COSTANZA GIANNI'

Dottoressa di ricerca

ciclo: XXXIV


supervisore: Prof.ssa Patrizia Pantano
relatore: Prof.ssa Patrizia Pantano

Titolo della tesi: Structural and functional connectivity alterations in focal dystonia: a focus on the cerebellum and basal ganglia.

Background and aims: Neuroimaging studies suggest that changes in the cerebellar-basal ganglia-thalamo-cortical sensorimotor circuit are a pathophysiological feature of focal dystonia. However, it remains unclear whether structural and functional alterations vary in different forms of focal dystonia. Thus, in patients with cervical dystonia (CD) and blepharospasm (BSP), we aimed at investigating structural and microstructural damage, and resting-state functional alterations of the whole brain and in specific regions/circuits of interest, to identify common and distinguishing features. Specifically, we applied voxel- and surface-based morphometry, and a probabilistic tractography approach to reveal global brain structural alterations and microstructural damage of specific subcortical-cortical white matter (WM) tracts, respectively. Also, using whole-brain and seed-based approaches we tested the hypothesis of possible functional connectivity (FC) alterations in specific circuits, including the cerebellum, basal ganglia, and cerebral cortex, in the context of preserved global functional connectivity (FC). Methods: Seventeen CD patients, 18 BSP patients, and 17 healthy subjects (HS) were studied cross-sectionally with multimodal 3T MRI. 3D T1-weighted images were used to calculate brain volumes and cortical thickness; with diffusion tensor imaging (DTI) we performed tractography and extracted DTI metrics from WM tracts reconstructed between primary motor, primary somatosensory and supplementary motor cortices, and thalamus, globus pallidus and putamen; with functional MRI at rest we studied both FC of the dentate nucleus and globus pallidus with a seed-based approach, and whole-brain FC with a graph theory approach. Results: CD patients, BSP patients, and HS did not differ in terms of cortical or subcortical volumes. Significant between-group differences in DTI metrics, namely in mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD), were found in the majority of the reconstructed WM tracts, with CD and BSP patients exhibiting higher MD, RD and AD compared to HS. In patients with BSP, a significant positive correlation was found between blepharospasm severity and both MD and RD of WM bundles. Compared to HS, common and distinguishing FC pattern changes in CD and BSP emerged. Both CD and BSP patients had a loss of dentate FC anticorrelation with the sensorimotor cortex. CD and BSP patients showed increased pallidal FC with the cerebellum, supplementary motor area, and prefrontal cortices with respect to HS. Increased dentate FC with the cerebellum and thalamus and increased pallidal FC with the bilateral thalamus, sensorimotor and temporo-occipital cortices, and right putamen were present in CD but not BSP patients, as compared to HS. Measures of global FC, i.e., global efficiency and small-worldness, did not differ between patients and HS. Conclusion: Despite the absence of focal damage and WM volume loss in focal dystonia, our data point to a diffuse and extensive alterations in WM integrity, i.e., axonal and myelin loss, as a common feature in CD and BSP, indicative of microstructural disruption of basal ganglia-thalamo-cortical circuit. Both CD and BSP patients showed altered dentate and pallidal FC with regions belonging to the integrated cerebellar-basal ganglia-thalamo-cortical sensorimotor circuit, supporting the concept that focal dystonia is a disorder of specific networks, and not merely a result of basal ganglia alterations. This study provides new insights into the role of microstructural and functional alterations of the integrated cerebellar-basal ganglia-thalamo-cortical sensorimotor circuit in CD and BSP pathophysiology, in the context of an intact whole brain macrostructural and functional architecture, with differences in functional interplay among specific brain structures potentially distinguishing the two clinical phenotypes.

Produzione scientifica

11573/1710257 - 2024 - Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis
Cortese, Rosa; Battaglini, Marco; Stromillo, Maria Laura; Luchetti, Ludovico; Leoncini, Matteo; Gentile, Giordano; Gasparini, Daniele; Plantone, Domenico; Altieri, Manuela; D'ambrosio, Alessandro; Gallo, Antonio; Gianni, Costanza; Piervincenzi, Claudia; Pantano, Patrizia; Pagani, Elisabetta; Valsasina, Paola; Preziosa, Paolo; Tedone, Nicolo'; Rocca, Maria Assunta; Filippi, Massimo; De Stefano, Nicola; Inni, Network - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: (0) - scopus: (0)

