ALESSIO CIRILLO

PhD Student

PhD program:: XXXVI
email: alessio.cirillo@uniroma1.it
phone: 06-4441378
building: Oncologia, Dermatologia I Piano, Sapienza-Policlinico Umberto

supervisor: Prof. Andrea Botticelli

Research: Comprehensive profile in head and neck cancer patients treated with immunotherapy

24/10/2013 Graduation in Medicine and Surgery at the University of Rome “Tor Vergata” with Experimental Degree Thesis.
Mark of the degree awarded: 110 cum laude.

November 2015 Winner of the National Competition in Medical Oncology
Medical Specializing in Medical Oncology

19.11.2020 Specialist in Medical Oncology; Score: 70 cum laude/70 Thesis: “Il ruolo predittivo delle sedi metastatiche nel predire la risposta all’immunoterapia”

2021-->2022 Coordination activities and partecipation to national Molecular Tumor Board (MTB) in Rome Trial; Management of genomical reports and clinical case discussion

CLINICAL TRIALS
Since November 2021 to nowadays I have been attending several clinical trials according to G.C.P as Sub-Investigator:

- BROADEN STUDY: Observational study aimed to evaluate the absolute percentage of head and neck neoplasms attributed to Human Papilloma Virus (HPV) classified by anatomical site, in two different bienniums (2008-2009) and (2018-2019)

- PRIME STUDY: Prospective phase II study, PARP inhibitor induction and maintenance treatment and immunotherapy in HPV-negative head and neck squamous cell carcinoma (HNSCC)

- REALKEY STUDY: Prospective cohort study in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with first-line systemic treatment.

- X RAY VISION: Phase III xevinapant and radiotherapy in resected LA SCCHN, high risk, cis-ineligible participants

RECENT PUBLICATIONS
1. The Role of Opioids in Cancer Response to Immunotherapy. Andrea Botticelli, Alessio Cirillo, Giulia Pomati, Bruna Cerbelli, Simone Scagnoli, Michela Roberto, Alain Gelibter, Giulia Mammone, Maria Letizia Calandrella, Edoardo Cerbelli, Gaetano Lanzetta, Enrico Cortesi, Sivia Mezi, Paolo Marchetti.
In: Journal of Translational Medicine, 2021 March 23. doi: 10.1186/s12967-021-02784-8.
Coprimary first author. IF 7.708

2. Anti-PD-1 and Anti-PD-L1 in Head and Neck Cancer: A Network Meta-Analysis.
Andrea Botticelli, Alessio Cirillo, Lidia Strigari, Filippo Valentini, Bruna Cerbelli, Simone Scagnoli, Edoardo Cerbelli, Ilaria Grazia Zizzari, Carlo Della Rocca, Giulia D'Amati, Antonella Polimeni, Marianna Nuti, Marco Carlo Merlano, Silvia Mezi, Paolo Marchetti.
In: Frontiers in Immunology, 2021 August 9. doi: 10.3389/fimmu.2021.705096.
Second name and Corresponding author. IF 7.561

3. Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era. Andrea Botticelli, Giulia Pomati, Alessio Cirillo, Giulia Mammone, Fabio Ciurluini, Bruna Cerbelli, Paolo Sciattella, Massimo Ralli, Umberto Romeo, Francesca De Felice, Carlo Catalano, Francesco Vullo, Marco Della Monaca, Sasan Amirhassankhani, Silverio Tomao, Valentino Valentini, Marco De Vincentiis, Vincenzo Tombolini, Carlo Della Rocca, Antonella Polimeni, Cira di Gioia, Alessandro Corsi, Giulia D'Amati, Silvia Mezi, Paolo Marchetti.
In: Journal of Translational Medicine. 2021 July 12. doi: 10.1186/s12967-021-02975-3.
Corresponding author. IF 7.708

4. The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy. Andrea Botticelli, Giulia Pomati, Alessio Cirillo, Simone Scagnoli, Simona Pisegna, Antonella Chiavassa, Ernesto Rossi, Giovanni Schinzari, Giampaolo Tortora, Francesca Romana Di Pietro, Bruna Cerbelli, Alessandra Di Filippo, Sasan Amirhassankhani, Alessandro Scala, Ilaria Grazia Zizzari, Enrico Cortesi, Silverio Tomao, Marianna Nuti, Silvia Mezi, Paolo Marchetti.
In: Frontiers in Immunology. 2022 Nov 3;13:974087. doi: 10.3389/fimmu.2022.974087.
Corresponding author. IF 7.561

5. The Agnostic Role of Site of Metastasis in Predicting Outcomes in Cancer Patients Treated with Immunotherapy. Andrea Botticelli, Alessio Cirillo, Simone Scagnoli, Bruna Cerbelli, Lidia Strigari, Alessio Cortellini, Laura Pizzuti, Patrizia Vici, Federica De Galitiis, Francesca Romana Di Pietro, Edoardo Cerbelli, Michele Ghidini, Giulia D'Amati, Carlo Della Rocca, Silvia Mezi, Alain Gelibter, Raffaele Giusti, Enrico Cortesi, Paolo Antonio Ascierto, Marianna Nuti, Paolo Marchetti.
In: Vaccines (Basel). 2020 Apr 28;8(2):E203.doi: 10.3390/vaccines8020203.
Second name. IF 4.961

