuilding process (inflammation/integration) is the key point in the clinical use of these materials.

Produzione scientifica

  • 11573/1681783 - 2021 - Non-adherence to Mediterranean diet and synergy with lifestyle habits in the occurrence of breast cancer: a case-control study in Italy (01a Articolo in rivista)
    LA TORRE, GIUSEPPE; DE CARLO, IRENE; SESTILI, CRISTINA; COCCHIARA, ROSARIO ANDREA; LIA, LORENZA; DI BELLA, ORNELLA; CIANFANELLI, SARA; D'EGIDIO, VALERIA; MANCINO, MARIA GRAZIA; PALMERI, VANESSA; DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; ACETI, VALERIO; AMABILE, MARIA IDA; CARDI, MAURIZIO; BACKHAUS, INSA LINNEA; MANNOCCI, ALICE; MONTI, MASSIMO
  • 11573/948397 - 2016 - Nipple-sparing mastectomy in patients with preoperative diagnosis of non-invasive breast carcinoma. A single-center experience (01a Articolo in rivista)
    AMABILE, MARIA IDA; MONTI, MASSIMO; MEROLA, RAFFAELE; FRUSONE, FEDERICO; D'ORAZI, VALERIO; PASTA, VITTORIO
  • 11573/1682312 - 2017 - Selective radio-guided axillary dissection (SeRAD): A prospective cohort study (01a Articolo in rivista)
    MONTI, MASSIMO; NASO, GIUSEPPE; PASTA, VITTORIO; FRUSONE, FEDERICO; ACETI, VALERIO; DE LUCA, ALESSANDRO; VERGINE, MASSIMO; D'ANDREA, VITO
  • 11573/978172 - 2014 - Nodal status assessment in breast cancer: strategies of clinical grounds and quality of life implications (01a Articolo in rivista)
    FRUSONE, FEDERICO
  • 11573/978171 - 2015 - Manuale di medicina generale per specializzazioni mediche (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1146070 - 2018 - Stress in ballet: looking for the mind body unit for a chance to cure (04d Abstract in atti di convegno)
    MELCARNE, ROSSELLA; GEBHARDT, EVA CHRISTINA SIGRID; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO
  • 11573/1680897 - 2019 - Premio "miglior abstract" Congresso AIS 2019, Firenze 6-8 novembre 2019 (14a Premio o riconoscimento scientifico)
    MELCARNE, ROSSELLA; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; AMABILE, MARIA IDA; TRIPODI, DOMENICO; BORCEA, MARIA CAROLA; ACETI, VALERIO; VERGINE, MASSIMO; MONTI, MASSIMO
  • 11573/1146170 - 2017 - NIpple-sparing mastectomy e ricostruzione con protesi definitiva e mesh biologica - impatto sulla qualità di vita (04f Poster)
    DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; ACETI, VALERIO; LA TORRE, GIUSEPPE; LO TORTO, FEDERICO; MARCASCIANO, MARCO; VERGINE, MASSIMO; RIBUFFO, DIEGO; MONTI, MASSIMO
  • 11573/1146176 - 2017 - Tumore sincrono a primitività cutanea e mammaria: case report e revisione della letteratura (04d Abstract in atti di convegno)
    ACETI, VALERIO; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; VERGINE, MASSIMO; MARCASCIANO, MARCO; LO TORTO, FEDERICO; RIBUFFO, DIEGO; AMABILE, MARIA IDA; MONTI, MASSIMO
  • 11573/1457387 - 2020 - Locoregional surgery in metastatic breast cancer. Do concomitant metabolic aspects have a role on the management and prognosis in this setting? (01g Articolo di rassegna (Review))
    AMABILE, MARIA IDA; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; TRIPODI, DOMENICO; IMBIMBO, GIOVANNI; LAI, SILVIA; D'ANDREA, VITO; SORRENTI, SALVATORE; MOLFINO, ALESSIO
  • 11573/1146175 - 2017 - Minilinfectomia radioguidata (SeRAD) nelle pazienti affetta da cancro della mammella cN0: proposta di tecnica e risultati preliminari (04f Poster)
    FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; ACETI, VALERIO; VERGINE, MASSIMO; MANNOCCI, ALICE; LA TORRE, GIUSEPPE; MONTI, MASSIMO
  • 11573/1681491 - 2020 - Diagnosis and Clinical Management of Neuroendocrine Tumor of the Breast: Report of Six Cases and Systematic Review of Existing Literature (01a Articolo in rivista)
    DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/884717 - 2016 - Oncoplastic central quadrantectomies (01g Articolo di rassegna (Review))
    PASTA, VITTORIO; D'ORAZI, VALERIO; MEROLA, RAFFAELE; FRUSONE, FEDERICO; AMABILE, MARIA IDA; DE LUCA, ALESSANDRO; MONTI, MARCO