11573/1679647 - 2023 - Cortico-Subcortical White Matter Bundle Changes in Cervical Dystonia and Blepharospasm
Gianni', Costanza; Piervincenzi, Claudia; Belvisi, Daniele; Tommasin, Silvia; De Bartolo, Maria Ilenia; Ferrazzano, Gina; Petsas, Nikolaos; Leodori, Giorgio; Fantoni, Nicoletta; Conte, Antonella; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel: MDPI) pp. 753- - issn: 2227-9059 - wos: WOS:000954260200001 (2) - scopus: 2-s2.0-85151496637 (3)

11573/1689825 - 2023 - Neuroimaging markers of Alice in Wonderland syndrome in patients with migraine with aura
Mastria, Giulio; Mancini, Valentina; Viganò, Alessandro; Piervincenzi, Claudia; Petsas, Nikolaos; Puma, Marta; Gianni, Costanza; Pantano, Patrizia; Di Piero, Vittorio - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. 1210811- - issn: 1664-2295 - wos: WOS:001070315100001 (3) - scopus: 2-s2.0-85172785584 (3)

11573/1677362 - 2023 - Parkinsonism Is Associated with Altered SMA-Basal Ganglia Structural and Functional Connectivity in Frontotemporal Degeneration
Piervincenzi, Claudia; Suppa, Antonio; Petsas, Nikolaos; Fabbrini, Andrea; Trebbastoni, Alessandro; Asci, Francesco; Giannì, Costanza; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel: MDPI) pp. 522- - issn: 2227-9059 - wos: WOS:000938415800001 (0) - scopus: 2-s2.0-85148910023 (0)

11573/1701886 - 2023 - The brief repeatable battery of neuropsychological tests (BRB-N) version a: update of Italian normative data from the Italian Neuroimaging Network Initiative (INNI)
Tedone, Nicolò; Vizzino, Carmen; Meani, Alessandro; Gallo, Antonio; Altieri, Manuela; D’Ambrosio, Alessandro; Pantano, Patrizia; Piervincenzi, Claudia; Tommasin, Silvia; De Stefano, Nicola; Cortese, Rosa; Stromillo, Maria L.; Rocca, Maria A.; Storelli, Loredana; Sala, Stefania; Valsasina, Paola; Pagani, Elisabetta; Preziosa, Paolo; Giannì, Costanza; Petsas, Nikolaos; Bisecco, Alvino; Esposito, Fabrizio; Rosa, Alessandro; Filippi, Massimo; Null, Null - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:001115643800001 (0) - scopus: 2-s2.0-85184869022 (0)

11573/1656320 - 2022 - White matter alterations in drug-naïve children with Tourette syndrome and obsessive-compulsive disorder
Bharti, Komal; Conte, Giulia; Tommasin, Silvia; Gianni', Costanza; Suppa, Antonio; Mirabella, Giovanni; Cardona, Francesco Carmelo Giovanni; Pantano, Patrizia - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2295 - wos: WOS:000870430600001 (2) - scopus: 2-s2.0-85139928276 (4)

11573/1663112 - 2022 - Differential white matter involvement in drug-naïve children with obsessive-compulsive disorder and Tourette syndrome
Conte, Giulia; Bharti, Komal; Suppa, Antonio; Tikoo, Sankalp; Tommasin, Silvia; Gianni, Costanza; Mirabella, Giovanni; Pantano, Patrizia; Cardona, Francesco - 04c Atto di convegno in rivista
rivista: NEUROSCIENCE APPLIED (Amsterdam: Elsevier B.V) pp. - - issn: 2772-4085 - wos: (0) - scopus: (0)
congresso: 35th ECNP Congress (Vienna)

11573/1701955 - 2022 - Tourette Syndrome and Obsessive-Compulsive Disorder: different neural correlates from a multimodal neuroimaging study in drug-naïve children
Conte, Giulia; Tikoo, Sankalp; Barthi, Komal; Tommasin, Silvia; Gianni, Costanza; Suppa, Antonio; Pantano, Patrizia; Cardona, Francesco - 04f Poster
congresso: 14th European Conference on Tourette Syndrome & Tic Disorders (Lausanne)
libro: Congress book of the 14th European Conference on Tourette Syndrome & Tic Disorder - ()

