CHIARA DELLA ROCCA

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Investigative leads in forensic genetics: BioGeographical Ancestry (BGA) and Kinship Analyses.

The fundamental goal of forensic genetics is personal identification but it is common to obtain inconclusive results from both direct and indirect STR-profile comparisons. In such cases, it is necessary looking for alternative approaches to generate crucial forensic leads and identify unknown perpetrators. In this thesis, we propose alternative tools to predict BioGeographical Ancestry (BGA) and to identify males sharing the same Y-haplotype by utilizing multivariate techniques and Rapidly Mutating Y-chromosome short tandem repeats (RM Y-STRs), respectively. Concerning ethnic inference, we proposed novel statistical approaches (consisting in SLPCA, PLSDA and SVM methods) to group samples into BGA-classes, by testing both autosomal STRs (in African populations) and microhaplotypes (in U.S. populations). The predictive power of such statistics resulted extremely high; in fact, they enhance cluster separation providing misleading classifications for genetically mixed populations only. As to Y haplotype discrimination improvement, we proved the efficiency in individualization power of RM Y-STRs – reaching a total of 48 markers genotyped – in African populations characterized by high levels of endogamy, patrilinearity and population structuring. Together, these two innovative approaches converge in demonstrating they represent powerful tools to maximize the information inferable from biological evidence collected at the crime scene.

Produzione scientifica

11573/1726443 - 2024 - Analysis of rapidly mutating Y-STRs enables almost complete discrimination of unrelated and related males from the African continent
Barni, Filippo; Ralf, Arwin; Della Rocca, Chiara; Cannistrà, Federica; Gigliucci, Marco; Trombetta, Beniamino; Berti, Andrea; Kayser, Manfred; Cruciani, Fulvio - 01f Lettera, Nota
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS (Elsevier) pp. - - issn: 1872-4973 - wos: WOS:001316544700001 (0) - scopus: 2-s2.0-85202786549 (0)

11573/1688475 - 2023 - A Brief Overview on Vulvodynia: Pain Pharmacological Management Approach
Merlino, L.; Matys, V.; Dovidio, G.; Piccioni, M. G.; Porpora, M. G.; Titi, L.; Viscardi, M. F.; Volpicelli, A. I.; Della Rocca, C. - 02a Capitolo o Articolo
libro: Current Overview on Pharmaceutical Science - (9788119102181)

11573/1652396 - 2022 - Improving discrimination capacity through rapidly mutating Y-{STRs} in structured populations from the African continent
Della Rocca, Chiara; Trombetta, Beniamino; Barni, Filippo; D'atanasio, Eugenia; Hajiesmaeil, Mogge; Berti, Andrea; Hadi, Sibte; Cruciani, Fulvio - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS (Elsevier) pp. - - issn: 1872-4973 - wos: WOS:000857116300006 (4) - scopus: 2-s2.0-85135902590 (4)

11573/1661283 - 2022 - Investigation of 74 microhaplotypes for kinship testing in US populations
Oldoni, F.; Della Rocca, C.; Podini, D. - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES (Amsterdam : Elsevier) pp. 40-41 - issn: 1875-1768 - wos: WOS:001037205100016 (1) - scopus: 2-s2.0-85139317196 (1)

11573/1549652 - 2021 - Sequence Read Depth Analysis of a Monophyletic Cluster of Y Chromosomes Characterized by Structural Rearrangements in the AZFc Region Resulting in DYS448 Deletion and DYF387S1 Duplication
Ravasini, F.; D'atanasio, E.; Bonito, M.; Bonucci, B.; Della Rocca, C.; Berti, A.; Trombetta, B.; Cruciani, F. - 01a Articolo in rivista
rivista: FRONTIERS IN GENETICS (Lausanne : Frontiers Research Foundation, 2010-) pp. 1-8 - issn: 1664-8021 - wos: WOS:000645544300001 (6) - scopus: 2-s2.0-85105192457 (6)

11573/1441887 - 2020 - Ethnic fragmentation and degree of urbanization strongly affect the discrimination power of Y-STR haplotypes in central Sahel
Della Rocca, C.; Cannone, F.; D'atanasio, E.; Bonito, M.; Anagnostou, P.; Russo, G.; Barni, F.; Alladio, E.; Destro-Bisol, G.; Trombetta, B.; Berti, A.; Cruciani, F. - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS (Elsevier) pp. 1-9 - issn: 1872-4973 - wos: WOS:000587824500012 (7) - scopus: 2-s2.0-85090049481 (9)

11573/1664509 - 2019 - A multivariate statistical approach to for the evaluation of the biogeographical ancestry information from traditional STRs
Alladio, E; Della Rocca, C; Cruciani, F; Vincenti, M; Garofano, P; Berti, A; Barni, F - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES (Amsterdam : Elsevier) pp. 253-255 - issn: 1875-1768 - wos: WOS:000508217000098 (0) - scopus: (0)

11573/1335629 - 2019 - A multivariate statistical approach for the estimation of the ethnic origin of unknown genetic profiles in forensic genetics
Alladio, Eugenio; Della Rocca, Chiara; Barni, Filippo; Dugoujon, Jean-Michel; Garofano, Paolo; Semino, Ornella; Berti, Andrea; Novelletto, Andrea; Vincenti, Marco; Cruciani, Fulvio - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS (Elsevier) pp. - - issn: 1872-4973 - wos: WOS:000508656600004 (12) - scopus: 2-s2.0-85075817621 (14)

11573/1335625 - 2019 - LOW DISCRIMINATION POWER OF THE YFILER™ PLUS PCR AMPLIFICATION KIT IN AFRICAN POPULATIONS. DO WE NEED MORE RM Y-STRs?
Della Rocca, Chiara; Alladio, Eugenio; Barni, Filippo; Cannone, Francesco; D’Atanasio, Eugenia; Trombetta, Beniamino; Berti, Andrea; Cruciani, Fulvio - 01a Articolo in rivista
rivista: FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES (Amsterdam : Elsevier) pp. 671-673 - issn: 1875-1768 - wos: WOS:000508217000261 (4) - scopus: 2-s2.0-85076881368 (6)

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