ANNA CECCARELLI

PhD Student

PhD program:: XLI
email: anna.ceccarelli@uniroma1.it




supervisor: Prof.ssa Elisabetta Ferretti

Research: Identification of novel biomarkers and therapeutic strategies to improve patient stratification and response to immunotherapy, integrating spatial transcriptomics, molecular profiling, and clinical data

Education and Training
November 2025 - Present: PhD in Network Oncology and Precision Medicine Sapienza University of Rome, Italy 
November 2021 - Present: Residency in Medical Oncology Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy 
October 2016 - June 2021: MD Degree Faculty of Medicine and Surgery, Sapienza University of Rome, Italy 
October 2012 - March 2016: Bachelor’s Degree in Biotechnology University of Sannio, Italy 

Work Experience
November 2021 - Present: Medical Oncology Resident Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy 
October 2020 - October 2021: Medical Intern - Neuro-Oncology Unit Bambino Gesù Children’s Hospital, Rome, Italy 
September 2015 - December 2015: Student intern Center for Neuroscience and Cell Biology, University of Coimbra, Portugal 

Research project
My PhD research focuses on translational oncology, with particular emphasis on tumor-immune-microbiome interactions and cancer immunogenomics.
The overall goal is to identify novel biomarkers and therapeutic strategies to improve patient stratification and response to immunotherapy, integrating spatial transcriptomics, molecular profiling, and clinical data.

Skills
Technical and Methodological Skills single-cell RNA sequencing, clinical trial management, GCP compliance, RECIST evaluation, CTCAE adverse event grading, Python for data analysis.
Soft Skills Scientific writing, interdisciplinary collaboration, patient communication, teamwork in international and multicultural research environments.

Mobility
Erasmus Research Fellowship University of Coimbra, Portugal - 2015

Research products

11573/1767252 - 2026 - Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives
Ottaiano, Alessandro; Santorsola, Mariachiara; Sabbatino, Francesco; Sirica, Roberto; Caraglia, Francesco; Ceccarelli, Anna; Granata, Vincenza; Simeone, Ines; Zappavigna, Silvia; Berretta, Massimiliano; Savarese, Giovanni; Caraglia, Michele - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-105034454356 (0)

11573/1767249 - 2026 - Formyl peptide receptor 2 activation by MR-39 inhibits glioblastoma cell proliferation and invasiveness through suppression of multiple oncogenic pathways
Ferraro, Maria Grazia; Bocchetti, Marco; Affinito, Marianna; Ercolano, Giuseppe; Dalim Filiz, Kardelen; Speranza, Luisa; Lacivita, Enza; Leopoldo, Marcello; Crispino, Marianna; Ceccarelli, Anna; Perrone-Capano, Carla; Miniaci, Maria Concetta; Caraglia, Michele; Volpicelli, Floriana - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-105033287412 (0)

11573/1767377 - 2026 - Transcriptional and epigenetic plasticity drive an alternative non-clonal mechanism of resistance to KRASG12D inhibition in pancreatic cancer
Caggiano, Alessia; Agostini, Antonio; Iacuone, Diego; Priori, Lorenzo; Esposito, Annachiara; Ceccarelli, Anna; Rosa, Diego; Pasini, Davide; Ugel, Stefano; De Sanctis, Francesco; Cinti, Federica; Sette, Claudio; Rampioni Vinciguerra, Gian Luca; Bronte, Vincenzo; Piro, Geny; Corbo, Vincenzo; Tortora, Giampaolo; Carbone, Carmine - 01a Articolo in rivista
paper: CANCER COMMUNICATIONS (London: BioMed Central) pp. - - issn: 2523-3548 - wos: (0) - scopus: (0)

11573/1767385 - 2025 - A phase II study of encorafenib and cetuximab (EC) beyond progression in combination with FOLFIRI in BRAF V600E-mutated metastatic colorectal cancer (mCRC).
Ceccarelli, Anna - 04d Abstract in atti di convegno
conference: 2025 ASCO Annual Meeting (Chicago)
book: Journal of Clinical Oncology - ()

