Name: Antonella
Last name: De Jaco
Place of birth: Rome, Italy
Date of birth: June 18, 1972
Citizenship: Italian
Work phone Number: (+39) 06.4991.2310
e-mail: antonella.dejaco@uniroma1.it
SSD: BIO/06
Personal identification id: https://orcid.org/0000-0002-9394-0207
Present position
September 2020 Associate Professor
Sapienza University of Rome,
Department of Biology and Biotechnologies “Charles Darwin”
Neurobiology Research Unit “Daniel Bovet” (CRIN)
Education
1998-2001 Ph.D. in Cell and Developmental Biology at Sapienza University of Rome
1990-1996 B.Sc. in Biology cum laude at Sapienza University of Rome
Fellowships
2001–2002 Rotary International Ambassadorial Scholarship
1997 ABCD short-term fellowship, Neuroscience Department, University of Turin.
1996-1997 Neuroscience Research Fellowship
Positions Held
2008-2020 Assistant Professor
Dept. Biology and Biotechnologies “Charles Darwin”, Sapienza University of Rome,
2007-2008 Assistant Project Scientist
Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego (UCSD)
2001-2007 Post-Graduate Researcher
Dept. of Pharmacology, UCSD
1998-2001 Graduate Research Student
Dept. of Cell and Developmental Biology, Sapienza University of Rome
1994-1996 Undergraduate Research Student Dept. of Cell and Developmental Biology, Sapienza University.
Current and Past Sources of Research Funding
2009-2012 Institute Pasteur-Foundation Cenci Bolognetti
2009-2012 Compagnia San Paolo-Foundation
2009-2020 Sapienza University Funding
2018 Institute Pasteur-Foundation Cenci Bolognetti (as a group member)
Oral presentations at National and International Meetings
2008: Gordon Research Conferences "Neurobiology of Brain Disorders". Oxford, UK
2009: 10th International Meeting on Cholinesterases, Sibenik, Croatia.
2009: ABCD Meeting "Membrane Trafficking and Organelle Biogenesis", Bertinoro, Italy.
2011: ABCD International Congress, Ravenna, Italy
Award Grant for Young Investigators as best oral comunication (250Euro)
2012: Italian Federation for Life Sciences (FISV), Rome, Italy
2014: Synapses as therapeutic targets for Autism Spectrum Disorders
(satellite symposium, 9th FENS Forum of Neurosciences. Pavia, Italy).
2016: International Symposium on “Is autism a treatable disorder?”, Roma, Italy
2017: GEI (Società Italiana di Biologia dello Sviluppo e della Cellula), Roma, Italy
2017: The Neuronal Surfaceome in Circuit Formation: From Structure to Function, Anzola d’Ossola, Italy.
2023: SINS (Italian Society for Neuroscience) Torino, Italy
Invited speaker
2009: Dept of Medicine, University of Cambridge, Cambridge Institute for Medical Research. 2010: PhD program in Anatomy, Pharmacology and Legal Medicine at Turin University
2012: Santa Lucia Foundation, Rome.
2012: Dip. di Medicina Università degli Studi di Roma "Tor Vergata".
2016: Istituto C.S.S. Mendel, Rome
2018: European Brain Research Institute, Roma
Visitor professor in foreign Universities
2012: Dept. of Neuroscience and Cell Biology Rutgers, New Brunswick, New Jersey, USA
2013: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego.
2015: Dept. Neuroscience and Cell Biology, Rutgers, New Brunswick, New Jersey
Publications:
Total Citations: 873
H-index: 17
Publications
1. Diamanti T., Trobiani L, Mautone L, Serafini F, Gioia R, Ferrucci L, Lauro C, Bianch S, Perfetto C, Guglielmo S, Sollazzo R, Giorda E, Setini A, Ragozzino D, Miranda E, Comoletti D, Di Angelantonio S, Cacci E, De Jaco A. Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation. Traffic 2024. (in press)
2. Gioia R, Seri T, Diamanti T, Fimmanò S, Vitale M, Ahlenius H, Kokaia Z, Tirone F, Micheli L, Biagioni S, Lupo G, Rinaldi A, De Jaco A, Cacci E. Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine. J Neurochem. 2023;165(3):318-333.
