DONATO COLELLA

Dottore di ricerca

ciclo: XXXVI



Titolo della tesi: NEUROIMAGING CORRELATES OF BRADYKINESIA IN PATIENTS WITH ESSENTIAL TREMOR

Essential tremor (ET) is a movement disorder characterized primarily by postural and kinetic tremor of the upper limbs. The presence of etiological variability and additional symptoms of uncertain significance configures it as heterogeneous clinical syndrome. In ET, movement slowness without sequence effect has objectively been documented by kinematic analysis of repetitive movements of the upper limb and fingers. When movement slowness (bradykinesia) or other soft neurological signs are present, the new tremor classification suggests the term ET-plus. Bradykinesia is the cardinal symptom of Parkinson's disease (PD) and is typically related to basal ganglia (BG) dysfunction. Although the role of the cerebellum as a central tremor oscillator is well known in ET, the involvement of other brain areas, such as the BG, as determinants of bradykinesia is unclear. Recently, a dysfunction of brain networks was hypothesized as the substrate of bradykinesia in PD, and it is not excluded that the same occurs in ET. In the present thesis, we will first provide an updated overview of altered voluntary movement execution in ET and discuss major findings from clinical and experimental studies. In the experimental part of this thesis, we will show the results of two studies aimed at identifying voluntary movement abnormalities in ET patients using an optoelectronic kinematic system. Repetitive finger movements, the most useful task for bradykinesia assessment in PD clinical practice, were analysed. Various parameters were measured, including movement velocity, amplitude and velocity and amplitude reduction during movement repetition. Then, we will aim to demonstrate the possible neuroradiological substrates of bradykinesia in ET, correlating the kinematic parameters of finger movements to the results provided by dopamine transporter single-photon emission computed tomography (DAT-SPECT) in the first study and volumetric and functional magnetic resonance imaging (MRI) in the second. The data suggested a possible role of the BG and cerebellum in the genesis of impaired voluntary movement in ET, further confirming the heterogeneity of this neurological condition.

Produzione scientifica

11573/1713457 - 2024 - Clinical and kinematic characterization of parkinsonian soft signs in essential tremor
Angelini, Luca; Paparella, Giulia; Cannavacciuolo, Antonio; Costa, Davide; Birreci, Daniele; De Riggi, Martina; Passaretti, Massimiliano; Colella, Donato; Guerra, Andrea; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: JOURNAL OF NEURAL TRANSMISSION (Wien : Springer) pp. - - issn: 1435-1463 - wos: WOS:001222378400001 (0) - scopus: 2-s2.0-85193360220 (0)

11573/1704371 - 2024 - Theta-tACS modulates cerebellar-related motor functions and cerebellar-cortical connectivity
Guerra, Andrea; Paparella, Giulia; Passaretti, Massimiliano; Costa, Davide; Birreci, Daniele; De Biase, Alessandro; Colella, Donato; Angelini, Luca; Cannavacciuolo, Antonio; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 159-169 - issn: 1388-2457 - wos: WOS:001156826200001 (4) - scopus: 2-s2.0-85182515746 (4)

11573/1704243 - 2024 - Interhemispheric imbalance and bradykinesia features in Parkinson’s disease
Paparella, Giulia; De Riggi, Martina; Cannavacciuolo, Antonio; Costa, Davide; Birreci, Daniele; Passaretti, Massimiliano; Angelini, Luca; Colella, Donato; Guerra, Andrea; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: BRAIN COMMUNICATIONS ([Oxford]: Oxford University Press on behalf of the Guarantors of Brain) pp. - - issn: 2632-1297 - wos: WOS:001163597900001 (2) - scopus: 2-s2.0-85185252151 (1)

11573/1713463 - 2024 - The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor
Passaretti, Massimiliano; Piervincenzi, Claudia; Baione, Viola; Pasqua, Gabriele; Colella, Donato; Pietracupa, Sara; Petsas, Nikolaos; Angelini, Luca; Cannavacciuolo, Antonio; Paparella, Giulia; Berardelli, Alfredo; Pantano, Patrizia; Bologna, Matteo - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4230 - wos: (0) - scopus: (0)

11573/1704372 - 2023 - Objective assessment of the effects of opicapone in Parkinson’s disease through kinematic analysis
Bologna, Matteo; Guerra, Andrea; Colella, Donato; Birreci, Daniele; Costa, Davide; Cannavacciuolo, Antonio; Angelini, Luca; Paparella, Giulia; Antonini, Angelo; Berardelli, Alfredo; Fabbrini, Giovanni - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:001124115300001 (2) - scopus: 2-s2.0-85179727859 (1)

