ALESSIO CIRILLO

Dottore di ricerca

ciclo: XXXVI


supervisore: Prof. Andrea Botticelli

Titolo della tesi: COMPREHENSIVE PROFILE IN HEAD AND NECK CANCER PATIENTS TREATED WITH IMMUNOTHERAPY

Background Immunotherapy has a crucial role in the treatment of recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a small percentage of patients achieve long-term benefit in terms of overall response and survival. It was shown that HNSCC has an immunosuppressive microenvironment due to high levels of regulatory T cells and immunosuppressive molecules, such as LAG3 and CD73. The aim of our study was to investigate if the expression of CD73 by neoplastic and immune cells could affect the efficacy of anti-PD-1 immunotherapy and we evaluated the role of circulating CD137+ T cells in (R/M) HNSCC patients undergoing pembrolizumab treatment. Methods We reviewed data from 50 patients with R/M HNSCC receiving first line immunotherapy with or without chemotherapy based on a combined positive score (CPS). CD73 expression by cancer and immune cells was evaluated on pre-treatment and the percentage of stained cells was recorded. We analysed the association between CD73 expression on neoplastic and immune cells and early progression (EP), defined as progression occurring within 3 months. PBMCs obtained from 40 (R/M) HNSCC patients with a PD-L1 combined positive score (CPS) ≥1 were analysed at baseline via cytofluorimetry for the expression of CD137, and it was found that the percentage of CD3+CD137+ cells is correlated with the clinical benefit rate (CBR), PFS, and OS. Results In 88% of patients the primary tumour site was in the oral cavity or larynx. All patients received pembrolizumab associated in 40% of cases to chemotherapy. CD73 was positive in 82% and 96% of cases on neoplastic and immune cells, respectively. The median value of CD73 was 32% for neoplastic cells and 10% for the immune ones. We observed a significant association between CD73 expression over the median value and EP disease. We didn’t record a correlation between the expression of CD73 on immune cells and early progression. The results show that levels of circulating CD137+ T cells are significantly higher in responder patients than in non-responders (p = 0.03). Moreover, patients with CD3+CD137+ percentage ≥1.65% had prolonged OS (p = 0.02) and PFS (p = 0.02). Multivariate analysis, on a combination of biological and clinical parameters, showed that high levels of CD3+CD137+ cells (≥1.65%) and performance status (PS) = 0 are independent prognostic factors of PFS (CD137+ T cells, p = 0.007; PS, p = 0.002) and OS (CD137+ T cells, p = 0.006; PS, p = 0.001). Conclusions Our findings suggest that higher expression of CD73 on neoplastic cells could predict resistance to immunotherapy in patients with CPS positive R/M HNSCC. The addition of this biomarker to routine evaluation of CPS could help to select the patients primary resistant to anti-PD-1 immunotherapy. Furthermore our results suggest that levels of circulating CD137+ T cells could serve as biomarkers for predicting the response of (R/M) HNSCC patients to pembrolizumab treatment, thus contributing to the success of anti-cancer treatment.

Produzione scientifica

11573/1724839 - 2024 - Novel circulating biomarkers in HNSCC patients receiving anti-PD1 therapy: the predictive and prognostic role of immunosuppressive CD137+Treg cells and Lox-1+PMN-MDSCs
Asquino, A.; Cirillo, A.; Strigari, L.; Pace, A.; Napoletano, C.; Tuosto, L.; Valentino, F.; Santini, D.; Nuti, M.; Botticelli, A.; Rughetti, A.; Zizzari, I. G. - 04f Poster
congresso: SIPMeT 2024 Translational Pathophysiology (Udine)
libro: SIPMeT 2024 Translational Pathophysiology - ()

11573/1730486 - 2024 - Soluble immune biomarkers to predict clinical outcome in head and neck patients treated with immunotherapy
Asquino, Angela; Cirillo, Alessio; Strigari, Lidia; Pace, Angelica; Napoletano, Chiara; Tuosto, Lucrezia; Valentino, Flavio; Santini, Daniele; Nuti, Marianna; Botticelli, Andrea; Rughetti, Aurelia; Zizzari, Ilaria Grazia - 04f Poster
congresso: 36th AICC INTERNATIONAL MEETING (Roma)
libro: 36th AICC INTERNATIONAL MEETING - ()