6. Ideal regimen for induction chemotherapy in nasopharyngeal cancer: Still a hot issue?
Francesca De Felice, Alessio Cirillo, Andrea Botticelli. Radiotherapy and Oncology. 2022 Nov 3;177:111-112. doi: 10.1016/j.radonc.2022.10.033
IF 6.901

7. The Role of the CDK4/6 Inhibitor Ribociclib in Locally Advanced and Oligometastatic Hormone Receptor Positive, Her2 Negative, Advanced Breast Cancer: Case Series and Review of the Literature. Andrea Botticelli, Agnese Fabbri, Michela Roberto, Daniele Alesini, Alessio Cirillo, Giuliana D’Auria, Eriseld Krasniqi, Eleonora Marrucci, Margherita Muratore, Francesco Pantano, Laura Pizzuti, Ilaria Portarena, Rosalina Rossi, Simone Scagnoli, Paolo Marchetti.
In: Frontiers in Oncology, 2022 February. doi: 10.3389/fonc.2022.797157.
IF 6.244

8. The Impact of Locoregional Treatment on Response to Nivolumab in Advanced Platinum Refractory Head and Neck Cancer: The Need Trial. Andrea Botticelli, Silvia Mezi, Giulia Pomati, Paolo Sciattella, Bruna Cerbelli, Michela Roberto, Giulia Mammone, Alessio Cirillo, Alessandra Cassano, Carmela Di Dio, Alessio Cortellini, Laura Pizzuti, Graziana Ronzino, Massimiliano Salati, Patrizia Vici, Antonella Polimeni, Marco Carlo Merlano, Marianna Nuti, Paolo Marchetti.
In: Vaccines (Basel). 2020 Apr 20;8(2):191. doi: 10.3390/vaccines8020191
IF 4.961

9. Renal Function Outcomes in Metastatic Non-Small-Cell Lung Carcinoma Patients Treated with Chemotherapy or Immune Checkpoint Inhibitors: An Unexpected Scenario. Francesco Trevisani, Federico Di Marco, Matteo Floris, Antonello Pani, Roberto Minnei, Mario Scartozzi, Alessio Cirillo, Alain Gelibter, Andrea Botticelli, Erika Rijavec, Monica Cattaneo, Ornella Garrone, Michele Ghidini. Vaccines (Basel). 2022 Apr 24;10(5):679. doi: 10.3390/vaccines10050679.
IF 4.961

10. 10. Genomic and Immune Approach in Platinum Refractory HPV-Negative Head and Neck Squamous Cell Carcinoma Patients Treated with Immunotherapy: A Novel Combined Profile. Silvia Mezi, Giulia Pomati, Ilaria Grazia Zizzari, Alessandra Di Filippo, Bruna Cerbelli, Alessio Cirillo, Giulia Fiscon, Sasan Amirhassankhani, Valentino Valentini, Marco De Vincentiis, Alessandro Corsi, Cira Di Gioia, Vincenzo Tombolini, Carlo Della Rocca, Antonella Polimeni, Marianna Nuti, Paolo Marchetti, Andrea Botticelli.
In: Biomedicines. 2022 Oct 28;10(11):2732. doi: 10.3390/biomedicines10112732.
IF: 4.757

11. 11. The Role of Soluble LAG3 and Soluble Immune Checkpoints Profile in Advanced Head and Neck Cancer: A Pilot Study. Andrea Botticelli, Ilaria Grazia Zizzari, Simone Scagnoli, Giulia Pomati, Lidia Strigari, Alessio Cirillo, Bruna Cerbelli, Alessandra Di Filippo, Chiara Napoletano, Fabio Scirocchi, Aurelia Rughetti, Marianna Nuti, Silvia Mezi, Paolo Marchetti.
In: Journal of Personalized Medicine, 2021 July 10. doi: 10.3390/jpm11070651.
IF 4.453

12. Dental Implant Failure Risk in Post Oncological Patients, a Retrospective Study and Sapienza Head and Neck Unit Decisional Protocol- 7 Years of Follow-Up. Edoardo Brauner, Valentino Valentini, Umberto Romeo, Marco Cantore, Federico Laudoni, Oriana Rajabtork Zadeh, Valeria Formisano, Andrea Cassoni, Marco Della Monaca, Andrea Battisti, Silvia Mezi, Alessio Cirillo, Francesca De Felice, Andrea Botticelli, Vincenzo Tombolini, Marco De Vincentiis, Andrea Colizza, Gianluca Tenore, Antonella Polimeni, Stefano Di Carlo. In: Diagnostics (Basel). 2022 Aug 2;12(8):1863. doi: 10.3390/diagnostics12081863.
IF: 3.992

