AGNESE PO

Professore associato

email: agnese.po@uniroma1.it

POSITIONS AND APPOINTMENTS
1/7/2019 – present: Associate Professor MED/46 at Sapienza University of Rome, Dept of Molecular Medicine
1/7/2016 –30/906/2019: Assistant Professor at Sapienza University of Rome, Dept of Molecular Medicine
1/7/2015 – 30/06/2016: Research fellow at Sapienza University of Rome, Dept of Molecular Medicine
1/5/2012 – 30/04/2015: Assistant Professor at Sapienza University of Rome, Dept of Molecular Medicine
1/1/2012 – 30/4/2012: post doctoral fellow at Sapienza University of Rome, Dept of Molecular Medicine
1/1/2009 - 31/12/2011: Postdoctoral fellowship – founded from FIRC (Cancer Research Italian Foundation)

EDUCATION
2004 - B. S. in Biology - Sapienza University of Rome.
2009 - PhD in Molecular Oncology - Sapienza University of Rome.

OTHER EXPERIENCE AND PROFESSIONAL MEMBERSHIPS
2005 – ongoing: Research Fellow, Molecular Oncology Group “Alberto Gulino” (Sapienza Univ, Molecular Medicine Dept)
2010 – 2015: Research Fellow, Special Program Molecular Clinical Oncology 5 per mille “development of effective cancer therapies based on functional proteomics and cancer stem cells targeting”. PI: Ruggero de Maria
2015 – ongoing: Member, SIOPE-LGG (low grade gliomas) preclinical working group
2017 – ongoing: President of the Scientific Committee, Umberto di Mario foundation.
2019 – ongoing: Member of EACR (membership number: EACR27444)
2017 – ongoing: included in REPRISE list (Register of Expert Peer Reviewers for Italian Scientific Evaluation)

PHD PROGRAM – BOARD MEMBER
2017, 2018, 2019: "tecnologie biomediche in medicina clinica" Sapienza University of Rome
2020 - ongoing: "network oncology and precision medicine" Sapienza University of Rome

TEACHING APPOINTMENTS
From 2014 helds teaching activities of General Pathology and Laboratory Medicine in several courses, including “Tecniche di Lab Biomedico”, “Fisioterapia”, “Biotecnologie Mediche”, “Bioinformatics”, “Medicine and Surgery”.

EDITOR OF INTERNATIONAL SCIENTIFIC JOURNALS
International Journal of Molecular Sciences (IF 2019: 4.556), Guest editor in special issue: “Special Issue "Molecular Biomarkers in Cancer and Metabolic Disease"

REFEREE FOR ANIMAL RESEARCH
2017 – ongoing: External referee for animal research welfare “Istituto Superiore di Sanità – Centro nazionale sperimentazione e benessere animale”

ORAL PRESENTATIONS IN CONFERENCES
2017 - Oral presentation: “Modelli cellulari in vitro e in vivo in neuro-oncologia pediatrica” “FUTURE BRAIN: I TUMORI CEREBRALI INFANTILI: DUBBI E PROSPETTIVE – 31 MARZO/1 APRILE 2017”
2014 - Oral presentation: “Hedgehog-Gli signalling in lung cancer stem cells and its drug mediated targeting” Dangerous Liaisons: translating cancer biology into better patients management - 56° Congresso Nazionale Società Italiana di Cancerologia. September 11 - 13, 2014, Ferrara.
2008 - Oral presentation: “Differential microRNA expression in human type 2 diabetic pancreatic islets” Islet Study Group Symposium 2008. Roma, 11-13 settembre 2008.

PARTICIPATION IN MEETING AND SEMINARS ORGANIZATION
- Seminar of Ferid Murad (Nobel Laureate in medicine 1998): Alberto Gulino Memorial Lecture 2017 "Role of nitric oxide and cyclic GMP in cell signaling”. Rome, 19 june 2017
- SIOP-LGG Pre-clinical working group, Rome, Sep. 17-18, 2015
- EMBO workshop – “Hedgehog‐Gli Signaling in Cancer and Stem Cells” Rome, 30 September to 4 October 2006 (Organized by A. Gulino, H. Hahn, A. Ruiz í Altaba, R. Toftgard, F. Watt, P. Therond and I. Guerrero)

FUNDINGS
2018 – FFABR (fondo per le attività base di ricerca) Funded by Italian Ministry of University and Research (18 mesi)
2020 – Funding for Seminars and Conference. Title: microRNA: piccole molecole con un grande ruolo come biomarcatori diagnostici, prognostici e predittivi delle malattie. Funded by Sapienza University
PARTICIPATION IN RESEARCH PROJECTS
2007 – Title: Analisi del profilo di espressione dei MicroRNA nel medulloblastoma; Funded by Sapienza University of Rome. PI: E. Ferretti. (24 months)
2007 - Title: Analisi dei profili di espressione dei microrna e loro ruolo nella regolazione del segnale di Hedgehog nel medulloblastoma umano; Funded by Italian Ministry of University and Research PI: I. Bozzoni (24 months)
2009 - Title: Hedgehog-Gli signalling and its pharmacological modulation for regenerative medicine-HEALING; Funded by European Council - FP7. PI: A. Gulino (48 months)
2009 - Title: Genomica, Proteomica e Metabolomica nello Spazio (GPM)- Funded by Agenzia Spaziale Italiana - PI: Prof. Alberto Gulino
2009 - Title: Design of new molecular strategies for the study of neuronal differentiation and for the therapy of neurodegenerative disorders and neuronal cancers. Funded by Italian Istitute of Technology (IIT). Project SEED P.I. I. Bozzoni. Responsabile Unità di ricerca prof. Alberto Gulino
2010 - Title: Hedgehog/Gli pathway regulatory networks in medulloblastoma and cancer stem cells; Funded by AIRC (Associazione Italiana per la ricerca sul cancro) PI: A. Gulino (36 months)
2013 - Title: Targeting Hedgehog pathway to control cancer stem cells; Funded by AIRC (Associazione Italiana per la ricerca sul cancro) PI: A. Gulino (36 months)
2015 - Title: Non communicable diseases in the elderly: Circulating microRNAs and long non coding RNAs as novel biomarkers of response to therapy in metabolic diseases, Funded by Fondazione Roma. PI: E. Ferretti (24 months)
2015 - Title: Meccanorecettori per la gravità e loro signaling. Effetti fisiopatologici correlati all’assenza di gravità e ruolo delle sirtuine. Funded by Agenzia Spaziale Italiana PI: M. Tafani (24 mesi)
2018: Title: Hedgehog/GLI signaling regulatory networks in colorectal cancer stem cells. Funded by Istituto Pasteur - Fondazione Cenci Bolognetti. PI: E. Ferretti (36 mesi)
2018 - Title: Caratterizzazione di microRNA circolanti come sensibili e precoci biomarcatori di alterazioni metaboliche nell’obesità: sviluppo di nuove piattaforme diagnostiche nelle patologie metaboliche croniche Funded by Lazioinnova, PI: E. Ferretti (24 months)
2018 - Title: Circulating microRNAs and DNA (cfDNA) as novel biomarkers for diagnostic, prognostic and therapeutic use in Medullary Thyroid Carcinoma; Funded by AIFA (Agenzia Italiana del Farmaco). PI: E. Ferretti (36 months)
2019 - Title: Metabolic therapy of immuno-inflammation: in search for the best strategy to counteract type 2 diabetes and its complications. Funded by Ministry of University and Research PI: E. Ferretti (36 months)