11573/1717732 - 2024 - Circulating immunosuppression correlates with worse clinical outcome in head and neck cancer patients undergoing immunotherapy treatment
Asquino, Angela; Pace, Angelica; Cirillo, Alessio; Strigari, Lidia; Napoletano, Chiara; Scirocchi, Fabio; Nuti, Marianna; Santini, Daniele; Botticelli, Andrea; Rughetti, Aurelia; Zizzari, Ilaria Grazia - 04f Poster
congresso: 6th SIICA International Conference of Translational Immunology (Monopoli)
libro: 6th SIICA International Conference of Translational Immunology - ()

11573/1730124 - 2024 - Study of Circulating MicroRNAs as biomarkers for guided Immunotherapy in Head and Neck carcinoma patients: A tool for personalized medicine
Autilio, Tanja Milena; Cirillo, Alessio; Besharat, Zein Mersini; Trocchianesi, Sofia; Citarella, Anna; Brunetti, Martina; Santini, Daniele; Botticelli, Andrea; Ferretti, Elisabetta - 04f Poster
congresso: 36th AICC INTERNATIONAL MEETING – HIJACKING THE «GOOD» PATHWAYS (Roma)
libro: 36th AICC INTERNATIONAL MEETING – HIJACKING THE «GOOD» PATHWAYS - ()

11573/1715913 - 2024 - The role of CD73 in predicting the response to immunotherapy in head and neck cancer patients
Botticelli, Andrea; Cirillo, Alessio; D'amati, Giulia; Di Gioia, Cira; Corsi, Alessandro; Della Rocca, Carlo; Santini, Daniele; Carletti, Raffaella; Pisano, Annalinda; Polimeni, Antonella; De Vincentiis, Marco; Valentini, Valentino; Di Cristofano, Claudio; Romeo, Umberto; Cerbelli, Edoardo; Messineo, Daniela; De Felice, Francesca; Leopizzi, Martina; Cerbelli, Bruna - 01a Articolo in rivista
rivista: PATHOLOGY RESEARCH AND PRACTICE (Urban & Fischer Verlag Jena:Postfach 100537, D-07705 Jena Germany:011 49 3641 626430, EMAIL: journals@urbanfischer.de, INTERNET: http://www.urbanfischer.de, Fax: 011 49 3641 626500) pp. 155415-155420 - issn: 0344-0338 - wos: WOS:001267291100001 (0) - scopus: 2-s2.0-85197784231 (0)

11573/1703913 - 2024 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
Cerbelli, Bruna; Cirillo, Alessio; Pomati, Giulia; Pernazza, Angelina; Ascione, Andrea; Pisegna, Simona; Pisano, Annalinda; Leopizzi, Martina; Pignataro, Maria Gemma; Costarelli, Leopoldo; Mulè, Antonino; Vecchione, Andrea; Catalano, Piera; Coppola, Luigi; Perrone, Giuseppe; Perracchio, Letizia; Anemona, Lucia; Mastracchio, Antonio; Nardi, Stefano; Reitano, Renato; Massari, Annalisa; Grillo, Lucia Rosalba; Liberati, Fabrizio; Della Rocca, Carlo; Marchetti, Paolo; Botticelli, Andrea; D’Amati, Giulia - 01a Articolo in rivista
rivista: TUMORI (-Roma: Il Pensiero Scientifico Editore srl -Milano: Istituto nazionale per to studio e la cura dei tumori -Milan Italy: Casa Editrice Ambrosiana) pp. 44-48 - issn: 0300-8916 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1708991 - 2024 - Pembrolizumab-based first-line treatment for PD-L1-positive, recurrent or metastatic head and neck squamous cell carcinoma: a retrospective analysis
Cirillo, Alessio; Marinelli, Daniele; Romeo, Umberto; Messineo, Daniela; De Felice, Francesca; De Vincentiis, Marco; Valentini, Valentino; Mezi, Silvia; Valentini, Filippo; Vivona, Luca; Chiavassa, Antonella; Cerbelli, Bruna; Santini, Daniele; Bossi, Paolo; Polimeni, Antonella; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista
rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 1-9 - issn: 1471-2407 - wos: WOS:001199827900009 (0) - scopus: 2-s2.0-85189606694 (1)

