ANDREA FABBRINI

Dottore di ricerca

ciclo: XXXV

Titolo della tesi: Investigating cortical network dynamics in Parkinson’s disease and Dementia with Lewy Bodies using TMS-EEG

Motor impairment in Parkinson’s disease (PD) reflects changes in the basal ganglia-thalamocortical circuit converging on the primary motor cortex (M1) and supplementary motor area (SMA). Visual hallucinations (VHs) are a core feature of Dementia with Lewy Bodies (DLB), Parkinson’s disease with (PDD) and without dementia (PD) and emerge due to dysfunction of specific cortical attentional networks. The aim of the thesis was to unveil motor cortical network changes in PD and attentional network dysfunction in PD and DLB patients with VH using transcranial magnetic stimulation techniques coupled with electroencephalographic recordings (TMS-EEG). Patients with PD showed reduced M1 and increased pre-SMA excitability, as measured with transcranial evoked potentials (TEPs). On the other hand, PD and DLB patients with VH showed decreased TMS-evoked cortical activation within the dorsal attentional network (DAN) compared to patients without hallucinations. These studies further strengthen the concept that TMS-EEG techniques can provide important insights on the pathophysiology of motor impairment and visual hallucinations in patients with PD and DLB.

Produzione scientifica

11573/1689138 - 2023 - Distal Upper Limb Tremor during Walking in Parkinson's Disease

Costanzo, Matteo; Cutrona, Carolina; Leodori, Giorgio; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Vivacqua, Giorgio; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo; Belvisi, Daniele - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 1198-1202 - issn: 2330-1619 - wos: WOS:001011839600001 (0) - scopus: 2-s2.0-85162654689 (0)

11573/1700202 - 2023 - Effective connectivity abnormalities in Lewy body disease with visual hallucinations

Leodori, Giorgio; Fabbrini, Andrea; Suppa, Antonio; Mancuso, Marco; Tikoo, Sankalp; Belvisi, Daniele; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 156-165 - issn: 1388-2457 - wos: WOS:001111952700001 (0) - scopus: 2-s2.0-85176578597 (0)

11573/1700208 - 2023 - Postural Instability and Risk of Falls in Patients with Parkinson's Disease Treated with Deep Brain Stimulation: A Stabilometric Platform Study

Leodori, Giorgio; Santilli, Marco; Modugno, Nicola; D'avino, Michele; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Rocchi, Lorenzo; Conte, Antonella; Fabbrini, Giovanni; Belvisi, Daniele - 01a Articolo in rivista

rivista: BRAIN SCIENCES (Basel : Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: WOS:001119212300001 (0) - scopus: 2-s2.0-85172202483 (1)

11573/1677362 - 2023 - Parkinsonism Is Associated with Altered SMA-Basal Ganglia Structural and Functional Connectivity in Frontotemporal Degeneration

Piervincenzi, Claudia; Suppa, Antonio; Petsas, Nikolaos; Fabbrini, Andrea; Trebbastoni, Alessandro; Asci, Francesco; Giannì, Costanza; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista

rivista: BIOMEDICINES (Basel : MDPI) pp. 522- - issn: 2227-9059 - wos: WOS:000938415800001 (0) - scopus: 2-s2.0-85148910023 (0)

11573/1705665 - 2023 - White and gray matter alterations in de novo PD patients: which matter most?

Pietracupa, Sara; Belvisi, Daniele; Piervincenzi, Claudia; Tommasin, Silvia; Pasqua, Gabriele; Petsas, Nikolaos; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Costanzo, Matteo; Manzo, Nicoletta; Berardelli, Alfredo; Pantano, Patrizia - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY () pp. - - issn: 1432-1459 - wos: WOS:000932870700002 (2) - scopus: 2-s2.0-85147744127 (2)

11573/1642015 - 2022 - Relationship between risk and protective factors and clinical features of Parkinson's disease

Belvisi, D.; Pellicciari, R.; Fabbrini, A.; Costanzo, M.; Ressa, G.; Pietracupa, S.; De Lucia, M.; Modugno, N.; Magrinelli, F.; Dallocchio, C.; Ercoli, T.; Nicoletti, A.; Zappia, M.; Solla, P.; Bologna, M.; Fabbrini, G.; Tinazzi, M.; Conte, A.; Berardelli, A.; Defazio, G. - 01d Recensione

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 80-85 - issn: 1353-8020 - wos: WOS:001012146300006 (8) - scopus: 2-s2.0-85129610188 (9)

11573/1612976 - 2022 - Visual hallucinations in Lewy body disease: pathophysiological insights from phenomenology