RESEARCH FIELDS
Agnese Po’s expertise and qualifications are mainly in the fields of molecular oncology of solid cancers (brain cancers, lung cancer, colorectal cancer) and non-coding RNAs. More specifically:

1. Characterization of the molecular events involved in tumorigenesis mainly focusing on solid tumors and dysregulated pathways (e.g. Hedgehog/Gli) controlling progenitor cell development.
2. Isolation and cryopreservation of primary cancer cells including stem cells.
3. Characterization of the microRNAs involved in the deregulation of signaling pathway sustaining tumors
4. Identification of novel molecules as oncosuppressor or oncogenes and investigation of their biological function in vitro and in vivo.
5. Development of approaches for large-scale analysis of gene expression and epigenetic networks including microRNAs and Long non coding RNAs.
6. Analysis and discovery of circulating biomarkers (e.g. microRNAs and cfDNA) in cancer.
7. Identification of new molecular markers of diseases susceptible to become therapeutic targets.
8. Development of mouse models for the study of solid tumors.

COLLABORATIONS
Agnese Po collaborated and collaborates with research groups of the same University, other Italian and foreign Organizations and Universities:
- Prof Felice Giangaspero – Sapienza University
- Prof Mariano Bizzarri – Sapienza University
- Prof Rosa Sessa – Sapienza University
- Prof Franco Locatelli – IRCCS Ospedale Pediatrico Bambino Gesù
- Prof Irene Bozzoni – Italian Istitute of Technology
- Prof Francesco Dotta – University of Siena
- Prof Edoardo Alesse – University of L’Aquila
- Dott. Alessandro Giuliani – Istituto Superiore di Sanità
- Prof. Luigi Boccuto - Clemson University, USA
- Prof. Dr. med. Stefan M. Pfister - Hopp-Kindertumorzentrum am NCT (KiTZ)

Scopus Id: 56017548300
ORCID ID: 0000-0002-9346-8782
RESEARCHID: G-8754-2015

BIBLIOMETRIC INDICATORS (source: Scopus)

Number of publications: 49
Number of citations: 1924 (Source: Scopus)
Total Impact factor (2020): 387,89
H index: 21

Produzione scientifica

11573/1696314 - 2024 - The endocrine disruptor cadmium modulates the androgen-estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer

Bimonte, Viviana M; Catanzaro, Giuseppina; Po, Agnese; Trocchianesi, Sofia; Besharat, Zein Mersini; Spinello, Zaira; Curreli, Mariaignazia; Fabi, Alessandra; Bei, Roberto; Milella, Michele; Vacca, Alessandra; Ferretti, Elisabetta; Migliaccio, Silvia - 01a Articolo in rivista

rivista: ENDOCRINE (New York, Berlin: Springer Totowa, N.J. : Humana Press) pp. - - issn: 1559-0100 - wos: WOS:001120921200002 (0) - scopus: 2-s2.0-85176741955 (0)

11573/1686292 - 2023 - β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum

Abballe, Luana; Alfano, Vincenzo; Antonacci, Celeste; Giuseppina Cefalo, Maria; Cacchione, Antonella; Del Baldo, Giada; Pezzullo, Marco; Po, Agnese; Moretti, Marta; Mastronuzzi, Angela; De Smaele, Enrico; Ferretti, Elisabetta; Locatelli, Franco; Miele, Evelina - 01a Articolo in rivista

rivista: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:000947908400001 (0) - scopus: 2-s2.0-85150019785 (0)

11573/1691548 - 2023 - The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice

Arena, Andrea; Romeo, Maria Anele; Po, Agnese; Benedetti, Rossella; Gilardini Montani, Maria Saveria; Gonnella, Roberta; Santarelli, Roberta; Gaeta, Aurelia; De Smaele, Enrico; Cirone, Mara - 01a Articolo in rivista

rivista: MICROBIOLOGY SPECTRUM (Washington, DC : ASM Press, 2014-) pp. 1-6 - issn: 2165-0497 - wos: WOS:001095474200001 (0) - scopus: 2-s2.0-85180012834 (0)

11573/1682746 - 2023 - Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients

Besharat, Z M; Trocchianesi, S; Verrienti, A; Ciampi, R; Cantara, S; Romei, C; Sabato, C; Noviello, T M R; Po, A; Citarella, A; Caruso, F P; Panariello, I; Gianno, F; Carpino, G; Gaudio, E; Chiacchiarini, M; Masuelli, L; Sponziello, M; Pecce, V; Ramone, T; Maino, F; Dotta, F; Ceccarelli, M; Pezzullo, L; Durante, C; Castagna, M G; Elisei, R; Ferretti, E - 01a Articolo in rivista

rivista: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (Sprimger Milano: Kurtis) pp. 2583-2599 - issn: 1720-8386 - wos: WOS:001002889000001 (2) - scopus: 2-s2.0-85161261291 (1)

11573/1691730 - 2023 - Network analysis identifies circulating miR-155 as predictive biomarker of type 2 diabetes mellitus development in obese patients: a pilot study

Catanzaro, Giuseppina; Conte, Federica; Trocchianesi, Sofia; Splendiani, Elena; Bimonte, Viviana Maria; Mocini, Edoardo; Filardi, Tiziana; Po, Agnese; Besharat, Zein Mersini; Gentile, Maria Cristina; Paci, Paola; Morano, Susanna; Migliaccio, Silvia; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 19496- - issn: 2045-2322 - wos: WOS:001106459000065 (3) - scopus: 2-s2.0-85176149771 (2)

11573/1691552 - 2023 - Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value

Citarella, Anna; Besharat, Zein Mersini; Trocchianesi, Sofia; Autilio, Tanja Milena; Verrienti, Antonella; Catanzaro, Giuseppina; Splendiani, Elena; Spinello, Zaira; Cantara, Silvia; Zavattari, Patrizia; Loi, Eleonora; Romei, Cristina; Ciampi, Raffaele; Pezzullo, Luciano; Castagna, Maria Grazia; Angeloni, Antonio; Elisei, Rosella; Durante, Cosimo; Po, Agnese; Ferretti, Elisabetta - 01f Lettera, Nota

rivista: BIOMARKER RESEARCH (London : BioMed Central) pp. - - issn: 2050-7771 - wos: WOS:001071556900001 (0) - scopus: 2-s2.0-85171850558 (0)

11573/1677425 - 2023 - Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy

Citarella, Anna; Catanzaro, Giuseppina; Besharat, Zein Mersini; Trocchianesi, Sofia; Barbagallo, Federica; Gosti, Giorgio; Leonetti, Marco; Di Fiore, Annamaria; Coppola, Lucia; Autilio, Tanja Milena; Spinello, Zaira; Vacca, Alessandra; De Smaele, Enrico; Venneri, Mary Anna; Ferretti, Elisabetta; Masuelli, Laura; Po, Agnese - 01a Articolo in rivista

rivista: CANCERS (Basel: MDPI) pp. 1471- - issn: 2072-6694 - wos: WOS:000947305400001 (4) - scopus: 2-s2.0-85149860378 (5)