11573/1719044 - 2024 - Correction: Pembrolizumab-based first-line treatment for PD-L1-positive, recurrent or metastatic head and neck squamous cell carcinoma: a retrospective analysis
Cirillo, Alessio; Marinelli, Daniele; Romeo, Umberto; Messineo, Daniela; De Felice, Francesca; De Vincentiis, Marco; Valentini, Valentino; Mezi, Silvia; Valentini, Filippo; Vivona, Luca; Chiavassa, Antonella; Cerbelli, Bruna; Santini, Daniele; Bossi, Paolo; Polimeni, Antonella; Marchetti, Paolo; Botticelli, Andrea - 01b Commento, Erratum, Replica e simili
rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 1-2 - issn: 1471-2407 - wos: WOS:001205163800007 (0) - scopus: 2-s2.0-85190544415 (0)

11573/1728593 - 2024 - Exploring Genomic Biomarkers for Pembrolizumab Response: A Real-World Approach and Patient Similarity Network Analysis Reveal DNA Response and Repair Gene Mutations as a Signature
Filetti, Marco; Occhipinti, Mario; Cirillo, Alessio; Scirocchi, Fabio; Ugolini, Alessio; Giusti, Raffaele; Lombardi, Pasquale; Daniele, Gennaro; Botticelli, Andrea; Lo Russo, Giuseppe; De Braud, Filippo; Marchetti, Paolo; Nuti, Marianna; Ferretti, Elisabetta; Farina, Lorenzo; Rughetti, Aurelia; Petti, Manuela - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:001376127300001 (0) - scopus: 2-s2.0-85211906149 (0)

11573/1722094 - 2024 - Clinical impact of drug-drug interactions on abemaciclib in the real-world experience of AB-ITALY study
Scagnoli, Simone; Pisegna, Simona; Toss, Angela; Caputo, Roberta; De Laurentiis, Michelino; Palleschi, Michela; De Giorgi, Ugo; Cortesi, Enrico; Fabbri, Agnese; Fabi, Alessandra; Paris, Ida; Orlandi, Armando; Curigliano, Giuseppe; Criscitiello, Carmen; Garrone, Ornella; Tomasello, Gianluca; D'auria, Giuliana; Vici, Patrizia; Ricevuto, Enrico; Domati, Federica; Piombino, Claudia; Parola, Sara; Scafetta, Roberta; Cirillo, Alessio; Taurelli Salimbeni, Beatrice; Di Lisa, Francesca Sofia; Strigari, Lidia; Preissner, Robert; Simmaco, Maurizio; Santini, Daniele; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista
rivista: NPJ BREAST CANCER (New York, NY : Breast Cancer Research Foundation : Nature Publishing Group, [2015]-) pp. - - issn: 2374-4677 - wos: WOS:001271964000001 (3) - scopus: 2-s2.0-85198841780 (2)

11573/1674348 - 2023 - Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cortesi, Enrico; Rossi, Ernesto; Schinzari, Giovanni; Tortora, Giampaolo; Tomao, Silverio; Fiscon, Giulia; Farina, Lorenzo; Scagnoli, Simone; Pisegna, Simona; Ciurluini, Fabio; Chiavassa, Antonella; Amirhassankhani, Sasan; Ceccarelli, Fulvia; Conti, Fabrizio; Di Filippo, Alessandra; Zizzari, Ilaria Grazia; Napoletano, Chiara; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: CANCER IMMUNOLOGY, IMMUNOTHERAPY (Heidelberg; Berlin: Springer) pp. - - issn: 1432-0851 - wos: WOS:000943090400001 (3) - scopus: 2-s2.0-85149261068 (3)

