CURRENT POSITION
Research Director at Microbiology and Virology laboratory, San Gallicano Dermatological Institute, IRCCS, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
EDUCATION
2020 National Scientific Qualification as University Professor in Microbiology
2020 Specialization School in Microbiology and Virology at Sapienza University of Rome, Italy (Registration 2020).
2010
Ph.D. in Genetics and Cell Biology at the University of Tuscia in Viterbo, Italy
2006
Master in "Biotechnological Applications and Controls" at Sapienza University of Rome, Italy
Magna cum laude
2005 Degree in Biological Sciences from the Department of Cellular and Developmental Biology, Sapienza University of Rome, Italy
Magna cum laude
RESEARCH EXPERIENCE
2024 - Today Research Director at Microbiology and Virology laboratory, San Gallicano Dermatological Institute, IRCCS, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
2021 - 2024 Assistant professor at the Department of Biology and Biotechnology "C. Darwin"
Sapienza University of Rome, Italy.
2014 - 2021
Senior Scientist at Microbiology and Virology, San Gallicano Dermatological Institute, IRCCS, Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy.
2012 Post-Doc FEMS (Federation of European Microbiological Societies) scholarship for the project "The impact of current on the fermentation of C6 sugars, with a focus on alcohol production relative to fatty acids", at the Faculty of Bioscience Engineering, Ghent University, Belgium.
2010 – 2014
2008 - 2009 Postdoctoral Fellow at the Department of Biology and Biotechnology "Charles Darwin," Sapienza University of Rome, Italy.
Ph.D. fellowship for the project "Role of Tel1 and Rad51 in the maintenance of telomeres with capping deficiency", at the Department of Molecular Biology Princeton University, New Jersey, U.S.A.
2009 – 2013
2007 - 2010
2005 - 2006 Scientific Consultant at the Nanog International Group, a biotechnology and molecular biology company, Rome, Italy.
Ph.D. student at the Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome in collaboration with the University of Tuscia in Viterbo.
Graduate Researcher at the Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Italy
SCIENTIFIC INDICATORS
Author of 66 publications in international scientific journals (Source Scopus and Web of Science).
Books: 3
Total number of citations (Scopus): 1,738
Hirsch index (Scopus): 25
PUBLICATIONS (Source Scopus and Web of Science; IF refers to the year of publication).
1. Sivori F, Cavallo I, Truglio M, Pelagalli L, Mariani V, Fabrizio G, Abril E, Santino I, Fradiani PA, Solmone M, Pimpinelli F, Toma L, Arcioni R, De Blasi RA, Di Domenico EG. Biofilm-mediated antibiotic tolerance in Staphylococcus aureus from spinal cord stimulation device-related infections. Microbiol Spectr. 2024 Oct 29:e0168324. doi: 10.1128/spectrum.01683-24. IF: 3.7
2. Sivori F, Cavallo I, Truglio M, De Maio F, Sanguinetti M, Fabrizio G, Licursi V, Francalancia M, Fraticelli F, La Greca I, Lucantoni F, Camera E, Mariano M, Ascenzioni F, Cristaudo A, Pimpinelli F, Di Domenico EG. Staphylococcus aureus colonizing the skin microbiota of adults with severe atopic dermatitis exhibits genomic diversity and convergence in biofilm traits. Biofilm. 2024 Sep 19;8:100222. doi: 10.1016/j.bioflm.2024.100222. IF: 6.0
3. Truglio M, Sivori F, Cavallo I, Abril E, Licursi V, Fabrizio G, Cardinali G, Pignatti M, Toma L, Valensise F, Cristaudo A, Pimpinelli F, Di Domenico EG. Modulating the skin mycobiome-bacteriome and treating seborrheic dermatitis with a probiotic-enriched oily suspension. Sci Rep. 2024 Feb 1;14(1):2722. doi: 10.1038/s41598-024-53016-0. IF: 3.8
4. Fabrizio G, Sivori F, Cavallo I, Truglio M, Toma L, Sperati F, Francalancia M, Obregon F, Pamparau L, Kovacs D, Pimpinelli F, Di Domenico EG. Efficacy of sodium hypochlorite in overcoming antimicrobial resistance and eradicating biofilms in clinical pathogens from pressure ulcers. Front Microbiol. 2024 Jul 10;15:1432883. doi: 10.3389/fmicb.2024.1432883. IF: 4.0