D'antonio, F.; Boccia, M.; Di Vita, A.; Suppa, A.; Fabbrini, A.; Canevelli, M.; Caramia, F.; Fiorelli, M.; Guariglia, C.; Ferracuti, S.; De Lena, C.; Aarsland, D.; Ffytche, D. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000749743500002 (6) - scopus: 2-s2.0-85123943517 (7)

11573/1660141 - 2022 - A combined panel of salivary biomarkers in de novo Parkinson's Disease

De Bartolo, Maria Ilenia; Vivacqua, Giorgio; Belvisi, Daniele; Mancinelli, Romina; Fabbrini, Andrea; Manzo, Nicoletta; Costanzo, Matteo; Leodori, Giorgio; Conte, Antonella; Fabbrini, Giovanni; Morini, Sergio; Berardelli, Alfredo; Md, - 01a Articolo in rivista

rivista: ANNALS OF NEUROLOGY ([Boston] : American Neurological Association, c1977-) pp. - - issn: 1531-8249 - wos: WOS:000906409600001 (10) - scopus: 2-s2.0-85145367515 (14)

11573/1631592 - 2022 - Transcranial alternating current stimulation modulates cortical processing of somatosensory information in a frequency- and time-specific manner

Fabbrini, A.; Guerra, A.; Giangrosso, M.; Manzo, N.; Leodori, G.; Pasqualetti, P.; Conte, A.; Di Lazzaro, V.; Berardelli, A. - 01a Articolo in rivista

rivista: NEUROIMAGE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 119119- - issn: 1053-8119 - wos: WOS:000806921500006 (5) - scopus: 2-s2.0-85127472722 (7)

11573/1660642 - 2022 - The Role of the Motor Cortex in Tremor Suppression in Parkinson's Disease

Leodori, Giorgio; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Costanzo, Matteo; Mancuso, Marco; Belvisi, Daniele; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: JOURNAL OF PARKINSON'S DISEASE (Amsterdam : b IOS Press) pp. 1957-1963 - issn: 1877-7171 - wos: WOS:000852648500016 (2) - scopus: 2-s2.0-85137170562 (3)

11573/1601298 - 2022 - Motor Cortical Network Excitability in Parkinson's Disease

Leodori, Giorgio; De Bartolo, Maria Ilenia; Guerra, Andrea; Fabbrini, Andrea; Rocchi, Lorenzo; Latorre, Anna; Paparella, Giulia; Belvisi, Daniele; Conte, Antonella; Bhatia, Kailash P.; Rothwell, John C.; Berardelli, Alfredo - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS (-WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 0885-3185 - wos: WOS:000740642500001 (17) - scopus: 2-s2.0-85122683781 (17)

11573/1617760 - 2021 - The role of frailty in Parkinson’s disease: a cross-sectional study

Belvisi, D.; Canevelli, M.; Costanzo, M.; Giangrosso, M.; Fabbrini, A.; Borraccino, A.; Bruno, G.; Berardelli, A.; Fabbrini, G. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000719696700002 (7) - scopus: 2-s2.0-85119171932 (7)

11573/1555338 - 2021 - Pathophysiological mechanisms and experimental pharmacotherapy for L-Dopa-induced dyskinesia

Fabbrini, A.; Guerra, A. - 01g Articolo di rassegna (Review)

rivista: JOURNAL OF EXPERIMENTAL PHARMACOLOGY ([Auckland, N.Z.] : Dove Medical Press, c2009-) pp. 469-485 - issn: 1179-1454 - wos: (0) - scopus: 2-s2.0-85105655655 (21)

11573/1555359 - 2021 - Salivary caffeine in Parkinson’s disease

Leodori, G.; De Bartolo, M. I.; Belvisi, D.; Ciogli, A.; Fabbrini, A.; Costanzo, M.; Manetto, S.; Conte, A.; Villani, C.; Fabbrini, G.; Berardelli, A. - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 9823- - issn: 2045-2322 - wos: WOS:000658740400009 (7) - scopus: 2-s2.0-85105556727 (9)

11573/1579386 - 2021 - Cortical mechanisms underlying variability in intermittent theta-burst stimulation-induced plasticity: A TMS-EEG study

Leodori, G.; Fabbrini, A.; De Bartolo, M. I.; Costanzo, M.; Asci, F.; Palma, V.; Belvisi, D.; Conte, A.; Berardelli, A. - 01a Articolo in rivista

rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 2519-2531 - issn: 1388-2457 - wos: WOS:000704914800024 (9) - scopus: 2-s2.0-85113362527 (12)

11573/1449313 - 2020 - The Pathophysiological Correlates of Parkinson's Disease Clinical Subtypes