11573/1698315 - 2023 - Rheumatic Diseases Development in Patients Treated by Anti-PD1 Immune Checkpoint Inhibitors: A Single-Centre Descriptive Study
Ceccarelli, Fulvia; Natalucci, Francesco; Picciariello, Licia; Olivieri, Giulio; Cirillo, Alessio; Gelibter, Alain; Picone, Vincenzo; Botticelli, Andrea; Conti, Fabrizio - 01a Articolo in rivista
rivista: LIFE (Basel: MDPI) pp. - - issn: 2075-1729 - wos: WOS:000977559100001 (6) - scopus: 2-s2.0-85154594030 (6)

11573/1693735 - 2023 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
Cerbelli, Bruna; Cirillo, Alessio; Pomati, Giulia; Pernazza, Angelina; Ascione, Andrea; Pisegna, Simona; Pisano, Annalinda; Leopizzi, Martina; Pignataro, Maria Gemma; Costarelli, Leopoldo; Mulè, Antonino; Vecchione, Andrea; Catalano, Piera; Coppola, Luigi; Perrone, Giuseppe; Perracchio, Letizia; Anemona, Lucia; Mastracchio, Antonio; Nardi, Stefano; Reitano, Renato; Massari, Annalisa; Grillo, Lucia Rosalba; Liberati, Fabrizio; Della Rocca, Carlo; Marchetti, Paolo; Botticelli, Andrea; D'amati, Giulia - 01a Articolo in rivista
rivista: TUMORI (Roma : Il Pensiero Scientifico Editore) pp. 3008916231196781- - issn: 2038-2529 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1683371 - 2023 - Circulating CD137+ T cell levels are correlated with response to Pembrolizumab treatment in advanced head and neck cancer patients
Cirillo, Alessio; Zizzari, Ilaria Grazia; Botticelli, Andrea; Strigari, Lidia; Asquino, Angela; Rahimi Koshkaki, Hassan; Scagnoli, Simone; Scirocchi, Fabio; Pernazza, Angelina; Pace, Angelica; Cerbelli, Bruna; D'amati, Giulia; Marchetti, Paolo; Nuti, Marianna; Rughetti, Aurelia; Napoletano, Chiara - 04f Poster
congresso: 41a CONFERENZA NAZIONALE DI CITOMETRIA (Auditorium Biotecnologie - Università degli Studi di Napoli Federico II)
libro: http://www.citometriagic2023.it/ - ()

11573/1677631 - 2023 - Circulating CD137+ T cell levels are correlated with response to pembrolizumab treatment in advanced head and neck cancer patients
Cirillo, Alessio; Zizzari, Ilaria Grazia; Botticelli, Andrea; Strigari, Lidia; Rahimi Koshkaki, Hassan; Scagnoli, Simone; Scirocchi, Fabio; Pernazza, Angelina; Pace, Angelica; Cerbelli, Bruna; D'amati, Giulia; Marchetti, Paolo; Nuti, Marianna; Rughetti, Aurelia; Napoletano, Chiara - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-11 - issn: 1661-6596 - wos: WOS:000979339600001 (4) - scopus: 2-s2.0-85156135313 (3)

11573/1723335 - 2023 - Immune responses and clinical outcomes following the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in advanced breast cancer patients receiving targeted therapies: a prospective study
Nelli, Fabrizio; Fabbri, Agnese; Botticelli, Andrea; Giannarelli, Diana; Marrucci, Eleonora; Fiore, Cristina; Virtuoso, Antonella; Berrios, Julio Rodrigo Giron; Scagnoli, Simone; Pisegna, Simona; Cirillo, Alessio; Panichi, Valentina; Massari, Annalisa; Silvestri, Maria Assunta; Ruggeri, Enzo Maria - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: (0) - scopus: (0)

