DOMIZIANA RINALDI

Dottoressa di ricerca

ciclo: XXXVII

supervisore: Prof. Francesco Ernesto Pontieri

Titolo della tesi: Motor and Non-Motor Symptoms in Advanced Parkinson’s Disease: Current Insights and Future Directions

Advanced Parkinson’s disease (PD) is characterized by significant motor and non-motor complications, including levodopa-resistant symptoms such as freezing of gait (FoG), postural instability, and dysphagia, alongside autonomic dysfunction. As the disease progresses, managing these symptoms becomes increasingly complex. This thesis explores the role of advanced therapies, including levodopa-carbidopa intestinal gel (LCIG) and deep brain stimulation (DBS), in addressing some disabling symptoms such as postural abnormalities, freezing of gait (Fog), speech disturbance, and some non motor symptoms such as dysautonomic disturbance and pain. Additionally, it investigates the role of monoamine oxidase type B (MAO-B) inhibitors in managing both motor and cognitive fluctuations in advanced PD. Integrating wearable sensor technologies allows continuous monitoring of motor complications such as dyskinesias and FoG daily, offering a novel approach to individualized treatment. This thesis stresses the demand for a multidisciplinary, patient-centered approach to managing advanced PD, with particular attention to autonomic dysfunctions and axial symptoms, potentially aided by using wearable sensors to obtain an objective measurement to improve the patient’s quality of life.

Produzione scientifica

11573/1730581 - 2025 - Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease

Di Menna, Luisa; Alborghetti, Marika; De Bartolo, Maria Ilenia; Borro, Marina; Gentile, Giovanna; Zinni, Manuela; Bologna, Matteo; Cutrona, Carolina; D'errico, Giovanna; Imbriglio, Tiziana; Bucci, Domenico; Merlo, Sara; Ginerete, Roxana Paula; Orlando, Rosamaria; Carrillo, Federica; Fortunato, Giorgio; Cannella, Milena; Sortino, Maria Angela; Pansiot, Julien; Baud, Olivier; Nicoletti, Ferdinando; Bruno, Valeria; Simmaco, Maurizio; Pontieri, Francesco Ernesto; Bianchini, Edoardo; Rinaldi, Domiziana; De Curtis, Amalia; De Gaetano, Giovanni; Iacoviello, Licia; Esposito, Teresa; Berardelli, Alfredo; Battaglia, Giuseppe - 01a Articolo in rivista

rivista: NPJ PARKINSON'S DISEASE ([New York NY] : Nature Publishing Group; Parkinson's Disease Foundation , [2015]-) pp. 1-14 - issn: 2373-8057 - wos: WOS:001389412200001 (0) - scopus: 2-s2.0-85213999507 (0)

11573/1700495 - 2024 - The Story behind the Mask: A Narrative Review on Hypomimia in Parkinson’s Disease

Bianchini, Edoardo; Rinaldi, Domiziana; Alborghetti, Marika; Simonelli, Marta; D’Audino, Flavia; Onelli, Camilla; Pegolo, Elena; Pontieri, Francesco E. - 01g Articolo di rassegna (Review)

rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: WOS:001149505900001 (2) - scopus: (0)

11573/1720106 - 2024 - Incidence and predictors of postural abnormalities in Parkinson’s disease: a PPMI cohort study

Fabbri, Margherita; Campisi, Corrado; Ledda, Claudia; Rinaldi, Domiziana; Tsukita, Kazuto; Romagnolo, Alberto; Imbalzano, Gabriele; Zibetti, Maurizio; Rizzone, Mario Giorgio; Pontieri, Francesco Ernesto; Lopiano, Leonardo; Artusi, Carlo Alberto - 01b Commento, Erratum, Replica e simili

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 4628-4634 - issn: 0340-5354 - wos: WOS:001234583700001 (0) - scopus: 2-s2.0-85194475057 (0)

11573/1728868 - 2024 - Effects of levodopa/carbidopa intestinal gel infusion on autonomic symptoms in advanced Parkinson’s disease: a systematic review

Galli, Silvia; De Carolis, Lanfranco; Bianchini, Edoardo; Alborghetti, Marika; Caliò, Bianca; Pacilio, Pierre; Fanciulli, Alessandra; Pontieri, Francesco E.; Rinaldi, Domiziana - 01g Articolo di rassegna (Review)

rivista: CLINICAL AUTONOMIC RESEARCH (-Heidelberg : Springer-Medizin-Verl. Darmstadt Germany: Dr Dietrich Steinkopff Verlag) pp. 1-24 - issn: 0959-9851 - wos: (0) - scopus: (0)

11573/1720108 - 2024 - CACNA1A variant associated with generalized dystonia

Rinaldi, Domiziana; Tangari, Marta Maria; Ledda, Claudia; Dematteis, Francesca; Rizzone, Mario Giorgio; Lopiano, Leonardo; Artusi, Carlo Alberto - 01i Case report

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 4589-4592 - issn: 1590-1874 - wos: WOS:001222561600002 (0) - scopus: 2-s2.0-85193011262 (0)