11573/1643308 - 2022 - Focal Dystonia: Functional Connectivity Changes in Cerebellar-Basal Ganglia-Cortical Circuit and Preserved Global Functional Architecture
Gianni', Costanza; Pasqua, Gabriele; Ferrazzano, Gina; Tommasin, Silvia; De Bartolo, Maria Ilenia; Petsas, Nikolaos; Belvisi, Daniele; Conte, Antonella; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. 10.1212/WNL.0000000000200022- - issn: 0028-3878 - wos: WOS:000776605500021 (10) - scopus: 2-s2.0-85128244893 (14)

11573/1662696 - 2022 - Multicenter data harmonization for regional brain atrophy and application in multiple sclerosis
Pagani, Elisabetta; Storelli, Loredana; Pantano, Patrizia; Petsas, Nikolaos; Tedeschi, Gioacchino; Gallo, Antonio; De Stefano, Nicola; Battaglini, Marco; A Rocca, Maria; Filippi, Massimo; Valsasina, Paola; Sibilia, Mauro; Preziosa, Paolo; Bisecco, Alvino; D'ambrosio, Alessandro; Altieri, Manuela; Capuano, Rocco; Tommasin, Silvia; Ruggieri, Serena; Piervincenzi, Claudia; Gianni', Costanza; Laura Stromillo, Maria; Cortese, Rosa Maria; Zaratin, Paola - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000859822500001 (3) - scopus: 2-s2.0-85138960332 (4)

11573/1657997 - 2022 - Functional connectivity alterations in migraineurs with Alice in Wonderland syndrome
Piervincenzi, Claudia; Petsas, Nikolaos; Viganò, Alessandro; Mancini, Valentina; Mastria, Giulio; Puma, Marta; Gianni', Costanza; Di Piero, Vittorio; Pantano, Patrizia - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000854412400002 (3) - scopus: 2-s2.0-85138184770 (5)

11573/1662586 - 2022 - Evaluation of Disability Progression in Multiple Sclerosis via Magnetic-Resonance-Based Deep Learning Techniques
Taloni, Alessandro; Farrelly, Francis Allen; Pontillo, Giuseppe; Petsas, Nikolaos; Gianni', Costanza; Ruggieri, Serena; Petracca, Maria; Brunetti, Arturo; Pozzilli, Carlo; Pantano, Patrizia; Tommasin, Silvia - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 10651- - issn: 1422-0067 - wos: WOS:000856461500001 (2) - scopus: 2-s2.0-85138347653 (2)

11573/1662587 - 2022 - Relation of sensorimotor and cognitive cerebellum functional connectivity with brain structural damage in patients with multiple sclerosis and no disability
Tommasin, Silvia; Iakovleva, Viktoriia; Assunta Rocca, Maria; Gianni', Costanza; Tedeschi, Gioacchino; De Stefano, Nicola; Pozzilli, Carlo; Filippi, Massimo; Pantano, Patrizia; Petsas, Nikolaos; Ruggieri, Serena; Piervincenzi, Claudia; Valsasina, Paola; Sibilia, Mauro; Preziosa, Paolo; Storelli, Loredana; Gallo, Antonio; Bisecco, Alvino; D'ambrosio, Alessandro; Laura Stromillo, Maria; Tappa Brocci And, Riccardo - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF NEUROLOGY ([Oxford]: Blackwell Science.) pp. 2036-2046 - issn: 1468-1331 - wos: WOS:000777691500001 (5) - scopus: 2-s2.0-85130017898 (5)

11573/1542386 - 2021 - Abnormal motor surround inhibition associated with cortical and deep grey matter involvement in multiple sclerosis
Belvisi, D.; Gianni, C.; Tartaglia, M.; Petsas, N.; Baione, V.; Crisafulli, S. G.; Pantano, P.; Berardelli, A.; Conte, A. - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 1151-1156 - issn: 1388-2457 - wos: WOS:000646996100018 (1) - scopus: 2-s2.0-85103075630 (1)

11573/1523897 - 2021 - Shaken Baby Syndrome: Magnetic Resonance Imaging Features in Abusive Head Trauma
Cartocci, Gaia; Fineschi, Vittorio; Padovano, Martina; Scopetti, Matteo; Rossi-Espagnet, Maria Camilla; Giannì, Costanza - 01g Articolo di rassegna (Review)
rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: WOS:000622247500001 (6) - scopus: 2-s2.0-85100523606 (14)

