ANTONIO CIACCIARELLI

Dottore di ricerca

ciclo: XXXVII

Titolo della tesi: The prognostic role of iron deficiency in acute ischemic stroke patients: a prospective multicentric cohort study

Background and Aims: Iron deficiency (ID) is a prognostic factor in heart failure and acute coronary syndrome. However, its role in cerebrovascular diseases is controversial. We aim to determine the impact of ID on the functional outcome of acute ischemic stroke patients. Methods: This is an observational prospective multicentric cohort study. From January to December 2023, we enrolled acute ischemic stroke patients admitted to the stroke units of four comprehensive stroke centers. Venous blood samples were collected at admission to determine the iron status (serum iron, ferritin, transferrin). ID was defined as a serum ferritin concentration <100 ng/mL or 100–299 ng/mL with transferrin saturation (TSAT) <20%. The primary endpoint was the poor functional outcome at 90 days defined as modified Rankin Scale (mRS) 3-6. We used binary logistic regression models including confounding factors to test the association between ID and the primary outcome. Results: The analysis included 442 patients (mean age 7313, 47.5% female, median NIHSS 7 [IQR 3-15], 61.3% treated with intravenous thrombolysis and/or endovascular treatment). ID prevalence was 65.6%. In all binary logistic regression models, ID predicted poor functional outcome at 3 months irrespective from demographics, stroke severity and characteristics, anemia, risk factors, signs/symptoms of heart failure, glucose at admission, and inflammatory biomarkers (aOR 2.328, 95% CI 1.272-4.263, p=0.006). Conclusions: ID is strongly associated with poor functional outcome at 90 days in acute ischemic stroke patients. Further research is required to explore whether iron supplementation could be a potential therapeutic strategy to improve patient outcomes.

Produzione scientifica

11573/1729937 - 2024 - Secondary Brain Injury After Parenchymal Cerebral Hemorrhage in Humans: The Role of NOX2-Mediated Oxidative Stress and Endothelin-1

De Michele, Manuela; Amisano, Paolo; Schiavo, Oscar G.; Cammisotto, Vittoria; Carnevale, Roberto; Forte, Maurizio; Picchio, Vittorio; Ciacciarelli, Antonio; Berto, Irene; Angeloni, Ugo; Pugliese, Silvia; Toni, Danilo; Lorenzano, Svetlana - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: (0) - scopus: 2-s2.0-85211922973 (0)

11573/1729952 - 2024 - Outcomes of Mechanical Thrombectomy in Acute Basilar Artery Occlusion with Mild to Moderate Symptoms.

Nicolini, E Ttore; De Michele, Manuela; Saia, Valentina; Lorenzano, Svetlana; Ciacciarelli, Antonio; Pracucci, Giovanni; Mangiafico, Salvatore; Ahmed, Niaz; Toni, Danilo; Cereda, Carlo. - 01h Abstract in rivista

rivista: EUROPEAN STROKE JOURNAL (London : SAGE Publications Ltd, 2016-) pp. 229-229 - issn: 2396-9881 - wos: (0) - scopus: (0)

11573/1729936 - 2024 - Outcomes of Mechanical Thrombectomy in Patients With Acute Basilar Artery Occlusion With Mild to Moderate Symptoms

Nicolini, Ettore; Pracucci, Giovanni; Ciacciarelli, Antonio; Saia, Valentina; Limbucci, Nicola; Nencini, Patrizia; Ruggiero, Maria; Longoni, Marco; Cosottini, Mirco; Orlandi, Giovanni; Bergui, Mauro; Cerrato, Paolo; Vallone, Stefano; Bigliardi, Guido; Cioni, Samuele; Tassi, Rossana; Da Ros, Valerio; Diomedi, Marina; Simonetti, Luigi; Zini, Andrea; Velo, Mariano; La Spina, Paolo La; Castellan, Lucio; Del Sette, Massimo; De Michele, Manuela; Lorenzano, Svetlana; Casetta, Ilaria; Fainardi, Enrico; Sallustio, Fabrizio; Menozzi, Roberto; Pezzini, Alessandro; Romano, Daniele G.; Frauenfelder, Giulia; Nappini, Sergio; Loizzo, Nicola; Saletti, Andrea; De Vito, Alessandro; Augelli, Raffaele; Cappellari, Manuel; Zimatore, Domenico Sergio; Petruzzellis, Marco; Allegretti, Luca; Tassinari, Tiziana; Ajello, Daniele; Marcheselli, Simona; Ganimede, Maria Porzia; Boero, Giovanni; Mangiafico, Salvatore; Ahmed, Niaz; Toni, Danilo; Cereda, Carlo W.; Null, Null - 01a Articolo in rivista

rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. - - issn: 0028-3878 - wos: WOS:001363169000004 (0) - scopus: 2-s2.0-85210463380 (0)

11573/1672222 - 2023 - Prevalence, clinical features, and radiological pattern of artery of Percheron infarction. a challenging diagnosis