11573/1675332 - 2023 - A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas

Díaz Méndez, Ab; Sacconi, A; Tremante, E; Lulli, V; Caprara, V; Rosanò, L; Goeman, F; Carosi, M; Di Giuliani, M; Vari, G; Silvani, A; Pollo, B; Garufi, C; Ramponi, S; Simonetti, G; Ciusani, E; Mandoj, C; Scalera, S; Villani, V; Po, A; Ferretti, E; Regazzo, G; Rizzo, Mg - 01a Articolo in rivista

rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 66- - issn: 1756-9966 - wos: WOS:000954409300003 (4) - scopus: 2-s2.0-85150665933 (4)

11573/1667587 - 2023 - Extra-cellular vesicles derived from thyroid cancer cells promote the Epithelial to Mesenchymal Transition (EMT) and the transfer of malignant phenotypes through immune mediated mechanisms

Mardente, Stefania; Aventaggiato, Michele; Splendiani, Elena; Mari, Emanuela; Zicari, Alessandra; Catanzaro, Giuseppina; Po, Agnese; Coppola, Lucia; Tafani, Marco - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 2754- - issn: 1422-0067 - wos: WOS:000930897400001 (3) - scopus: 2-s2.0-85147892402 (3)

11573/1691546 - 2023 - HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression

Mardente, Stefania; Romeo, Maria Anele; Asquino, Angela; Po, Agnese; Gilardini Montani, Maria Saveria; Cirone, Mara - 01a Articolo in rivista

rivista: VIRUSES (Basel: MDPI) pp. - - issn: 1999-4915 - wos: WOS:001093625400001 (0) - scopus: 2-s2.0-85175165732 (0)

11573/1687858 - 2023 - Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs

Pace, Angelica; Scirocchi, Fabio; Napoletano, Chiara; Zizzari, Ilaria Grazia; Po, Agnese; Megiorni, Francesca; Asquino, Angela; Pontecorvi, Paola; Rahimi, Hassan; Marchese, Cinzia; Ferretti, Elisabetta; Nuti, Marianna; Rughetti, Aurelia - 01a Articolo in rivista

rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:001068888800001 (0) - scopus: 2-s2.0-85171363405 (1)

11573/1682747 - 2023 - Molecular mechanisms of the tyrosine kinase inhibitor pralsetinib activity in in-vitro models of medullary thyroid carcinoma: Aberrant activation of the HH-Gli signaling pathway in acquired resistance

Trocchianesi, Sofia; Po, Agnese; Citarella, Anna; Spinello, Zaira; Rughetti, Aurelia; Besharat, Zein Mersini; Autilio, Tanja Milena; Pecce, Valeria; Verrienti, Antonella; Elisei, Rossella; Durante, Cosimo; Catanzaro, Giuseppina; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: BIOMÉDECINE & PHARMACOTHÉRAPIE (Paris: Editions Scientifique & Medical Elsevier) pp. 114995- - issn: 0753-3322 - wos: WOS:001020719000001 (1) - scopus: 2-s2.0-85161303043 (0)

11573/1649691 - 2022 - MiR-1248: a new prognostic biomarker able to identify supratentorial hemispheric pediatric low-grade gliomas patients associated with progression

Catanzaro, Giuseppina; Besharat, Zein Mersini; Carai, Andrea; Jäger, Natalie; Splendiani, Elena; Colin, Carole; Po, Agnese; Chiacchiarini, Martina; Citarella, Anna; Gianno, Francesca; Cacchione, Antonella; Miele, Evelina; Diomedi Camassei, Francesca; Gessi, Marco; Massimi, Luca; Locatelli, Franco; Jones, David T W; Figarella-Branger, Dominique; Pfister, Stefan M; Mastronuzzi, Angela; Giangaspero, Felice; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: BIOMARKER RESEARCH (London : BioMed Central) pp. - - issn: 2050-7771 - wos: WOS:000812504600001 (2) - scopus: 2-s2.0-85132122098 (2)

11573/1639205 - 2022 - Circulating microRNAs as clinically useful biomarkers for Type 2 Diabetes Mellitus: miRNomics from bench to bedside

Grieco, G. E.; Besharat, Z. M.; Licata, G.; Fignani, D.; Brusco, N.; Nigi, L.; Formichi, C.; Po, A.; Sabato, C.; Dardano, A.; Natali, A.; Dotta, F.; Sebastiani, G.; Ferretti, E. - 01g Articolo di rassegna (Review)

rivista: TRANSLATIONAL RESEARCH (ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710) pp. - - issn: 1931-5244 - wos: WOS:000829453100008 (10) - scopus: 2-s2.0-85129080551 (11)

11573/1667583 - 2022 - Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation

Grieco, Giuseppina E; Brusco, Noemi; Fignani, Daniela; Nigi, Laura; Formichi, Caterina; Licata, Giada; Marselli, Lorella; Marchetti, Piero; Salvini, Laura; Tinti, Laura; Po, Agnese; Ferretti, Elisabetta; Sebastiani, Guido; Dotta, Francesco - 01a Articolo in rivista

rivista: CELL DEATH DISCOVERY ([London]: Nature Publishing Group, 2015-) pp. 340- - issn: 2058-7716 - wos: WOS:000833026200003 (3) - scopus: 2-s2.0-85135141331 (4)

11573/1613981 - 2022 - HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples

Loi, E.; Zavattari, C.; Tommasi, A.; Moi, L.; Canale, M.; Po, A.; Sabato, C.; Vega-Benedetti, A. F.; Ziranu, P.; Puzzoni, M.; Lai, E.; Faloppi, L.; Rullan, M.; Carrascosa, J.; Amat, I.; Urman, J. M.; Arechederra, M.; Berasain, C.; Ferretti, E.; Casadei-Gardini, A.; Avila, M. A.; Alonso, S.; Scartozzi, M.; Zavattari, P. - 01a Articolo in rivista

rivista: BRITISH JOURNAL OF CANCER (London: Springer Nature Basingstoke Hampshire UK: 3 London: H K Lewis and Co Ltd, 1947-) pp. - - issn: 0007-0920 - wos: WOS:000757350600001 (10) - scopus: 2-s2.0-85124734133 (11)

11573/1657751 - 2022 - A novel microRNA signature for the detection of melanoma by liquid biopsy

Sabato, Claudia; Noviello, Teresa Maria Rosaria; Covre, Alessia; Coral, Sandra; Caruso, Francesca Pia; Besharat, Zein Mersini; Splendiani, Elena; Masuelli, Laura; Battistelli, Cecilia; Vacca, Alessandra; Catanzaro, Giuseppina; Po, Agnese; Anichini, Andrea; Maio, Michele; Ceccarelli, Michele; Di Giacomo, Anna Maria; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000868387300003 (5) - scopus: 2-s2.0-85139885995 (8)

11573/1696444 - 2021 - Upfront treatment with mTOR inhibitor everolimus in pediatric low-grade gliomas: A single-center experience