11573/1710166 - 2024 - Unveiling the Unpredictable in Parkinson’s Disease: Sensor-Based Monitoring of Dyskinesias and Freezing of Gait in Daily Life

Zampogna, Alessandro; Borzi', Luigi; Rinaldi, Domiziana; Alberto Artusi, Carlo; Imbalzano, Gabriele; Patera, Martina; Lopiano, Leonardo; Pontieri, Francesco; Olmo, Gabriella; Suppa, Antonio - 01a Articolo in rivista

rivista: BIOENGINEERING (Basel : MDPI AG, 2014-) pp. - - issn: 2306-5354 - wos: WOS:001234368400001 (5) - scopus: (0)

11573/1682848 - 2023 - Type-B monoamine oxidase inhibitors in neurological diseases: clinical applications based on preclinical findings

Alborghetti, Marika; Bianchini, Edoardo; De Carolis, Lanfranco; Galli, Silvia; Pontieri, Francesco E.; Rinaldi, Domiziana - 01g Articolo di rassegna (Review)

rivista: NEURAL REGENERATION RESEARCH (Shenyang : Publishing House of Neural Regeneration Research.) pp. - - issn: 1673-5374 - wos: WOS:001116418500003 (17) - scopus: (0)

11573/1692946 - 2023 - Axial symptoms as main predictors of short-term subthalamic stimulation outcome in Parkinson's disease

Artusi, Carlo Alberto; Ledda, Claudia; Rinaldi, Domiziana; Montanaro, Elisa; Romagnolo, Alberto; Imbalzano, Gabriele; Rizzone, Mario Giorgio; Zibetti, Maurizio; Lopiano, Leonardo; Bozzali, Marco - 01a Articolo in rivista

rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 120818- - issn: 0022-510X - wos: WOS:001092068900001 (0) - scopus: 2-s2.0-85172325881 (0)

11573/1664957 - 2023 - Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study

De Carolis, Lanfranco; Galli, Silvia; Bianchini, Edoardo; Rinaldi, Domiziana; Raju, Manikandan; Caliò, Bianca; Alborghetti, Marika; Pontieri, Francesco E. - 01a Articolo in rivista

rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. 157- - issn: 2076-3425 - wos: WOS:000938373600001 (8) - scopus: 2-s2.0-85148855591 (9)

11573/1681001 - 2023 - How resistant are levodopa-resistant axial symptoms? Response of freezing, posture, and voice to increasing levodopa intestinal infusion rates in Parkinson disease

Imbalzano, Gabriele; Rinaldi, Domiziana; Calandra-Buonaura, Giovanna; Contin, Manuela; Amato, Federica; Giannini, Giulia; Sambati, Luisa; Ledda, Claudia; Romagnolo, Alberto; Olmo, Gabriella; Cortelli, Pietro; Zibetti, Maurizio; Lopiano, Leonardo; Artusi, Carlo Alberto - 01a Articolo in rivista

rivista: EUROPEAN JOURNAL OF NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 96-106 - issn: 1351-5101 - wos: WOS:000866123700001 (5) - scopus: 2-s2.0-85139680786 (5)

11573/1680397 - 2023 - Levodopa/carbidopa intestinal gel via percutaneous endoscopic transgastric jejunostomy in advanced Parkinson's disease: hitting two birds with one stone?

Rinaldi, Domiziana; Galli, Silvia; Fanciulli, Alessandra; Pontieri, Francesco E. - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS ([S.l.] : Elsevier Science) pp. 105394- - issn: 1873-5126 - wos: WOS:001035165500001 (1) - scopus: 2-s2.0-85152643131 (1)

11573/1674603 - 2023 - The impact of dysphagia in Parkinson's disease patients treated with levodopa/carbidopa intestinal gel

Rinaldi, Domiziana; Imbalzano, Gabriele; Galli, Silvia; Bianchini, Edoardo; Ledda, Claudia; De Carolis, Lanfranco; Zibetti, Maurizio; Lopiano, Leonardo; Pontieri, Francesco Ernesto; Artusi, Carlo Alberto - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 105368- - issn: 1353-8020 - wos: WOS:000957580700001 (3) - scopus: 2-s2.0-85150037963 (4)

11573/1625707 - 2022 - Deep brain stimulation for atypical parkinsonism: A systematic review on efficacy and safety

Artusi, C. A.; Rinaldi, D.; Balestrino, R.; Lopiano, L. - 01g Articolo di rassegna (Review)

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. - - issn: 1353-8020 - wos: WOS:000810115300003 (11) - scopus: 2-s2.0-85126334450 (11)

11573/1663165 - 2022 - Step-Counting Accuracy of a Commercial Smartwatch in Mild-to-Moderate PD Patients and Effect of Spatiotemporal Gait Parameters, Laterality of Symptoms, Pharmacological State, and Clinical Variables

Bianchini, Edoardo; Caliò, Bianca; Alborghetti, Marika; Rinaldi, Domiziana; Hansen, Clint; Vuillerme, Nicolas; Maetzler, Walter; Pontieri, Francesco E. - 01a Articolo in rivista

rivista: SENSORS (Basel : Molecular Diversity Preservation International (MDPI), 2001-) pp. 214- - issn: 1424-8220 - wos: WOS:000909119600001 (3) - scopus: 2-s2.0-85145880125 (3)