Ciacciarelli, Antonio; Francalanza, Isabella; Giammello, Fabrizio; Galletta, Karol; Toscano, Antonio; Musolino Rosa, Fortunata; Granata, Francesca; La Spina, Paolino - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000936120800002 (2) - scopus: 2-s2.0-85148224274 (4)

11573/1685257 - 2023 - No-reflow phenomenon in acute ischemic stroke: an angiographic evaluation

Nicolini, Ettore; Iacobucci, Marta; De Michele, Manuela; Ciacciarelli, Antonio; Berto, Irene; Petraglia, Luca; Falcou, Anne; Cirelli, Carlo; Biraschi, Francesco; Lorenzano, Svetlana; Linfante, Italo; Toni, Danilo - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (Springer-Verlag Italia Srl:via Decembrio 28, 20137 Milan Italy:011 39 2 5425971, EMAIL: riccardi@springer.it, Fax: 011 39 2 55193360) pp. - - issn: 1590-3478 - wos: WOS:001019414500001 (5) - scopus: 2-s2.0-85162866669 (4)

11573/1672386 - 2022 - A NEW TIMEFRAME INDICATOR FOR ISCHEMIC STROKE TREATMENT: THE TREATMENT TO STROKE UNIT ADMISSION TIME

Ciacciarelli, Antonio; Gentile, Luana; Falcou, Anne Albertine; Galardo, Gioacchino; Toni, Danilo - 01h Abstract in rivista

rivista: EUROPEAN STROKE JOURNAL (London : SAGE Publications Ltd, 2016-) pp. 3-545 - issn: 2396-9881 - wos: WOS:000790837700004 (4) - scopus: (0)

11573/1614232 - 2022 - Ischemic Stroke and Asymptomatic Pulmonary Opacities

Curro, C. T.; Cotroneo, M.; Ciacciarelli, A.; Dell'aera, C.; Grillo, F.; La Spina, P.; Fazio, M. C.; Lagana, A.; De Caro, J.; Trimarchi, G.; Toscano, A.; Musolino, R. F.; Casella, C. - 01a Articolo in rivista

rivista: JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 1-8 - issn: 1052-3057 - wos: WOS:000727460100005 (0) - scopus: 2-s2.0-85120431223 (0)

11573/1669604 - 2022 - Sleep and sleep-modifying factors in chronic migraine patients during the COVID-19 lockdown

Currò, Carmelo; Ciacciarelli, Antonio; Vitale, Chiara; La Spina, Paolino; Toscano, Antonio; Vita, Giuseppe - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (Springer-Verlag Italia Srl:via Decembrio 28, 20137 Milan Italy:011 39 2 5425971, EMAIL: riccardi@springer.it, Fax: 011 39 2 55193360) pp. 1-17 - issn: 1590-3478 - wos: WOS:000858800200001 (2) - scopus: 2-s2.0-85138559677 (2)

11573/1614234 - 2022 - Repeated reperfusion treatment in recurrent ischemic stroke. A retrospective single-center case series

Dell'aera, C.; Giammello, F.; Caragliano, A. A.; Ciacciarelli, A.; Francalanza, I.; Curro, C. T.; Pitrone, A.; Grillo, F.; Casella, C.; Fazio, M. C.; La Spina, P.; Cotroneo, M.; Crea, P.; Toscano, A.; Vinci, S. L.; Musolino, R. F. - 01a Articolo in rivista

rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-9 - issn: 0022-510X - wos: WOS:000791273900025 (2) - scopus: 2-s2.0-85122665249 (2)

11573/1614240 - 2021 - Chronic migraine in the first COVID-19 lockdown. the impact of sleep, remote working, and other life/psychological changes

Curro, C. T.; Ciacciarelli, A.; Vitale, C.; Vinci, E. S.; Toscano, A.; Vita, G.; Trimarchi, G.; Silvestri, R.; Autunno, M. - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 1-16 - issn: 1590-1874 - wos: WOS:000682819300001 (11) - scopus: 2-s2.0-85112117029 (13)

11573/1614244 - 2021 - Pimozide and pancreatic cancer in diabetic chorea. a case report

Curro, C. T.; Nicocia, G.; Ziccone, V.; Ciacciarelli, A.; Russo, G.; Toscano, A.; Terranova, C.; Girlanda, P. - 01i Case report

rivista: INTERNATIONAL JOURNAL OF NEUROSCIENCE (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 1-4 - issn: 0020-7454 - wos: WOS:000614510800001 (2) - scopus: 2-s2.0-85100425763 (2)

11573/1614238 - 2021 - Variants of the circle of Willis in ischemic stroke patients

De Caro, J.; Ciacciarelli, A.; Tessitore, A.; Buonomo, O.; Calzoni, A.; Francalanza, I.; Dell'aera, C.; Cosenza, D.; Curro, C. T.; Granata, F.; Vinci, S. L.; Trimarchi, G.; Toscano, A.; Musolino, R. F.; La Spina, P. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 1-9 - issn: 0340-5354 - wos: WOS:000635052800001 (23) - scopus: 2-s2.0-85103990320 (25)

