VALENTINA DE PASCALE

PhD Student

PhD program:: XXXVIII
email: valentina.depascale@ifo.it
phone: 0652662571
building: Translational Oncology Research Unit, Department of Research and Advanced Technologies, IRCSS Regina Elena National Cancer Institute

supervisor: Prof. Gianluca Canettieri
co-supervisor: Dott. Giovanni Blandino

Research: Lymph node micrometastases in HNSCC: molecular profiling of histologically negative lymph nodes for prognostic and therapeutic purposes

• PERSONAL DATA
Date and place of birth: 26/09/1997, Salerno (SA), Italy
Work address: IRCCS Regina Elena National Cancer Institute, Rome, Italy
Phone number: +39 06 52662533 e-mail address: valentina.depascale@ifo.it

• EDUCATION
2019-2021: Master Degree in Biology, University of Perugia, Perugia, Italy
2017-2019: Bachelor Degree in Biology, University of Perugia, Perugia, Italy

• RESEARCH EXPERIENCE
2023: Health Researcher, Lab. Translational Oncology Research (head Dr. Giovanni Blandino), IRCCS Regina Elena National Cancer Institute, Rome, Italy
2022: Sapienza Fellowship, Lab. Translational Oncology Research (head Dr. Giovanni Blandino), IRCCS Regina Elena National Cancer Institute, Rome, Italy
2020-2021: Master Degree Internship, Laboratory of Gastroenterology, University of Perugia, Perugia, Italy

• TECHNICAL SKILLS AND COMPETENCES
Establishment and maintenance of adherent/suspension cell cultures; Separation of mononuclear cells from BM or PB by density gradient centrifugation; Cell sorting (BD FACSMelody); Isolation and purification of nucleic acids from cells and blood (DNAs/RNAs, circulating-free DNAs/RNAs/microRNAs); PCR, RT-qPCR and digital PCR (QuantStudio3D and Absolute Q); NGS analysis (IonTorrent GeneStudio S5); Preparation of protein lysates from cell cultures; Analysis of protein expression (Western Blotting, FACS); Cytometric evaluation of MM population (BD FACSLyric), cell cycle (Acridin Orange, PI, BrdU, EdU), and apoptosis (AnnV/PI); Database Interrogation and bioinformatics.

• AWARDS
2022: Winner of Sapienza-IRE 1-year fellowship for the project NANO-COVD-TEST

• PUBLICATIONS
2023 - Detection of anti-SARS CoV-2 antibodies in human serum by means of Bloch surface waves on 1D photonic crystal biochips
2023 - It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Research products

11573/1749637 - 2025 - Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy

Cortile, Clelia; Cappelletto, Maria Chiara; Bruno, Tiziana; Di Giovenale, Stefano; Amadio, Bruno; De Nicola, Francesca; Falcone, Italia; Giuliani, Stefano; Palermo, Belinda; Catena, Valeria; Ciuffreda, Ludovica; Cerruti, Fulvia; Cascio, Paolo; Merola, Roberta; Masi, Serena; De Pascale, Valentina; Annibali, Ombretta; Ferraro, Silvia; Gumenyuk, Svitlana; Pisani, Francesco; Marchesi, Francesco; Mengarelli, Andrea; Fanciulli, Maurizio; Corleone, Giacomo - 01a Articolo in rivista

paper: BLOOD (New York: Elsevier Inc. [Washington DC etc.]: American Society of Hematology) pp. - - issn: 0006-4971 - wos: (0) - scopus: (0)

11573/1744938 - 2025 - Development of an innovative duplex digital PCR assay for circulating MiRNA ratio quantification in metastatic melanoma

De Gregorio, Alex; Sacconi, Andrea; Mandoj, Chiara; Valenti, Fabio; De Pascale, Valentina; Madonna, Gabriele; Capone, Mariaelena; Meinardi, Teresa; Guerresi, Francesca; Terrenato, Irene; Cigliana, Giovanni; Russillo, Michelangelo; Ferraresi, Virginia; Fanciulli, Maurizio; Blandino, Giovanni; Ascierto, Paolo Antonio; Ciliberto, Gennaro; Mancini, Rita; Fattore, Luigi - 01a Articolo in rivista

paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central-Springer London) pp. 1-13 - issn: 1479-5876 - wos: WOS:001551181300001 (0) - scopus: 2-s2.0-105013532047 (0)