Cacchione, Antonella; Lodi, Mariachiara; Carai, Andrea; Miele, Evelina; Tartaglia, Marco; Megaro, Giacomina; Del Baldo, Giada; Alessi, Iside; Colafati, Giovanna Stefania; Carboni, Alessia; Boccuto, Luigi; Diomedi Camassei, Francesca; Catanzaro, Giuseppina; Po, Agnese; Ferretti, Elisabetta; Pedace, Lucia; Pizzi, Simone; Folgiero, Valentina; Pezzullo, Marco; Corsetti, Tiziana; Secco, Domitilla Elena; Cefalo, Maria Giuseppina; Locatelli, Franco; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF CANCER (New York, NY : Wiley-Liss) pp. 2522-2534 - issn: 1097-0215 - wos: WOS:000602188800001 (15) - scopus: 2-s2.0-85098115203 (16)

11573/1449521 - 2021 - Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer

Chiacchiarini, Martina; Trocchianesi, Sofia; Besharat, Zein Mersini; Po, Agnese; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: PHARMACOLOGY & THERAPEUTICS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 107708- - issn: 0163-7258 - wos: WOS:000619674700001 (7) - scopus: 2-s2.0-85095586540 (9)

11573/1683419 - 2021 - Hedgehog driven regulatory network sustains chemoresistance and mesenchymal phenotype in Colorectal Cancer cells

Citarella, A.; Catanzaro, G.; Besharat, Z. M.; Barbagallo, F.; Trocchianesi, S.; Sabato, C.; Autilio, T. M.; Asquino, A.; Vacca, A.; Venneri, M. A.; Ferretti, E.; Po, A. - 04f Poster

congresso: ITALIAN SOCIETY OF PATHOLOGY AND TRANSLATIONAL MEDICINE (Perugia)

libro: https://www.sipmet.org/ - ()

11573/1447549 - 2021 - Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth

Miele, Evelina; Po, Agnese; Mastronuzzi, Angela; Carai, Andrea; Besharat, Zein Mersini; Pediconi, Natalia; Abballe, Luana; Catanzaro, Giuseppina; Sabato, Claudia; De Smaele, Enrico; Canettieri, Gianluca; Di Marcotullio, Lucia; Vacca, Alessandra; Mai, Antonello; Levrero, Massimo; Pfister, Stefan M; Kool, Marcel; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: MOLECULAR ONCOLOGY (Amsterdam : Elsevier Science) pp. - - issn: 1574-7891 - wos: WOS:000603687900001 (8) - scopus: 2-s2.0-85098446777 (8)

11573/1639208 - 2021 - Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling

Nazio, Francesca; Po, Agnese; Abballe, Luana; Ballabio, Claudio; Diomedi Camassei, Francesca; Bordi, Matteo; Camera, Antonio; Caruso, Simona; Caruana, Ignazio; Pezzullo, Marco; Ferraina, Caterina; Milletti, Giacomo; Gianesello, Matteo; Reddel, Sofia; Dolores De Luca, Carmen; Ceglie, Donatella; Marinelli, Sara; Campello, Silvia; Papaleo, Elena; Miele, Evelina; Cacchione, Antonella; Carai, Andrea; Vinci, Maria; Velardi, Enrico; De Angelis, Biagio; Tiberi, Luca; Quintarelli, Concetta; Mastronuzzi, Angela; Ferretti, Elisabetta; Locatelli, Franco; Cecconi, Francesco - 01a Articolo in rivista

rivista: ACTA NEUROPATHOLOGICA (Springer Verlag Germany: Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229 SPRINGER, 233 SPRING STREET, NEW YORK, USA, NY, 10013) pp. 537-564 - issn: 0001-6322 - wos: WOS:000677246200001 (18) - scopus: 2-s2.0-85111133392 (23)

11573/1449516 - 2020 - Cancer predisposition syndromes and medulloblastoma in the molecular era

Carta, Roberto; Del Baldo, Giada; Miele, Evelina; Po, Agnese; Besharat, Zein Mersini; Nazio, Francesca; Colafati, Giovanna Stefania; Piccirilli, Eleonora; Agolini, Emanuele; Rinelli, Martina; Lodi, Mariachiara; Cacchione, Antonella; Carai, Andrea; Boccuto, Luigi; Ferretti, Elisabetta; Locatelli, Franco; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:000588477400001 (14) - scopus: 2-s2.0-85095984558 (13)

11573/1436017 - 2020 - Chlamydia trachomatis elicits TLR3 expression but disrupts the inflammatory signaling down-modulating NFκB and IRF3 transcription factors in human Sertoli cells

Di Pietro, M; Filardo, S; Alfano, V; Pelloni, M; Splendiani, E; Po, A; Paoli, D; Ferretti, E; Sessa, R - 01a Articolo in rivista

rivista: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS (Milano: Wichtig.) pp. 977-986 - issn: 1724-6083 - wos: WOS:000550697300026 (11) - scopus: 2-s2.0-85088007973 (11)

11573/1449512 - 2020 - Low-grade gliomas in patients with Noonan syndrome: case-based review of the literature

Lodi, M.; Boccuto, L.; Carai, A.; Cacchione, A.; Miele, E.; Colafati, G. S.; Camassei, F. D.; De Palma, L.; De Benedictis, A.; Ferretti, E.; Catanzaro, G.; Po, A.; De Luca, A.; Rinelli, M.; Lepri, F. R.; Agolini, E.; Tartaglia, M.; Locatelli, F.; Mastronuzzi, A. - 01i Case report

rivista: DIAGNOSTICS (Basel: MDPI) pp. 1-11 - issn: 2075-4418 - wos: WOS:000564777200001 (15) - scopus: 2-s2.0-85090344318 (18)

11573/1392340 - 2020 - BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors

Miele, Evelina; Abballe, Luana; Spinelli Gian, Paolo; Besharat, Zein Mersini; Catanzaro, Giuseppina; Chiacchiarini, Martina; Vacca, Alessandra; Po, Agnese; Capalbo, Carlo; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 129-140 - issn: 1471-2407 - wos: WOS:000518638700003 (8) - scopus: 2-s2.0-85079614789 (9)

11573/1444376 - 2020 - Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

Po, A.; Citarella, A.; Catanzaro, G.; Besharat, Z. M.; Trocchianesi, S.; Gianno, F.; Sabato, C.; Moretti, M.; De Smaele, E.; Vacca, A.; Fiori, M. E.; Ferretti, E. - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000567440100012 (25) - scopus: 2-s2.0-85089600783 (28)

11573/1359878 - 2019 - Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile

Po, A.; Giuliani, A.; Masiello, M. G.; Cucina, A.; Catizone, A.; Ricci, G.; Chiacchiarini, M.; Tafani, M.; Ferretti, E.; Bizzarri, M. - 01a Articolo in rivista

rivista: NPJ MICROGRAVITY ([S.l.] : Nature Publ. Group.) pp. 1-13 - issn: 2373-8065 - wos: WOS:000497729800001 (20) - scopus: 2-s2.0-85075481102 (23)