11573/1648666 - 2022 - Feasibility, Safety, and Effectiveness of Telerehabilitation in Mild-to-Moderate Parkinson's Disease

Bianchini, Edoardo; Onelli, Camilla; Morabito, Carmen; Alborghetti, Marika; Rinaldi, Domiziana; Anibaldi, Paolo; Marcolongo, Adriano; Salvetti, Marco; Pontieri, Francesco E. - 01a Articolo in rivista

rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2295 - wos: WOS:000819247600001 (19) - scopus: 2-s2.0-85133530259 (23)

11573/1612757 - 2022 - Time to onset and duration of botulinum toxin efficacy in movement disorders

Ledda, C.; Artusi, C. A.; Tribolo, A.; Rinaldi, D.; Imbalzano, G.; Lopiano, L.; Zibetti, M. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000750700100001 (14) - scopus: 2-s2.0-85124214711 (14)

11573/1655876 - 2022 - Monoamine-Oxidase type B- Inhibitors and Cognitive Functions in Parkinson's Disease: Beyond the Primary Mechanism of Action

Rinaldi, Domiziana; Alborghetti, Marika; Bianchini, Edoardo; Sforza, Michela; Galli, Silvia; Pontieri, Francesco E - 01g Articolo di rassegna (Review)

rivista: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. - - issn: 1570-159X - wos: WOS:001006678700012 (4) - scopus: 2-s2.0-85159493262 (4)

11573/1631866 - 2022 - Levodopa/carbidopa intestinal gel for pain related to levodopa-induced motor complications in Parkinson’s disease

Rinaldi, Domiziana; De Carolis, Lanfranco; Ceriello, Francesco; Bianchini, Edoardo; Pontieri, Francesco E. - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000780786400001 (0) - scopus: 2-s2.0-85127959956 (1)

11573/1581370 - 2021 - Magnetically controlled growing rods for early scoliosis treatment in coffin-siris syndrome. Case report and literature review

Andreozzi, Valerio; Princi, Giorgio; Labianca, Luca; Rinaldi, Domiziana; Ferretti, Andrea - 01i Case report

rivista: THE IOWA ORTHOPAEDIC JOURNAL ([Iowa City, IA] : Residents and Faculty of the Dept. of Orthopaedics, University of Iowa,) pp. 55-59 - issn: 1541-5457 - wos: (0) - scopus: 2-s2.0-85116760586 (1)

11573/1561414 - 2021 - Switch from rasagiline to safinamide in fluctuating Parkinson’s disease patients. a retrospective, pilot study

Bianchini, E.; Sforza, M.; Rinaldi, D.; Alborghetti, M.; De Carolis, L.; Della Gatta, F.; Pontieri, F. E. - 01a Articolo in rivista

rivista: NEUROLOGICAL RESEARCH (Forefront Publishing Group:5 River Road, Suite 113, Private Mail Box 113:Wilton, CT 06897:(203)834-0631, EMAIL: info@forefrontpublishing.com, Fax: (203)834-0940 Previous: New York: Crane, Russak & Co.) pp. 1-6 - issn: 0161-6412 - wos: WOS:000663181800001 (10) - scopus: 2-s2.0-85108182663 (10)

11573/1461219 - 2021 - Safinamide improves executive functions in fluctuating Parkinson's disease patients. an exploratory study

Rinaldi, D; Sforza, M; Assogna, F; Savini, C; Salvetti, M; Caltagirone, C; Spalletta, G; Pontieri, Fe. - 01a Articolo in rivista

rivista: JOURNAL OF NEURAL TRANSMISSION (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 3-7 - issn: 0300-9564 - wos: WOS:000579602600001 (20) - scopus: 2-s2.0-85092666645 (19)

11573/1461240 - 2020 - The tolerability, safety and efficacy of safinamide in elderly Parkinson's disease patients: a retrospective study

Rinaldi, D; Bianchini, E; Sforza, M; Alborghetti, M; Galli, S; Salvetti, M; Giovannelli, M; Pontieri, Fe. - 01a Articolo in rivista

rivista: AGING CLINICAL AND EXPERIMENTAL RESEARCH (Springer Nature Milano: Editrice Kurtis) pp. 1-4 - issn: 1594-0667 - wos: WOS:000549678800001 (7) - scopus: 2-s2.0-85088141169 (6)

11573/1118641 - 2018 - Rasagiline for dysexecutive symptoms during wearing-off in parkinson's disease: a pilot study.

Rinaldi, D; Assogna, F; Sforza, M; Tagliente, S; Pontieri, Fe - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 141-143 - issn: 1590-1874 - wos: WOS:000422796600019 (9) - scopus: 2-s2.0-85030115570 (9)

11573/1118635 - 2018 - Orthostatic hypotension acutely impairs executive functions in Parkinson's disease

Sforza, M; Assogna, F; Rinaldi, D; Sette, G; Tagliente, S; Pontieri, Fe - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 1459-1462 - issn: 1590-1874 - wos: WOS:000439465800018 (10) - scopus: 2-s2.0-85045075504 (9)