5. Di Domenico EG, Oliva A, Guembe M. Biofilm-Related Infections in Healthcare: Moving towards New Horizons. Microorganisms 2024, 12, 784. https://doi.org/10.3390/microorganisms12040784. IF 4.5
6. Cavallo I, Sivori F, Mastrofrancesco A, Abril E, Pontone M, Di Domenico EG, Pimpinelli F. Bacterial biofilm in chronic wounds and possible therapeutic approaches. Biology. 2024; 13:109. https://doi.org/10.3390/biology13020109. IF: 4.2
7. Virgilio E, Solmone M, Scardigno A, Fradiani P, Ceci D, Teggi A, Di Domenico E.G., Cavallo I, Ensoli F, Borro M, Simmaco M, Santino I, Cavallini M. Hard-to-heal peripheral wounds infected with Corynebacterium striatum: a prospective study. J Wound Care. 2023; 32:811-820. doi: 10.12968/jowc.2023.32.12.811. IF: 1.9
8. Binaymotlagh R, Haghighi FH, Di Domenico EG, Sivori F, Truglio M, Del Giudice A, Fratoddi I, Chronopoulou L, Palocci C. Biosynthesis of Peptide Hydrogel–Titania Nanoparticle Composites with Antibacterial Properties. Gels 2023, 9, 940; https://doi.org/10.3390/gels9120940. IF: 4.6
9. Cavallo I, Oliva A, Pages R, Sivori F, Truglio M, Fabrizio G, Pasqua M, Pimpinelli F, Di Domenico EG. Acinetobacter baumannii in the critically ill: complex infections get complicated. Front Microbiol. 2023; 14:1196774. doi: 10.3389/fmicb.2023.1196774. IF: 6.064
10. Oliva A, Carbonara S, Cianci V, Crapis M, Di Domenico Enea G, Falcone M, Galardo G, Durante Mangoni E, Venditti M. Direct or early discharge of Acute Bacterial Skin and Skin Structure Infection patients from the Emergency Department/Unit: Place of therapy of Dalbavancin. Expert Rev Anti Infect Ther. 2023, 25. doi: 10.1080/14787210.2023.2214727. IF: 5.854
11. Chronopoulou L, Binaymotlagh R, Cerra S, Haghighi FH, Di Domenico EG, Sivori F, Fratoddi I, Mignardi S, Palocci C. Preparation of Hydrogel Composites Using a Sustainable Approach for In Situ Silver Nanoparticles Formation. Materials (Basel). 2023 Mar 7;16(6):2134. doi: 10.3390/ma16062134. IF: 3.748
12. Cavallo I, Sivori F, Truglio M, De Maio F, Lucantoni F, Cardinali G, Pontone M, Bernardi T, Sanguinetti M, Capitanio B, Cristaudo A, Ascenzioni F, Morrone A, Pimpinelli F, Di Domenico EG. Skin dysbiosis and Cutibacterium acnes biofilm in inflammatory acne lesions of adolescents. Sci Rep. 2022 Dec 6;12(1):21104. doi: 10.1038/s41598-022-25436-3. IF: 4.997
13. Binaymotlagh R, Del Giudice A, Mignardi S, Amato F, Marrani AG, Sivori F, Cavallo I, Di Domenico EG, Palocci C, Chronopoulou L. Green In Situ Synthesis of Silver Nanoparticles-Peptide Hydrogel Composites: Investigation of Their Antibacterial Activities. Gels. 2022 Oct 29;8(11):700. doi: 10.3390/gels8110700. IF: 4.432
14. Cavallo I, Lesnoni La Parola I, Sivori F, Toma L, Koudriavtseva T, Sperduti I, Kovacs D, D'Agosto G, Trento E, Cameli N, Mussi A, Latini A, Morrone A, Pimpinelli F, Di Domenico EG. Homocysteine and Inflammatory Cytokines in the Clinical Assessment of Infection in Venous Leg Ulcers. Antibiotics (Basel). 2022 Sep 18;11(9):1268. doi: 10.3390/antibiotics11091268. IF: 5.222
15. Di Domenico EG, Oliva A, Guembe M. The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections. Microorganisms. 2022 Jun 21;10(7):1259. doi: 10.3390/microorganisms10071259. IF: 4.926
16. Sivori F, Cavallo I, Kovacs D, Guembe M, Sperduti I, Truglio M, Pasqua M, Prignano G, Mastrofrancesco A, Toma L, Pimpinelli F, Morrone A, Ensoli F, Di Domenico EG. Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections. Microbiol Spectr. 2022 Apr 27;10(2):e0035122. doi: 10.1128/spectrum.00351-22. IF: 9.043
17. Donzelli S, Spinella F, di Domenico EG, Pontone M, Cavallo I, Orlandi G, Iannazzo S, Ricciuto GM, Isg Virology Covid Team, Pellini R, Muti P, Strano S, Ciliberto G, Ensoli F, Zapperi S, La Porta CAM, Blandino G, Morrone A, Pimpinelli F. Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects. Comput Struct Biotechnol J. 2022;20:733-744. doi: 10.1016/j.csbj.2022.01.021. Epub 2022 Jan 21. IF: 7.271