11573/1338842 - 2019 - KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

Spiombi, Eleonora; Angrisani, Annapaola; Fonte, Simone; De Feudis, Giuseppina; Fabretti, Francesca; Cucchi, Danilo; Izzo, Mariapaola; Infante, Paola; Miele, Evelina; Po, Agnese; Di Magno, Laura; Magliozzi, Roberto; Guardavaccaro, Daniele; Maroder, Marella; Canettieri, Gianluca; Giannini, Giuseppe; Ferretti, Elisabetta; Gulino, Alberto; Di Marcotullio, Lucia; Moretti, Marta; De Smaele, Enrico - 01a Articolo in rivista

rivista: ONCOGENESIS (London Nature Publishing Group) pp. 64- - issn: 2157-9024 - wos: WOS:000494423700001 (20) - scopus: 2-s2.0-85074354238 (20)

11573/1182080 - 2018 - Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Abballe, Luana; Mastronuzzi, Angela; Miele, Evelina; Carai, Andrea; Besharat, Zein Mersini; Moretti, Marta; De Smaele, Enrico; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta; Po, Agnese - 01a Articolo in rivista

rivista: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2360 - wos: WOS:000449006100001 (10) - scopus: 2-s2.0-85057200346 (10)

11573/1079555 - 2018 - Foxm1 controls a pro-stemness microRNA network in neural stem cells

Besharat, Zein Mersini; Abballe, Luana; Cicconardi, Francesco; Bhutkar, Arjun; Grassi, Luigi; Le Pera, Loredana; Moretti, Marta; Chinappi, Mauro; D'andrea, Daniel; Mastronuzzi, Angela; Ianari, Alessandra; Vacca, Alessandra; De Smaele, Enrico; Locatelli, Franco; Po, Agnese; Miele, Evelina; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 3523- - issn: 2045-2322 - wos: WOS:000425934200011 (27) - scopus: 2-s2.0-85042534913 (29)

11573/1206786 - 2018 - Low expression of miR-466f-3p sustains epithelial to mesenchymal transition in sonic hedgehog medulloblastoma stem cells through Vegfa-Nrp2 signaling pathway

Besharat, Zein Mersini; Sabato, Claudia; Po, Agnese; Gianno, Francesca; Abballe, Luana; Napolitano, Maddalena; Miele, Evelina; Giangaspero, Felice; Vacca, Alessandra; Catanzaro, Giuseppina; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. 1281- - issn: 1663-9812 - wos: WOS:000449858600001 (15) - scopus: 2-s2.0-85056909837 (16)

11573/1103174 - 2018 - Circulating MicroRNAs in Elderly Type 2 Diabetic Patients

Catanzaro, Giuseppina; Besharat, Zein Mersini; Chiacchiarini, Martina; Abballe, Luana; Sabato, Claudia; Vacca, Alessandra; Borgiani, Paola; Dotta, Francesco; Tesauro, Manfredi; Po, Agnese; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Cairo: Hindawi Publishing Corporation) pp. 1-11 - issn: 1687-8337 - wos: WOS:000430857800001 (27) - scopus: 2-s2.0-85048133178 (29)

11573/1079614 - 2018 - The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling

Catanzaro, Giuseppina; Besharat, Zein Mersini; Miele, Evelina; Chiacchiarini, Martina; Po, Agnese; Carai, Andrea; Marras, Carlo Efisio; Antonelli, Manila; Badiali, Manuela; Raso, Alessandro; Mascelli, Samantha; Schrimpf, Daniel; Stichel, Damian; Tartaglia, Marco; Capper, David; Von Deimling, Andreas; Giangaspero, Felice; Mastronuzzi, Angela; Locatelli, Franco; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. 687-706 - issn: 0305-1846 - wos: WOS:000450597300004 (30) - scopus: 2-s2.0-85044241660 (32)

11573/1188504 - 2018 - Interrogating molecular data for medulloblastoma risk stratification

Ferretti, Elisabetta; Po, Agnese - 01b Commento, Erratum, Replica e simili

rivista: THE LANCET ONCOLOGY (The Lancet:6277 Sea Harbor:Orlando, FL 32887:(800)462-6198, EMAIL: uslancetcs@elsevier.com, INTERNET: http://www.thelancet.com, Fax: (407)363-1354) pp. - - issn: 1470-2045 - wos: WOS:000451633800041 (3) - scopus: 2-s2.0-85059304218 (3)

11573/1085264 - 2018 - Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

Infante, Paola; Faedda, Roberta; Bernardi, Flavia; Bufalieri, Francesca; Lospinoso Severini, Ludovica; Alfonsi, Romina; Mazzà, Daniela; Siler, Mariangela; Coni, Sonia; Po, Agnese; Petroni, Marialaura; Ferretti, Elisabetta; Mori, Mattia; De Smaele, Enrico; Canettieri, Gianluca; Capalbo, Carlo; Maroder, Marella; Screpanti, Isabella; Kool, Marcel; Pfister, Stefan M.; Guardavaccaro, Daniele; Gulino, Alberto; Di Marcotullio, Lucia - 01a Articolo in rivista

rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. ...-... - issn: 2041-1723 - wos: WOS:000426899000002 (48) - scopus: 2-s2.0-85044632076 (49)

11573/1182557 - 2018 - Adoptive immunotherapy using prame-specific t cells in medulloblastoma

Orlando, Domenico; Miele, Evelina; De Angelis, Biagio; Guercio, Marika; Boffa, Iolanda; Sinibaldi, Matilde; Po, Agnese; Caruana, Ignazio; Abballe, Luana; Carai, Andrea; Caruso, Simona; Camera, Antonio; Moseley, Annemarie; Hagedoorn, Renate S.; Heemskerk, Mirjam H. M.; Giangaspero, Felice; Mastronuzzi, Angela; Ferretti, Elisabetta; Locatelli, Franco; Quintarelli, Concetta - 01a Articolo in rivista

rivista: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 3337-3349 - issn: 0008-5472 - wos: WOS:000435462000019 (55) - scopus: 2-s2.0-85048707363 (63)

11573/1174165 - 2018 - Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel functional networks

Po, A.; Abballe, L.; Sabato, Claudia; Gianno, F.; Chiacchiarini, Martina; Catanzaro, G.; De Smaele, E.; Giangaspero, F.; Ferretti, E.; Miele, E.; Besharat, Z. M. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000442869800178 (13) - scopus: 2-s2.0-85052083051 (14)

11573/1063175 - 2017 - Loss of miR-107, miR-181c and miR-29a-3p promote activation of Notch2 signaling in pediatric high-grade gliomas (pHGGs)

Catanzaro, Giuseppina; Sabato, Claudia; Russo, Michele; Rosa, Alessandro; Abballe, Luana; Besharat, Zein Mersini; Po, Agnese; Miele, Evelina; Bellavia, Diana; Chiacchiarini, Martina; Gessi, Marco; Peruzzi, Giovanna; Napolitano, Maddalena; Antonelli, Manila; Mastronuzzi, Angela; Giangaspero, Felice; Locatelli, Franco; Screpanti, Isabella; Vacca, Alessandra; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000418896700243 (18) - scopus: 2-s2.0-85038414048 (19)

11573/946738 - 2017 - The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity

Laneve, Pietro; Po, Agnese; Favia, Annarita; Legnini, Ivano; Alfano, Vincenzo; Rea, Jessica; Carlo, Valerio Di; Bevilacqua, Valeria; Miele, Evelina; Mastronuzzi, Angela; Carai, Andrea; Locatelli, Franco; Bozzoni, Irene; Ferretti, Elisabetta; Caffarelli, Elisa - 01a Articolo in rivista

rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 31003-31015 - issn: 1949-2553 - wos: WOS:000401003200030 (39) - scopus: 2-s2.0-85019163554 (39)

11573/1024175 - 2017 - β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells

Miele, Evelina; Po, Agnese; Begalli, Federica; Antonucci, Laura; Mastronuzzi, Angela; Marras, Carlo Efisio; Carai, Andrea; Cucchi, Danilo; Abballe, Luana; Besharat, Zein Mersini; Catanzaro, Giuseppina; Infante, Paola; Di Marcotullio, Lucia; Canettieri, Gianluca; De Smaele, Enrico; Screpanti, Isabella; Locatelli, Franco; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 488- - issn: 1471-2407 - wos: WOS:000405865300002 (52) - scopus: 2-s2.0-85024120271 (51)

11573/1017610 - 2017 - The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Borovika, Diana; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Milite, Ciro; Castellano, Sabrina; Tafani, Marco; Trapencieris, Peteris; Mai, Antonello; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 68557-68570- - issn: 1949-2553 - wos: WOS:000410790500145 (34) - scopus: 2-s2.0-85040235337 (36)

11573/932686 - 2017 - β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest

Po, Agnese; Begalli, Federica; Abballe, Luana; Alfano, Vincenzo; Besharat, Zein Mersini; Catanzaro, Giuseppina; Vacca, Alessandra; Napolitano, Maddalena; Tafani, Marco; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta; Miele, Evelina - 01a Articolo in rivista

rivista: STEM CELLS INTERNATIONAL (Cairo: Hindawi Publishing Corporation) pp. 1-11 - issn: 1687-966X - wos: WOS:000395134100001 (6) - scopus: 2-s2.0-85014344723 (6)

11573/952694 - 2017 - Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

Po, Agnese; Silvano, Marianna; Miele, Evelina; Capalbo, Carlo; Eramo, A.; Salvati, V.; Todaro, M.; Besharat, Zein Mersini; Catanzaro, Giuseppina; Cucchi, Danilo; Coni, Sonia; Di Marcotullio, Lucia; Canettieri, Gianluca; Vacca, Alessandra; Stassi, G.; De Smaele, Enrico; Tartaglia, M.; Screpanti, Isabella; De Maria, R.; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. - - issn: 0950-9232 - wos: WOS:000407246200011 (79) - scopus: 2-s2.0-85016980676 (82)

11573/1020174 - 2017 - Role of Natural Killer Cells in Sonic Hedgehog driven Medulloblastoma

Schiavone, Francesco; Carlino, Claudia; Ascenzi, Sonia; Po, Agnese; Sanseviero, Emilio; Ferretti, Elisabetta; Gismondi, Angela; Santoni, Angela - 04c Atto di convegno in rivista

rivista: JOURNAL OF IMMUNOLOGY (American Association of Immunologists:9650 Rockville Pike:Bethesda, MD 20814:(301)634-7024, EMAIL: staff@dues.faseb.org, INTERNET: http://www.aai.org, Fax: (301)634-7099) pp. - - issn: 0022-1767 - wos: WOS:000407750400785 (1) - scopus: (0)

congresso: Annual Meeting of American Association of Immunologists (Washington DC)

11573/844056 - 2016 - MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

Catanzaro, Giuseppina; Besharat, Zein Mersini; Garg, Neha; Ronci, Maurizio; Pieroni, Luisa; Miele, Evelina; Mastronuzzi, Angela; Carai, Andrea; Alfano, Vincenzo; Po, Agnese; Screpanti, Isabella; Locatelli, Franco; Urbani, Andrea; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: STEM CELLS INTERNATIONAL (Cairo: Hindawi Publishing Corporation) pp. 1-10 - issn: 1687-966X - wos: WOS:000372969500001 (8) - scopus: 2-s2.0-84955481687 (9)

11573/960536 - 2016 - Anomalous vascularization in a Wnt medulloblastoma: A case report

Di Giannatale, Angela; Carai, Andrea; Cacchione, Antonella; Marrazzo, Antonio; Dell'anna, Vito Andrea; Colafati, Giovanna Stefania; Diomedi Camassei, Francesca; Miele, Evelina; Po, Agnese; Ferretti, Elisabetta; Locatelli, Franco; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: BMC NEUROLOGY ([London]: BioMed Central.) pp. 103- - issn: 1471-2377 - wos: WOS:000379740800002 (7) - scopus: 2-s2.0-84987761779 (7)

11573/870700 - 2016 - IDO1 involvement in mTOR pathway: A molecular mechanism of resistance to mTOR targeting in medulloblastoma

Folgiero, Valentina; Miele, Evelina; Carai, Andrea; Ferretti, Elisabetta; Alfano, Vincenzo; Po, Agnese; Bertaina, Valentina; Goffredo, Bianca Maria; Benedetti, Maria Chiara; Camassei, Francesca Diomedi; Cacchione, Antonella; Locatelli, Franco; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. -12 - issn: 1949-2553 - wos: WOS:000385433000023 (33) - scopus: 2-s2.0-84982275958 (34)

11573/1344941 - 2016 - Group 4 Medulloblastoma driver gene expression is regulated by the long noncoding RNA linc-NeD125 through its natural microRNA sponge activity

Laneve, P.; Po, A.; Favia, A.; Legnini, I.; Alfano, V.; Rea, J.; Di Carlo, V.; Bevilacqua, V.; Bozzoni, I; Ferretti, E.; Caffarelli, E. - 04f Poster

congresso: EMBO | EMBL Symposium “The complex life of mRNA” (Heidelberg, Germania)

libro: EMBO | EMBL Symposium “The complex life of mRNA” - ()

11573/1293606 - 2016 - Linc-NeD125 establishes a ceRNA network in Group 4 Medulloblastoma

Laneve, Pietro; Po, Agnese; Favia, Annarita; Rea, Jessica; Alfano, Vincenzo; Miele, Evelina; Di Carlo, Valerio; Bevilacqua, Valeria; Legnini, Ivano; Bozzoni, Irene; Ferretti, Elisabetta; Caffarelli, Elisa - 04d Abstract in atti di convegno

congresso: XIV Congress of the Italian Federation of Life Sciences (FISV) (Sapienza, University of Rome, Italy)

libro: Program and Abstracts of the XIV FISV CONGRESS - ()

11573/840557 - 2015 - Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications

Cefalo, Maria Giuseppina; Carai, Andrea; Miele, Evelina; Po, Agnese; Ferretti, Elisabetta; Mastronuzzi, Angela; Germano, Isabelle M. - 01g Articolo di rassegna (Review)

rivista: STEM CELLS INTERNATIONAL (Cairo: Hindawi Publishing Corporation) pp. 1-11 - issn: 1687-966X - wos: WOS:000371083600001 (19) - scopus: 2-s2.0-84949967594 (25)

