The research focuses on the activity of the Foreign Office in the Rome Police Headquarters from the end of 1938 until the liberation of Rome in June 1944. Head officer was at the time police commissioner Angelo De Fiore who was later recognised by Yad Vashem as “Righteous among the Nations”. It is interesting to know though, that he was also put on trial as a collaborator by the Assize Court of Milan to be acquitted on all charges in February 1946. Analysing the activity of the Roman Foreign Office headed by Angelo De Fiore, could help us understand if some action against the policy of persecution and deportation of the foreigners who resided in Rome was taken in response to the fascist directives first and then to the German ones. As recent historiography has rightly pointed out, Italians, and more specifically those who were in charge of the various departments of the State Amministration, actively contributed to the persecution of the Jews and yet, at the same time, many Jews, including numerous foreigners, managed to save their lives even in the hardest phases of the deportation. The aim of this work is to understand whether the Foreign Office in the Rome Police Headquarters played a key role in the rescue operations or, on the contrary, De Fiore and his action should be framed within that “grey area” to which many citizens as well as important figures in the State administration belonged.