18. Ascenzioni F, Cloeckaert A, Di Domenico EG, Dunyach-Remy C, Guembe M. Editorial: Microbial Biofilms in Chronic and Recurrent Infections. Front Microbiol. 2021, 12:803324. doi: 10.3389/fmicb.2021.803324. IF: 5.640
19. Oliva A, Stefani S, Venditti M, Di Domenico EG. Biofilm-Related Infections in Gram-Positive Bacteria and the Potential Role of the Long-Acting Agent Dalbavancin. Front. Microbiol. 2021, 12:749685. doi: 10.3389/fmicb.2021.749685. IF: 5.640
20. Di Domenico EG, Marchesi F, Cavallo I, Toma L, Sivori F, Papa E, Spadea A, Cafarella G, Terrenato I, Prignano G, Pimpinelli F, Mastrofrancesco A, D'Agosto G, Trento E, Morrone A, Mengarelli A, Ensoli F. The Impact of Bacterial Biofilms on End-Organ Disease and Mortality in Patients with Hematologic Malignancies Developing a Bloodstream Infection. Microbiol Spectr. 2021 Aug 18:e0055021. doi: 10.1128/Spectrum.00550-21. IF: 7.171
21. Pimpinelli F, Marchesi F, Piaggio G, Giannarelli D, Papa E, Falcucci P, Spadea A, Pontone M, Di Martino S, Laquintana V, La Malfa A, Di Domenico EG, Di Bella O, Falzone G, Ensoli F, Vujovic B, Morrone A, Ciliberto G, Mengarelli A. Lower response to BNT162b2 vaccine in patients with myelofibrosis compared to polycythemia vera and essential thrombocythemia. J Hematol Oncol. 2021 Jul 29;14(1):119. doi: 10.1186/s13045-021-01130-1. IF: 17.388
22. Campo F, Venuti A, Pimpinelli F, Abril E, Blandino G, Conti L, De Virgilio A, De Marco F, Di Noia V, Di Domenico EG, Di Martino S, Ensoli F, Giannarelli D, Mandoj C, Mazzola F, Moretto S, Petruzzi G, Petrone F, Pichi B, Pontone M, Vidiri A, Vujovic B, Piaggio G, Sperandio E, Rosati V, Cognetti F, Morrone A, Ciliberto G, Pellini R. Antibody Persistence 6 Months Post-Vaccination with BNT162b2 among Health Care Workers. Vaccines (Basel). 2021 Oct 3;9(10):1125. doi: 10.3390/vaccines9101125. IF: 4.760
23. Marchesi F, Pimpinelli F, Giannarelli D, Ronchetti L, Papa E, Falcucci P, Pontone M, Di Domenico EG, di Martino S, Laquintana V, Mandoj C, Conti L, Cordone I, La Malfa A, Viggiani C, Renzi D, Palombi F, Romano A, Pisani F, Gumenyuk S, Di Bella O, Vujovic B, Morrone A, Ciliberto G, Ensoli F, Mengarelli A. Impact of anti-CD20 monoclonal antibodies on serologic response to BNT162b2 vaccine in B-cell Non-Hodgkin's lymphomas. Leukemia. 2021 Sep 20:1–3. doi: 10.1038/s41375-021-01418-8. IF: 11.528
24. Pimpinelli F, Marchesi F, Piaggio G, Giannarelli D, Papa E, Falcucci P, Pontone M, Di Martino S, Laquintana V, La Malfa A, Di Domenico EG, Di Bella O, Falzone G, Ensoli F, Vujovic B, Morrone A, Ciliberto G, Mengarelli A. Fifth-week immunogenicity and safety of anti-SARS-CoV-2 BNT162b2 vaccine in patients with multiple myeloma and myeloproliferative malignancies on active treatment: preliminary data from a single institution. J Hematol Oncol. 2021 May 17;14(1):81. doi: 10.1186/s13045-021-01090-6. IF: 17.388
25. Koudriavtseva T, Lorenzano S, Anelli V, Sergi D, Stefanile A, Di Domenico EG, Maschio M, Galiè E, Piantadosi C. Case Report: Probable Cerebral Amyloid Angiopathy-Related Inflammation During Bevacizumab Treatment for Metastatic Cervical Cancer. Front Oncol. 2021 Jul 27;11:669753. doi: 10.3389/fonc.2021.669753. IF: 6.244
26. Pellini R, Venuti A, Pimpinelli F, Abril E, Blandino G, Campo F, Conti L, De Virgilio A, De Marco F, Di Domenico EG, Di Bella O, Di Martino S, Ensoli F, Giannarelli D, Mandoj C, Manciocco V, Marchesi P, Mazzola F, Moretto S, Petruzzi G, Petrone F, Pichi B, Pontone M, Zocchi J, Vidiri A, Vujovic B, Piaggio G, Morrone A, Ciliberto G. Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI. Vaccines (Basel). 2021 Jun 22;9(7):685. doi: 10.3390/vaccines9070685. IF: 4.760
27. Koudriavtseva T, Villani V, Lorenzano S, Giannarelli D, Di Domenico EG, Stefanile A, Maschio M, D'Agosto G, Pimpinelli F, Tanzilli A, Galiè E, Pace A. Neutrophil-to-lymphocyte ratio, Factor VIII and Antithrombin III: inflammatory-clotting biomarkers in glioma. EXCLI J. 2021 Jul 8;20:1152-1169. doi: 10.17179/excli2021-3831. IF: 3.130
