ELISA STURABOTTI

Dottoressa di ricerca

ciclo: XXXIII

Titolo della tesi: Functionalization of hyaluronic acid with a chondroprotective molecule and preparation of sulfonated HA-based materials

In the work of thesis, several aspects of hyaluronic acid chemical modification have been explored. In particular, the polysaccharide has been functionalized with NAPA, an amino acidic derivative of D-glucosamine and N-Acetyl-L-phenylalanine with chondroprotective properties, by means of esterification of the glucuronic unit. Preliminary biological studies on human primary chondrocytes (HPCs) has also been presented. The procedure discussed so far represents an innovative and fascinating method for the linkage of a glucosamine derivative to hyaluronic acid that could be useful also in the case of other GlcN-based products. The new HA bioconjugates could gain high relevance as injectable treatments against osteoarthritic disorders. An insight on racemization mechanism that occurs for N-acetylated amino acid was also conducted. In addition, hyaluronic acid was subjected to sulfonation in water. Two sulfonating agents, such as Tau and Bes, were reacted in order to synthetized soluble HA-SO3H derivatives and 3D hydrogels enriched in polar sulfonic groups. Sulfonated polymer demonstrated to have tunable properties depending upon reaction conditions and showed to be promising HA-based materials for biomedical applications.

Produzione scientifica

11573/1693973 - 2024 - Targeting the antifungal activity of carbon dots against Candida albicans biofilm formation by tailoring their surface functional groups

Sturabotti, Elisa; Camilli, Alessandro; Moldoveanu, Vyali Georgian; Bonincontro, Graziana; Simonetti, Giovanna; Valletta, Alessio; Serangeli, Ilaria; Miranda, Elena; Amato, Francesco; Marrani, Andrea Giacomo; Migneco, Luisa Maria; Sennato, Simona; Simonis, Beatrice; Vetica, Fabrizio; Leonelli, Francesca - 01a Articolo in rivista

rivista: CHEMISTRY-A EUROPEAN JOURNAL (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1-11 - issn: 0947-6539 - wos: WOS:001158843800001 (2) - scopus: 2-s2.0-85184430967 (3)

11573/1669322 - 2023 - Synthesis of sustainable eugenol/hydroxyethylmethacrylate-based polymers with antioxidant and antimicrobial properties

Di Consiglio, Micol; Sturabotti, Elisa; Brugnoli, Benedetta; Piozzi, Antonella; Migneco, Luisa; Francolini, Iolanda - 01a Articolo in rivista

rivista: POLYMER CHEMISTRY (Cambridge,UK: Royal Society of Chemistry) pp. 432-442 - issn: 1759-9954 - wos: WOS:000899254700001 (14) - scopus: 2-s2.0-85144788191 (14)

11573/1680686 - 2023 - Surface modification of polyester films with polyfunctional amines: Effect on bacterial biofilm formation

Mallamaci, Gianmarco; Brugnoli, Benedetta; Mariano, Alessia; Scotto D'abusco, Anna; Piozzi, Antonella; Di Lisio, Valerio; Sturabotti, Elisa; Alfano, Sara; Francolini, Iolanda - 01a Articolo in rivista

rivista: SURFACES AND INTERFACES ([Amsterdam] : Elsevier BV) pp. 1-12 - issn: 2468-0230 - wos: WOS:000999286200001 (6) - scopus: 2-s2.0-85159122577 (6)

11573/1684104 - 2023 - Nano-organocatalytic Michael reactions promoted by Chiral Carbon Dots

Moldoveanu, Vyali Georgian; Sturabotti, Elisa; Leonelli, Francesca; Vetica, Fabrizio - 04f Poster

congresso: XLVII “A. CORBELLA” INTERNATIONAL SUMMER SCHOOL ON ORGANIC SYNTHESIS (Gargnano, Italia)

libro: ISOS2023 - ()

11573/1688012 - 2023 - Chiral Carbon Dots as nano-organocatalysts to promote Michael Reactions

