Research: Glycan-lectin interactions and their role in immunosuppression in GBM patients: a network analysis approach to assess novel therapeutic targets
EDUCATION AND TRAINING
29/07/2022
Winner ot tutorship scholarship
Faculty of Medicine and Surgery, Sapienza University of Rome, Italy, pz Aldo Moro 5, 00185, Rome
05/2022
Attendance of CIVIS Course Mobility in Madrid included in "Technical Innovations in Basic and Translational Research: Applications to Immunology-Oncology" Civis Course
CIVIS European University alliance
1/11/2021 – on going
PhD Student in Network Oncology and Precision Medicine,
Laboratory of Tumor Immunology and Cell Therapy (prof. Marianna Nuti) Department of Experimental Medicine, “Sapienza” University of Rome, Italy, pz Aldo Moro 5, 00185, Rome, Italy.
09/2021-12/2021
Attendance of CIVIS Course on "Technical Innovations in Basic and Translational Research: Applications to Immunology-Oncology"
CIVIS European University alliance
01/05/2021-31/10/2021
Winner of Junior Researcher Scholarship
Laboratory of Tumor Immunology and Cell Therapy (prof. Marianna Nuti) Department of Experimental Medicine, “Sapienza” University of Rome, Italy, pz Aldo Moro 5, 00185, Rome, Italy.
2019-2020
Advanced Professional Courses (as auditor)
Immuno-Oncology. Personalized Medicine foundation, Rome, Italy (Scientific director: Prof. Paolo Marchetti).
30/03/2021
Medical Biotechnologies master degree. Vote 110/110 magna cum laude.
Thesis Title: “TKI in metastatic renal carcinoma: modulation of immune response in vitro and in vivo”.
Laboratory of Tumor Immunology and Cell Therapy (prof. Marianna Nuti) “Sapienza” University of Rome, Italy
28/06/2018
Biological Science bachelor degree.
Thesis Title: “Vaccines between past and future: the impact of vaccinations schedules in Italy”
“Sapienza” University of Rome, Italy
07/07/2014
Scientific High School Diploma.
Galileo Galilei Scientific High School, Via Balilla, 34 - 65121 Pescara (PE)
LABORATORY SKILLS AND COMPETENCIES
Adherent and suspension cell cultures. Immunological assays and functional studies with Dendritic Cells, Macrophages, T-Cells, PMN-MDSC, M-MDSC, Tumor cells, primary tumor cell. Separation of blood components (PBMCs). Flow cytometry. ELISA, Immunofluorescence, immunoblotting, Western blotting, ELISpot. Scientific Databases. Data processing.
PUBLICATIONS
Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor miRNAs. Pace A, Scirocchi F, Napoletano C, Zizzari IG, Po A,
Megiorni F, Asquino A, Pontecorvi P, Rahimi H, Marchese C, Ferretti E, Nuti M, Rughetti A Journal of Translational Medicine, 2023 10.1186/s12967-023-04450-7
Circulating CD137+ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients. Alessio Cirillo, Ilaria Grazia Zizzari, Andrea Botticelli, Lidia Strigari, Hassan Rahimi, Simone Scagnoli, Fabio Scirocchi, Angelina Pernazza, Angelica Pace, Bruna Cerbelli, Giulia d’Amati, Paolo Marchetti, Marianna Nuti, Aurelia Rughetti and Chiara Napoletano. Int. J. Mol. Sci. 2023, 24(8), 7114; https://doi.org/10.3390/ijms24087114
Soluble PD-L1 as a Prognostic Factor for Immunotherapy Treatment in Solid Tumors: Systematic Review and Meta-Analysis. Fabio Scirocchi, Lidia Strigari,Alessandra Di Filippo, Chiara Napoletano, Angelica Pace, Hassan Rahimi, Andrea Botticelli, Aurelia Rughetti, Marianna Nuti and Ilaria Grazia Zizzari Int. J. Mol. Sci. 2022, 23(22), 14496; https://doi.org/10.3390/ijms232214496
Glycan-Lectin interactions as novel immunosuppression drivers in glioblastoma. Pace, A.; Scirocchi, F.;
Napoletano, C.; Zizzari, I.G.; D’Angelo, L.; Santoro, A.; Nuti, M.; Rahimi, H.; Rughetti, A. Int. J. Mol. Sci. 2022,
23, 6312. https://doi.org/10.3390/ ijms23116312
Immunogenic Cell Death and Immunomodulatory Effects of Cabozantinib. 2021 10.3389/fonc.2021.755433
Fabio Scirocchi, Chiara Napoletano, Angelica Pace, Hassan Rahimi Koshkaki, Alessandra Di Filippo, Ilaria Grazia Zizzari, Marianna Nuti, Aurelia Rughetti. Frontiers in oncology, 20 October 2021, 4301.