28. Pellini R, Venuti A, Pimpinelli F, Abril E, Blandino G, Campo F, Conti L, De Virgilio A, De Marco F, Di Domenico EG, Di Bella O, Di Martino S, Ensoli F, Giannarelli D, Mandoj C, Manciocco V, Marchesi P, Mazzola F, Moretto S, Petruzzi G, Petrone F, Pichi B, Pontone M, Zocchi J, Vidiri A, Vujovic B, Piaggio G, Morrone A, Ciliberto G. Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine. EClinicalMedicine. 2021 Jun;36:100928. doi: 10.1016/j.eclinm.2021.100928. IF: 3.490
29. Morrone A, Dell'Anna ML, Cristaudo A, Wubayehu T, Godefay H, Barnabas GA, Dassoni F, Padovese V, Latini O, Lotti T, Saraceni P, Di Domenico EG, Lora V. Psoriasis in Tigray, Ethiopia: Focusing on available treatments. Dermatol Ther. 2020, Dec 27;e14718. doi: 10.1111/dth.14718. IF:2.327
30. Alonso B, Fernández-Barat L, Di Domenico EG, Marín M, Cercenado E, Merino I, de Pablos M, Muñoz P, Guembe M. Correction to: Characterization of the virulence of Pseudomonas aeruginosa strains causing ventilator-associated pneumonia. BMC Infect Dis. 2020, Dec 11;20(1):951. doi: 10.1186/s12879-020-05691-3. IF: 2.688
31. Di Domenico EG, Cavallo I, Sivori F, Marchesi F, Prignano G, Pimpinelli F, Sperduti I, Pelagalli L, Di Salvo F, Celesti I, Paluzzi S, Pronesti C, Koudriavtseva T, Ascenzioni F, Toma L, De Luca A, Mengarelli A, Ensoli F. Biofilm Production by Carbapenem-Resistant Klebsiella pneumoniae Significantly Increases the Risk of Death in Oncological Patients. Front Cell Infect Microbiol. 2020, 10:561741. doi: 10.3389/fcimb.2020.561741. IF: 4.123
32. Alonso B, Fernández-Barat L, Di Domenico EG, Marín M, Cercenado E, Merino I, de Pablos M, Muñoz P, Guembe M. Characterization of the virulence of Pseudomonas aeruginosa strains causing ventilator-associated pneumonia. BMC Infect Dis. 2020, Dec 1;20(1):909. doi: 10.1186/s12879-020-05534-1. IF: 2.688
33. Di Domenico EG, De Angelis B, Cavallo I, Sivori F, Orlandi F, Fernandes Lopes Morais D'Autilio M, Di Segni C, Gentile P, Scioli MG, Orlandi A, D'Agosto G, Trento E, Kovacs D, Cardinali G, Stefanile A, Koudriavtseva T, Prignano G, Pimpinelli F, Lesnoni La Parola I, Toma L, Cervelli V, Ensoli F. Silver Sulfadiazine Eradicates Antibiotic-Tolerant Staphylococcus aureus and Pseudomonas aeruginosa Biofilms in Patients with Infected Diabetic Foot Ulcers. J Clin Med. 2020, Nov 25;9(12). doi: 10.3390/jcm9123807. IF: 3.303
34. Di Bella S, Campisciano G, Luzzati R, Di Domenico EG, Lovecchio A, Pappalardo A, Comar M, Gatti G. Bacterial colonization of explanted non-endocarditis cardiac valves: evidence and characterization of the valvular microbiome. Interact Cardiovasc Thorac Surg. 2020, Nov 22;. doi: 10.1093/icvts/ivaa285. IF: 1.112
35. Koudriavtseva T, Stefanile A, Fiorelli M, Lapucci C, Lorenzano S, Zannino S, Conti L, D'Agosto G, Pimpinelli F, Di Domenico EG, Mandoj C, Giannarelli D, Donzelli S, Blandino G, Salvetti M, Inglese M. Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-Remitting Multiple Sclerosis. Front Immunol. 2020, 11:548604. doi: 10.3389/fimmu.2020.548604. eCollection 2020. IF: 5.085
36. Marchesi F, Toma L, Di Domenico EG, Cavallo I, Spadea A, Prignano G, Pimpinelli F, Papa E, Terrenato I, Ensoli F, Mengarelli A. Ceftolozane-Tazobactam for Febrile Neutropenia Treatment in Hematologic Malignancy Patients Colonized by Multi-Resistant Enterobacteriaceae: Preliminary Results from a Prospective Cohort Study. Mediterr J Hematol Infect Dis. 2020, 12(1):e2020065. doi: 10.4084/MJHID.2020.065. eCollection 2020. IF: 1.600
37. Cavinato L, Genise E, Luly FR, Di Domenico EG, Del Porto P, Ascenzioni F. Escaping the Phagocytic Oxidative Burst: The Role of SODB in the Survival of Pseudomonas aeruginosa Within Macrophages. Front Microbiol. 2020, 11:326. doi: 10.3389/fmicb.2020.00326. eCollection 2020. IF: 4.235
38. Di Domenico EG, Rimoldi SG, Cavallo I, D'Agosto G, Trento E, Cagnoni G, Palazzin A, Pagani C, Romeri F, De Vecchi E, Schiavini M, Secchi D, Antona C, Rizzardini G, Dichirico RB, Toma L, Kovacs D, Cardinali G, Gallo MT, Gismondo MR, Ensoli F. Microbial biofilm correlates with an increased antibiotic tolerance and poor therapeutic outcome in infective endocarditis. BMC Microbiol. 2019, Oct 21;19(1):228. doi: 10.1186/s12866-019-1596-2. IF: 2.989