11573/1579450 - 2021 - Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study
Gianni', C.; Belvisi, D.; Conte, A.; Tommasin, S.; Cortese, A.; Petsas, N.; Baione, V.; Tartaglia, M.; Millefiorini, E.; Berardelli, A.; Pantano, P. - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 2191-2198 - issn: 1388-2457 - wos: WOS:000691755500023 (4) - scopus: 2-s2.0-85110418186 (8)

11573/1551241 - 2021 - Increased Within-Network Functional Connectivity May Predict NEDA Status in Fingolimod-Treated MS Patients
Piervincenzi, C.; Petsas, N.; De Giglio, L.; Carmellini, M.; Giannì, Costanza.; Tommasin, S.; Pozzilli, C.; Pantano, P. - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2295 - wos: WOS:000630338900001 (3) - scopus: 2-s2.0-85102952122 (3)

11573/1617037 - 2021 - Alice in Wonderland syndrome: a lesion mapping study
Piervincenzi, C.; Petsas, N.; Giannì, Costanza; Di Piero, V.; Pantano, P. - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000725410400002 (3) - scopus: 2-s2.0-85120542025 (6)

11573/1553114 - 2021 - A matter of atrophy: differential impact of brain and spine damage on disability worsening in multiple sclerosis
Ruggieri, S.; Petracca, M.; De Giglio, L.; De Luca, F.; Giannì, C.; Gurreri, F.; Petsas, N.; Tommasin, S.; Pozzilli, C.; Pantano, P. - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000646557500001 (11) - scopus: 2-s2.0-85105395895 (11)

11573/1573580 - 2021 - The Cerebellum in Drug-naive Children with Tourette Syndrome and Obsessive–Compulsive Disorder
Tikoo, Sankalp; Suppa, Antonio; Tommasin, Silvia; Gianni', Costanza; Conte, Giulia; Mirabella, Giovanni; Cardona, Francesco Carmelo Giovanni; Pantano, Patrizia - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4230 - wos: WOS:000702233800002 (15) - scopus: 2-s2.0-85116162642 (13)

11573/1553110 - 2021 - Machine learning classifier to identify clinical and radiological features relevant to disability progression in multiple sclerosis
Tommasin, S.; Cocozza, S.; Taloni, A.; Gianni', C.; Petsas, N.; Pontillo, G.; Petracca, M.; Ruggieri, S.; De Giglio, L.; Pozzilli, C.; Brunetti, A.; Pantano, P. - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 4834-4845 - issn: 0340-5354 - wos: WOS:000648826600001 (17) - scopus: 2-s2.0-85105600464 (22)

11573/1277208 - 2020 - Aberrant functional connectivity in patients with Parkinson's disease and freezing of gait: a within- and between-network analysis
Bharti, Komal; Suppa, Antonio; Pietracupa, Sara; Upadhyay, Neeraj; Giannì, Costanza; Leodori, Giorgio; Di Biasio, Francesca; Modugno, Nicola; Petsas, Nikolaos; Grillea, Giovanni; Zampogna, Alessandro; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: BRAIN IMAGING AND BEHAVIOR (New York, NY : Springer) pp. 1543-1554 - issn: 1931-7557 - wos: WOS:000579512100023 (28) - scopus: 2-s2.0-85063191272 (30)

11573/1277228 - 2020 - Deep grey matter involvement and altered sensory gating in multiple sclerosis
Conte, Antonella; Giannì, Costanza; Belvisi, Daniele; Cortese, Antonio; Petsas, Nikolaos; Tartaglia, Matteo; Cimino, Paola; Millefiorini, Enrico; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. - - issn: 1352-4585 - wos: WOS:000540055900008 (10) - scopus: 2-s2.0-85066822880 (12)

11573/1409202 - 2020 - Loss in grey matter in a small network of brain areas underpins poor reactive inhibition in Obsessive-Compulsive Disorder patients
Mirabella, G.; Upadhyay, N.; Mancini, C.; Gianni, C.; Panunzi, S.; Petsas, N.; Suppa, A.; Cardona, F.; Pantano, P. - 01a Articolo in rivista
rivista: PSYCHIATRY RESEARCH. NEUROIMAGING (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 111044- - issn: 0925-4927 - wos: WOS:000517803200004 (10) - scopus: 2-s2.0-85079383599 (10)