11573/1690818 - 2023 - Facial emotion expressivity in patients with Parkinson's and Alzheimer's disease
Cannavacciuolo, Antonio; Paparella, Giulia; Salzillo, Martina; Colella, Donato; Canevelli, Marco; Costa, Davide; Birreci, Daniele; Angelini, Luca; Guerra, Andrea; Ricciardi, Lucia; Bruno, Giuseppe; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: JOURNAL OF NEURAL TRANSMISSION (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 1-11 - issn: 0300-9564 - wos: WOS:001091524700001 (0) - scopus: 2-s2.0-85173749329 (1)

11573/1690817 - 2023 - Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
Colella, Donato; Passaretti, Massimiliano; Frantellizzi, Viviana; De Feo, Maria Silvia; Cannavacciuolo, Antonio; Angelini, Luca; Birreci, Daniele; Costa, Davide; Paparella, Giulia; Guerra, Andrea; De Vincentis, Giuseppe; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: NEUROIMAGE. CLINICAL (Amsterdam : Elsevier) pp. 103526- - issn: 2213-1582 - wos: WOS:001098956900001 (5) - scopus: 2-s2.0-85174001884 (6)

11573/1690816 - 2023 - One-Year Follow-Up on Essential Tremor Worsening After SARS-CoV-2 Infection: a Series of Two Cases
Costa, Davide; Birreci, Daniele; Passaretti, Massimiliano; Angelini, Luca; Colella, Donato; Cannavacciuolo, Antonio; Paparella, Giulia; Berardelli, Alfredo; Bologna, Matteo - 01i Case report
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4222 - wos: WOS:001063662100001 (0) - scopus: 2-s2.0-85169079800 (0)

11573/1680944 - 2023 - Short-term plasticity of the motor cortex compensates for bradykinesia in Parkinson's disease
Guerra, Andrea; Colella, Donato; Cannavacciuolo, Antonio; Giangrosso, Margherita; Paparella, Giulia; Fabbrini, Giovanni; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE ([Oxford] : Blackwell Science) pp. 106137- - issn: 1095-953X - wos: WOS:000989977200001 (10) - scopus: 2-s2.0-85153881215 (10)

11573/1677549 - 2023 - Relationship between the interlimb transfer of a visuomotor learning task and interhemispheric inhibition in healthy humans
Paparella, Giulia; De Riggi, Martina; Cannavacciuolo, Antonio; Colella, Donato; Costa, Davide; Birreci, Daniele; Passaretti, Massimiliano; Angelini, Luca; Guerra, Andrea; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: CEREBRAL CORTEX (New York, NY : Oxford University Press, c1991-) pp. - - issn: 1047-3211 - wos: WOS:000945332700001 (4) - scopus: 2-s2.0-85163489766 (4)

11573/1660560 - 2022 - Kinematic assessment of bradykinesia due to focal basal ganglia lesions: a series of two ischemic stroke cases
Cannavacciuolo, A.; Paparella, G.; Guerra, A.; Colella, D.; Angelini, L.; De Biase, A.; Passaretti, M.; Berardelli, A.; Bologna, M. - 01f Lettera, Nota
rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 35-37 - issn: 1353-8020 - wos: WOS:000869182800008 (0) - scopus: 2-s2.0-85139304033 (0)

11573/1659038 - 2022 - Tremor and Movement Slowness Are Two Unrelated Adverse Effects Induced by Valproate Intake
De Biase, Alessandro; Paparella, Giulia; Angelini, Luca; Cannavacciuolo, Antonio; Colella, Donato; Cerulli Irelli, Emanuele; Giallonardo, Anna Teresa; Di Bonaventura, Carlo; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 1062-1073 - issn: 2330-1619 - wos: WOS:000859060400001 (10) - scopus: 2-s2.0-85138713375 (9)

11573/1660559 - 2022 - Validating a Portable Device for Blinking Analyses through Laboratory Neurophysiological Techniques
Paparella, G.; De Biase, A.; Cannavacciuolo, A.; Colella, D.; Passaretti, M.; Angelini, L.; Guerra, A.; Berardelli, A.; Bologna, M. - 01a Articolo in rivista
rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: WOS:000858569000001 (3) - scopus: 2-s2.0-85138785819 (3)

11573/1617748 - 2022 - Worsening of Essential Tremor After SARS-CoV-2 Infection
Passaretti, M.; De Biase, A.; Paparella, G.; Angelini, L.; Cannavacciuolo, A.; Colella, D.; Berardelli, A.; Bologna, M. - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4222 - wos: WOS:000739776800001 (9) - scopus: 2-s2.0-85122340986 (8)

11573/1652994 - 2022 - Neurophysiological assessment of juvenile parkinsonism due to primary monoamine neurotransmitter disorders
Passaretti, Massimiliano; Pollini, Luca; Paparella, Giulia; De Biase, Alessandro; Colella, Donato; Angelini, Luca; Galosi, Serena; Manti, Filippo; Guerra, Andrea; Leuzzi, Vincenzo; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: JOURNAL OF NEURAL TRANSMISSION (Wien : Springer) pp. 1011-1021 - issn: 1435-1463 - wos: WOS:000824240600001 (1) - scopus: 2-s2.0-85134333674 (0)