39. Di Domenico EG, Cavallo I, Capitanio B, Ascenzioni F, Pimpinelli F, Morrone A, Ensoli F. Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis. Microorganisms. 2019, Aug 29;7(9). doi: 10.3390/microorganisms7090301. Review. IF: 4.152
40. Sardo C, Di Domenico EG, Porsio B, De Rocco D, Santucci R, Ascenzioni F, Giammona G, Cavallaro G. Nanometric ion pair complexes of tobramycin forming microparticles for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. Int J Pharm. 2019, May 30;563:347-357. doi: 10.1016/j.ijpharm.2019.03.060. IF: 4.845
41. Marchesi F, Pimpinelli F, Di Domenico EG, Renzi D, Gallo MT, Regazzo G, Rizzo MG, Gumenyuk S, Toma L, Marino M, Cordone I, Cantonetti M, Liberati AM, Montanaro M, Ceribelli A, Prignano G, Palombi F, Romano A, Papa E, Pisani F, Spadea A, Arcese W, Ensoli F, Mengarelli A. Association between CMV and Invasive Fungal Infections After Autologous Stem Cell Transplant in Lymphoproliferative Malignancies: Opportunistic Partnership or Cause-Effect Relationship? Int J Mol Sci. 2019, Mar 19;20(6). doi: 10.3390/ijms20061373. IF: 4.556
42. Bordignon V, Cavallo I, D'Agosto G, Trento E, Pontone M, Abril E, Di Domenico EG, Ensoli F. Nucleic Acid Sensing Perturbation: How Aberrant Recognition of Self-Nucleic Acids May Contribute to Autoimmune and Autoinflammatory Diseases. Int Rev Cell Mol Biol. 2019, 344:117-137. doi: 10.1016/bs.ircmb.2018.09.001. IF: 4.934
43. Di Domenico EG, Cavallo I, Bordignon V, D'Agosto G, Pontone M, Trento E, Gallo MT, Prignano G, Pimpinelli F, Toma L, Ensoli F. The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. Front Neurol. 2018, 9:1048. doi: 10.3389/fneur.2018.01048. eCollection 2018. Review. IF: 2.635
44. Di Domenico EG, Cavallo I, Bordignon V, Prignano G, Sperduti I, Gurtner A, Trento E, Toma L, Pimpinelli F, Capitanio B, Ensoli F. Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis. Sci Rep. 2018, Jun 28;8(1):9573. doi: 10.1038/s41598-018-27421-1. IF: 4.011
45. Di Domenico EG, Cavallo I, Guembe M, Prignano G, Gallo MT, Bordignon V, D'Agosto G, Sperduti I, Toma L, Ensoli F. The clinical Biofilm Ring Test: a promising tool for the clinical assessment of biofilm-producing Candida species. FEMS Yeast Res. 2018, May 1;18(3). doi: 10.1093/femsyr/foy025. IF: 2.458
46. Abrami M, Ascenzioni F, Di Domenico EG, Maschio M, Ventura A, Confalonieri M, Di Gioia S, Conese M, Dapas B, Grassi G, Grassi M. A novel approach based on low-field NMR for the detection of the pathological components of sputum in cystic fibrosis patients. Magn Reson Med. 2018, Apr;79(4):2323-2331. doi: 10.1002/mrm.26876. Epub 2017 Aug 22. IF: 3.858
47. Bordignon V, Di Domenico EG, Trento E, D'Agosto G, Cavallo I, Pontone M, Pimpinelli F, Mariani L, Ensoli F. How Human Papillomavirus Replication and Immune Evasion Strategies Take Advantage of the Host DNA Damage Repair Machinery. Viruses. 2017, Dec 19;9(12). doi: 10.3390/v9120390. Review. IF: 3.761
48. Di Domenico EG, Cavallo I, Pontone M, Toma L, Ensoli F. Biofilm Producing Salmonella Typhi: Chronic Colonization and Development of Gallbladder Cancer. Int J Mol Sci. 2017, Aug 31;18(9). doi: 10.3390/ijms18091887. Review. IF: 3.687
49. Di Domenico EG, Farulla I, Prignano G, Gallo MT, Vespaziani M, Cavallo I, Sperduti I, Pontone M, Bordignon V, Cilli L, De Santis A, Di Salvo F, Pimpinelli F, Lesnoni La Parola I, Toma L, Ensoli F. Biofilm is a Major Virulence Determinant in Bacterial Colonization of Chronic Skin Ulcers Independently from the Multidrug Resistant Phenotype. Int J Mol Sci. 2017, May 17;18(5). doi: 10.3390/ijms18051077. IF: 3.687
50. Lucarelli C, Di Domenico EG, Toma L, Bracco D, Prignano G, Fortunati M, Pelagalli L, Ensoli F, Pezzotti P, García-Fernández A, Pantosti A, Ingrosso L. Ralstonia mannitolilytica infections in an oncologic day ward: description of a cluster among high-risk patients. Antimicrob Resist Infect Control. 2017, 6:20. doi: 10.1186/s13756-017-0178-z. eCollection 2017. IF: 3.568