13. Immune checkpoint inhibitors and pre existing antinuclear antibodies: the rheumatologist point of view.
Fulvia Ceccarelli, Andrea Botticelli, Francesco Natalucci, Giulio Olivieri, Alessio Cirillo, Cristiano Alessandri, Paolo Marchetti, Fabrizio Conti.
In: Clinical and Translational Oncology. 2021 March 17. doi: 10.1007/s12094-021-02584-y.
IF: 3.340

14. Induction chemotherapy in nonlaryngeal human papilloma virus-negative high-risk head and neck cancer: a real-world experience.
Silvia Mezia, Giulia Pomati, Andrea Botticelli, Michela Roberto, Bruna Cerbelli, Alessio Cirillo, Cira Di Gioia, Alessandro Corsi, Francesco Vullo, Marco De Vincentiis, Antonella Polimeni, Vincenzo Tombolini, Valentino Valentini and Paolo Marchetti. In: Anticancer Drugs. 2020 Nov;31(10):1074-1083. doi: 10.1097/CAD.0000000000000977.
IF: 2.248

15. Oral Immune-Related Adverse Events Associated with PD-1 Inhibitor Treatment: A Case Series.
Daniele Pergolini, Andrea Botticelli, Roberta Fascetti, Federica Rocchetti, Alessio Cirillo, Gianluca Tenore, Gaspare Palaia, Antonella Polimeni, Umberto Romeo. In: Applied Sciences. 2022, 12, 12994. https://doi.org/10.3390/app122412994.
IF: 2.838

16. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey.
Cerbelli B, Cirillo A, Pomati G, Pernazza A, Ascione A, Pisegna S, PisanoA, Leopizzi M, Pignataro MG, Costarelli L, Mulè A, Vecchione A, Catalano P, Coppola L, Perrone G, Perracchio L, Anemona L, Mastracchio A, Nardi S, Reitano R, Massari A, Grillo LR, Liberati F, Della Rocca C, Marchetti P, Botticelli A, D'Amati G. Tumori. 2023 Sep 19:3008916231196781. doi: 10.1177/03008916231196781
IF: 2.3

17. Circulating CD137+ T Cell Levels Are Correlated with Response to Pembrolizumab Treatment in Advanced Head and Neck Cancer Patients.
Cirillo A, Zizzari IG, Botticelli A, Strigari L, Rahimi H, Scagnoli S, Scirocchi F, Pernazza A, Pace A, Cerbelli B, d'Amati G, Marchetti P, Nuti M, Rughetti A, Napoletano C. Int J Mol Sci. 2023 Apr 12;24(8):7114. doi: 10.3390/ijms24087114. PMID: 37108276; PMCID: PMC10138766.
IF: 5.6

18. Immune responses and clinical outcomes following the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in advanced breast cancer patients receiving targeted therapies: a prospective study. Nelli F, Fabbri A, Botticelli A, Giannarelli D, Marrucci E, Fiore C, Virtuoso A, Berrios JRG, Scagnoli S, Pisegna S, Cirillo A, Panichi V, Massari A, Silvestri MA, Ruggeri EM. Front Oncol. 2023 Nov 7;13:1280416. doi: 10.3389/fonc.2023.1280416.
IF: 5.738

19. Rheumatic Diseases Development in Patients Treated by Anti-PD1 Immune Checkpoint Inhibitors: A Single-Centre Descriptive Study.
Ceccarelli F, Natalucci F, Picciariello L, Olivieri G, Cirillo A, Gelibter A, Picone V, Botticelli A, Conti F. Rheumatic Diseases Development in Patients Treated by Anti-PD1 Immune Checkpoint Inhibitors: A Single-Centre Descriptive Study. Life (Basel). 2023 Mar 25;13(4):877. doi: 10.3390/life13040877.
IF: 3.2

20. Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach. Botticelli A, Cirillo A, Pomati G, Cortesi E, Rossi E, Schinzari G, Tortora G, Tomao S, Fiscon G, Farina L, Scagnoli S, Pisegna S, Ciurluini F, Chiavassa A, Amirhassankhani S, Ceccarelli F, Conti F, Di Filippo A, Zizzari IG, Napoletano C, Rughetti A, Nuti M, Mezi S, Marchetti P. Cancer Immunol Immunother. 2023 Jul;72(7):2217-2231. doi: 10.1007/s00262-023-03384-9. Epub 2023 Mar 3.
IF: 5.8

ABSTRACTS
- Immune-related toxicity and soluble profile in patients affected by solid tumours: a network approach. Andrea Botticelli, Alessio Cirillo 1, Giulia Pomati, Enrico Cortesi, Ernesto Rossi, Giovanni Schinzari, Giampaolo Tortora, Silverio Tomao, Giulia Fiscon, Lorenzo Farina, Simone Scagnoli, Simona Pisegna, Fabio Ciurluini, Antonella Chiavassa, Sasan Amirhassankhani, Alessandra Di Filippo, Ilaria Zizzari, Marianna Nuti, Silvia Mezi, Paolo Marchetti. Accepted ASCO 2022.

