VALENTINA DE PASCALE

PhD Student

PhD program:: XXXVIII
email: valentina.depascale@ifo.it
phone: 0652662571
building: Translational Oncology Research Unit, Department of Research and Advanced Technologies, IRCSS Regina Elena National Cancer Institute

supervisor: Prof. Gianluca Canettieri
co-supervisor: Dott. Giovanni Blandino

Research: Lymph node micrometastases in HNSCC: molecular profiling of histologically negative lymph nodes for prognostic and therapeutic purposes

• PERSONAL DATA
Date and place of birth: 26/09/1997, Salerno (SA), Italy
Work address: IRCCS Regina Elena National Cancer Institute, Rome, Italy
Phone number: +39 06 52662533 e-mail address: valentina.depascale@ifo.it

• EDUCATION
2019-2021: Master Degree in Biology, University of Perugia, Perugia, Italy
2017-2019: Bachelor Degree in Biology, University of Perugia, Perugia, Italy

• RESEARCH EXPERIENCE
2023: Health Researcher, Lab. Translational Oncology Research (head Dr. Giovanni Blandino), IRCCS Regina Elena National Cancer Institute, Rome, Italy
2022: Sapienza Fellowship, Lab. Translational Oncology Research (head Dr. Giovanni Blandino), IRCCS Regina Elena National Cancer Institute, Rome, Italy
2020-2021: Master Degree Internship, Laboratory of Gastroenterology, University of Perugia, Perugia, Italy

• TECHNICAL SKILLS AND COMPETENCES
Establishment and maintenance of adherent/suspension cell cultures; Separation of mononuclear cells from BM or PB by density gradient centrifugation; Cell sorting (BD FACSMelody); Isolation and purification of nucleic acids from cells and blood (DNAs/RNAs, circulating-free DNAs/RNAs/microRNAs); PCR, RT-qPCR and digital PCR (QuantStudio3D and Absolute Q); NGS analysis (IonTorrent GeneStudio S5); Preparation of protein lysates from cell cultures; Analysis of protein expression (Western Blotting, FACS); Cytometric evaluation of MM population (BD FACSLyric), cell cycle (Acridin Orange, PI, BrdU, EdU), and apoptosis (AnnV/PI); Database Interrogation and bioinformatics.

• AWARDS
2022: Winner of Sapienza-IRE 1-year fellowship for the project NANO-COVD-TEST

• PUBLICATIONS
2023 - Detection of anti-SARS CoV-2 antibodies in human serum by means of Bloch surface waves on 1D photonic crystal biochips
2023 - It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Research products

11573/1726434 - 2024 - Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI

Campo, Flaminia; Paolini, Francesca; Manciocco, Valentina; Moretto, Silvia; Pichi, Barbara; Moretti, Claudio; Blandino, Giovanni; De Pascale, Valentina; Benevolo, Maria; Pimpinelli, Fulvia; Vidiri, Antonello; Marzi, Simona; Ruggiero, Sergio; Terrenato, Irene; Iocca, Oreste; Venuti, Aldo; Pellini, Raul - 01a Articolo in rivista

paper: HEAD & NECK ([New York, NY] : Wiley Periodicals, Inc., c1989-) pp. - - issn: 1097-0347 - wos: WOS:001265560000001 (2) - scopus: 2-s2.0-85197744627 (0)

11573/1726439 - 2024 - Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer

Ganci, Federica; Allegretti, Matteo; Frascolla, Carlotta; Spinella, Francesca; Rollo, Francesca; Sacconi, Andrea; De Pascale, Valentina; Palcau, Alina Catalina; Manciocco, Valentina; Vescovo, Mariavittoria; Cotroneo, Ettore; Blandino, Francesca; Benevolo, Maria; Covello, Renato; Muti, Paola; Strano, Sabrina; Vidiri, Antonello; Fontemaggi, Giulia; Pellini, Raul; Blandino, Giovanni - 01a Articolo in rivista

paper: BIOMARKER RESEARCH (London : BioMed Central) pp. - - issn: 2050-7771 - wos: (1) - scopus: 2-s2.0-85186925530 (2)

11573/1694206 - 2023 - Detection of anti-SARS CoV-2 antibodies in human serum by means of Bloch surface waves on 1D photonic crystal biochips

Occhicone, A.; Sinibaldi, A.; Chiappetta, D.; Di Matteo, P.; Pileri, T.; Danz, N.; Sonntag, F.; Munzert, P.; Allegretti, M.; De Pascale, V.; Mandoj, C.; Michelotti, F. - 01a Articolo in rivista

paper: BIOSENSORS AND BIOELECTRONICS. X (Amsterdam: Elsevier B.V.) pp. - - issn: 2590-1370 - wos: (0) - scopus: 2-s2.0-85176470180 (4)

11573/1697539 - 2023 - It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: systematic review and meta‐analysis

Paolini, Francesca; Campo, Flaminia; Iocca, Oreste; Manciocco, Valentina; De Virgilio, Armando; De Pascale, Valentina; Moretto, Silvia; Dalfino, Gianluca; Vidiri, Antonello; Blandino, Giovanni; Pimpinelli, Fulvia; Venuti, Aldo; Pellini, Raul - 01g Articolo di rassegna (Review)

paper: HEAD & NECK (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 2945-2954 - issn: 1043-3074 - wos: WOS:001067687100001 (5) - scopus: 2-s2.0-85171298818 (4)