ANDREA WLDERK

Dottore di ricerca

ciclo: XXXIII



Titolo della tesi: European Multicenter Study of ET-COVID-19

Background and Purpose: Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for large vessel occlusion in patients with COVID-19 are substantially unknown. Our aim was to study early outcomes after MT in patients with COVID-19. Methods: Multicenter, European, cohort study involving 34 stroke centers in France, Italy, Spain, and Belgium. Data were collected between March 1, 2020 and May 5, 2020. Consecutive laboratory-confirmed COVID-19 cases with large vessel occlusion, who were treated with MT, were included. Primary investigated outcome: 30-day mortality. Secondary outcomes: early neurological improvement (National Institutes of Health Stroke Scale improvement ≥8 points or 24 hours National Institutes of Health Stroke Scale 0–1), successful reperfusion (modified Thrombolysis in Cerebral Infarction grade ≥2b), and symptomatic intracranial hemorrhage. Results: We evaluated 93 patients with COVID-19 with large vessel occlusion who underwent MT (median age, 71 years [interquartile range, 59–79]; 63 men [67.7%]). Median pretreatment National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT Score were 17 (interquartile range, 11–21) and 8 (interquartile range, 7–9), respectively. Anterior circulation acute ischemic stroke represented 93.5% of cases. The rate modified Thrombolysis in Cerebral Infarction 2b to 3 was 79.6% (74 patients [95% CI, 71.3–87.8]). Thirty-day mortality was 29% (27 patients [95% CI, 20–39.4]). Early neurological improvement was 19.5% (17 patients [95% CI, 11.8–29.5]), and symptomatic intracranial hemorrhage was 5.4% (5 patients [95% CI, 1.7–12.1]). Patients who died at 30 days exhibited significantly lower lymphocyte count, higher levels of aspartate, and LDH (lactate dehydrogenase). After adjustment for age, initial National Institutes of Health Stroke Scale, Alberta Stroke Program Early CT Score, and successful reperfusion, these biological markers remained associated with increased odds of 30-day mortality (adjusted odds ratio of 2.70 [95% CI, 1.21–5.98] per SD-log decrease in lymphocyte count, 2.66 [95% CI, 1.22–5.77] per SD-log increase in aspartate, and 4.30 [95% CI, 1.43–12.91] per SD-log increase in LDH). Conclusions: The 29% rate of 30-day mortality after MT among patients with COVID-19 is not negligible. Abnormalities of lymphocyte count, LDH and aspartate may depict a patient’s profiles with poorer outcomes after MT.

Produzione scientifica

11573/1679682 - 2023 - Is Mechanical Thrombectomy or Thrombolysis Universally Cost-Effective? A Systematic Review of the Literature
De Rubeis, Gianluca; Fabiano, Sebastiano; Bertaccini, Luca; Wlderk, Andrea; Pezzella, Francesca Romana; Anticoli, Sabrina; Saba, Luca; Gasperini, Claudio; Pampana, Enrico - 01a Articolo in rivista
rivista: WORLD NEUROSURGERY. X ([New York]: Elsevier Inc.) pp. 29-39 - issn: 2590-1397 - wos: WOS:000917394500001 (1) - scopus: 2-s2.0-85142278560 (2)