Moldoveanu, Vyali Georgian; Sturabotti, Elisa; Leonelli, Francesca; Vetica, Fabrizio - 04f Poster

congresso: XLI Convegno Nazionale della Divisione di Chimica Organica della Società Chimica Italiana (Roma, Italia)

libro: XLI Convegno Nazionale della Divisione di Chimica Organica della Società Chimica Italiana - ()

11573/1687780 - 2023 - Colorimetric transition of polydiacetylene/cyclodextrin supramolecular assemblies and implications as colorimetric sensors for food phenolic antioxidants

Sergi, Riccardo; Brugnoli, Benedetta; Sturabotti, Elisa; Piozzi, Antonella; Galantini, Luciano; Taresco, Vincenzo; Francolini, Iolanda - 01a Articolo in rivista

rivista: MACROMOLECULAR CHEMISTRY AND PHYSICS (Weinheim: Wiley-VCH-Verlag) pp. - - issn: 1022-1352 - wos: WOS:001009678400001 (4) - scopus: 2-s2.0-85162059316 (4)

11573/1685168 - 2023 - Thymol-functionalized hyaluronic acid as promising preservative biomaterial for the inhibition of Candida albicans biofilm formation

Sturabotti, Elisa; Moldoveanu, Vyali Georgian; Camilli, Alessandro; Martinelli, Andrea; Simonetti, Giovanna; Valletta, Alessio; Serangeli, Ilaria; Giustini, Alessandro; Miranda, Elena; Migneco, Luisa Maria; Vetica, Fabrizio; Leonelli, Francesca - 01f Lettera, Nota

rivista: ACS MACRO LETTERS (Washington, D.C. : American Chemical Society) pp. 1079-1084 - issn: 2161-1653 - wos: WOS:001031259800001 (7) - scopus: 2-s2.0-85166756054 (7)

11573/1664403 - 2023 - N-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(N-Acetyl)-l-phenylalanylamido-2-deoxy-d-glucose (NAPA)

Sturabotti, Elisa; Vetica, Fabrizio; Toscano, Giorgia; Calcaterra, Andrea; Martinelli, Andrea; Migneco, Luisa Maria; Leonelli, Francesca - 01a Articolo in rivista

rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000918673200001 (4) - scopus: 2-s2.0-85146749903 (4)

11573/1605996 - 2022 - One-Pot preparation of hydrophilic polylactide porous scaffolds by using safe solvent and choline taurinate ionic liquid

De Felice, A. C.; Di Lisio, V.; Francolini, I.; Mariano, A.; Piozzi, A.; Scotto D'abusco, A.; Sturabotti, E.; Martinelli, A. - 01a Articolo in rivista

rivista: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 158- - issn: 1999-4923 - wos: WOS:000756293000001 (8) - scopus: 2-s2.0-85122881970 (8)

11573/1652439 - 2022 - Decomposition of Deep Eutectic Solvent Aids Metals Extraction in Lithium-Ion Batteries Recycling

Schiavi, Pier Giorgio; Altimari, Pietro; Sturabotti, Elisa; Marrani, Andrea Giacomo; Simonetti, Giulia; Pagnanelli, Francesca - 01a Articolo in rivista

rivista: CHEMSUSCHEM (WEINHEIM, GERMANY: WILEY-V C H VERLAG GMBH) pp. 1-9 - issn: 1864-5631 - wos: WOS:000838153400001 (37) - scopus: 2-s2.0-85135850935 (37)

11573/1652413 - 2022 - Synthesis of novel hyaluronic acid sulfonated hydrogels using safe reactants: a chemical and biological characterization

Sturabotti, Elisa; Consalvi, Silvia; Tucciarone, Luca; Macrì, Elisa; Di Lisio, Valerio; Francolini, Iolanda; Minichiello, Carmen; Piozzi, Antonella; Vuotto, Claudia; Martinelli, Andrea - 01a Articolo in rivista

rivista: GELS (Basel : MDPI) pp. 1-15 - issn: 2310-2861 - wos: WOS:000845991000001 (4) - scopus: 2-s2.0-85137407225 (4)