- DNA Damage Response and Repair (DDR) Gene Mutations as an alternative mechanism to generate high TMB in never smokers NSCLC patients. Marco Filetti, Mario Occhipinti, Alessio Cirillo, Fabio Scirocchi, Alessio Ugolini, Manuela Petti, Raffaele Giusti, Pasquale Lombardi, Andrea Botticelli, Giuseppe Lo Russo, Filippo Maria De Braud, Paolo Marchetti, Marianna Nuti, Elisabetta Ferretti, Aurelia Rughetti* and Lorenzo Farina. Accepted ESMO 2022

INVITED TALKS:

1. Best of the Year 2023- AIOM LAZIO- Neoplasie del distretto testa collo- Immunoterapia e farmaci biologici: l’anno che è stato e che verrà, 18.12.2023

2. Preceptorship Head and Neck Cancer, Policlinico Umberto I di Roma, 26 - 27.09.2023

3. Oncogeriatria Traslazionale – Ordine Provinciale dei medici-chirurghi e degli odontroiatri di Roma, 15.09.2023

4. Future in progress. XXXIV Congresso Nazionale S.P.I.G.C - SESSIONE MULTIDISCIPLINARE ONCOLOGICA TESTA – COLLO, 15.06.2023

5. Congresso SIO, Congresso Nazionale Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale – Il Ruolo dell’immunoterapia nel tumore della laringe - 26.05.2023

6. Winner Oral Presentation ECHNO 08.03.2023 2023- European Congress on Head and Neck Oncology -; Lisbon, 08.03.2023:
- The immunosuppressive role of CD73 in head and neck cancer patients treated with immunotherapy
- Circulating CD137+ T cells correlate with response to immunotherapy in head and neck cancer patients

7. TORRE DI BABELE, 4.0: OLTRE LA DISCUSSIONE MULTIDISCIPLINARE, Webinar, 14/12/2022

8. CASI DIFFICILI IN ONCOLOGIA DI PRECISIONE, Webinar, 02/12/2022

9. YO-IO 3.0: YOUNG ONCOLOGISTS IN IMMUNONCOLOGY, Webinar, 11/11/2022

10. IMMUNOTERAPIA E NEOPLASIE DEL DISTRETTO TESTA-COLLO E TERAPIA DI SUPPORTO NELLE NEOPLASIE DEL DISTRETTO TESTA-COLLO” PRECEPTORSHIP HEAD AND NECK CANCER” Roma, Policlinico Umberto I, 13/10/2022 e 14/10/2022

11. I TUMORI SQUAMOCELLULARI CUTANEI DEL DISTRETTO TESTA-COLLO, Webinar di Formazione per gli specializzandi, 19/09/2022

12. BREAST TALENT 3.0, Webinar, 18/03/2022

13. LE NUOVE FRONTIERE DEI TUMORI TESTA-COLLO: LE SFIDE DEL TEAM MULTISCIPLINARE, Webinar, 16/12/2021

14. CASI DIFFICILI IN IMMUNO-ONCOLOGIA 4.0, Webinar, 15/12/2021

15. YO-IO 2.0: young oncologists in immunoncology, Webinar, 19/11/2021

16. DALLO STUDIO CLINICO AL REAL WORLD: NUOVE TECNOLOGIE E NUOVI DATI NEL CARCINOMA MAMMARIO, Webinar, 15/09/2021

17. NEOPLASIA DEL COLON-RETTO: DALLA RICERCA ALLA PRATICA CLINICA, Webinar, 07/07/2021

18. ABCDAY, ADVANCED BREAST CANCER DAY, Webinar, 15/06/2021

19. BREAST TALENT 2.0, Webinar, 18/03/2021

20. TORRE DI BABELE 2.0 -IL TEAM IN IMMUNONCOLOGIA, Webinar, 25/11/2020

21. YO BREAST-YOUNG ONCOLOGISTS IN BREAST CANCER, Webinar, 24/11/2020

22. CARCINOMA DELLA MAMMELLA NELLA PAZIENTE ANZIANA, Roma, 11/09/2020

23. COMU TORNA DA CHICAGO. LE NOVITÀ, LE CONFERME E LE DISILLUSIONI IN ONCOLOGIA CLINICA. National Congress. Webinar, 06/06/2020

24. TORRE DI BABELE-IL TEAM IN IMMUNONCOLOGIA, Roma, 15/11/2019

25. CARCINOMA DEL COLON-RETTO NEL PAZIENTE ANZIANO, Policlinico Umberto I Roma, 21/10/2019

26. MELANOMA CONVENTION, Sapienza University of Rome, 09/11/2018

PARTICIPATION AS TEACHER AT THE MASTER OF IMMUNO- ONCOLOGY II LEVEL, Sapienza University of Rome:
a) Squamous skin neoplasms and immunotherapy,14.05.2021
b) Pulmonary, muscular, neurological and immunotherapy toxicities, 09.07.2021
c) From clinical trials to clinical practice: sharing clinical cases in immunoncology: Squamous skin neoplasia and immunotherapy, 22.10.2021
d) Up Date post ASCO and post ESMO, Neoplasms of the gastro-intestinal tract, 26.11.2021