11573/1472982 - 2020 - A Comprehensive Approach to Disentangle the Effect of Cerebellar Damage on Physical Disability in Multiple Sclerosis
Ruggieri, S.; Bharti, K.; Prosperini, L.; Gianni, C.; Petsas, N.; Tommasin, S.; Giglio, L. D.; Pozzilli, C.; Pantano, P. - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. 529- - issn: 1664-2295 - wos: WOS:000615356600001 (11) - scopus: 2-s2.0-85087807948 (11)

11573/1442373 - 2020 - Resting-state functional connectivity in drug-naive pediatric patients with Tourette syndrome and obsessive-compulsive disorder
Tikoo, S.; Cardona, F.; Tommasin, S.; Gianni, C.; Conte, G.; Upadhyay, N.; Mirabella, G.; Suppa, A.; Pantano, P. - 01a Articolo in rivista
rivista: JOURNAL OF PSYCHIATRIC RESEARCH (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 129-140 - issn: 0022-3956 - wos: WOS:000571186500021 (14) - scopus: 2-s2.0-85087959991 (14)

11573/1408800 - 2020 - Multi-scale resting state functional reorganization in response to multiple sclerosis damage
Tommasin, Silvia; De Giglio, Laura; Ruggieri, Serena; Petsas, Nikolaos; Giannì, Costanza; Pozzilli, Carlo; Pantano, Patrizia - 01a Articolo in rivista
rivista: NEURORADIOLOGY (Berlin; Heidelberg: Springer) pp. 693-704-704 - issn: 0028-3940 - wos: WOS:000520792800001 (10) - scopus: 2-s2.0-85082801871 (11)

11573/1336236 - 2019 - A matter of atrophy: differential impact of brain and spine volume loss on disability worsening in MS
Ruggieri, S; Petracca, M; De Giglio, L; De Luca, Francesca; Gianni, C; Gurreri, F; Petsas, N; Tommasin, S; Pozzilli, C; Pantano, P - 04d Abstract in atti di convegno
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. 242-243 - issn: 1352-4585 - wos: WOS:000485303101086 (0) - scopus: (0)
congresso: 35° Congress of the European Committe for Treatment and Research in Multiple Sclerosis (Stockholm)
libro: onlinelibrary.ectrims-congress.eu - ()

11573/1513131 - 2019 - Resting state Functional Connectivity differences in Pediatric Patients with Tourette syndrome and Obsessive-compulsive disorder
Tikoo, S.; Cardona, F.; Tommasin, S.; Giannì, C.; Upadhyay, N.; Bharti, K.; Conte, G.; Mirabella, G.; Suppa, A.; Pantano, P. - 04c Atto di convegno in rivista
rivista: MOVEMENT DISORDERS (New York, N.Y. : John Wiley & Sons) pp. 833-833 - issn: 1531-8257 - wos: WOS:000487785005007 (0) - scopus: (0)
congresso: International Congress of Parkinson's Disease and Movement Disorders (Nice, France)

11573/1113040 - 2019 - Neuroimaging techniques to assess inflammation in multiple sclerosis
Tommasin, Silvia; Giannì, Costanza; De Giglio, Laura; Pantano, Patrizia - 01a Articolo in rivista
rivista: NEUROSCIENCE (Oxford: Elsevier Ltd. Oxford; New York: Pergamon Press) pp. 4-16 - issn: 0306-4522 - wos: WOS:000462916000002 (28) - scopus: 2-s2.0-85028297969 (38)

11573/1226544 - 2018 - Abnormal cerebellar connectivity patterns in patients with parkinson’s disease and freezing of gait
Bharti, Komal; Suppa, Antonio; Pietracupa, Sara; Upadhyay, Neeraj; Giannì, Costanza; Leodori, Giorgio; Di Biasio, Francesca; Modugno, Nicola; Petsas, Nikolaos; Grillea, Giovanni; Zampogna, Alessandro; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4222 - wos: WOS:000468112900002 (45) - scopus: 2-s2.0-85055970074 (45)

