ALINA CATALINA PALCAU

Dottoressa di ricerca

ciclo: XXXVI

supervisore: Giovanni Blandino
relatore: Irene Bozzoni

Titolo della tesi: CircPVT1 as non-coding mediator of breast cancer metabolism

The role of circular RNAs in cancer has started to be deeply investigated in order to identify new molecular targets for future personalized anti tumoral therapies. Here, we investigated the pivotal role of a peculiar circRNA called circPVT1 demonstrating for the first time that it is able to act as miRNA sponge for the well-known metabolic miRNA, miR-33a-5p leading to the upregulation of its targets among them c-Myc, located in the same locus of PVT1 gene. Previous studies showed that c-Myc could regulate indirectly through miRNAs expression Glutaminase, the first enzyme involved in glutaminolysis, the metabolic pathway deregulated in breast cancer. Notably, we demonstrated for the first time that c-Myc acts as transcriptional factor directly regulating Glutaminase expression. These data provide new insights about the role of non-coding RNAs as upstream regulators of cell metabolism which contributes to cancer onset and progression.

Produzione scientifica

11573/1689220 - 2023 - The new world of RNA diagnostics and therapeutics

Blandino, Giovanni; Dinami, Roberto; Marcia, Marco; Anastasiadou, Eleni; Ryan, Brid M.; Palcau, Alina Catalina; Fattore, Luigi; Regazzo, Giulia; Sestito, Rosanna; Loria, Rossella; Belén Díaz Méndez, Ana; Cappelletto, Maria Chiara; Pulito, Claudio; Monteonofrio, Laura; Calin, George A.; Sozzi, Gabriella; Kong Cheong, Jit; Aharonov, Ranit; Gennaro Ciliberto, And - 01a Articolo in rivista

rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:001040515200001 (0) - scopus: 2-s2.0-85165951933 (0)

11573/1685493 - 2023 - Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids

Cioce, M; Fumagalli, Mr; Donzelli, S; Goeman, F; Canu, V; Rutigliano, D; Orlandi, G; Sacconi, A; Pulito, C; Palcau, Ac; Fanciulli, M; Morrone, A; Diodoro, Mg; Caricato, M; Crescenzi, A; Verri, M; Fazio, Vm; Zapperi, S; Levrero, M; Strano, S; Grazi, Gl; La Porta, C; Blandino, G. - 01a Articolo in rivista

rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:001028780900001 (1) - scopus: 2-s2.0-85165009717 (1)

11573/1689219 - 2023 - Exploiting Long Non-Coding RNAs and Circular RNAs as Pharmacological Targets in Triple-Negative Breast Cancer Treatment

Palcau, Alina Catalina; Brandi, Renata; Hristov Mehterov, Nikolay; Botti, Claudio; Blandino, Giovanni; Pulito, Claudio - 01g Articolo di rassegna (Review)

rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:001057141100001 (0) - scopus: 2-s2.0-85168807846 (0)

11573/1662477 - 2022 - Biomarkers of response and resistance to CDK4/6 inhibitors in breast cancer: hints from liquid biopsy and microRNA exploration

Krasniqi, Eriseld; Goeman, Frauke; Pulito, Claudio; Palcau, Alina Catalina; Ciuffreda, Ludovica; Di Lisa, Francesca Sofia; Filomeno, Lorena; Barba, Maddalena; Pizzuti, Laura; Cappuzzo, Federico; Sanguineti, Giuseppe; Maugeri-Saccà, Marcello; Ciliberto, Gennaro; Fanciulli, Maurizio; Blandino, Giovanni; Vici, Patrizia - 01g Articolo di rassegna (Review)

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000897319500001 (2) - scopus: 2-s2.0-85143710014 (3)

11573/1616587 - 2022 - CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

Palcau, A. C.; Canu, V.; Donzelli, S.; Strano, S.; Pulito, C.; Blandino, G. - 01g Articolo di rassegna (Review)

rivista: MOLECULAR CANCER (London : BioMed Central.) pp. 33- - issn: 1476-4598 - wos: WOS:000749200200001 (21) - scopus: 2-s2.0-85123797175 (23)