Belvisi, D.; Fabbrini, A.; De Bartolo, M. I.; Costanzo, M.; Manzo, N.; Fabbrini, G.; Defazio, G.; Conte, A.; Berardelli, A. - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS (-WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 0885-3185 - wos: WOS:000578436500001 (18) - scopus: 2-s2.0-85092267171 (22)

11573/1449311 - 2020 - Risk factors of Parkinson’s disease: Simultaneous assessment, interactions and etiological subtypes

Belvisi, Daniele; Pellicciari, Roberta; Fabbrini, Andrea; Costanzo, Matteo; Pietracupa, Sara; Maria, De Lucia; Modugno, Nicola; Magrinelli, Francesca; Dallocchio, Carlo; Ercoli, Tommaso; Terravecchia, Claudio; Nicoletti, Alessandra; Solla, Paolo; Fabbrini, Giovanni; Tinazzi, Michele; Berardelli, Alfredo; Defazio, Giovanni - 01a Articolo in rivista

rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. 10.1212/WNL.0000000000010813- - issn: 0028-3878 - wos: WOS:000587818100015 (34) - scopus: 2-s2.0-85095461540 (39)

11573/1450279 - 2020 - Tools to assess the quality of life in patients with Parkinson’s disease. A systematic review

Berardi, Anna; Regoli, Erik; Tofani, Marco; Valente, Donatella; Fabbrini, Giovanni; Fabbrini, Andrea; Ruggieri, Marcello; Panuccio, Francescaroberta; Galeoto, Giovanni - 01g Articolo di rassegna (Review)

rivista: EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH (-London : Expert Reviews Ltd, -London : Future Drugs, 2001-) pp. - - issn: 1473-7167 - wos: WOS:000585450500001 (29) - scopus: 2-s2.0-85095765301 (35)

11573/1472678 - 2020 - Functional alterations in visual networks underlie differences in the phenomenology of visual hallucinations in Lewy body disease

D'antonio, Fabrizia; Boccia, Maddalena; Di Vita, Antonella; Canevelli, Marco; Fabbrini, Andrea; Leodori, Giorgio; Caramia, Francesca; Ferracuti, Stefano; Guariglia, Cecilia; De Lena, Carlo; Aarsland, Dag; H. Ffytche., Dominic - 04c Atto di convegno in rivista

rivista: ALZHEIMER'S & DEMENTIA (New York : Elsevier, c2005-) pp. - - issn: 1552-5260 - wos: (0) - scopus: (0)

congresso: Alzheimer's Association International Conference (virtual event)

11573/1388981 - 2020 - Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex

Leodori, G.; Belvisi, D.; De Bartolo, M. I.; Fabbrini, A.; Costanzo, M.; Vial, F.; Conte, A.; Hallett, M.; Berardelli, A. - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS (-WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 0885-3185 - wos: WOS:000541254900017 (23) - scopus: 2-s2.0-85081717317 (25)

11573/1397512 - 2020 - Altered speech-related cortical network in frontotemporal dementia

Suppa, A.; Fabbrini, A.; Guerra, A.; Petsas, N.; Asci, F.; Di Stasio, F.; Trebbastoni, A.; Vasselli, F.; De Lena, C.; Pantano, P.; Berardelli, A. - 01a Articolo in rivista

rivista: BRAIN STIMULATION (Amsterdam, Oxford : Elsevier, 2008-) pp. 765-773 - issn: 1935-861X - wos: WOS:000531560100012 (7) - scopus: 2-s2.0-85080147509 (7)

11573/1450448 - 2020 - Efficacy of occupational therapy interventions on quality of life in patients with Parkinson's disease. A systematic review and meta‐analysis

Tofani, Marco; Ranieri, Alessandro; Fabbrini, Giovanni; Berardi, Anna; Pelosin, Elisa; Valente, Donatella; Fabbrini, Andrea; Costanzo, Matteo; Galeoto, Giovanni - 01g Articolo di rassegna (Review)

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 891-901 - issn: 2330-1619 - wos: WOS:000574213400001 (9) - scopus: 2-s2.0-85091757484 (11)

11573/1348567 - 2019 - Treatment of psychiatric disturbances in hypokinetic movement disorders

Berardelli, I.; Belvisi, D.; Pasquini, M.; Fabbrini, A.; Petrini, Federica; Fabbrini, G. - 01a Articolo in rivista

rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. 965-981 - issn: 1473-7175 - wos: WOS:000474108300001 (9) - scopus: 2-s2.0-85072746883 (9)

11573/1279094 - 2019 - Parkinson's disease among migrants in Europe: estimating the magnitude of an emerging phenomenon