3. Diamanti T, Prete R, Battista N, Corsetti A, De Jaco A. Exposure to Antibiotics and Neurodevelopmental Disorders: Could Probiotics Modulate the Gut-Brain Axis? Antibiotics (Basel) 2022;11(12):1767.
4. Bonsi P, De Jaco A, Gubellini P. Editorial to the special issue: The neurobiology of synaptic dysfunction in brain disorders. Neurobiol Dis.2023 Jan; 176:105968.
5. Elisa Maria Turco, Angela Maria Giada Giovenale, Laura Sireno, Martina Mazzoni, Alessandra Cammareri, Caterina Marchioretti, Laura Goracci, Alessandra Di Veroli, Elena Marchesan, Daniel D’Andrea, Antonella Falconieri, Barbara Torres, Laura Bernardini, Maria Chiara Magnifico, Alessio Paone, Serena Rinaldo, Matteo Della Monica, Stefano D’Arrigo, Diana Postorivo, Anna Maria Nardone, Giuseppe Zampino, Roberta Onesimo, Chiara Leoni, Federico Caicci, Domenico Raimondo, Elena Binda, Laura Trobiani, Antonella De Jaco, Ada Maria Tata, Daniela Ferrari, Francesca Cutruzzolà, Gianluigi Mazzoccoli, Elena Ziviani, Maria Pennuto, Angelo Luigi Vescovi and Jessica Rosati.
6. Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome. Cell Death Dis 2022; 13: 981. DOI: 10.1038/s41419-022-05410-7.
7. Bonsi P, De Jaco A*, Fasano L, Gubellini P. Postsynaptic autism spectrum disorder genes and synaptic dysfunction. Neurobiol Dis. 2022; 162:105564. *first co-author
8. D'Acunto E, Gianfrancesco L, Serangeli I, D'Orsi M, Sabato V, Guadagno NA, Bhosale G, Caristi S, Failla AV, De Jaco A, Cacci E, Duchen MR, Lupo G, Galliciotti G, Miranda E. Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB. Cell Mol Life Sci. 2022; 79:437.
9. Trobiani L, Meringolo M, Diamanti T, Bourne Y, Marchot P, Martella G, Dini L, Pisani A, De Jaco A*, Bonsi P. The neuroligins and the synaptic pathway in Autism Spectrum Disorder. Neurosci Biobehav Rev. 2020; 119:37-51. *co-corresponding author
10. Salome Azoulay-Ginsburg S; Trobiani L; Setini A; Favaloro FL; Giorda E; Jacobs A; Hauschner H; Levy L; Cestra G; De Jaco A*; Gruzman A. The lipophilic 4-phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins. Chemistry. 2020; 26(8):1834-1845. *co-corresponding author
11. Ranaivoson FM, Turk LS, Ozgul S, Kakehi S, von Daake S, Lopez N, Trobiani L, De Jaco A, Denissova N, Demeler B, Özkan E, Montelione GT, Comoletti D. A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as structurally Conserved Interaction Modules at the Synapse. Structure. 2019; 27:893-906.
12. Trobiani L, Favaloro FL, Di Castro MA, Di Mattia M, Cariello M, Miranda E, Canterini S, De Stefano ME, Comoletti D, Limatola C, De Jaco A. UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism. Neurobiol Dis. 2018; 120:139-150.
13. Di Bari M, Bevilacqua V, De Jaco A, Laneve P, Piovesana R, Trobiani L, Talora C, Caffarelli E, Tata AM. Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation. Int J Mol Sci. 2018;19(6). pii: E1631. doi: 10.3390/ijms19061631.
14. Altieri F, Turco EM, Vinci E, Torres B, Ferrari D, De Jaco A, Mazzoccoli G, Lamorte G, Nardone A, Della Monica M, Bernardini L, Vescovi AL, Rosati J. Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (IPSCS) carrying a novel puntiform mutation in RAI1 gene, causative of Smith-Magenis syndrome. Stem Cell Research 2018 Stem Cell Res. Feb 21; 28:153-156.
15. Martella G, Meringolo M, Trobiani L, De Jaco A, Pisani A, Bonsi P. The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum. Eur J Neurosci. 2018; 47:701-708.
16. De Jaco A, Mango D, De Angelis F, Favaloro FL, Andolina D, Nisticò R, Fiori E, Colamartino M, Pascucci T. Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism. Int J Mol Sci. 2017;18(5). pii: E941.