ABSTRACT
35th AICC INTERNATIONAL MEETING-TRANSLATIONAL AND PRECISION MEDICINE, L'Aquila 2023 :Dissecting Immunosuppression in glioblastoma: the MGL C-type lectin and its ligands in the tumor microenvironment Angelica Pace, Fabio Scirocchi, Caterina Alfano, Simone Minasi, Angela Asquino, Chiara Napoletano, Ilaria Grazia Zizzari, Luca D’Angelo, Antonio Santoro, Lorenzo Farina, Francesca Buttarelli, Manuela Petti, Marianna Nuti, Aurelia Rughetti
35th AICC INTERNATIONAL MEETING-TRANSLATIONAL AND PRECISION MEDICINE, L'Aquila 2023 : Circulating CD137+ T cell subsets and MDCSs as Immune Biomarkers for Response to anti-PD1 Immunotherapy in NSCLC Patients. Asquino A, Tuosto L, Scirocchi F, Pace A, Zizzari IG, Siringo M, Tramontano E, Gelibter A, Cortesi E, Nuti M, Rughetti A, Napoletano C
SIPMet Young Scientist Meeting 2023 in Parma 22-23 September 2023 “Circulating CD137+ T cells as immune biomarker for response to immunotherapy in NSCLC patients” Asquino A, Scirocchi F, Pace A, Zizzari IG, Siringo M, Tramontano E, Cortesi E, Gelibiter A, Nuti
M, Rughetti A, Napoletano C
SIPMeT in Parma 22-23 settembre 2023 “ MGL lectin receptor and immunosuppression networks in glioblastoma” Pace A , Scirocchi F, Rahimi H, Minasi S, Napoletano C, Asquino A,Zizzari IG, D’Angelo L, Santoro A, Buttarelli F, Nuti M, Rughetti A
41a National Conference in Cytometry, Naples 17-19 may 2023. Poster: Circulating CD137+ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients. Alessio Cirillo, Ilaria Grazia Zizzari, Andrea Botticelli, Lidia Strigari, Hassan Rahimi, Simone Scagnoli, Fabio Scirocchi, Angelina Pernazza, Angelica Pace, Bruna Cerbelli, Giulia d’Amati, Paolo Marchetti, Marianna Nuti, Aurelia Rughetti and Chiara Napoletano
Oral Presentation SIICA 2023 XIV National Congress : Macrophage Galactose-Like Lectin mediated interactions: investigating immunosuppressive networks in glioblastoma. Angelica Pace, Fabio Scirocchi, Hassan Rahimi, Simone Minasi, Chiara Napoletano, Ilaria Grazia Zizzari, Luca D’Angelo, Antonio Santoro, Francesca Buttarelli, Marianna Nuti, Aurelia Rughetti
SIICA 2023 XIV National Congress, Poster: Circulating CD137+ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients. Alessio Cirillo, Ilaria Grazia Zizzari, Andrea Botticelli, Lidia Strigari, Hassan Rahimi, Simone Scagnoli, Fabio Scirocchi, Angelina Pernazza, Angelica Pace, Bruna Cerbelli, Giulia d’Amati, Paolo Marchetti, Marianna Nuti, Aurelia Rughetti and Chiara Napoletano
SIICA Abstract 2021, XII National Congress: “Inflammatory HMGB1 modulation in primary and metastatic breast cancer patients treated with different therapy” Fabio Scirocchi, Andrea Botticelli, Simone Scagnoli, Angelica Pace, Alessandra Di Filippo, Chiara Napoletano, Ilaria Grazia Zizzari, Hassan Rahimi Koshkaki, Paolo Marchetti, Marianna Nuti and Aurelia Rughetti