Canevelli, M; Bruno, G; Valletta, M; Fabbrini, A; Vanacore, N; Berardelli, A; Fabbrini, G. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 1120-1126 - issn: 0340-5354 - wos: WOS:000464833000009 (3) - scopus: 2-s2.0-85061578255 (2)

11573/1409183 - 2019 - Progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration

Fabbrini, G.; Fabbrini, A.; Suppa, A. - 02a Capitolo o Articolo

libro: Handbook of Clinical Neurology - (9780444640123)

11573/1277202 - 2019 - Writing, reading, and speaking in blepharospasm

Ferrazzano, Gina; Conte, Antonella; Belvisi, Daniele; Fabbrini, Andrea; Baione, Viola; Berardelli, Alfredo; Fabbrini, Giovanni - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 1136-1140 - issn: 0340-5354 - wos: WOS:000464833000011 (6) - scopus: 2-s2.0-85061738098 (6)

11573/1254380 - 2019 - Salivary alpha-synuclein in the diagnosis of parkinson's disease and progressive supranuclear palsy

Vivacqua, Giorgio; Suppa, Antonio; Mancinelli, Romina; Belvisi, Daniele; Fabbrini, Andrea; Costanzo, Matteo; Formica, Alessandra; Onori, Paolo; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 143-148 - issn: 1353-8020 - wos: WOS:000482247500023 (49) - scopus: 2-s2.0-85061641627 (58)

11573/1205392 - 2018 - Neuropsychiatric disturbances in atypical Parkinsonian disorders

Belvisi, Daniele; Berardelli, Isabella; Suppa, Antonio; Fabbrini, Andrea; Pasquini, Massimo; Pompili, Maurizio; Fabbrini, Giovanni - 01a Articolo in rivista

rivista: NEUROPSYCHIATRIC DISEASE AND TREATMENT (Auckland, N.Z. : Dove Medical Press, c2005-c2008.) pp. 2643-2656 - issn: 1176-6328 - wos: WOS:000446657200002 (22) - scopus: 2-s2.0-85057533396 (23)

11573/1137731 - 2018 - Parkinsonism is associated with altered primary motor cortex plasticity in frontotemporal dementia–primary progressive aphasia variant

Di Stasio, Flavio; Suppa, Antonio; Fabbrini, Andrea; Marsili, Luca; Asci, Francesco; Conte, Antonella; Trebbastoni, Alessandro; De Lena, Carlo; Berardelli, Alfredo - 01a Articolo in rivista

rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 230-238 - issn: 0197-4580 - wos: WOS:000439651000024 (12) - scopus: 2-s2.0-85048434371 (14)

11573/1166967 - 2018 - Quality of life in Parkinson’s disease: Italian validation of the Parkinson’s Disease Questionnaire (PDQ-39-IT)

Galeoto, Giovanni; Colalelli, Francesca; Massai, Perla; Berardi, Anna; Tofani, Marco; Pierantozzi, Mariangela; Servadio, Annamaria; Fabbrini, Andrea; Fabbrini, Giovanni - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000448510000011 (29) - scopus: 2-s2.0-85051742750 (39)

11573/1166961 - 2018 - Reliability and validity of the geriatric depression scale in Italian subjects with Parkinson's disease

Massai, Perla; Colalelli, Francesca; Sansoni, Julita; Valente, Donatella; Tofani, Marco; Fabbrini, Giovanni; Fabbrini, Andrea; Scuccimarri, Michela; Galeoto, Giovanni - 01a Articolo in rivista

rivista: PARKINSON'S DISEASE (London : Sage-Hindawi Access to Research) pp. 1-6 - issn: 2042-0080 - wos: WOS:000441608000001 (28) - scopus: 2-s2.0-85051597310 (36)

11573/1455798 - 2016 - Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia

Bologna, Matteo; Paparella, Giulia; Fabbrini, Andrea; Leodori, Giorgio; Rocchi, Lorenzo; Hallett, Mark; Berardelli, Alfredo - 01a Articolo in rivista

rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 3472-3479 - issn: 1388-2457 - wos: WOS:000389510200009 (42) - scopus: 2-s2.0-84990062978 (47)

11573/780846 - 2015 - Spread of muscle spasms in hemifacial spasm

Conte, Antonella; Falla, Marika; Maria Concetta Diana, ; Bologna, Matteo; Suppa, Antonio; Fabbrini, Andrea; Colosimo, Carlo; Berardelli, Alfredo; Fabbrini, Giovanni - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 53-55 - issn: 2330-1619 - wos: WOS:000218634300014 (4) - scopus: 2-s2.0-84989181513 (5)