11573/1020829 - 2018 - Freezing of gait in parkinson's disease. gray and white matter abnormalities
Pietracupa, Sara; Suppa, Antonio; Upadhyay, Neeraj; Gianni', Costanza; Grillea, Giovanni; Leodori, Giorgio; Modugno, Nicola; Di Biasio, Francesca; Zampogna, Alessandro; Colonnese, Claudio; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 1-11 - issn: 0340-5354 - wos: WOS:000419777000008 (48) - scopus: 2-s2.0-85033460833 (54)

11573/1210082 - 2018 - Relation between functional connectivity and disability in multiple sclerosis. a non-linear model
Tommasin, Silvia; De Giglio, Laura; Ruggieri, Serena; Petsas, Nikolaos; Giannì, Costanza; Pozzilli, Carlo; Pantano, Patrizia - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 2881-2892 - issn: 0340-5354 - wos: WOS:000450470900014 (18) - scopus: 2-s2.0-85054293022 (20)

11573/1081726 - 2018 - Role of cerebellar dentate functional connectivity in balance deficits in patients with multiple sclerosis
Tona, Francesca; De Giglio, Laura; Petsas, Nikolaos; Sbardella, Emilia; Prosperini, Luca; Upadhyay, Neeraj; Giannì, Costanza; Pozzilli, Carlo; Pantano, Patrizia - 01a Articolo in rivista
rivista: RADIOLOGY (Radiological Society of North America:820 Jorie Boulevard:Oak Brook, IL 60523:(630)571-7873, EMAIL: subscrib@rsna.org, INTERNET: http://www.rsna.org, Fax: (630)571-7837) pp. 267-275 - issn: 0033-8419 - wos: WOS:000427992600033 (25) - scopus: 2-s2.0-85044306180 (25)

11573/1080974 - 2017 - Abnormal resting-state functional connectivity in progressive supranuclear palsy and corticobasal syndrome
Bharti, Komal; Bologna, Matteo; Upadhyay, Neeraj; Piattella, Maria Cristina; Suppa, Antonio; Petsas, Nikolaos; Gianni', Costanza; Tona, Francesca; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2295 - wos: WOS:000403387900001 (24) - scopus: 2-s2.0-85020732084 (35)

11573/957354 - 2017 - The Italian Neuroimaging Network Initiative (INNI): enabling the use of advanced MRI techniques in patients with MS
Filippi, M.; Tedeschi, G.; Pantano, Patrizia; De Stefano, N.; Zaratin, P.; Rocca, M. A.; Valsasina, Paola; Sibilia, Mauro; Preziosa, Paolo; Gallo, Antonio; Bisecco, Alvino; Docimo, Renato; Petsas, Nikolaos; Ruggieri, Serena; Gianni', Costanza; Stromillo, Maria Laura; Brocci, Riccardo Tappa - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 1029-1038 - issn: 1590-1874 - wos: WOS:000403353900015 (16) - scopus: 2-s2.0-85015244190 (16)

11573/957346 - 2017 - Functional disconnection of thalamic and cerebellar dentate nucleus networks in progressive supranuclear palsy and corticobasal syndrome
Upadhyay, Neeraj; Suppa, Antonio; Piattella, Maria Cristina; Gianni', Costanza; Bologna, Matteo; Di Stasio, Flavio; Petsas, Nikolaos; Tona, Francesca; Fabbrini, Giovanni; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista
rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 000-000 - issn: 1353-8020 - wos: WOS:000405880100008 (15) - scopus: 2-s2.0-85015409821 (17)

11573/959143 - 2016 - Neuroinflammatory component of gray matter pathology in multiple sclerosis
Herranz, Elena; Gianni', Costanza; Louapre, Céline; Treaba, Constantina A.; Govindarajan, Sindhuja T.; Ouellette, Russell; Loggia, Marco L.; Sloane, Jacob A.; Madigan, Nancy; Izquierdo Garcia, David; Ward, Noreen; Mangeat, Gabriel; Granberg, Tobias; Klawiter, Eric C.; Catana, Ciprian; Hooker, Jacob M.; Taylor, Norman; Ionete, Carolina; Kinkel, Revere P.; Mainero, Caterina - 01a Articolo in rivista
rivista: ANNALS OF NEUROLOGY (-attuale: WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 776-790 - issn: 0364-5134 - wos: WOS:000388570800014 (139) - scopus: 2-s2.0-84995761576 (153)