  • 11573/1336704 - 2019 - Breast cancer and multiple primary malignant tumors. Case report and review of the literature (01i Case report)
    DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; VERGINE, MASSIMO; COCCHIARA, ROSARIO ANDREA; LA TORRE, GIUSEPPE; BALLESIO, LAURA; MONTI, MASSIMO; AMABILE, MARIA IDA
  • 11573/1681487 - 2021 - First Surgical National Consensus Conference of the Italian Breast Surgeons association (ANISC) on breast cancer management in neoadjuvant setting: Results and summary (01a Articolo in rivista)
    DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; BUZZACCHINO, FEDERICA; AMABILE, MARIA IDA
  • 11573/1336697 - 2019 - Mucinous breast cancer: A narrative review of the literature and a retrospective tertiary single-centre analysis (01g Articolo di rassegna (Review))
    FRUSONE, FEDERICO; DE LUCA, ALESSANDRO
  • 11573/1213219 - 2018 - Functional assessment of cancer therapy questionnaire for breast cancer (FACT-B+4): Italian version validation (01a Articolo in rivista)
    DI BELLA, ORNELLA; COCCHIARA, ROSARIO ANDREA; DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; ACETI, VALERIO; SESTILI, CRISTINA; D'EGIDIO, VALERIA; MANNOCCI, ALICE; MONTI, MASSIMO; LA TORRE, GIUSEPPE
  • 11573/1244367 - 2019 - Breast cancer subtypes affect the nodal response after neoadjuvant chemotherapy in locally advanced breast cancer: are we ready to endorse axillary conservation? (01a Articolo in rivista)
    CERBELLI, BRUNA; BOTTICELLI, ANDREA; PISANO, ANNALINDA; DE VINCENTIIS, LUDOVICA; PERNAZZA, ANGELINA; FRUSONE, FEDERICO; MONTI, MASSIMO; D'AMATI, GIULIA
  • 11573/1430696 - 2020 - Retrospective Evaluation of the Effectiveness of a Synthetic Glue and a Fibrin-Based Sealant for the Prevention of Seroma Following Axillary Dissection in Breast Cancer Patients (01a Articolo in rivista)
    DE LUCA, ALESSANDRO; TRIPODI, DOMENICO; FRUSONE, FEDERICO; CERBELLI, BRUNA; BOTTICELLI, ANDREA; VERGINE, MASSIMO; D'ANDREA, VITO; PIRONI, DANIELE; SORRENTI, SALVATORE; AMABILE, MARIA IDA
  • 11573/1461022 - 2019 - Nasal flap or cutaneous grafting in basal cell cancer of the nose. Comparison of two reconstructive possibilities (01a Articolo in rivista)
    VERGINE, MASSIMO; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; ACETI, VALERIO; MARCASCIANO, MARCO; AMABILE, MARIA IDA; MONTI, MASSIMO
  • 11573/978538 - 2017 - Counseling interventions delivered in women with breast cancer to improve health-related quality of life: a systematic review (01g Articolo di rassegna (Review))
    D'EGIDIO, VALERIA; SESTILI, CRISTINA; MANCINO, MARIA GRAZIA; SCIARRA, ILIANA; COCCHIARA, ROSARIO ANDREA; BACKHAUS, INSA LINNEA; MANNOCCI, ALICE; DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; MONTI, MASSIMO; LA TORRE, GIUSEPPE
  • 11573/1680896 - 2019 - "Disturbo depressivo maggiore e carcinoma mammario: esperienza in un singolo centro" (04f Poster)
    MELCARNE, ROSSELLA; FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; AMABILE, MARIA IDA; TRIPODI, DOMENICO; BORCEA, MARIA CAROLA; ACETI, VALERIO; VERGINE, MASSIMO; MONTI, MASSIMO
  • 11573/1147289 - 2018 - Paget's disease of the male breast: case report and a point of view from actual literature (01a Articolo in rivista)
    VERGINE, MASSIMO; MUSELLA, ANGELA; FRUSONE, FEDERICO; ACETI, VALERIO; DE LUCA, ALESSANDRO; LIBIA, ANNARITA; BENEDETTI PANICI, PIERLUIGI; MONTI, MARCO
  • 11573/1362664 - 2020 - Diagnosis and Clinical Management of Neuroendocrine Tumor of the Breast: Report of Six Cases and Systematic Review of Existing Literature (01a Articolo in rivista)
    DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1374837 - 2015 - Manuale di medicina generale. Sintesi e schemi teorici (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1374836 - 2017 - Manuale di medicina generale per medici di base e specializzazioni mediche (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1364299 - 2016 - Plasma cell mastitis in men. A single-center experience and review of the literature (01g Articolo di rassegna (Review))