11573/1693343 - 2023 - Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke
Sallustio, Fabrizio; Pracucci, Giovanni; Cappellari, Manuel; Saia, Valentina; Mascolo, Alfredo Paolo; Marrama, Federico; Gandini, Roberto; Koch, Giacomo; Diomedi, Marina; D'agostino, Federica; Rocco, Alessandro; Da Ros, Valerio; Wlderk, Andrea; Nezzo, Marco; Argirò, Renato; Morosetti, Daniele; Renieri, Leonardo; Nencini, Patrizia; Vallone, Stefano; Zini, Andrea; Bigliardi, Guido; Pitrone, Antonio; Grillo, Francesco; Bracco, Sandra; Tassi, Rossana; Bergui, Mauro; Naldi, Andrea; Carità, Giuseppe; Casetta, Ilaria; Gasparotti, Roberto; Magoni, Mauro; Simonetti, Luigi; Haznedari, Nicolò; Paolucci, Matteo; Mavilio, Nicola; Malfatto, Laura; Menozzi, Roberto; Genovese, Antonio; Cosottini, Mirco; Orlandi, Giovanni; Comai, Alessio; Franchini, Enrica; Pedicelli, Alessandro; Frisullo, Giovanni; Puglielli, Edoardo; Casalena, Alfonsina; Cester, Giacomo; Baracchini, Claudio; Castellano, Davide; Di Liberto, Alessandra; Ricciardi, Giuseppe Kenneth; Chiumarulo, Luigi; Petruzzellis, Marco; Lafe, Elvis; Persico, Alessandra; Cavasin, Nicola; Critelli, Adriana; Semeraro, Vittorio; Tinelli, Angelica; Giorgianni, Andrea; Carimati, Federico; Auteri, William; Rizzuto, Stefano; Biraschi, Francesco; Nicolini, Ettore; Ferrari, Antonio; Melis, Maurizio; Calia, Stefano; Tassinari, Tiziana; Nuzzi, Nunzio Paolo; Corato, Manuel; Sacco, Simona; Squassina, Guido; Invernizzi, Paolo; Gallesio, Ivan; Ruiz, Luigi; Dui, Giovanni; Carboni, Nicola; Amistà, Pietro; Russo, Monia; Maiore, Mario; Zanda, Bastianina; Craparo, Giuseppe; Mannino, Marina; Inzitari, Domenico; Toni, Danilo; Mangiafico, Salvatore - 01a Articolo in rivista
rivista: ACTA NEUROLOGICA BELGICA (Milano: Springer Verlag Italia) pp. 475-485 - issn: 2240-2993 - wos: WOS:000849147700002 (4) - scopus: 2-s2.0-85137446770 (6)

11573/1473874 - 2020 - Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke
Salsano, G.; Pracucci, G.; Mavilio, N.; Saia, V.; Di Poggio, M. B.; Malfatto, L.; Sallustio, F.; Wlderk, A.; Limbucci, N.; Nencini, P.; Vallone, S.; Zini, A.; Bigliardi, G.; Velo, M.; Francalanza, I.; Gennari, P.; Tassi, R.; Bergui, M.; Cerrato, P.; Carita, G.; Azzini, C.; Gasparotti, R.; Magoni, M.; Isceri, S.; Commodaro, C.; Cordici, F.; Menozzi, R.; Latte, L.; Cosottini, M.; Mancuso, M.; Comai, A.; Franchini, E.; Alexandre, A.; Marca, G. D.; Puglielli, E.; Casalena, A.; Causin, F.; Baracchini, C.; Di Maggio, L.; Naldi, A.; Grazioli, A.; Forlivesi, S.; Chiumarulo, L.; Petruzzellis, M.; Sanfilippo, G.; Toscano, G.; Cavasin, N.; Adriana, C.; Ganimede, M. P.; Prontera, M. P.; Andrea, G.; Mauri, M.; Auteri, W.; Petrone, A.; Cirelli, C.; Falcou, A.; Corraine, S.; Piras, V.; Ganci, G.; Tassinari, T.; Nuzzi, N. P.; Corato, M.; Sacco, S.; Squassina, G.; Invernizzi, P.; Gallesio, I.; Ferrandi, D.; Dui, G.; Deiana, G.; Amista, P.; Russo, M.; Pintus, F.; Baule, A.; Craparo, G.; Mannino, M.; Castellan, L.; Toni, D.; Mangiafico, S. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF STROKE (Oxford : Blackwell., 2006-) pp. - - issn: 1747-4930 - wos: WOS:000627511000001 (12) - scopus: 2-s2.0-85097312714 (13)