11573/1767386 - 2025 - Prognostic value of unplanned hospital attendances in early phase cancer trial participants
Ceccarelli, Anna - 01h Abstract in rivista
paper: ANNALS OF ONCOLOGY (Dordrecht: Kluwer) pp. - - issn: 1569-8041 - wos: (0) - scopus: (0)

11573/1767243 - 2025 - Tumor mutational burden modulates the prognostic effect of RAS mutations in metastatic colon cancer: mechanistic insights and genotype-phenotype correlations
Ianniello, Monica; Ottaiano, Alessandro; Bocchetti, Marco; Ruggiero, Raffaella; Santorsola, Mariachiara; Sirica, Roberto; Caraglia, Francesco; Ceccarelli, Anna; Toscano, Enrica; Picone, Carmine; Ciappina, Giuliana; Cossu, Alessia Maria; Petrillo, Nadia; Fico, Antonio; Circelli, Luisa; Sabbatino, Francesco; Barone, Antonio; Sperlongano, Rossella; Berretta, Massimiliano; Caraglia, Michele; Savarese, Giovanni - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-105020935232 (1)

11573/1767237 - 2025 - The Impact of a Multidisciplinary Tumor Board (MDTB) in the Management of Colorectal Cancer (CRC)
Schietroma, Francesco; Bensi, Maria; Calegari, Maria Alessandra; Pozzo, Carmelo; Basso, Michele; Valente, Giustina; Caira, Giulia; Trovato, Giovanni; Spring, Alexia; Beccia, Viria; Ceccarelli, Anna; Perazzo, Serena; Chiofalo, Laura; Barbaro, Brunella; Tatulli, Giulia; Alfieri, Sergio; De Sio, Davide; Lorenzon, Laura; Persiani, Roberto; Lococo, Filippo; Nachira, Dania; Giuliante, Felice; Ardito, Francesco; Cellini, Francesco; Panza, Giulia; Cozza, Valerio; Giovinazzo, Francesco; Pafundi, Donato Paolo; Sofo, Luigi; Santullo, Francesco; Tondolo, Vincenzo; Tortora, Giampaolo; Salvatore, Lisa - 01a Articolo in rivista
paper: CLINICAL COLORECTAL CANCER (Dallas, Tex. : Cancer Information Group, c2001-) pp. 231-238 - issn: 1533-0028 - wos: (0) - scopus: 2-s2.0-85216619371 (2)

11573/1767245 - 2024 - Exosomes multiplex profiling, a promising strategy for early diagnosis of laryngeal cancer
Bocchetti, Marco; Luce, Amalia; Iannarone, Clara; Pasquale, Lucia Stefania; Falco, Michela; Tammaro, Chiara; Abate, Marianna; Ferraro, Maria Grazia; Addeo, Raffaele; Ricciardiello, Filippo; Motta, Giovanni; De Stefano, Luca; Caraglia, Francesco; Ceccarelli, Anna; Zappavigna, Silvia; Scrima, Marianna; Cossu, Alessia Maria; Caraglia, Michele; Misso, Gabriella - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-85196359325 (16)

11573/1767247 - 2024 - Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment
Ottaiano, Alessandro; Santorsola, Mariachiara; Ianniello, Monica; Ceccarelli, Anna; Casillo, Marika; Sabbatino, Francesco; Petrillo, Nadia; Cascella, Marco; Caraglia, Francesco; Picone, Carmine; Perri, Francesco; Sirica, Roberto; Zappavigna, Silvia; Nasti, Guglielmo; Savarese, Giovanni; Caraglia, Michele - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-85190885086 (7)

11573/1767253 - 2024 - High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients
Di Mauro, Annabella; Santorsola, Mariachiara; Savarese, Giovanni; Sirica, Roberto; Ianniello, Monica; Cossu, Alessia Maria; Ceccarelli, Anna; Sabbatino, Francesco; Bocchetti, Marco; Carratù, Anna Chiara; Pentimalli, Francesca; Ferrara, Gerardo; Nasti, Guglielmo; Caraglia, Michele; Ottaiano, Alessandro - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-85211119448 (13)