11573/1600284 - 2021 - Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease
Guerra, Andrea; Colella, Donato; Giangrosso, Margherita; Cannavacciuolo, Antonio; Paparella, Giulia; Fabbrini, Giovanni; Suppa, Antonio; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: BRAIN (-Oxford: Oxford University Press -Oxford: Clarendon Press -London: Macmillan -London: Butterworths Scientific Publications, 1878-) pp. - - issn: 0006-8950 - wos: WOS:000756454600001 (57) - scopus: 2-s2.0-85128159956 (59)

11573/1550472 - 2021 - Effects of Transcranial Ultrasound Stimulation on Trigeminal Blink Reflex Excitability
Guerra, Andrea; Vicenzini, Edoardo; Cioffi, Ettore; Colella, Donato; Cannavacciuolo, Antonio; Pozzi, Silvia; Caccia, Barbara; Paparella, Giulia; Di Stefano, Giulia; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: WOS:000653561800001 (10) - scopus: 2-s2.0-85106942825 (11)

11573/1723389 - 2021 - Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)
Lattanzi, Simona; Canafoglia, Laura; Canevini, Maria Paola; Casciato, Sara; Chiesa, Valentina; Dainese, Filippo; De Maria, Giovanni; Didato, Giuseppe; Falcicchio, Giovanni; Fanella, Martina; Ferlazzo, Edoardo; Fisco, Giacomo; Gangitano, Massimo; Giallonardo, Anna Teresa; Giorgi, Filippo Sean; La Neve, Angela; Mecarelli, Oriano; Montalenti, Elisa; Piazza, Federico; Pulitano, Patrizia; Quarato, Pier Paolo; Ranzato, Federica; Rosati, Eleonora; Tassi, Laura; Di Bonaventura, Carlo; Null, Null; Alicino, Angela; Ascoli, Michele; Assenza, Giovanni; Avorio, Federica; Badioni, Valeria; Banfi, Paola; Bartolini, Emanuele; Basili, Luca Manfredi; Belcastro, Vincenzo; Beretta, Simone; Berto, Irene; Biggi, Martina; Billo, Giuseppe; Boero, Giovanni; Bonanni, Paolo; Bongorno, Jole; Brigo, Francesco; Caggia, Emanuele; Cagnetti, Claudia; Calvello, Carmen; Irelli, Emanuele Cerulli; Cesnik, Edward; Chianale, Gigliola; Ciampanelli, Domenico; Ciuffini, Roberta; Cocito, Dario; Colella, Donato; Contento, Margerita; Costa, Cinzia; Cumbo, Eduardo; D‘Aniello, Alfredo; Deleo, Francesco; Difrancesco, Jacopo C.; Di Gennaro, Giancarlo; Di Giacomo, Roberta; Di Liberto, Alessandra; Domina, Elisabetta; Donato, Francesco; Dono, Fedele; Durante, Vania; Elia, Maurizio; Estraneo, Anna; Evangelista, Giacomo; Faedda, Maria Teresa; Failli, Ylenia; Fallica, Elisa; Fattouch, Jinane; Ferrari, Alessandra; Ferreri, Florinda; Fonti, Davide; Fortunato, Francesco; Foschi, Nicoletta; Francavilla, Teresa; Galli, Rosita; Gazzina, Stefano; Giuliano, Loretta; Habetswallner, Francesco; Izzi, Francesca; Kassabian, Benedetta; Labate, Angelo; Luisi, Concetta; Magliani, Matteo; Maira, Giulia; Mari, Luisa; Marino, Daniela; Mascia, Addolorata; Mazzeo, Alessandra; Meletti, Stefano; Morano, Alessandra; Nilo, Annacarmen; Orlando, Biagio; Paladin, Francesco; Pascarella, Maria Grazia; Pastori, Chiara; Pauletto, Giada; Peretti, Alessia; Perri, Gabriella; Pezzella, Marianna; Piccioli, Marta; Pignatta, Pietro; Pilolli, Nicola; Pisani, Francesco; Pisani, Laura Rosa; Placidi, Fabio; Pollicino, Patrizia; Porcella, Vittoria; Pradella, Silvia; Puligheddu, Monica; Quadri, Stefano; Quintas, Rui; Renna, Rosaria; Rossi, Jessica; Rum, Adriana; Salamone, Enrico Michele; Savastano, Ersilia; Sessa, Maria; Stokelj, David; Tartara, Elena; Tombini, Mario; Tumminelli, Gemma; Ventura, Maria; Viganò, Ilaria; Viglietta, Emanuela; Vignoli, Aglaia; Villani, Flavio; Zambrelli, Elena; Zummo, Lelia - 01a Articolo in rivista
rivista: CNS DRUGS (Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766) pp. 1289-1301 - issn: 1172-7047 - wos: WOS:000692067300001 (34) - scopus: 2-s2.0-85114117218 (34)