Scientific Board:

1. TORRE DI BABELE, 4.0: OLTRE LA DISCUSSIONE MULTIDISCIPLINARE, Webinar, 14/12/2022

2. CASI DIFFICILI IN ONCOLOGIA DI PRECISIONE, Webinar, 02/12/2022

3. YO-IO 3.0: YOUNG ONCOLOGISTS IN IMMUNONCOLOGY, Webinar, 11/11/2022

4. HER 2 WIN, Webinar, 07/10/2022

5. LE OLIMPIADI DELL’ONCOLOGIA, Roma, Istituto S. E. De Vialar, Via Paolo III, 16, 20/09.2022

6. BREAST TALENT 3.0, Webinar, 18/03/2022

7. GESTIONE MULTIDISCIPLINARE DEL CARCINOMA RENALE METASTATICO: ESPERIENZA DEL POLO ONCOLOGICO DI SAPIENZA, Webinar, 20/12/2021

8. CASI DIFFICILI IN IMMUNO-ONCOLOGIA 3.0, Webinar, 15/12/2021

9. YO-IO: YOUNG ONCOLOGISTS IN IMMUNONCOLOGY, Webinar, 19/11/2021

10. WORKSHOP NEOPLASIE RENALI 4.0: NUOVE FRONTIERE DELLA RICERCA E DELLA PRATICA CLINICA, Roma, Istituto S. E. De Vialar, Via Paolo III, 26/11/2021

11. LE NUOVE FRONTIERE DEI TUMORI TESTA-COLLO: LE SFIDE DEL TEAM MULTIDISCIPLINARE, Webinar, 16/12/2021

12. DALLO STUDIO CLINICO AL REAL WORLD: NUOVE TECNOLOGIE E NUOVI DATI NEL CARCINOMA MAMMARIO, Webinar, 15/09/2021

13. NEOPLASIA DEL COLON-RETTO: DALLA RICERCA ALLA PRATICA CLINICA, ROMA, Webinar, 07/07/2021

14. BREAST TALENT 2.0, Webinar, 18/03/2021

15. Casi difficili in immuno oncologia 2.0, Webinar, 15/12/2020

16. Workshop - neoplasie renali 3.0: focus classi di rischio, Webinar, 27/11/2020

17. YO Breast-Young Oncologists In Breast Cancer, Webinar, 24/11/2020

18. Young oncologists in immunoncology, Webinar, 18/11/2020

Other:

- Correlator of experimental degree thesis “Profilo immunosoppressivo nei pazienti affetti da neoplasia del distretto testa-collo CPS positivi in trattamento immunoterapico”
Sapienza University of Rome, 26/10/2022

- Correlator of experimental degree thesis" Impatto dei livelli circolanti dei linfociti T CD137+ sulla risposta all’immunoterapia"
Sapienza University of Rome, 27/06/2023

- Correlator of experimental degree thesis " Profilo mutazionale ed immunologico del carcinoma squamocellulare della testa e del collo"
Sapienza University of Rome, 29/09/2023

Awards:
- Winner: BANDO PER PROGETTI PER AVVIO ALLA RICERCA - TIPO 1 ANNO 2022: “T-REX TRIAL: The impact of medication Reconciliation on toXicities and efficacy on TKI-based cancer therapy”, “Sapienza” University of Rome 11.10.2022

ROLE IN THE DRAFTING OF:
University Applications “Head and Neck e Network Medicine” Facoltà di Medicina e Chirurgia, Università di Roma la Sapienza. July 2020.

Research products

11573/1703913 - 2024 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

Cerbelli, Bruna; Cirillo, Alessio; Pomati, Giulia; Pernazza, Angelina; Ascione, Andrea; Pisegna, Simona; Pisano, Annalinda; Leopizzi, Martina; Pignataro, Maria Gemma; Costarelli, Leopoldo; Mulè, Antonino; Vecchione, Andrea; Catalano, Piera; Coppola, Luigi; Perrone, Giuseppe; Perracchio, Letizia; Anemona, Lucia; Mastracchio, Antonio; Nardi, Stefano; Reitano, Renato; Massari, Annalisa; Grillo, Lucia Rosalba; Liberati, Fabrizio; Della Rocca, Carlo; Marchetti, Paolo; Botticelli, Andrea; D’Amati, Giulia - 01a Articolo in rivista

paper: TUMORI (-Roma: Il Pensiero Scientifico Editore srl -Milano: Istituto nazionale per to studio e la cura dei tumori -Milan Italy: Casa Editrice Ambrosiana) pp. 44-48 - issn: 0300-8916 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1708991 - 2024 - Pembrolizumab-based first-line treatment for PD-L1-positive, recurrent or metastatic head and neck squamous cell carcinoma: a retrospective analysis