11573/1614246 - 2021 - Intravenous Thrombolysis and Three Mechanical Thrombectomies in 15 Days in a Patient with Carotid Web. a Case Report

Giammello, Fabrizio; Dell'aera, Cristina; Cotroneo, Masina; Armando Caragliano, Antonio; Casella, Carmela; Carolina Fazio, Maria; La Spina, Paolino; Ciacciarelli, Antonio; Tessitore, Agostino; Toscano, Antonio; Musolino, Rosa; Grillo, Francesco - 01i Case report

rivista: SN COMPREHENSIVE CLINICAL MEDICINE ([Cham]: Springer International Publishing) pp. 710-714 - issn: 2523-8973 - wos: (0) - scopus: (0)

11573/1574290 - 2020 - Chronic cerebral hypoperfusion. An undefined, relevant entity

Ciacciarelli, A; Sette, G; Giubilei, F; Orzi, F - 01g Articolo di rassegna (Review)

rivista: JOURNAL OF CLINICAL NEUROSCIENCE (Amsterdam: Elsevier Science Ltd. South Melbourne Vic.: Churchill Livingstone Harcourt Publishers Limited) pp. 8-12 - issn: 0967-5868 - wos: WOS:000527309400002 (42) - scopus: 2-s2.0-85077735153 (47)

11573/1613571 - 2020 - Hemiballism. Unusual clinical manifestation in three patients with frontoparietal infarct

Cotroneo, M.; Ciacciarelli, A.; Cosenza, D.; Casella, C.; Dell'aera, C.; Grillo, F.; Fazio, M. C.; La Spina, P.; Musolino, R. F. - 01a Articolo in rivista

rivista: CLINICAL NEUROLOGY AND NEUROSURGERY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-3 - issn: 0303-8467 - wos: WOS:000509787500024 (7) - scopus: 2-s2.0-85075778169 (7)

11573/1613569 - 2019 - Acute Stroke Treatment in Patients with Basilar Artery Occlusion: A Single-Center Observational Study

Francalanza, Isabella.; Ciacciarelli, Antonio.; Caragliano, A. A.; Casella, Carmela.; Cotroneo, M.; Dell'aera, C.; Fazio, M. C.; Grillo, Francesco.; Pitrone, A.; Vinci, S. L.; Trimarchi, G.; Musolino, R. F.; La Spina, P. - 01a Articolo in rivista

rivista: CEREBROVASCULAR DISEASES. EXTRA (Basel: S. Karger, 2011-) pp. 90-97 - issn: 1664-5456 - wos: WOS:000494835000006 (6) - scopus: 2-s2.0-85071523078 (7)

11573/1613573 - 2019 - Eating habits in the population of the Aeolian Islands. An observational study

La Spina, P.; Savica, R.; Ciacciarelli, A.; Cotroneo, M.; Dell'aera, C.; Grillo, F.; Casella, C.; Fazio, M. C.; Trimarchi, G.; Musolino, R. F. - 01a Articolo in rivista

rivista: PUBLIC HEALTH NUTRITION (CABI Publishing:CAB International, Wallingford OX10 8DE United Kingdom:011 44 1491 832111, 011 44 1491 829293, EMAIL: cabi-journals@cabi.org, INTERNET: http://www.cabi.org, Fax: 011 44 1491 829292) pp. 1-7 - issn: 1368-9800 - wos: WOS:000466563500006 (0) - scopus: 2-s2.0-85065082556 (0)

11573/1186191 - 2018 - Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma. The Diagnosis through the “Hartel's Route”

Casolla, Barbara; Candela, Serena; Ciacciarelli, Antonio; Ciolli, L; Romano, A; Acqui, Michele; Cox, M. C.; Sette, Giuliano; Orzi, Francesco - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGICAL SURGERY. PART B, SKULL BASE (Stuttgart ; New York : Thieme) pp. 1-3 - issn: 2193-634X - wos: WOS:000458922400017 (0) - scopus: 2-s2.0-85048376513 (1)

11573/1613563 - 2018 - Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

Koizumi, K.; Hattori, Y.; Ahn, S. J.; Buendia, I.; Ciacciarelli, A.; Uekawa, K.; Wang, G.; Hiller, A.; Zhao, L.; Voss, H. U.; Paul, S. M.; Schaffer, C.; Park, L.; Iadecola, C. - 01a Articolo in rivista

rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. 1-11 - issn: 2041-1723 - wos: WOS:000445029700007 (108) - scopus: 2-s2.0-85053546641 (118)

11573/1613567 - 2018 - Agenesis of the internal carotid artery associated with generalized epilepsy

La Spina, P.; Grillo, F.; Granata, F.; Casella, C.; Fazio, M. C.; Colella, M.; Cotroneo, M.; Dell'aera, C.; Ciacciarelli, A.; Vita, G.; Musolino, R. - 01i Case report

rivista: THE JOURNAL OF CLINICAL NEUROLOGY (Seoul : Korean Neurological Association) pp. 1-3 - issn: 1738-6586 - wos: WOS:000438155200024 (1) - scopus: 2-s2.0-85051640529 (1)