51. Chronopoulou L, Di Domenico EG, Ascenzioni F, Palocci C. Positively charged biopolymeric nanoparticles for the inhibition of Pseudomonas aeruginosa biofilms. Journal of Nanoparticle Research. 2016 18, 10:1-10. doi:10.1007/s11051-016-3611-y IF: 2.020
52. Di Domenico EG, Toma L, Provot C, Ascenzioni F, Sperduti I, Prignano G, Gallo MT, Pimpinelli F, Bordignon V, Bernardi T, Ensoli F. Development of an in vitro Assay, Based on the BioFilm Ring Test®, for Rapid Profiling of Biofilm-Growing Bacteria. Front Microbiol. 2016, 7:1429. doi: 10.3389/fmicb.2016.01429. eCollection 2016. IF: 4.076
53. Di Domenico EG, Toma L, Bordignon V, Trento E, D'Agosto G, Cordiali-Fei P, Ensoli F. Activation of DNA Damage Response Induced by the Kaposi's Sarcoma-Associated Herpes Virus. Int J Mol Sci. 2016 Jun 1;17(6). doi: 10.3390/ijms17060854. Review. IF: 3.226
54. Gallo MT, Di Domenico EG, Toma L, Marchesi F, Pelagalli L, Manghisi N, Ascenzioni F, Prignano G, Mengarelli A, Ensoli F. Campylobacter jejuni Fatal Sepsis in a Patient with Non-Hodgkin's Lymphoma: Case Report and Literature Review of a Difficult Diagnosis. Int J Mol Sci. 2016, Apr 12;17(4):544. doi: 10.3390/ijms17040544. Review. IF: 3.226
55. Di Domenico EG. Microbial Biofilms in Dermatology: a Matter of Skin. Esperienze Dermatologiche. 2015, 17(4):163-6.
56. Di Domenico EG, Petroni G, Mancini D, Geri A, Di Palma L, Ascenzioni F. Development of Electroactive and Anaerobic Ammonium-Oxidizing (Anammox) Biofilms from Digestate in Microbial Fuel Cells. Biomed Res Int. 2015, 2015:351014. doi: 10.1155/2015/351014. IF: 2.134
57. Di Domenico EG, Toma L, Prignano G, Pelagalli L, Police A, Cavallotti C, Torelli R, Sanguinetti M, Ensoli F. Misidentification of Streptococcus uberis as a human pathogen: a case report and literature review. Int J Infect Dis. 2015, Apr;33:79-81. doi: 10.1016/j.ijid.2015.01.002. Epub 2015 Jan 8. Review. PubMed PMID: 25578263. IF: 2.229
58. Cifani N, Chronopoulou L, Pompili B, Di Martino A, Bordi F, Sennato S, Di Domenico EG, Palocci C, Ascenzioni F. Improved stability and efficacy of chitosan/pDNA complexes for gene delivery. Biotechnol Lett. 2015, Mar;37(3):557-65. doi: 10.1007/s10529-014-1727-7. Epub 2014 Nov 12. PubMed PMID: 25388452. IF: 1.639
59. Di Domenico EG, Romano E, Del Porto P, Ascenzioni F. Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. Biomed Res Int. 2014, 2014:787404. doi: 10.1155/2014/787404. Epub 2014 Aug 28. Review. IF: 1.579
60. Toma L, Di Domenico EG, Prignano G, Ensoli F. Comment on "Intravitreal Ampicillin Sodium for Antibiotic-Resistant Endophthalmitis: Streptococcus uberis First Human Intraocular Infection Report". J Ophthalmol. 2014, 2014:395480. doi: 10.1155/2014/395480. Epub 2014 Jul 22. IF: 1.425
61. Martini I, Di Domenico EG, Scala R, Caruso F, Ferreri C, Ubaldi FM, Lenzi A, Valensise H. Optimization of the viability of stem cells derived from umbilical cord blood after maternal supplementation with DHA during the second or third trimester of pregnancy: study protocol for a randomized controlled trial. Trials. 2014, May 10;15:164. doi: 10.1186/1745-6215-15-164. IF: 1.731
62. Cifani N, Pompili B, Anile M, Patella M, Diso D, Venuta F, Cimino G, Quattrucci S, Di Domenico EG, Ascenzioni F, Del Porto P. Reactive-oxygen-species-mediated P. aeruginosa killing is functional in human cystic fibrosis macrophages. PLoS One. 2013, 8(8):e71717. doi: 10.1371/journal.pone.0071717. IF: 3.534
63. Di Domenico EG, Mattarocci S, Cimino-Reale G, Parisi P, Cifani N, D'Ambrosio E, Zakian VA, Ascenzioni F. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Res. 2013, Jul;41(13):6490-500. doi: 10.1093/nar/gkt365. Epub 2013 May 15. IF: 8.808