11573/1723602 - 2023 - Immune responses and clinical outcomes following the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in advanced breast cancer patients receiving targeted therapies: a prospective study
Nelli, Fabrizio; Fabbri, Agnese; Botticelli, Andrea; Giannarelli, Diana; Marrucci, Eleonora; Fiore, Cristina; Virtuoso, Antonella; Berrios, Julio Rodrigo Giron; Scagnoli, Simone; Pisegna, Simona; Cirillo, Alessio; Panichi, Valentina; Massari, Annalisa; Silvestri, Maria Assunta; Ruggeri, Enzo Maria - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:001104931700001 (1) - scopus: 2-s2.0-85177447843 (1)

11573/1661193 - 2022 - The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy
Botticelli, A.; Pomati, G.; Cirillo, A.; Scagnoli, S.; Pisegna, S.; Chiavassa, A.; Rossi, E.; Schinzari, G.; Tortora, G.; Di Pietro, F. R.; Cerbelli, B.; Di Filippo, A.; Amirhassankhani, S.; Scala, A.; Zizzari, I. G.; Cortesi, E.; Tomao, S.; Nuti, M.; Mezi, S.; Marchetti, P. - 01a Articolo in rivista
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000888273100001 (14) - scopus: 2-s2.0-85142215079 (14)

11573/1659852 - 2022 - Network analysis to determine association between immuno-related toxicities and immune soluble profile in patients treated with anti-PD-1
Botticelli, A; Cirillo, A; Pomati, G; Cortesi, E; Rossi, E; Schinzari, G; Tortora, G; Tomao, S; Nuti, M; Fiscon, G; Farina, L; Pisegna, S; Ciurluini, F; Chiavassa, A; Amirhassankhani, S; Di Filippo, A; Zizzari, I; Mezi, S; Marchetti, P - 04f Poster
rivista: JOURNAL OF CLINICAL ONCOLOGY (editori attuale: -American Society of Clinical Oncology. , 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, USA, VA, 22314 precedente: -W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. - - issn: 0732-183X - wos: WOS:000863680300776 (0) - scopus: (0)
congresso: 2022 ASCO Annual Meeting I (Chicago)
libro: Journal of clinical oncology - ()

11573/1645535 - 2022 - The Role of the CDK4/6 Inhibitor Ribociclib in Locally Advanced and Oligometastatic Hormone Receptor Positive, Her2 Negative, Advanced Breast Cancer: Case Series and Review of the Literature
Botticelli, A; Fabbri, A; Roberto, M; Alesini, D; Cirillo, A; D'auria, G; Krasniqi, E; Marrucci, E; Muratore, M; Pantano, F; Pizzuti, L; Portarena, I; Rossi, R; Scagnoli, S; Marchetti, P. - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. 1-8 - issn: 2234-943X - wos: WOS:000760719900001 (2) - scopus: 2-s2.0-85125136649 (1)

11573/1652660 - 2022 - Dental implant failure risk in post oncological patients, a retrospective study and Sapienza Head and Neck Unit decisional protocol- 7 years of follow-up
Brauner, Edoardo; Valentini, Valentino; Romeo, Umberto; Cantore, Marco; Laudoni, Federico; Rajabtork Zadeh, Oriana; Formisano, Valeria; Cassoni, Andrea; Della Monaca, Marco; Battisti, Andrea; Mezi, Silvia; Cirillo, Alessio; De Felice, Francesca; Botticelli, Andrea; Tombolini, Vincenzo; De Vincentiis, Marco; Colizza, Andrea; Tenore, Gianluca; Polimeni, Antonella; Di Carlo, Stefano - 01a Articolo in rivista
rivista: DIAGNOSTICS (Basel: MDPI) pp. - - issn: 2075-4418 - wos: WOS:000846070400001 (0) - scopus: 2-s2.0-85137588773 (0)

11573/1676492 - 2022 - Ideal regimen for induction chemotherapy in nasopharyngeal cancer: still a hot issue?
De Felice, Francesca; Cirillo, Alessio; Botticelli, Andrea - 01m Editorial/Introduzione in rivista
rivista: RADIOTHERAPY AND ONCOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 111-112 - issn: 0167-8140 - wos: WOS:000896787100007 (1) - scopus: 2-s2.0-85141491847 (0)