11573/1767234 - 2024 - Differential methylation of circulating free DNA assessed through cfMeDiP as a new tool for breast cancer diagnosis and detection of BRCA1/2 mutation
Grisolia, Piera; Tufano, Rossella; Iannarone, Clara; De Falco, Antonio; Carlino, Francesca; Graziano, Cinzia; Addeo, Raffaele; Scrima, Marianna; Caraglia, Francesco; Ceccarelli, Anna; Nuzzo, Pier Vitale; Cossu, Alessia Maria; Forte, Stefano; Giuffrida, Raffaella; Orditura, Michele; Caraglia, Michele; Ceccarelli, Michele - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: (0) - scopus: 2-s2.0-85206549146 (14)

11573/1767235 - 2024 - Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance
Esposito, A; Agostini, A; Quero, G; Piro, G; Priori, L; Caggiano, A; Scaglione, G; Battaglia, A; Calegari, M A; Salvatore, L; Bensi, M; Maratta, M G; Ceccarelli, A; Trovato, G; Genovese, G; Gurreri, E; Ascrizzi, S; Martini, M; Fiorillo, C; Fattorossi, A; De Sanctis, F; Ugel, S; Corbo, V; Alfieri, S; Tortora, G; Carbone, C - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (London: Nature Group-Springer London: Nature Publishing Group, 2001-) pp. - - issn: 2041-4889 - wos: (0) - scopus: 2-s2.0-85211109992 (20)

11573/1767236 - 2024 - Focus on RAS Codon 61 mutations in metastatic colorectal cancer. A retrospective analysis
Schietroma, Francesco; Anghelone, Annunziato; Valente, Giustina; Beccia, Viria; Caira, Giulia; Spring, Alexia; Trovato, Giovanni; Di Bello, Armando; Ceccarelli, Anna; Chiofalo, Laura; Perazzo, Serena; Bensi, Maria; Minucci, Angelo; Urbani, Andrea; Larocca, Luigi Maria; Basso, Michele; Pozzo, Carmelo; Salvatore, Lisa; Calegari, Maria Alessandra; Tortora, Giampaolo - 01a Articolo in rivista
paper: CANCERS (Basel: MDPI) pp. 1-12 - issn: 2072-6694 - wos: (0) - scopus: 2-s2.0-85187699754 (3)

11573/1767233 - 2023 - An integrated tumor, immune and microbiome atlas of colon cancer
Roelands, Jessica; Kuppen, Peter J K; Ahmed, Eiman I; Mall, Raghvendra; Masoodi, Tariq; Singh, Parul; Monaco, Gianni; Raynaud, Christophe; De Miranda, Noel F C C; Ferraro, Luigi; Carneiro-Lobo, Tatiana C; Syed, Najeeb; Rawat, Arun; Awad, Amany; Decock, Julie; Mifsud, William; Miller, Lance D; Sherif, Shimaa; Mohamed, Mahmoud G; Rinchai, Darawan; Van Den Eynde, Marc; Sayaman, Rosalyn W; Ziv, Elad; Bertucci, Francois; Petkar, Mahir Abdulla; Lorenz, Stephan; Mathew, Lisa Sara; Wang, Kun; Murugesan, Selvasankar; Chaussabel, Damien; Vahrmeijer, Alexander L; Wang, Ena; Ceccarelli, Anna; Fakhro, Khalid A; Zoppoli, Gabriele; Ballestrero, Alberto; Tollenaar, Rob A E M; Marincola, Francesco M; Galon, Jérôme; Khodor, Souhaila Al; Ceccarelli, Michele; Hendrickx, Wouter; Bedognetti, Davide - 01a Articolo in rivista
paper: NATURE MEDICINE (New York, N.Y. : Nature America, Inc.) pp. 1273-1286 - issn: 1546-170X - wos: (0) - scopus: 2-s2.0-85159688758 (160)

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