17. Guadagno NA, Moriconi C, Licursi V, D'Acunto E, Nisi PS, Carucci N, De Jaco A, Cacci E, Negri R, Lupo G, Miranda E. Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB. Neurobiol Dis. 2017; 103:32-44.
18. De Jaco A, Bernardini L, Rosati J, Tata AM. Alpha-7 nicotinic receptors in nervous system disorders: from function to therapeutic perspectives. Cent Nerv Syst Agents Med Chem. 2017;17(2):100-108.
19. Rubio-Marrero EN, Vincelli G, Jeffries CM, Shaikh TR, Pakos IS, Ranaivoson FM, von Daake S, Demeler B, De Jaco A, Perkins G, Ellisman MH, Trewhella J, Comoletti D. Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1. J Biol Chem. 2016; 291(11):5788-802.
20. Ulbrich L, Favaloro FL, Marchetti V, Pascucci T, Comoletti D, Marciniak SJ, De Jaco A. Autism associated R451C mutation in Neuroligin3 leads to the activation of the unfolded protein response in a PC12 Tet-On inducible system. Biochem J. 2016; 473(4):423-34.
21. Romano E, De Angelis F, Ulbrich L, De Jaco A, Fuso A, Laviola G. Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice. Psychopharmacology 2014; 231(8):1775-87.
22. Ulbrich L, Cozzolino M, Marini ES, Amori I, De Jaco A, Carrì MT, Augusti-Tocco G. Cystatin B and SOD1: Protein-Protein Interaction and Possible Relation to Neurodegeneration. Cell Mol Neurobiol. 2014, 34 (2):205-13.
23. Taylor P, De Jaco A, Comoletti D, Miller M, Camp S. Cholinesterase confabs and cousins: Approaching forty years.
a. Chem Biol Interact. 2013; 203(1): 10-3
24. De Jaco A, Dubi N, Camp S, Taylor P. Congenital hypothyroidism mutations affect common folding and trafficking in the hydrolase fold proteins. FEBS J. 2012; 279(23):4293-305.
25. Falivelli G, De Jaco A, Favaloro FL, Kim H, Wilson J, Dubi N, Ellisman MH, Abrahams BS, Taylor P, Comoletti D. Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. Hum Mol Genet. 2012; 21(21):4761-73.
26. De Jaco A, Comoletti D, Dubi N, Camp S and Taylor P. Processing of Cholinesterase-like alpha/beta-Hydrolase fold Proteins: Alterations Associated with Congenital Disorders". Special thematic issue of Protein & Peptide Letters. Protein Pept Lett. 2012; 19(2):173-9.
27. De Jaco, A; Lin, MZ; Dubi, N; Comoletti, D; Miller, M; Camp, S; Ellisman, M; Butko, MT; Tsien, RY; Taylor, P. Neuroligin trafficking deficiencies arising from mutations in the {alpha}/{beta}-hydrolase fold protein family. J Biol.Chem. 2010; 285(37):28674-82.
28. De Jaco A, Dubi N, Comoletti D, Taylor P. Folding anomalies of neuroligin3 caused by a mutation in the alpha/beta-hydrolase fold domain. Chem Biol Interact. 2010; 187(1-3):56-8.
29. Camp S, Zhang L, Krejci E, Dobbertin A, Bernard V, Girard E, Duysen EG, Lockridge O, De Jaco A, Taylor P. Contributions of selective knockout studies to understanding cholinesterase disposition and function. Chem Biol Interact. 2010;187(1-3):72-7.
30. De Jaco A, Comoletti D, King CC, Taylor P. Trafficking of cholinesterases and neuroligins mutant proteins. An association with autism. Chem Biol Interact. 2008 Sep 25; 175(1-3):349-51.
31. Camp S, De Jaco A, Zhang L, Marquez M and Taylor P. Upstream intron elements selectively control acetylcholinesterase expression in skeletal muscle. J Neurosci. Mar 5; 2008; 28(10): 459-70.
32. De Jaco A, Comoletti D, Kovarik Z, Gaietta G, Radić Z, Lockridge O, Ellisman MH and Taylor P. A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the hydrolase fold protein family. J Biol Chem. 2006; 281 (14): 9667-76. Featured in: Phelps J. Misfolded proteins presents potential molecular explanation for autism spectrum disorders. Environmental Health Perspectives 2006 vol. 114 (7): 409.
33. De Jaco A, Camp S, Taylor P. Influence of the 5' intron in the control of acetylcholinesterase gene expression during myogenesis. Chem Biol Interact. 2005; 157-158:372-3.
34. De Jaco A, Kovarik Z, Comoletti D, Jennings LL, Gaietta G, Ellisman MH and Taylor P. A single mutation near the C-terminus in hydrolase fold protein family causes a defect in protein processing. Chem Biol Interact. 2005; 157-158:371-2.
35. Comoletti D, De Jaco A, Jennings L, Flynn R, Gaietta G, Tsigelny I, Ellisman MH, Taylor P. The Arg451Cys-Neuroligin-3 Mutation Associated with Autism Reveals a Defect in Protein Processing. J Neurosci. 2004; 24 (20): 4889-93.
36. Biagioni S, Tata AM, De Jaco A and Augusti-Tocco G. Acetylcholine and regulation of gene expression in nerve system development. Curr. Topics in Neurochem. 2002; 3: 177-188
37. Uccelletti D, De Jaco A, Farina F, Mancini P, Augusti-Tocco G, Biagioni S and Palleschi C. Cell surface expression of a GPI-anchored form of mouse acetylcholinesterase in Klpmr1 cells of Kluyveromyceslactis. Biochem and Biophy Res Commun. 2002; 298, 559-565.
38. De Jaco A, Augusti-Tocco G and Biagioni S. Muscarinic acetylcholine receptors induce neurite outgrowth and activate the synapsin I gene promoter in neuroblastoma clones. Neuroscience 2002; 113(2), 330-337.
39. De Jaco A, Augusti-Tocco G and Biagioni S. Alternative AChE molecular forms induce neurite outgrowth in transfected neuroblastoma clones. J Neurosci Res. 2002; 15, 756-65.
40. De Jaco A, Ajmone-Cat MA, Baldelli P, Carbone E, Augusti-Tocco G, Biagioni S. Modulation of acetylcholinesterase and voltage-gated Na+ channels in choline acetyltransferase-transfected neuroblastoma clones. J Neurochem. 2000; 75,1123-31.
41. Biagioni S, Ciuffini L, De Jaco A, Vignoli AL and Augusti-Tocco G. Activation of neurospecific gene expression by Antennapedia Homeobox peptide. Int J Dev Neurosci. 2000, 18, 93-99.
42. Biagioni S, Tata AM, De Jaco A and Augusti-Tocco G. Acetylcholine synthesis and neuron differentiation. Int J Dev Biol. 2000; 44, 689-697.
43. Bignami F, Bevilacqua P, Biagioni S, De Jaco A, Casamenti F, Felsani A, and Augusti-Tocco G. Cellular Acetylcholine content and neuronal differentiation. J Neurochem. 1997; 69, 1374-1381.
Book Chapters
1. M. Di Bari, V. Bevilacqua, A. De Jaco, P. Laneve, R. Piovesana, L. Trobiani, C. Talora, E. Caffarelli and AM Tata. “The Cross-Talk Between M2 Muscarinic Receptors and Notch-1/EGFR Pathways is mediated by Mir-34a-5p in U87 Glioblastoma Cell Line”
eBook-Top 5 contributions in molecular sciences: 6th Edition (in press).
Publisher: Avid Science
2. G. Galliciotti, A. De Jaco, D. Sepulveda-Falla, E. D’Acunto, E. Miranda "Role of cellular oxidative stress in dementia” In: The Neuroscience of Dementia 2019. Ed. Prof. Colin Martin, Prof. Victor Preedy. Editorial: Elsevier
3. P. Taylor, A. De Jaco and D. Comoletti “Key molecules: The Neuroligins: Partners and Cousins” In: New Encyclopedia of Neuroscience 2010, pages 493-496
4. Augusti-Tocco G., De Jaco A. and Biagioni S. “Alternative AChE molecular forms exhibit similar ability to induce neurite outgrowth in transfected neuroblastoma clones” Cholinesterases in the Second Millenium: Biomolecular and Pathological Aspects. (VII International Meeting on Cholinesterases, Pucon-Chile) 2004, 55-60, Ed. Inestrosa N. C. and Campos E.O. Diseno Impresiones Ltda Chile.