Cirillo, Alessio; Marinelli, Daniele; Romeo, Umberto; Messineo, Daniela; De Felice, Francesca; De Vincentiis, Marco; Valentini, Valentino; Mezi, Silvia; Valentini, Filippo; Vivona, Luca; Chiavassa, Antonella; Cerbelli, Bruna; Santini, Daniele; Bossi, Paolo; Polimeni, Antonella; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista

paper: BMC CANCER (London: BioMed Central, [2001]-) pp. 1-9 - issn: 1471-2407 - wos: WOS:001199827900009 (0) - scopus: 2-s2.0-85189606694 (1)

11573/1674348 - 2023 - Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach

Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cortesi, Enrico; Rossi, Ernesto; Schinzari, Giovanni; Tortora, Giampaolo; Tomao, Silverio; Fiscon, Giulia; Farina, Lorenzo; Scagnoli, Simone; Pisegna, Simona; Ciurluini, Fabio; Chiavassa, Antonella; Amirhassankhani, Sasan; Ceccarelli, Fulvia; Conti, Fabrizio; Di Filippo, Alessandra; Zizzari, Ilaria Grazia; Napoletano, Chiara; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista

paper: CANCER IMMUNOLOGY, IMMUNOTHERAPY (Heidelberg; Berlin: Springer) pp. - - issn: 1432-0851 - wos: WOS:000943090400001 (2) - scopus: 2-s2.0-85149261068 (2)

11573/1698315 - 2023 - Rheumatic Diseases Development in Patients Treated by Anti-PD1 Immune Checkpoint Inhibitors: A Single-Centre Descriptive Study

Ceccarelli, Fulvia; Natalucci, Francesco; Picciariello, Licia; Olivieri, Giulio; Cirillo, Alessio; Gelibter, Alain; Picone, Vincenzo; Botticelli, Andrea; Conti, Fabrizio - 01a Articolo in rivista

paper: LIFE (Basel: MDPI) pp. - - issn: 2075-1729 - wos: WOS:000977559100001 (2) - scopus: 2-s2.0-85154594030 (3)

11573/1693735 - 2023 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey

paper: TUMORI (Roma : Il Pensiero Scientifico Editore) pp. 3008916231196781- - issn: 2038-2529 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1683371 - 2023 - Circulating CD137+ T cell levels are correlated with response to Pembrolizumab treatment in advanced head and neck cancer patients

Cirillo, Alessio; Zizzari, Ilaria Grazia; Botticelli, Andrea; Strigari, Lidia; Asquino, Angela; Rahimi Koshkaki, Hassan; Scagnoli, Simone; Scirocchi, Fabio; Pernazza, Angelina; Pace, Angelica; Cerbelli, Bruna; D'amati, Giulia; Marchetti, Paolo; Nuti, Marianna; Rughetti, Aurelia; Napoletano, Chiara - 04f Poster

conference: 41a CONFERENZA NAZIONALE DI CITOMETRIA (Auditorium Biotecnologie - Università degli Studi di Napoli Federico II)

book: http://www.citometriagic2023.it/ - ()

11573/1677631 - 2023 - Circulating CD137+ T cell levels are correlated with response to pembrolizumab treatment in advanced head and neck cancer patients

Cirillo, Alessio; Zizzari, Ilaria Grazia; Botticelli, Andrea; Strigari, Lidia; Rahimi Koshkaki, Hassan; Scagnoli, Simone; Scirocchi, Fabio; Pernazza, Angelina; Pace, Angelica; Cerbelli, Bruna; D'amati, Giulia; Marchetti, Paolo; Nuti, Marianna; Rughetti, Aurelia; Napoletano, Chiara - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-11 - issn: 1661-6596 - wos: WOS:000979339600001 (1) - scopus: 2-s2.0-85156135313 (2)

11573/1661193 - 2022 - The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy

Botticelli, A.; Pomati, G.; Cirillo, A.; Scagnoli, S.; Pisegna, S.; Chiavassa, A.; Rossi, E.; Schinzari, G.; Tortora, G.; Di Pietro, F. R.; Cerbelli, B.; Di Filippo, A.; Amirhassankhani, S.; Scala, A.; Zizzari, I. G.; Cortesi, E.; Tomao, S.; Nuti, M.; Mezi, S.; Marchetti, P. - 01a Articolo in rivista

paper: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000888273100001 (8) - scopus: 2-s2.0-85142215079 (8)

11573/1659852 - 2022 - Network analysis to determine association between immuno-related toxicities and immune soluble profile in patients treated with anti-PD-1