64. Del Porto P, Cifani N, Guarnieri S, Di Domenico EG, Mariggiò MA, Spadaro F, Guglietta S, Anile M, Venuta F, Quattrucci S, Ascenzioni F. Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa. PLoS One. 2011, 6(5):e19970. doi: 10.1371/journal.pone.0019970. Epub 2011 May 18. IF: 4.092
65. Tilesi F, Di Domenico EG, Pariset L, Bosco L, Willems D, Valentini A, Ascenzioni F. Telomere Length Diversity in Cattle Breeds. DIVERSITY. 2010, 2; 1118-1129, doi:10.3390/d2091118. IF: 1.402
66. Auriche C, Di Domenico EG, Pierandrei S, Lucarelli M, Castellani S, Conese M, Melani R, Zegarra-Moran O, Ascenzioni F. CFTR expression and activity from the human CFTR locus in BAC vectors, with regulatory regions, isolated by a singlestep procedure. Gene Ther. 2010, Nov;17(11):1341-54. doi: 10.1038/gt.2010.89. IF: 4.538
67. Di Domenico EG, Auriche C, Viscardi V, Longhese MP, Gilson E, Ascenzioni F. The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions. DNA Repair (Amst). 2009, Feb 1;8(2):209-18. doi: 10.1016/j.dnarep.2008.10.005. Epub 2008 Nov 28. IF: 5.095
68. Auriche C, Di Domenico EG, Ascenzioni F. Budding yeast with human telomeres: a puzzling structure. Biochimie. 2008, Jan;90(1):108-15. doi: 10.1016/j.biochi.2007.09.009. IF: 2.899
COMMUNICATIONS AT NATIONAL AND INTERNATIONAL MEETINGS
Speaker at 161 national and international conferences.
2019 Scientific organizer and coordinator for the conference "Antibiotic-resistance and wound care: theoretical-practical updates" Rome, Italy.
2017 Scientific organizer and coordinator for the conference "Difficult infections in oncology and dermatology", Rome 23 June 2017.
2016 Scientific organizer and coordinator for the conference "Difficult infections in oncology and dermatology", Rome, Italy 2016.
2016 Participation in the "Researchers' Night" organizing committee at the Istituti Fisioterapici Ospitalieri - IFO, Rome, Italy.
TEACHING AND TRAINING ACTIVITIES
2022 - Today Teaching activity within the course of "Microbiology", Faculty of Pharmacy and Medicine, Bioinformatics Bachelor Degree Course, Sapienza University of Rome, Italy.
2022 - Today Teaching activity within the course of "Molecular Microbiology and Microbial Genomics", Master's Degree in Industrial and Environmental Genomic Biotechnology, Sapienza University of Rome, Italy.
2022 - Today Teaching activity within the course of “Microbiology for the course in Materials of animal origin.” Master's Degree in Technologies for the restoration and conservation of cultural heritage, Sapienza University of Rome, Italy
2021
2019 – 2021
2015 – 2021
2007
2010 – 2014
2010 – 2014
2010 – 2014
2006 - 2010
2007
Teaching activity within the doctoral course of the Institute of Environmental Medicine, UNIKA-T, Technical University Munich, and the Helmholtz Zentrum München, Germany.
Teaching activity within the Master's course in "Ecoguided Vascular Access" at S. Andrea Hospital, Sapienza University of Rome, Italy.
Teaching activity within the course of "Molecular Microbiology and Microbial Genomics", Master's Degree in Industrial and Environmental Genomic Biotechnology, Sapienza University of Rome, Italy.
Teaching activity within the Master's course in "Biotechnological Applications and Controls" at Sapienza University of Rome, Italy.
Teaching activity for the "Molecular Genetics of microorganisms" course, Master's Degree in Cell Biology and Biotechnology, Sapienza University of Rome, Italy.
Teaching activity for the course of "Microbial Vectors and Applications in Gene and Cellular Therapy", Master's Degree in Cell Biology and Biotechnology, Sapienza University of Rome, Italy.
Tutor of practical exercises in "Molecular Genetics of Microorganisms" of the Master's Degree Course in Cell Biology and Biotechnology, Sapienza University of Rome, Italy.
Tutor of practical exercises of "Microbial Vectors and Applications in Gene and Cell Therapy" Master's Degree Course in Cell Biology and Biotechnology, Sapienza University of Rome, Italy.
Tutor of practical exercises for the first level Master in "Biotechnological Applications and Controls" at Sapienza University of Rome, Italy.