11573/866360 - 2016 - Is the relationship between cortical and white matter pathologic changes in multiple sclerosis spatially specific? A multimodal 7-T and 3-T MR imaging study with surface and tract-based analysis
Louapre, Céline; Govindarajan, Sindhuja T.; Gianni', Costanza; Cohen Adad, Julien; Gregory, Michael D.; Nielsen, A. Scott; Madigan, Nancy; Sloane, Jacob A.; Kinkel, Revere P.; Mainero, Caterina - 01a Articolo in rivista
rivista: RADIOLOGY (Radiological Society of North America:820 Jorie Boulevard:Oak Brook, IL 60523:(630)571-7873, EMAIL: subscrib@rsna.org, INTERNET: http://www.rsna.org, Fax: (630)571-7837) pp. 524-535 - issn: 0033-8419 - wos: WOS:000377702200027 (10) - scopus: 2-s2.0-84955604270 (12)

11573/960111 - 2016 - The association between intra- and juxta-cortical pathology and cognitive impairment in multiple sclerosis by quantitative T2* mapping at 7 T MRI
Louapre, Céline; Govindarajan, Sindhuja T.; Gianni', Costanza; Madigan, Nancy; Nielsen, A. Scott; Sloane, Jacob A.; Kinkel, Revere P.; Mainero, Caterina - 01a Articolo in rivista
rivista: NEUROIMAGE. CLINICAL (Amsterdam : Elsevier) pp. 879-886 - issn: 2213-1582 - wos: WOS:000390196400100 (26) - scopus: 2-s2.0-84994528917 (26)

11573/866238 - 2015 - Beyond focal cortical lesions in MS: an in vivo quantitative and spatial imaging study at 7T
Louapre, Céline; Govindarajan, Sindhuja T.; Gianni', Costanza; Langkammer, Christian; Sloane, Jacob A.; Kinkel, Revere P.; Mainero, Caterina - 01a Articolo in rivista
rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. 1702-1709 - issn: 0028-3878 - wos: WOS:000364338500012 (32) - scopus: 2-s2.0-84946900071 (35)

11573/866358 - 2015 - A gradient in cortical pathology in multiple sclerosis by in vivo quantitative 7 T imaging
Mainero, Caterina; Louapre, Céline; Govindarajan, Sindhuja T.; Gianni', Costanza; Scott Nielsen, A.; Cohen Adad, Julien; Sloane, Jacob; Kinkel, Revere P. - 01a Articolo in rivista
rivista: BRAIN (-Oxford: Oxford University Press -Oxford: Clarendon Press -London: Macmillan -London: Butterworths Scientific Publications, 1878-) pp. 932-945 - issn: 0006-8950 - wos: WOS:000353522100020 (118) - scopus: 2-s2.0-84929074022 (118)

11573/794841 - 2015 - Functional and structural brain plasticity enhanced by motor and cognitive rehabilitation in multiple sclerosis
Prosperini, Luca; Piattella, Maria Cristina; Gianni', Costanza; Pantano, Patrizia - 01a Articolo in rivista
rivista: NEURAL PLASTICITY (Cairo : Hindawi Publishing Corporation) pp. 1-12 - issn: 2090-5904 - wos: WOS:000354689700001 (77) - scopus: 2-s2.0-84929646377 (85)

11573/760200 - 2014 - A systematic review of factors associated with accidental falls in people with multiple sclerosis: a meta-analytic approach.
Gianni', Costanza; Prosperini, Luca; Jonsdottir, J; Cattaneo, D. - 01a Articolo in rivista
rivista: CLINICAL REHABILITATION (Arnold:338 Euston Road, London NW1 3BH United Kingdom:011 44 207 8736000, INTERNET: http://www.arnoldpublishers.com, Fax: 011 44 207 8736325) pp. - - issn: 0269-2155 - wos: WOS:000337477300009 (103) - scopus: 2-s2.0-84902346988 (115)
libro: Clinical rehabilitation - ()

11573/807890 - 2014 - Identifying responders and nonresponders to interferon therapy in multiple sclerosis
Prosperini, Luca; Capobianco, Marco; Gianni', Costanza - 01a Articolo in rivista
rivista: DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE (Auckland, N.Z.] : Dove Medical Press, [2011]-) pp. 75- - issn: 1179-9900 - wos: (0) - scopus: (0)