Botticelli, A; Cirillo, A; Pomati, G; Cortesi, E; Rossi, E; Schinzari, G; Tortora, G; Tomao, S; Nuti, M; Fiscon, G; Farina, L; Pisegna, S; Ciurluini, F; Chiavassa, A; Amirhassankhani, S; Di Filippo, A; Zizzari, I; Mezi, S; Marchetti, P - 04f Poster

paper: JOURNAL OF CLINICAL ONCOLOGY (editori attuale: -American Society of Clinical Oncology. , 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, USA, VA, 22314 precedente: -W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. - - issn: 0732-183X - wos: WOS:000863680300776 (0) - scopus: (0)

conference: 2022 ASCO Annual Meeting I (Chicago)

book: Journal of clinical oncology - ()

11573/1652660 - 2022 - Dental implant failure risk in post oncological patients, a retrospective study and Sapienza Head and Neck Unit decisional protocol- 7 years of follow-up

Brauner, Edoardo; Valentini, Valentino; Romeo, Umberto; Cantore, Marco; Laudoni, Federico; Rajabtork Zadeh, Oriana; Formisano, Valeria; Cassoni, Andrea; Della Monaca, Marco; Battisti, Andrea; Mezi, Silvia; Cirillo, Alessio; De Felice, Francesca; Botticelli, Andrea; Tombolini, Vincenzo; De Vincentiis, Marco; Colizza, Andrea; Tenore, Gianluca; Polimeni, Antonella; Di Carlo, Stefano - 01a Articolo in rivista

paper: DIAGNOSTICS (Basel: MDPI) pp. - - issn: 2075-4418 - wos: WOS:000846070400001 (0) - scopus: 2-s2.0-85137588773 (0)

11573/1676492 - 2022 - Ideal regimen for induction chemotherapy in nasopharyngeal cancer: still a hot issue?

De Felice, Francesca; Cirillo, Alessio; Botticelli, Andrea - 01m Editorial/Introduzione in rivista

paper: RADIOTHERAPY AND ONCOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 111-112 - issn: 0167-8140 - wos: WOS:000896787100007 (0) - scopus: 2-s2.0-85141491847 (0)

11573/1662822 - 2022 - DNA damage response and repair (DDR) gene mutations as an alternative mechanism to generate high TMB in never smoker NSCLC patients

Filetti, M; Occhipinti, M; Cirillo, A; Scirocchi, F; Ugolini, A; Petti, M; Giusti, R; Lombardi, P; Botticelli, A; Lo Russo, G; De Braud, Fgm; Marchetti, P; Nuti, M; Ferretti, E; Rughetti, A; Farina, L - 01h Abstract in rivista

paper: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. S1047-S1047 - issn: 0923-7534 - wos: WOS:000866211601346 (0) - scopus: (0)

11573/1660536 - 2022 - Genomic and immune approach in platinum refractory HPV-negative head and neck squamous cell carcinoma patients treated with Immunotherapy: a novel combined profile

Mezi, Silvia; Pomati, Giulia; Zizzari, Ilaria Grazia; Di Filippo, Alessandra; Cerbelli, Bruna; Cirillo, Alessio; Fiscon, Giulia; Amirhassankhani, Sasan; Valentini, Valentino; De Vincentiis, Marco; Corsi, Alessandro; Di Gioia, Cira Rosaria Tiziana; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Nuti, Marianna; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista

paper: BIOMEDICINES (Basel : MDPI) pp. - - issn: 2227-9059 - wos: WOS:000880889000001 (3) - scopus: 2-s2.0-85141779736 (3)

11573/1662616 - 2022 - Oral immune-related adverse events associated with PD-1 inhibitor treatment: a case series

Pergolini, Daniele; Botticelli, Andrea; Fascetti, Roberta; Rocchetti, Federica; Cirillo, Alessio; Tenore, Gianluca; Palaia, Gaspare; Polimeni, Antonella; Romeo, Umberto - 01a Articolo in rivista

paper: APPLIED SCIENCES (Basel: MDPI AG, 2011-) pp. - - issn: 2076-3417 - wos: WOS:000900370600001 (1) - scopus: 2-s2.0-85144850361 (1)

11573/1645553 - 2022 - Renal function outcomes in metastatic non-small-cell lung carcinoma patients treated with chemotherapy or immune checkpoint inhibitors: an unexpected scenario

Trevisani, F; Di Marco, F; Floris, M; Pani, A; Minnei, R; Scartozzi, M; Cirillo, A; Gelibter, A; Botticelli, A; Rijavec, E; Cattaneo, M; Garrone, O; Ghidini, M. - 01a Articolo in rivista

paper: VACCINES (Basel: MDPI) pp. - - issn: 2076-393X - wos: WOS:000802597600001 (4) - scopus: 2-s2.0-85129608760 (4)

11573/1566814 - 2021 - Anti–PD-1 and Anti–PD-L1 in head and neck cancer: a network meta-analysis

Botticelli, A.; Cirillo, A.; Strigari, L.; Valentini, F.; Cerbelli, B.; Scagnoli, S.; Cerbelli, E.; Zizzari, I. G.; Della Rocca, C.; D'amati, G.; Polimeni, A.; Nuti, M.; Merlano, M. C.; Mezi, S.; Marchetti, P. - 01a Articolo in rivista

paper: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000687848000001 (49) - scopus: 2-s2.0-85113294602 (52)