STUDENT PROJECT SUPERVISION
2020
2020 Ph.D. thesis in Cellular and Developmental Biology, XXXII Cycle, Faculty of Biology, Department of Biology and Biotechnology Charles Darwin, Sapienza University, Rome, Italy.
Master's thesis, Department of Biology and Biotechnology Charles Darwin, Sapienza University, Rome, Italy.
2018 Master's thesis Sciences of the Health Professions Diagnostic Techniques Faculty of Pharmacy and Medicine Sapienza University, Rome, Italy.
2017 Master's thesis, in Anesthesia and Intensive Care, Sapienza University, Rome, Italy.
2017 Master's thesis, in Biology for Molecular, Cellular and Pathophysiological Research, Roma Tre University
2015 Master's thesis in Anesthesia and Intensive Care. Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.
2013 Master's thesis, in Genetics and Molecular Biology, Sapienza University, Rome, Italy.
2013 Master's thesis, in Genetics and Molecular Biology, Sapienza University, Rome, Italy.
2012 Master's thesis, in Genetics and Molecular Biology, Sapienza University, Rome, Italy.
2011 Master's thesis, in Genetics and Molecular Biology, Sapienza University, Rome, Italy.
INSTITUTIONAL RESPONSABILITIES
2022 - Today Member of the PhD Program in Cellular and Developmental Biology, Sapienza University of Rome.
2020 - Today Member of the Committee for the Control of SARS-CoV-2 (CoroNET-Lazio laboratory network) for the Microbiology and Virology laboratory, San Gallicano Institute, Rome, Italy.
2017 – Today
Member of the Committee for the Healthcare-Associated Infections Control, for the Microbiology and Virology laboratory, San Gallicano Institute, Rome, Italy.
PATENTS AND PATENT APPLICATIONS
2019
"Method for determining the susceptibility profiles to antibiotics in biofilm-producing microorganisms." Patent number: 102019000013983.
2017
"Method for classifying biofilm-producing microorganisms," patent number: WO2017/121946°1.
PROJECTS (PRINCIPAL INVESTIGATOR OR RESEARCH UNIT)
2024 - 2026 Partner in the research project "Fighting antibiotic resistance by exploiting innovative strategies and targets", Sapienza University of Rome. Protocol number: RG123188B49A8CB3
2023 - 2024 Partner in the research project "Inhibition of colistin resistance by optimized inhibitor of ArnT in planktonic and biofilms of Gram-negative pathogens", Sapienza University of Rome. Protocol number: RM122181691CF4EF
2022 - 2023 Principal Investigator for the study "Activity of 0.05% electrolytic sodium hypochlorite solution against microbial isolates from patients with infected pressure ulcers (SHINE)," funded by ANGELINI Pharma. Approved, in the contract finalization stage.
2022 - 2023 Principal Investigator for the study "Antimicrobial and antibiofilm activity of cefiderocol against Acinetobacter baumannii isolates in oncological patients (ALERT)," funded by Shionogi & Company, Limited. Approved, in the contract finalization stage.
2021 – 2022
2020 Principal Investigator for the study "Analysis of biofilm production and tolerance to antibiotics in Borrelia burgdorferi sensu stricto e sensu lato - (BABEL)" funded by the Associazione Lyme Italia and Coinfections.
Principal Investigator for the study "In vitro activity of cefiderocol and comparable antimicrobials against a wide variety of pathogens from hospital-acquired infections in Europe" funded by the International Health Management Associates - IHMA Europe.
2020 – 2021 Principal Investigator for the study "Dalbavancin activity against biofilm-growing MRSA isolated from patients with complicated skin and soft tissue infections" funded by ANGELINI Pharma.
2018 – 2021 Principal Investigator for 11 research projects at the San Gallicano Institute, Istituti Fisioterapici Ospitalieri - IFO, Rome, Italy
2020 Coordinator of the research project "Study on the role of probiotic bacteria (L. crispatus P 17631 and L. paracasei I 1688) for the treatment of Seborrheic Dermatitis in counteracting Malassezia spp." funded by PROGE FARM R&D.
2015 – 2020 Coordinator of the research project "Development of an in vitro Assay, Based on the BioFilm Ring Test, for Rapid Profiling of Biofilm-Growing Bacteria", funded by the Biofilm Control Company, Biopôle Clermont Limagne - 63360 Saint Beauzire, France, Italy.
2013 – 2014 Collaborator of the research project "Synthesis of core-shell magnetic nanoparticles for the treatment of bacterial biofilms". Sapienza University of Rome, Italy.
2012 Partner for the research project "Characterization of the electrogenic microbial population in Microbial Fuel Cells", Faculty of Bioscience Engineering, Ghent University, Belgium.
2010 – 2011 Partner for the research project "Characterization of the electrogenic microbial population in Microbial Fuel Cells", at the Department of Chemical Engineering, Materials and Environment, Sapienza University of Rome.
2008 Partner for the research project "Analysis of the role of Tel1 in the maintenance of humanized telomeres in yeast", Department of Molecular Biology Princeton University, New Jersey, U.S.A.