11573/788216 - 2015 - EVAR: benefits of CEUS for monitoring stent-graft status
Cantisani, Vito; Grazhdani, Hektor; Clevert, Dirk André; Roberto, Iezzi; Aiani, Luca; Martegani, Alberto; Fanelli, Fabrizio; Di Marzo, Luca; Wlderk, Andrea; Cirelli, Carlo; Catalano, Carlo; Di Leo, Nicola; Di Segni, Mattia; Malpassini, Flavio; D'ambrosio, Ferdinando - 01g Articolo di rassegna (Review)
rivista: EUROPEAN JOURNAL OF RADIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114 -editore precedente: Georg Thieme, Stuttgart ; New York : Thieme, [c1981.) pp. 1658-1665 - issn: 0720-048X - wos: WOS:000359618700006 (48) - scopus: 2-s2.0-84939268766 (60)

11573/932114 - 2014 - Calcium burden assessment and impact on drug-eluting balloons in peripheral arterial disease
Fanelli, Fabrizio; Cannavale, Alessandro; Gazzetti, Marianna; Lucatelli, Pierleone; Wlderk, Andrea; Cirelli, Carlo; D'adamo, Alessandro; Salvatori, F. M. - 01a Articolo in rivista
rivista: CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 898-907 - issn: 0174-1551 - wos: WOS:000339729100006 (268) - scopus: 2-s2.0-84904557164 (311)

11573/932074 - 2013 - Trattamento minimamente invasivo delle fistole gastriche dopo sleeve gastrectomy
Corona, Mario; Zini, Chiara; Allegritti, Massimiliano; Boatta, Emanuele; Lucatelli, Pierleone; Cannavale, Alessandro; Wlderk, Andrea; Cirelli, Carlo; Fiocca, Fausto; Salvatori, Filippo Maria; Fanelli, Fabrizio - 01a Articolo in rivista
rivista: LA RADIOLOGIA MEDICA (- Milano : Springer Verlag Italia -Turin Italy: Edizioni Minerva Medica) pp. 962-970 - issn: 0033-8362 - wos: WOS:000324341900006 (27) - scopus: 2-s2.0-84890311180 (30)

11573/558984 - 2013 - Treatment of renal angiomyolipoma: surgery versus angioembolization
Urciuoli, Paolo; D'orazi, Valerio; Livadoti, Giada; E., Foresi; Panunzi, Andrea; S., Anichini; M., Cialini; Wlderk, Andrea; C., Cirelli; M., Colangelo; Mongardini, Massimo; Custureri, Filippo - 01a Articolo in rivista
rivista: IL GIORNALE DI CHIRURGIA (CIC Edizioni Internazionali:Corso Trieste N 42, I 00198 Rome Italy:011 39 06 8412673, EMAIL: abbonamenti@gruppocic.it, INTERNET: http://www.gruppocic.it, Fax: 011 39 06 8412688) pp. 326-331 - issn: 0391-9005 - wos: (0) - scopus: 2-s2.0-84892858733 (23)

11573/932072 - 2012 - Lower limb multilevel treatment with drug-Eluting balloons: 6-Month results from the DEBELLUM randomized trial
Fanelli, Fabrizio; Cannavale, Alessandro; Boatta, Emanuele; Corona, Mario; Lucatelli, Pierleone; Wlderk, Andrea; Cirelli, Carlo; Salvatori, Filippo Maria - 01a Articolo in rivista
rivista: JOURNAL OF ENDOVASCULAR THERAPY (Alliance Communication Group:810 East 10th Street:Lawrence, KS 66044:(800)627-0629, (785)843-1235, EMAIL: orders@allenpress.com, Fax: (785)843-1274) pp. 571-580 - issn: 1526-6028 - wos: WOS:000309639900001 (103) - scopus: 2-s2.0-84868381885 (122)

11573/932643 - 2012 - Percutaneous endoarterectomy: Unusual complication during thoracic endovascular repair
Fanelli, Fabrizio; Lucatelli, Pierleone; Allegritti, Massimiliano; Cannavale, Alessandro; Wlderk, Andrea; Passariello, Roberto - 01a Articolo in rivista
rivista: CLINICAL RADIOLOGY (-Oxford : Elsevier -LONDON, ENGLAND: W B SAUNDERS CO LTD -Harlow, Essex : Longman, 1960-) pp. 1124-1126 - issn: 0009-9260 - wos: WOS:000311134500013 (1) - scopus: 2-s2.0-84866982025 (1)

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