11573/1529260 - 2021 - The role of opioids in cancer response to immunotherapy

Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cerbelli, Bruna; Scagnoli, Simone; Roberto, Michela; Gelibter, Alain; Mammone, Giulia; Calandrella, Maria Letizia; Cerbelli, Edoardo; Di Pietro, Francesca Romana; De Galitiis, Federica; Lanzetta, Gaetano; Cortesi, Enrico; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista

paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000634783000001 (22) - scopus: 2-s2.0-85103161618 (23)

11573/1562486 - 2021 - Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era

Botticelli, Andrea; Pomati, Giulia; Cirillo, Alessio; Mammone, Giulia; Ciurluini, Fabio; Cerbelli, Bruna; Sciattella, Paolo; Ralli, Massimo; Romeo, Umberto; De Felice, Francesca; Catalano, Carlo; Vullo, Francesco; Della Monaca, Marco; Amirhassankhani, Sasan; Tomao, Silverio; Valentini, Valentino; De Vincentiis, Marco; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Di Gioia, Cira; Corsi, Alessandro; D'amati, Giulia; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista

paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000674445600002 (1) - scopus: 2-s2.0-85109717512 (2)

11573/1562092 - 2021 - The role of soluble LAG3 and soluble immune checkpoints profile in advanced head and neck cancer: a pilot study

Botticelli, Andrea; Zizzari, Ilaria Grazia; Scagnoli, Simone; Pomati, Giulia; Strigari, Lidia; Cirillo, Alessio; Cerbelli, Bruna; Di Filippo, Alessandra; Napoletano, Chiara; Scirocchi, Fabio; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista

paper: JOURNAL OF PERSONALIZED MEDICINE (Basel: MDPI AG, 2011-) pp. - - issn: 2075-4426 - wos: WOS:000677382600001 (27) - scopus: 2-s2.0-85110848603 (30)

11573/1555745 - 2021 - Immune checkpoint inhibitors and pre-existing antinuclear antibodies: the rheumatologist point of view

Ceccarelli, F.; Botticelli, A.; Natalucci, F.; Olivieri, G.; Cirillo, A.; Alessandri, C.; Marchetti, P.; Conti, F. - 01f Lettera, Nota

paper: CLINICAL & TRANSLATIONAL ONCOLOGY () pp. 1961-1962 - issn: 1699-3055 - wos: WOS:000629521300001 (1) - scopus: 2-s2.0-85102865767 (1)

11573/1394000 - 2020 - The agnostic role of site of metastasis in predicting outcomes in cancer patients treated with immunotherapy

Botticelli, A.; Cirillo, A.; Scagnoli, S.; Cerbelli, B.; Strigari, L.; Cortellini, A.; Pizzuti, L.; Vici, P.; De Galitiis, F.; Di Pietro, F. R.; Cerbelli, E.; Ghidini, M.; D'amati, G.; Rocca, C. D.; Mezi, S.; Gelibter, A.; Giusti, R.; Cortesi, E.; Ascierto, P. A.; Nuti, M.; Marchetti, P. - 01a Articolo in rivista

paper: VACCINES (Basel: MDPI) pp. 203- - issn: 2076-393X - wos: WOS:000550821300001 (38) - scopus: 2-s2.0-85084131135 (41)

11573/1387452 - 2020 - The impact of locoregional treatment on response to Nivolumab in advanced platinum refractory head and neck cancer: the NEED TRIAL

Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Sciattella, Paolo; Cerbelli, Bruna; Roberto, Michela; Mammone, Giulia; Cirillo, Alessio; Cassano, Alessandra; Di Dio, Carmela; Cortellini, Alessio; Pizzuti, Laura; Ronzino, Graziana; Salati, Massimiliano; Vici, Patrizia; Polimeni, Antonella; Carlo Merlano, Marco; Nuti, Marianna; Marchetti, Paolo - 01a Articolo in rivista

paper: VACCINES (Basel: MDPI) pp. - - issn: 2076-393X - wos: WOS:000553554200001 (8) - scopus: 2-s2.0-85083830456 (9)

11573/1440797 - 2020 - Induction chemotherapy in nonlaryngeal human papilloma virus-negative high-risk head and neck cancer: a real-world experience

Mezi, Silvia; Pomati, Giulia; Botticelli, Andrea; Roberto, Michela; Cerbelli, Bruna; Cirillo, Alessio; Di Gioia, Cira; Corsi, Alessandro; Vullo, Francesco; De Vincentiis, Marco; Polimeni, Antonella; Tombolini, Vincenzo; Valentini, Valentino; Marchetti, Paolo - 01a Articolo in rivista

paper: ANTI-CANCER DRUGS (London: Lippincott Williams & Wilkins Oxford UK: Rapid Communications of Oxford, [1990]-) pp. 1-10 - issn: 0959-4973 - wos: WOS:000580389200011 (1) - scopus: 2-s2.0-85093706069 (1)