11573/1457246 - 2020 - Application of temperature modulation to FTIR spectroscopy: an analysis of equilibrium and non-equilibrium conformational transitions of poly(ethylene terephthalate) in glassy and liquid states

Di Lisio, V.; Sturabotti, E.; Francolini, I.; Piozzi, A.; Martinelli, A. - 01a Articolo in rivista

rivista: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY (Akademiai Kiado:Prielle Kornelia U-19, H 1117 Budapest Hungary:011 36 1 4648222, 011 36 1 4648282, 011 36 1 4648282, EMAIL: journals@akkrt.hu, kiss.s@akkrt.hu, INTERNET: http://www.akkrt.hu/en/, Fax: 011 36 1 4648221) pp. 1835-1847 - issn: 1388-6150 - wos: WOS:000563610000017 (5) - scopus: 2-s2.0-85089981877 (5)

11573/1282210 - 2019 - Isotactic polypropylene reversible crystallization investigated by modulated temperature and quasi‐isothermal FTIR

Di Lisio, Valerio; Sturabotti, Elisa; Francolini, Iolanda; Piozzi, Antonella; Martinelli, Andrea - 01a Articolo in rivista

rivista: JOURNAL OF POLYMER SCIENCE. PART B, POLYMER PHYSICS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 922-931 - issn: 0887-6266 - wos: WOS:000474597700004 (2) - scopus: 2-s2.0-85067415138 (2)

11573/1198991 - 2019 - Effects of annealing above Tg on the physical aging of quenched PLLA studied by modulated temperature FTIR

Martinelli, Andrea; Piozzi, Antonella; Francolini, Iolanda; Sturabotti, Elisa; Di Lisio, Valerio - 01a Articolo in rivista

rivista: JOURNAL OF POLYMER SCIENCE. PART B, POLYMER PHYSICS (New York, N.Y.: Wiley, [1986]-) pp. 174-181 - issn: 1099-0488 - wos: WOS:000454540100005 (10) - scopus: 2-s2.0-85057086867 (12)

11573/1186563 - 2018 - Study on isotactic polypropylene melt-crystallization by temperature modulated FTIR

Di Lisio, V.; Francolini, I.; Piozzi, A.; Sturabotti, E.; Martinelli, A. - 04b Atto di convegno in volume

congresso: XXIII Convegno Nazionale dell'Associazione Italiana di Scienza e Tecnologia delle Macromolecole (Catania)

libro: XXIII convegno nazionale dell'associazione italiana di scienza e tecnologia delle macromolecole - (978-88-7751-449-3)

11573/1186576 - 2018 - Analisi FT-IR a modulazione di temperatura di trattamenti termici sul PLLA amorfo

Di Lisio, V.; Francolini, I.; Piozzi, A.; Sturabotti, E.; Martinelli, A. - 04f Poster

congresso: XXIII Convegno Nazionale dell'Associazione Italiana di Scienza e Tecnologia delle Macromolecole (Catania)

libro: XXIII convegno nazionale dell'associazione italiana di scienza e tecnologia delle macromolecole - (978-88-7751-449-3)

11573/1186432 - 2018 - An investigation on the non-isothermal reversing crystallization of isotactic polypropylene by Temperature Modulated FT-IR

Di Lisio, Valerio; Sturabotti, Elisa; Francolini, Iolanda; Piozzi, Antonella; Martinelli, Andrea - 04f Poster

congresso: 15 th Lähnwitzseminar on Calorimetry (Rostock-Warnemünde)

libro: 15 th Lähnwitzseminar on Calorimetry - ()

11573/1194126 - 2018 - Surface functionalized PLLA for scaffold preparation

Sturabotti, Elisa; Lopreiato, Mariangela; Scotto, D'abusco; Martinelli, Andrea - 04d Abstract in atti di convegno

congresso: Polymar 2018, 2nd Conference for Early Stage Researchers in Polymer Science throuth the Aegean (Aegean Sea, Greece)

libro: Book of Abstract Polymar 2018. 2nd Conference for Early Stage Researchers in Polymer Science through the Aegean Sea - ()