11573/1573092 - 2021 - Bradykinesia in motoneuron diseases
Paparella, Giulia; Ceccanti, Marco; Colella, Donato; Cannavacciuolo, Antonio; Guerra, Andrea; Inghilleri, Maurizio; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY ([S.l.] : Elsevier Science) pp. 2558-2566- - issn: 1872-8952 - wos: WOS:000704914800028 (6) - scopus: 2-s2.0-85117536664 (6)

11573/1380112 - 2020 - Bradykinesia in Alzheimer's disease and its neurophysiological substrates
Bologna, M.; Guerra, A.; Colella, D.; Cioffi, E.; Paparella, G.; Di Vita, A.; D'antonio, F.; Trebbastoni, A.; Berardelli, A. - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 850-858 - issn: 1388-2457 - wos: WOS:000520134900011 (37) - scopus: 2-s2.0-85079374464 (38)

11573/1416069 - 2020 - Is there evidence of bradykinesia in essential tremor?
Bologna, M.; Paparella, G.; Colella, D.; Cannavacciuolo, A.; Angelini, L.; Alunni-Fegatelli, D.; Guerra, A.; Berardelli, A. - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 1351-5101 - wos: WOS:000536415100001 (31) - scopus: 2-s2.0-85085625063 (29)

11573/1473878 - 2020 - MOTOR DYSFUNCTION IN MILD COGNITIVE IMPAIRMENT AS TESTED BY KINEMATIC ANALYSIS AND TRANSCRANIAL MAGNETIC STIMULATION
Colella, Donato; Guerra, Andrea; Paparella, Giulia; Cioffi, Ettore; Di Vita, Antonella; Trebbastoni, Alessandro; Berardelli, Alfredo; Bologna, Matteo - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 315-322 - issn: 1388-2457 - wos: WOS:000617547100001 (23) - scopus: 2-s2.0-85099191072 (26)

11573/1472804 - 2020 - Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor
Paparella, G.; Angelini, L.; De Biase, A.; Cannavacciuolo, A.; Colella, D.; Di Bonaventura, C.; Giallonardo, A. T.; Berardelli, A.; Bologna, M. - 01a Articolo in rivista
rivista: THE CEREBELLUM (New York: Springer London: Martin Dunitz Ltd, 2002-) pp. - - issn: 1473-4222 - wos: WOS:000589990300001 (20) - scopus: 2-s2.0-85096049643 (18)

11573/1472769 - 2020 - Painful stimulation increases spontaneous blink rate in healthy subjects
Paparella, G.; Di Stefano, G.; Fasolino, A.; Di Pietro, G.; Colella, D.; Truini, A.; Cruccu, G.; Berardelli, A.; Bologna, M. - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000604516000034 (7) - scopus: 2-s2.0-85096123502 (7)

11573/1291167 - 2019 - Transcranial alternating current stimulation has frequency-dependent effects on motor learning in healthy humans
Bologna, Matteo; Guerra, Andrea; Paparella, Giulia; Colella, Donato; Borrelli, Alessandro; Suppa, Antonio; Di Lazzaro, Vincenzo; Brown, Peter; Berardelli, Alfredo - 01a Articolo in rivista
rivista: NEUROSCIENCE (Oxford: Elsevier Ltd. Oxford; New York: Pergamon Press) pp. 130-139 - issn: 0306-4522 - wos: WOS:000473586500011 (37) - scopus: 2-s2.0-85066935829 (39)

11573/1137719 - 2018 - Effects of transcranial alternating current stimulation on repetitive finger movements in healthy humans
Guerra, Andrea; Bologna, Matteo; Paparella, Giulia; Suppa, Antonio; Colella, Donato; Di Lazzaro, Vincenzo; Brown, Peter; Berardelli, Alfredo - 01a Articolo in rivista
rivista: NEURAL PLASTICITY (Cairo : Hindawi Publishing Corporation) pp. - - issn: 2090-5904 - wos: WOS:000439734300001 (31) - scopus: 2-s2.0-85054643709 (32)

11573/897759 - 2016 - Bradykinesia in early and advanced Parkinson's disease
Bologna, Matteo; Leodori, Giorgio; Stirpe, Paola; Paparella, Giulia; Colella, Donato; Belvisi, Daniele; Fasano, Alfonso; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 286-291 - issn: 0022-510X - wos: WOS:000384861000056 (62) - scopus: 2-s2.0-84984677993 (69)

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