11573/866366 - 2014 - Oral dalfampridine improves standing balance detected at static posturography in multiple sclerosis
Prosperini, Luca; Gianni', Costanza; Marchetti, Maria Rita; Pozzilli, Carlo; Fortuna, Deborah - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS INTERNATIONAL (Cairo: Hindawi Publishing Corporation) pp. 1-5 - issn: 2090-2654 - wos: (0) - scopus: (0)

11573/866382 - 2013 - Home-based balance training using the wii balance board: A randomized, crossover pilot study in multiple sclerosis
Prosperini, Luca; Fortuna, Deborah; Giannì, Costanza; Leonardi, Laura; Marchetti, Maria Rita; Pozzilli, Carlo - 01a Articolo in rivista
rivista: NEUROREHABILITATION AND NEURAL REPAIR (Demos Publications Incorporated:386 Park Avenue South, Suite 201:New York, NY 10016:(800)532-8663, (212)683-0072, Fax: (212)683-0118) pp. 516-525 - issn: 1545-9683 - wos: WOS:000319987100005 (131) - scopus: 2-s2.0-84878829503 (151)

11573/477754 - 2013 - The diagnostic accuracy of static posturography in predicting accidental falls in people with multiple sclerosis
Prosperini, Luca; Gianni', Costanza; Pozzilli, Carlo; Fortuna, Deborah; Leonardi, Laura - 01a Articolo in rivista
rivista: NEUROREHABILITATION AND NEURAL REPAIR (Demos Publications Incorporated:386 Park Avenue South, Suite 201:New York, NY 10016:(800)532-8663, (212)683-0072, Fax: (212)683-0118) pp. 45-52 - issn: 1545-9683 - wos: WOS:000311853400005 (106) - scopus: 2-s2.0-84870597186 (121)

11573/477777 - 2012 - Pulse monthly steroids during an elective interruption of natalizumab: A post-marketing study
Borriello, Giovanna; Prosperini, Luca; Mancinelli, C.; Gianni', Costanza; Fubelli, F.; Pozzilli, Carlo - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 783-787 - issn: 1351-5101 - wos: WOS:000302908900023 (44) - scopus: 2-s2.0-84859812702 (47)

11573/762960 - 2012 - The diagnostic accuracy of static posturography in predicting accidental falls in people with multiple sclerosis.Neurorehabil Neural Repair. 2013 Jan;27(1):45-52. doi: 10.1177/1545968312445638. Epub 2012 May 15.
Prosperini, Luca; Fortuna, D; Gianni', Costanza; Leonardi, L; Pozzilli, Carlo - 01a Articolo in rivista
rivista: NEUROREHABILITATION AND NEURAL REPAIR (Demos Publications Incorporated:386 Park Avenue South, Suite 201:New York, NY 10016:(800)532-8663, (212)683-0072, Fax: (212)683-0118) pp. - - issn: 1545-9683 - wos: (0) - scopus: (0)

11573/762954 - 2012 - Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis. J Neurol Sci. 2012 Dec 15;323(1-2):104-12. doi: 10.1016/j.jns.2012.08.027. Epub 2012 Sep 21.
Prosperini, Luca; Gianni', Costanza; Barletta, V; Mancinelli, C; Fubelli, F; Borriello, Giovanna; Pozzilli, Carlo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0022-510X - wos: (0) - scopus: (0)

11573/866371 - 2012 - Predictors of freedom from disease activity in natalizumab treated-patients with multiple sclerosis
Prosperini, Luca; Gianni', Costanza; Barletta, Valeria Teresa; Mancinelli, Chiara; Fubelli, Federica; Borriello, Giovanna; Pozzilli, Carlo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 104-112 - issn: 0022-510X - wos: WOS:000311132700018 (40) - scopus: 2-s2.0-84867849114 (44)

11573/1150410 - 2012 - Escalation to natalizumab or switching among immunomodulators in relapsing multiple sclerosis
Prosperini, Luca; Giannì, Costanza; De Giglio, Laura; Borriello, Giovanna; Galgani, Simonetta; Pozzilli, Carlo; Gasperini, Claudio; Leonardi, Laura - 01a Articolo in rivista
rivista: MULTIPLE SCLEROSIS (Basingstoke: Stocktom, 1995-. United Kingdom: Arnold) pp. 64-71 - issn: 1352-4585 - wos: WOS:000299084600013 (69) - scopus: 2-s2.0-84855925874 (83)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma