Annual Report 2022/2023
The scientific activity in the Academic Year 2022-2023 focused on topics related to innovative biotechnologies in the pathologies of sensory organs, particularly in the Scientific-Disciplinary Sectors MED/30 and MED/31. Many of the results obtained by doctoral students were presented at national and international scientific conferences, with the findings published in international scientific journals.
The research lines in Ophthalmology and Otorhinolaryngology, developed during the second year of the 37th cycle, included:
ALECTOR Protocol: a phase 2 randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy of AL002 in participants with early Alzheimer’s disease.
SMALL Study: "Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study Report 1: internal limiting membrane peeling versus no peeling".
Retinal Structural Changes and Correlations with Brain MRI in Hypoxic-Ischemic Encephalopathy Infants Undergoing Therapeutic Hypothermia.
Characterization of interleukin 8 expression and its receptor CXCR-1 on the ocular surface of glaucomatous patients undergoing filtering surgery, as a potential predictive biomarker of surgical outcomes.
Neurotrophins in the treatment of glaucoma, literature review for the establishment of a research protocol on the use of an animal model for intravitreal administration of NGF; pharmacokinetic and pharmacodynamic assessment.
Third Mission Project “Ci vediamo a Corviale” for integration between the University and the Territory, in collaboration with the universities of Rome “La Sapienza” and “Tor Vergata”, the IRCCS Foundation Bietti, IAPB Italia Onlus, and the OneSight Essilor-Luxottica Foundation. Data collection on 1452 patients aimed at conducting an epidemiological survey on ophthalmic health and Eye Health Literacy of Nuovo Corviale residents.
International Multicentric project "Neurosensory Abnormalities in Symptomatic Ocular Surface Patients (NASA)". Prospective Observational Trial.
International Multicentric project "Prospective Study to Validate the Imaging Biomarker for Neuropathic Corneal Pain (NCP) (R33)". Prospective Observational Trial.
International project "Intracanalicular Dexamethasone Insert for the Treatment of Inflammation and Discomfort in Dry Eye Disease (DEcIDED). Prospective, single-center, randomized, double-masked, parallel comparison, sponsored Trial.
International Multicentric project "DEFENDO Long Term Follow-up Study in Stage 1 NK Patients (DEFENDO)". Observational Prospective Trial.
International Multicentric project "Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED (CHASE)". Interventional, Randomized Trial.
International project "The Efficacy of Quantitative Sensory Test (QST) in Assessing Corneal Nerve Functions in Patients With Ocular Surface Diseases". Interventional, non-Randomized Trial.
Dupilumab-associated ocular surface disease is the first cause of treatment discontinuation: identification of biomarkers and investigation of pathogenic mechanisms.
Safety and efficacy of topical applications of Hy-tissue PRP eyedrops in the treatment of dry eye secondary to graft versus host disease (GvHD).
Conjunctival expression of transient receptor potential (TRP) channels in inflammatory and degenerative ocular surface diseases.
A 4-week, Phase III, multicenter, double-masked, vehicle-controlled clinical study to evaluate safety and efficacy of Cenegermin (Oxervate®) 20 mcg/mL ophthalmic solution versus vehicle, in patients with severe Sjogren’s dry eye disease under treatment with Cyclosporine A (PROTEGO-2 study).
A 4-week, Phase III, multicenter, double-masked, vehicle-controlled clinical study to evaluate safety and efficacy of Oxervate® (cenegermin) 20 mcg/mL ophthalmic solution versus vehicle, in patients with severe Sjogren’s dry eye disease (PROTEGO-1 study).
Evaluation of anterior chamber cell numbers pre and post dilation with Visumidriatic Phenylephrine 10% + 5% and Visumidriatic 1% using anterior segment OCT.
Anterior vitreous objective assessment in uveitis: an anterior segment swept source optical coherence tomography study.
Inflammation, Langerhans cells, and small fiber neuropathy evaluated with corneal confocal microscopy.
Use of bromelain pre and post surgery of macular holes.
Evaluation of ocular biochemical and morphological biomarkers for early diagnosis and response to therapy in patients affected by Multiple Sclerosis and Parkinson's disease - SCLEREYE.
Bibliographic research and review of the scientific literature on topics related to ocular immunology, transplant rejection in animal models.
Endoscopic and exoscopic surgery of cervico-cephalic district pathology: functional results and learning curves of the surgical team.
The research lines in Ophthalmology and Otorhinolaryngology, developed during the first year of the 38th cycle, included:
Identification of early biomarkers in the aqueous humor and ocular surface of patients affected by glaucoma - SIRNEST.
Characterization of miRNA profile at the tear and conjunctival level in patients affected by inflammatory and degenerative ocular surface pathologies, including ocular mucous membrane pemphigoid - MIREYE.
Characterization of MIRNA in the ocular surface of patients affected by Basedow orbitopathy: novel biomarkers and potential therapeutical targets.
IMVT-1401-3201: A Phase 3, Multi-Center, Randomized, Quadruple-Masked, Placebo-Controlled Study Of Batoclimab For The Treatment Of Participants With Active Thyroid Eye Disease (TED).
Evaluation of the neurotrophic and electrofunctional pattern in migraine; prospective controlled study.
Predictive biomarkers of new intravitreal drugs in wet age-related macular degeneration.
Gene Therapy in Hereditary Retinal Dystrophies: The Usefulness of Diagnostic Tools in Candidate Patient Selections.
Genetic patterns in hereditary retinal dystrophies: role of instrumental tests in patient selection and follow-up for gene therapy.
Analysis of the long-term evolution of non-exudative macular neovascularizations.
Maculaflux - PreX Project: Continuation of OCT and AngioOCT tutoring activity in the integration of hospital-territory in the management of maculopathic patients undergoing repeated intravitreal therapies.
Rehabilitation through Tetra AnalyzerTM in children with visual perceptual dyslexia: a prospective randomized controlled cohort study.
The role of visual rehabilitation in the psychomotor recovery of motor coordination disorder: an outcome research study.
Organizational model for characterization and treatment of orphan bilateral blindness due to different forms of ocular surface stem cell deficiency: the bioengineered oral mucosa from bench to bedside.
A 4-Week, Phase II, Multicenter, Randomized, Double- Masked, Vehicle- Controlled, Parallel Group Study With 4 Weeks of Follow-Up to Evaluate Safety and Efficacy of a new formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution at two different Concentrations in patients with Dry Eye Disease (REDUCO).
Literature Review on current knowledge of etiology, diagnostics, and treatment of lamellar retinal holes.
Neuro-ophthalmology and senescence - ophthalmological implications of neurological aging diseases.
Misdiagnoses in oculoplastic and ocular surface diseases.
Evaluation of filtering bleb morphology after Preserflo TM microshunt implantation using in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT).
Evaluation of OCT parameters as biomarkers for recurrence of macular edema in patients affected by DME treated with anti-VEGF.
XPF-010-301: A Randomized, Double-blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures.
Integrating RET-CAM Imaging and Tear Biomarkers for Early Detection of Diabetic Retinopathy Progression.
Retinal Optical Coherence Tomography Angiography as a Potential Biomarker for Coronary Microvascular Disease Assessed by Coronary Angiographic Indices.
Digital Twin in Ophthalmology.
Application Of Optical Coherence Tomography Angiography In Lewy Body Dementia.
Novel potential plasma biomarkers in retinopathy of prematurity: identification of a microRNA signature for the prediction of disease outcomes.
Use of the Forced Oscillation Technique in the diagnosis and monitoring of bronchial hyperreactivity in patients undergoing total laryngectomy.
Secondary palatal collapses in sleep respiratory disorders.
Sleep respiratory disorders and their impact on state police workers.