11573/1662822 - 2022 - DNA damage response and repair (DDR) gene mutations as an alternative mechanism to generate high TMB in never smoker NSCLC patients
Filetti, M; Occhipinti, M; Cirillo, A; Scirocchi, F; Ugolini, A; Petti, M; Giusti, R; Lombardi, P; Botticelli, A; Lo Russo, G; De Braud, Fgm; Marchetti, P; Nuti, M; Ferretti, E; Rughetti, A; Farina, L - 01h Abstract in rivista
rivista: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. S1047-S1047 - issn: 0923-7534 - wos: WOS:000866211601346 (0) - scopus: (0)

11573/1660536 - 2022 - Genomic and immune approach in platinum refractory HPV-negative head and neck squamous cell carcinoma patients treated with Immunotherapy: a novel combined profile
Mezi, Silvia; Pomati, Giulia; Zizzari, Ilaria Grazia; Di Filippo, Alessandra; Cerbelli, Bruna; Cirillo, Alessio; Fiscon, Giulia; Amirhassankhani, Sasan; Valentini, Valentino; De Vincentiis, Marco; Corsi, Alessandro; Di Gioia, Cira Rosaria Tiziana; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Nuti, Marianna; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel: MDPI) pp. - - issn: 2227-9059 - wos: WOS:000880889000001 (3) - scopus: 2-s2.0-85141779736 (3)

11573/1662616 - 2022 - Oral immune-related adverse events associated with PD-1 inhibitor treatment: a case series
Pergolini, Daniele; Botticelli, Andrea; Fascetti, Roberta; Rocchetti, Federica; Cirillo, Alessio; Tenore, Gianluca; Palaia, Gaspare; Polimeni, Antonella; Romeo, Umberto - 01a Articolo in rivista
rivista: APPLIED SCIENCES (Basel: MDPI AG, 2011-) pp. - - issn: 2076-3417 - wos: WOS:000900370600001 (1) - scopus: 2-s2.0-85144850361 (1)

11573/1645553 - 2022 - Renal function outcomes in metastatic non-small-cell lung carcinoma patients treated with chemotherapy or immune checkpoint inhibitors: an unexpected scenario
Trevisani, F; Di Marco, F; Floris, M; Pani, A; Minnei, R; Scartozzi, M; Cirillo, A; Gelibter, A; Botticelli, A; Rijavec, E; Cattaneo, M; Garrone, O; Ghidini, M. - 01a Articolo in rivista
rivista: VACCINES (Basel: MDPI) pp. - - issn: 2076-393X - wos: WOS:000802597600001 (6) - scopus: 2-s2.0-85129608760 (5)

11573/1566814 - 2021 - Anti–PD-1 and Anti–PD-L1 in head and neck cancer: a network meta-analysis
Botticelli, A.; Cirillo, A.; Strigari, L.; Valentini, F.; Cerbelli, B.; Scagnoli, S.; Cerbelli, E.; Zizzari, I. G.; Della Rocca, C.; D'amati, G.; Polimeni, A.; Nuti, M.; Merlano, M. C.; Mezi, S.; Marchetti, P. - 01g Articolo di rassegna (Review)
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000687848000001 (63) - scopus: 2-s2.0-85113294602 (67)

11573/1529260 - 2021 - The role of opioids in cancer response to immunotherapy
Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cerbelli, Bruna; Scagnoli, Simone; Roberto, Michela; Gelibter, Alain; Mammone, Giulia; Calandrella, Maria Letizia; Cerbelli, Edoardo; Di Pietro, Francesca Romana; De Galitiis, Federica; Lanzetta, Gaetano; Cortesi, Enrico; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: WOS:000634783000001 (27) - scopus: 2-s2.0-85103161618 (31)

11573/1562486 - 2021 - Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era
Botticelli, Andrea; Pomati, Giulia; Cirillo, Alessio; Mammone, Giulia; Ciurluini, Fabio; Cerbelli, Bruna; Sciattella, Paolo; Ralli, Massimo; Romeo, Umberto; De Felice, Francesca; Catalano, Carlo; Vullo, Francesco; Della Monaca, Marco; Amirhassankhani, Sasan; Tomao, Silverio; Valentini, Valentino; De Vincentiis, Marco; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Di Gioia, Cira; Corsi, Alessandro; D'amati, Giulia; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. - - issn: 1479-5876 - wos: WOS:000674445600002 (2) - scopus: 2-s2.0-85109717512 (2)