    PALMIERI, ANDREA; D'ORAZI, VALERIO; FRUSONE, FEDERICO; CROCETTI, DANIELE; MONTI, MASSIMO
  • 11573/1429108 - 2020 - Manuale di Medicina e Chirurgia - Tomo 11 Scienze diagnostiche e discipline di base (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429105 - 2020 - Manuale di Medicina e Chirurgia - Tomo 10 Medicina dei servizi (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429095 - 2020 - Manuale di Medicina e Chirurgia - Tomo 7 Malattie ginecologiche e pediatriche (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429096 - 2020 - Manuale di Medicina e Chirurgia - Tomo 8 Malattie degli organi di senso (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429093 - 2020 - Manuale di Medicina e Chirurgia - Tomo 6 Malattie del sistema nervoso (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429109 - 2020 - Manuale di Medicina e Chirurgia (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429099 - 2020 - Manuale di Medicina e Chirurgia - Tomo 9 Malattie dell'apparato locomotore (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429090 - 2020 - Manuale di Medicina e Chirurgia - Tomo 4 Malattie oncoematologiche e medicina del dolore (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429088 - 2020 - Manuale di Medicina e Chirurgia - Tomo 2 Malattie dell'apparato digerente (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA; DE LUCA, ALESSANDRO; ACETI, VALERIO
  • 11573/1429089 - 2020 - Manuale di Medicina e Chirurgia - Tomo 3 Malattie endocrine e dell'apparato genito-urinario (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429087 - 2020 - Manuale di Medicina e Chirurgia - Tomo 1 Malattie dell'apparato cardiovascolare e respiratorio (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA
  • 11573/1429092 - 2020 - Manuale di Medicina e Chirurgia - Tomo 5 Malattie infettive e immunologiche (03c Manuale Didattico)
    FRUSONE, FEDERICO; PULIANI, GIULIA; ACETI, VALERIO; DE LUCA, ALESSANDRO
  • 11573/1529298 - 2021 - New classifications of axillary lymph nodes and their anatomical-clinical correlations in breast surgery (01g Articolo di rassegna (Review))
    AMABILE, MARIA IDA; DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; TRIPODI, DOMENICO; GENTILE, PATRIZIA ALBA; PIRONI, DANIELE; FORTE, FLAVIO; MONTI, MASSIMO; D'ANDREA, VITO; SORRENTI, SALVATORE
  • 11573/1563502 - 2021 - Algorithm of rational approach to reconstruction in Fournier's disease (01a Articolo in rivista)
    TRIPODI, DOMENICO; AMABILE, MARIA IDA; GAGLIARDI, FEDERICA; FRUSONE, FEDERICO; VARANESE, MARZIA; DE LUCA, ALESSANDRO; PIRONI, DANIELE; D'ANDREA, VITO; SORRENTI, SALVATORE
  • 11573/1666579 - 2023 - Ricostruzione mammaria immediata con protesi e copertura parziale o totale con membrane biologiche: valutazione di sicurezza, tollerabilità ed efficacia (07a Tesi di Dottorato)
    FRUSONE, FEDERICO
  • 11573/1213205 - 2018 - Returning to work after breast cancer. A systematic review of reviews (01g Articolo di rassegna (Review))
    COCCHIARA, ROSARIO ANDREA; SCIARRA, ILIANA; D'EGIDIO, VALERIA; SESTILI, CRISTINA; MANCINO, MARIA GRAZIA; BACKHAUS, INSA LINNEA; MANNOCCI, ALICE; DE LUCA, ALESSANDRO; FRUSONE, FEDERICO; DI BELLA, ORNELLA; DI MURRO, FRANCESCA; PALMERI, VANESSA; LIA, LORENZA; PARADISO, GIULIA; ACETI, VALERIO; LIBIA, ANNARITA; MONTI, MASSIMO; LA TORRE, GIUSEPPE
  • 11573/1672489 - 2020 - Evolution and time trends of nipple-sparing mastectomy: a single-center experience (01a Articolo in rivista)
    FRUSONE, FEDERICO; DE LUCA, ALESSANDRO; AMABILE, MARIA IDA
  • 11573/1619175 - 2021 - Non-adherence to Mediterranean diet and synergy with lifestyle habits in the occurrence of breast cancer: A case-control study in Italy (01b Commento, Erratum, Replica e simili)
    SESTILI, CRISTINA; COCCHIARA, ROSARIO ANDREA; CIANFANELLI, SARA; D'EGIDIO, VALERIA; PALMERI, VANESSA; FRUSONE, FEDERICO; ACETI, VALERIO; AMABILE, MARIA IDA; CARDI, MAURIZIO; BACKHAUS, INSA LINNEA; MANNOCCI, ALICE

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