11573/649688 - 2015 - Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

Infante, Paola; Mori, Mattia; Alfonsi, Romina; Ghirga, Francesca; Federica, Aiello; Toscano, Sara; Ingallina, Cinzia; Mariangela, Siler; Cucchi, Danilo; Po, Agnese; Miele, Evelina; Davide, D’Amico; Canettieri, Gianluca; De Smaele, Enrico; Ferretti, Elisabetta; Screpanti, Isabella; Gloria Uccello, Barretta; Maurizio, Botta; Botta, Bruno; Gulino, Alberto; Di Marcotullio, Lucia - 01a Articolo in rivista

rivista: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 200-217 - issn: 0261-4189 - wos: WOS:000347878900008 (146) - scopus: 2-s2.0-84921293370 (147)

11573/1667577 - 2015 - PTPS-03EPIGENETIC SILENCING OF β-ARRESTIN1 AND ITS INTRAGENIC miR-326 CONTROLS MEDULLOBLASTOMA GROWTH

Miele, Evelina; Mastronuzzi, Angela; Del Bufalo, Francesca; Po, Agnese; Valente, Sergio; Carai, Andrea; Screpanti, Isabella; Giangaspero, Felice; Levrero, Massimo; Locatelli, Franco; Ferretti, Elisabetta - 01h Abstract in rivista

rivista: NEURO-ONCOLOGY (First or current publisher Charlottesville, VA : Carden Jennings Pub., [1999- Intervening publisher Durham, NC : Duke University Press Current or last publisher Oxford, UK : Oxford University Press) pp. - - issn: 1523-5866 - wos: (0) - scopus: (0)

11573/804380 - 2015 - Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup

Miele, Evelina; Mastronuzzi, Angela; Po, Agnese; Carai, Andrea; Alfano, Vincenzo; Serra, Annalisa; Colafati, Giovanna Stefania; Strocchio, Luisa; Antonelli, Manila; Buttarelli, Francesca Romana; Zani, Massimo; Ferraro, Sergio; Buffone, Amelia; Vacca, Alessandra; Screpanti, Isabella; Giangaspero, Felice; Giannini, Giuseppe; Locatelli, Franco; Ferretti, Elisabetta - 01i Case report

rivista: BIOMARKER RESEARCH (London : BioMed Central) pp. - - issn: 2050-7771 - wos: WOS:000361109500002 (23) - scopus: 2-s2.0-85024104793 (26)

11573/840575 - 2015 - Metastatic Group 3 Medulloblastoma in a Patient With Tuberous Sclerosis Complex: Case Description and Molecular Characterization of the Tumor

Moavero, Romina; Folgiero, Valentina; Carai, Andrea; Miele, Evelina; Ferretti, Elisabetta; Po, Agnese; Diomedi Camassei, Francesca; Lepri, Francesca Romana; Vigevano, Federico; Curatolo, Paolo; Valeriani, Massimiliano; Colafati, Giovanna S; Locatelli, Franco; Tornesello, Assunta; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: PEDIATRIC BLOOD & CANCER (Wiley Liss:111 River Street:Hoboken, NY 07030:(201)748-6000, (212)850-6645, EMAIL: subinfo@wiley.com, INTERNET: http://www.wiley.co.uk, Fax: (201)748-6088) pp. 719-722 - issn: 1545-5009 - wos: WOS:000370497100027 (5) - scopus: 2-s2.0-84959556506 (5)

11573/854196 - 2015 - Proteomic analysis of human sonic hedgehog (SHH) medulloblastoma stem-like cells

Ronci, Maurizio; Catanzaro, Giuseppina; Pieroni, Luisa; Po, Agnese; Besharat, Zein Mersini; Greco, Viviana; Levi Mortera, Stefano; Screpanti, Isabella; Ferretti, Elisabetta; Urbani, Andrea - 01a Articolo in rivista

rivista: MOLECULAR BIOSYSTEMS (Cambridge : Royal Society of Chemistry, 2005-) pp. 1603-1611 - issn: 1742-206X - wos: WOS:000354792500014 (22) - scopus: 2-s2.0-84931279311 (22)

11573/656680 - 2015 - MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion.

Sebastiani, G; Po, Agnese; Miele, Evelina; Ventriglia, G; Ceccarelli, E; Bugliani, M; Marselli, L; Marchetti, Paolo; Gulino, Alberto; Ferretti, Elisabetta; Dotta, F. - 01a Articolo in rivista

rivista: ACTA DIABETOLOGICA (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 523-530 - issn: 0940-5429 - wos: WOS:000355233500012 (104) - scopus: 2-s2.0-84930086094 (116)

11573/796885 - 2015 - Consequences of simulated microgravity in neural stem cells: biological effects and metabolic response.

Silvano, Marianna; Miele, Evelina; Valerio, Mariacristina; Casadei, Luca; Begalli, Federica; Campese, Antonio Francesco; Besharat, Zein Mersini; Alfano, Vincenzo; Abballe, Luana; Catanzaro, Giuseppina; Napolitano, Maddalena; Vacca, Alessandra; Screpanti, Isabella; Manetti, Cesare; Ferretti, Elisabetta; Po, Agnese - 01a Articolo in rivista

rivista: JOURNAL OF STEM CELL RESEARCH AND THERAPY (Westlake, Los Angeles, CA: OMICS Publishing Group) pp. - - issn: 2157-7633 - wos: (0) - scopus: (0)

11573/527252 - 2014 - High-throughput microRNA profiling of pediatric high-grade gliomas

Miele, Evelina; Buttarelli, Francesca Romana; A., Arcella; Begalli, Federica; Garg, Neha; M., Silvano; Po, Agnese; Baldi, Caterina; G., Carissimo; Antonelli, Manila; Spinelli, Gian Paolo; Capalbo, Carlo; V., Donofrio; I., Morra; P., Nozza; Gulino, Alberto; Giangaspero, Felice; Ferretti, Elisabetta - 01a Articolo in rivista

rivista: NEURO-ONCOLOGY (Carden Jennings Pub.) pp. 228-240 - issn: 1522-8517 - wos: WOS:000330844300007 (26) - scopus: 2-s2.0-84893122766 (28)

11573/560261 - 2014 - Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

Miele, Evelina; Po, Agnese; Antonelli, Manila; Buttarelli, Francesca Romana; Giovanna Stefania Colafati, ; Francesca Del Bufalo, ; Faedda, Roberta; Spinelli, Gian Paolo; Andrea, Carai; Giangaspero, Felice; Gulino, Alberto; Locatelli, Franco; Ferretti, Elisabetta; Mastronuzzi, Angela - 01a Articolo in rivista

rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 262- - issn: 1471-2407 - wos: WOS:000335520800001 (12) - scopus: 2-s2.0-84899933474 (13)

11573/527314 - 2013 - microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1

Garg, Neha; Po, Agnese; Miele, Evelina; Campese, Antonio Francesco; Begalli, Federica; Marianna, Silvano; Infante, Paola; Capalbo, Carlo; De Smaele, Enrico; Canettieri, Gianluca; Di Marcotullio, Lucia; Screpanti, Isabella; Ferretti, Elisabetta; Gulino, Alberto - 01a Articolo in rivista

rivista: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 2819-2832 - issn: 0261-4189 - wos: WOS:000326504900006 (54) - scopus: 2-s2.0-84887046837 (54)