11573/1562092 - 2021 - The role of soluble LAG3 and soluble immune checkpoints profile in advanced head and neck cancer: a pilot study
Botticelli, Andrea; Zizzari, Ilaria Grazia; Scagnoli, Simone; Pomati, Giulia; Strigari, Lidia; Cirillo, Alessio; Cerbelli, Bruna; Di Filippo, Alessandra; Napoletano, Chiara; Scirocchi, Fabio; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF PERSONALIZED MEDICINE (Basel: MDPI AG, 2011-) pp. - - issn: 2075-4426 - wos: WOS:000677382600001 (36) - scopus: 2-s2.0-85110848603 (38)

11573/1555745 - 2021 - Immune checkpoint inhibitors and pre-existing antinuclear antibodies: the rheumatologist point of view
Ceccarelli, F.; Botticelli, A.; Natalucci, F.; Olivieri, G.; Cirillo, A.; Alessandri, C.; Marchetti, P.; Conti, F. - 01f Lettera, Nota
rivista: CLINICAL & TRANSLATIONAL ONCOLOGY () pp. 1961-1962 - issn: 1699-3055 - wos: WOS:000629521300001 (1) - scopus: 2-s2.0-85102865767 (1)

11573/1394000 - 2020 - The agnostic role of site of metastasis in predicting outcomes in cancer patients treated with immunotherapy
Botticelli, A.; Cirillo, A.; Scagnoli, S.; Cerbelli, B.; Strigari, L.; Cortellini, A.; Pizzuti, L.; Vici, P.; De Galitiis, F.; Di Pietro, F. R.; Cerbelli, E.; Ghidini, M.; D'amati, G.; Rocca, C. D.; Mezi, S.; Gelibter, A.; Giusti, R.; Cortesi, E.; Ascierto, P. A.; Nuti, M.; Marchetti, P. - 01a Articolo in rivista
rivista: VACCINES (Basel: MDPI) pp. 203- - issn: 2076-393X - wos: WOS:000550821300001 (44) - scopus: 2-s2.0-85084131135 (47)

11573/1387452 - 2020 - The impact of locoregional treatment on response to Nivolumab in advanced platinum refractory head and neck cancer: the NEED TRIAL
Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Sciattella, Paolo; Cerbelli, Bruna; Roberto, Michela; Mammone, Giulia; Cirillo, Alessio; Cassano, Alessandra; Di Dio, Carmela; Cortellini, Alessio; Pizzuti, Laura; Ronzino, Graziana; Salati, Massimiliano; Vici, Patrizia; Polimeni, Antonella; Carlo Merlano, Marco; Nuti, Marianna; Marchetti, Paolo - 01a Articolo in rivista
rivista: VACCINES (Basel: MDPI) pp. - - issn: 2076-393X - wos: WOS:000553554200001 (9) - scopus: 2-s2.0-85083830456 (10)

11573/1440797 - 2020 - Induction chemotherapy in nonlaryngeal human papilloma virus-negative high-risk head and neck cancer: a real-world experience
Mezi, Silvia; Pomati, Giulia; Botticelli, Andrea; Roberto, Michela; Cerbelli, Bruna; Cirillo, Alessio; Di Gioia, Cira; Corsi, Alessandro; Vullo, Francesco; De Vincentiis, Marco; Polimeni, Antonella; Tombolini, Vincenzo; Valentini, Valentino; Marchetti, Paolo - 01a Articolo in rivista
rivista: ANTI-CANCER DRUGS (London: Lippincott Williams & Wilkins Oxford UK: Rapid Communications of Oxford, [1990]-) pp. 1-10 - issn: 0959-4973 - wos: WOS:000580389200011 (1) - scopus: 2-s2.0-85093706069 (1)

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