11573/1740275 - 2025 - MicroRNA-mediated PTEN downregulation as a novel non-genetic mechanism of acquired resistance to PI3Kα inhibitors of head & neck squamous cell carcinoma

Pulito, C.; Vaccarella, S.; Palcau, A. C.; Ganci, F.; Brandi, R.; Frascolla, C.; Sacconi, A.; Canu, V.; Benedetti, A.; De Pascale, V.; Donzelli, S.; Fisch, A. -S.; Manciocco, V.; Covello, R.; Pimpinelli, F.; Morrone, A.; Fazi, F.; Pellini, R.; Muti, P.; Meens, J.; Karamboulas, C.; Nichols, A. C.; Strano, S.; Klinghammer, K.; Tinhofer, I.; Ailles, L.; Fontemaggi, G.; Blandino, G. - 01a Articolo in rivista

paper: DRUG RESISTANCE UPDATES (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 1-17 - issn: 1368-7646 - wos: WOS:001496049400002 (0) - scopus: 2-s2.0-105005357808 (1)

11573/1726434 - 2024 - Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI

Campo, Flaminia; Paolini, Francesca; Manciocco, Valentina; Moretto, Silvia; Pichi, Barbara; Moretti, Claudio; Blandino, Giovanni; De Pascale, Valentina; Benevolo, Maria; Pimpinelli, Fulvia; Vidiri, Antonello; Marzi, Simona; Ruggiero, Sergio; Terrenato, Irene; Iocca, Oreste; Venuti, Aldo; Pellini, Raul - 01a Articolo in rivista

paper: HEAD & NECK ([New York, NY] : Wiley Periodicals, Inc., c1989-) pp. 2206-2213 - issn: 1097-0347 - wos: WOS:001265560000001 (6) - scopus: 2-s2.0-85197744627 (6)

11573/1726439 - 2024 - Combined TP53 status in tumor-free resection margins and circulating microRNA profiling predicts the risk of locoregional recurrence in head and neck cancer

Ganci, Federica; Allegretti, Matteo; Frascolla, Carlotta; Spinella, Francesca; Rollo, Francesca; Sacconi, Andrea; De Pascale, Valentina; Palcau, Alina Catalina; Manciocco, Valentina; Vescovo, Mariavittoria; Cotroneo, Ettore; Blandino, Francesca; Benevolo, Maria; Covello, Renato; Muti, Paola; Strano, Sabrina; Vidiri, Antonello; Fontemaggi, Giulia; Pellini, Raul; Blandino, Giovanni - 01a Articolo in rivista

paper: BIOMARKER RESEARCH (London : BioMed Central) pp. - - issn: 2050-7771 - wos: (0) - scopus: 2-s2.0-85186925530 (2)

11573/1694206 - 2023 - Detection of anti-SARS CoV-2 antibodies in human serum by means of Bloch surface waves on 1D photonic crystal biochips

Occhicone, A.; Sinibaldi, A.; Chiappetta, D.; Di Matteo, P.; Pileri, T.; Danz, N.; Sonntag, F.; Munzert, P.; Allegretti, M.; De Pascale, V.; Mandoj, C.; Michelotti, F. - 01a Articolo in rivista

paper: BIOSENSORS AND BIOELECTRONICS. X (Amsterdam: Elsevier B.V.) pp. - - issn: 2590-1370 - wos: (0) - scopus: 2-s2.0-85176470180 (10)

11573/1697539 - 2023 - It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: systematic review and meta‐analysis

Paolini, Francesca; Campo, Flaminia; Iocca, Oreste; Manciocco, Valentina; De Virgilio, Armando; De Pascale, Valentina; Moretto, Silvia; Dalfino, Gianluca; Vidiri, Antonello; Blandino, Giovanni; Pimpinelli, Fulvia; Venuti, Aldo; Pellini, Raul - 01g Articolo di rassegna (Review)

paper: HEAD & NECK (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 2945-2954 - issn: 1043-3074 - wos: WOS:001067687100001 (16) - scopus: 2-s2.0-85171298818 (15)