11573/527250 - 2013 - PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

Mazza, Daniele; Infante, Paola; Colicchia, Valeria; Greco, Azzura; Alfonsi, Romina; M., Siler; Antonucci, Laura; Po, Agnese; De Smaele, Enrico; Ferretti, Elisabetta; Capalbo, Carlo; Bellavia, Diana; Canettieri, Gianluca; Giannini, Giuseppe; Screpanti, Isabella; Gulino, Alberto; Di Marcotullio, Lucia - 01a Articolo in rivista

rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 1688-1697 - issn: 1350-9047 - wos: WOS:000327010600012 (71) - scopus: 2-s2.0-84887619992 (78)

11573/81626 - 2010 - The tumor suppressor gene KCTD11(REN) is regulated by Sp1 and methylation and its expression is reduced in tumors

M., Michela Mancarelli; Francesca, Zazzeroni; Lucia, Ciccocioppo; Daria, Capece; Po, Agnese; Simona, Murgo; Raffaello Di, Camillo; Christian, Rinaldi; Ferretti, Elisabetta; Gulino, Alberto; Edoardo, Alesse - 01a Articolo in rivista

rivista: MOLECULAR CANCER (London : BioMed Central.) pp. 172-179 - issn: 1476-4598 - wos: WOS:000282456200001 (28) - scopus: 2-s2.0-77954051861 (28)

11573/364193 - 2010 - Hedgehog controls neural stem cells through p53-independent regulation of Nanog

Po, Agnese; Ferretti, Elisabetta; Miele, Evelina; De Smaele, Enrico; Arianna, Paganelli; Canettieri, Gianluca; Coni, Sonia; Di Marcotullio, Lucia; Biffoni, Marco; Luca, Massimi; Concezio Di, Rocco; Screpanti, Isabella; Gulino, Alberto - 01a Articolo in rivista

rivista: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 2646-2658 - issn: 0261-4189 - wos: WOS:000280658900017 (180) - scopus: 2-s2.0-77955362243 (189)

11573/224364 - 2009 - MicroRNA profiling in human medulloblastoma

Ferretti, Elisabetta; De Smaele, Enrico; Po, Agnese; Di Marcotullio, Lucia; Emanuele, Tosi; Maria Salome B., Espinola; Concezio Di, Rocco; Riccardo, Riccardi; Giangaspero, Felice; Farcomeni, Alessio; Nofroni, Italo; Pietro, Laneve; Ubaldo, Gioia; Elisa, Caffarelli; Bozzoni, Irene; Screpanti, Isabella; Gulino, Alberto - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF CANCER (Hoboken N.J.: Wiley New York NY: Wiley-Liss) pp. 568-577 - issn: 0020-7136 - wos: WOS:000262205400009 (258) - scopus: 2-s2.0-58149279841 (264)

11573/362261 - 2008 - An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma

De Smaele, Enrico; C., Fragomeli; Ferretti, Elisabetta; Pelloni, Marianna; Po, Agnese; Canettieri, Gianluca; Coni, Sonia; Di Marcotullio, Lucia; Greco, Azzura; Moretti, Marta; C., Di Rocco; S., Pazzaglia; Maroder, Marella; Screpanti, Isabella; Giannini, Giuseppe; Gulino, Alberto - 01a Articolo in rivista

rivista: NEOPLASIA (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 89-98 - issn: 1522-8002 - wos: WOS:000253614300009 (43) - scopus: 2-s2.0-38649132910 (44)

11573/359122 - 2008 - Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

Ferretti, Elisabetta; De Smaele, Enrico; Miele, Evelina; Pietro, Laneve; Po, Agnese; Pelloni, Marianna; Arianna, Paganelli; Di Marcotullio, Lucia; Elisa, Caffarelli; Screpanti, Isabella; Bozzoni, Irene; Gulino, Alberto - 01a Articolo in rivista

rivista: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 2616-2627 - issn: 0261-4189 - wos: WOS:000259891300014 (268) - scopus: 2-s2.0-53549129980 (283)

11573/224447 - 2008 - Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors

Ferretti, Elisabetta; Emanuele, Tosi; Po, Agnese; Scipioni, Angela; Roberta, Morisi; M. S., Espinola; D., Russo; Durante, Cosimo; M., Schlumberger; Screpanti, Isabella; Filetti, Sebastiano; Gulino, Alberto - 01a Articolo in rivista

rivista: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (-Springfield, Ill. : Charles C. Thomas -Philadelphia : J.B. Lippincott Co. -Baltimore, Md. : Issued for the Endocrine Society by the Williams & Wilkins Co. -Bethesda, MD : Endocrine Society -Chevy Chase, MD : Endocrine Society) pp. 4080-4087 - issn: 0021-972X - wos: WOS:000259903700061 (62) - scopus: 2-s2.0-53749106268 (65)

11573/55677 - 2006 - Numb is a suppressor of Hedgehog signaling and targets Gli1 for Itch-dependent ubiquitination.

Di Marcotullio, L; Ferretti, Elisabetta; Greco, A; De Smaele, Enrico; Po, Agnese; Alimandi, Maurizio; Giannini, G; Maroder, M; Screpanti, I; And Gulino, A. - 04b Atto di convegno in volume

congresso: EMBO Workshop Hedgehog-Gli signaling in cancer and stem cells (Roma)

libro: EMBO WORKSHOP ON HEDGEHOG-GLI SIGNALING IN CANCER AND STEM CELLS. - ()

11573/364857 - 2006 - Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination

Di Marcotullio, Lucia; Ferretti, Elisabetta; Greco, Azzura; De Smaele, Enrico; Po, Agnese; Maria Anna, Sico; Alimandi, Maurizio; Giannini, Giuseppe; Maroder, Marella; Screpanti, Isabella; Gulino, Alberto - 01a Articolo in rivista

rivista: NATURE CELL BIOLOGY (Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108) pp. 1415-U68 - issn: 1465-7392 - wos: WOS:000242419800018 (236) - scopus: 2-s2.0-33751503224 (244)

11573/55669 - 2006 - Alternative splicing of ErbB-4 cdytoplasmic domain and regulation by hedgehog signaling identità distinct medulloblastoma subsets.

Ferretti, E; Di Marcotullio, L; Gessi, M; Mattei, T; Greco, A; Po, Agnese; De Smaele, Enrico; Giangaspero, Felice; Riccardi, R; Di Rocco, C; Pazzaglia, S; Maroder, M; Alimandi, Maurizio; Screpanti, I; And Gulino A., Roma; Italy, - 04a Atto di comunicazione a congresso

libro: EMBO WORKSHOP ON HEDGEHOG-GLI SIGNALING IN CANCER AND STEM CELLS. - ()

11573/362834 - 2006 - Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets

Ferretti, Elisabetta; Di Marcotullio, Lucia; M., Gessi; T., Mattei; Greco, Azzura; Po, Agnese; De Smaele, Enrico; Giangaspero, Felice; R., Riccardi; C., Di Rocco; S., Pazzaglia; Maroder, Marella; Alimandi, Maurizio; Screpanti, Isabella; Gulino, Alberto - 01a Articolo in rivista

rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 7267-7273 - issn: 0950-9232 - wos: WOS:000242244700005 (40) - scopus: 2-s2.0-33751307615 (39)