PRESENT POSITION: Associate Professor, General Pathology, MED/04
DEPARTMENT OF EXPERIMENTAL MEDICINE
EDUCATION AND CAREER
2015-present Associate Professor, General Pathology, MED/04
2010-2015 Assistant professor, General Pathology, MED/04
2007-2010 Assistant professor, Department of Cellular and Molecular Pathology, IRCCS San Raffaele Pisana, Rome.
2004-2007 Post-Doctoral Fellow, Department of Experimental Medicine, Sapienza University.
2000-2004 Assistant professor, Thomas Jefferson, Philadelphia, PA, USA
1997-2000 Research Technician, Thomas Jefferson, Philadelphia, PA, USA
1999-2003 PhD in Human Pathology, Department of Experimental Medicine, Sapienza University.
1994 Degree in Biology, Tor Vergata University, Rome.
MOST RELEVANT RESEARCH LINES
1) Hypoxia and inflammation in tumor progression
2) Sirtuins in cellular physiology and pathology
3) Mechanoreceptors and sirtuins in space biomedicine
COLLABORATIONS
Prof. Pankaj K Singh, University of Nebraska, Omaha, NB, USA
Prof. Gregg L Semenza, Johns Hopkins University, Baltimora, MD, USA
Prof. Matteo A Russo, MEBIC, San Raffaele Pisana, Roma
Dr Federica Limana, Università San Raffeale, Roma.
Prof. Antonello Mai, Università Sapienza
Prof. Mariano Bizzarri, Università Sapienza
Prof. Marco Cordani, Complutense University, 28040 Madrid, Spain.
FIVE SELECTED PUBLICATIONS
1) Barreca F, Aventaggiato M, Vitiello L, Sansone L, Russo MA, Mai A, Valente S, Tafani M. SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS. Antioxidants (Basel). 2023 Aug 18;12(8):1635. doi: 10.3390/antiox12081635.
2) Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. PMID: 34245764; PMCID: PMC8546779.
3) Aventaggiato M, Vernucci E, Barreca F, Russo MA, Tafani M. Sirtuins' control of autophagy and mitophagy in cancer. Pharmacol Ther. 2021 May;221:107748. doi: 10.1016/j.pharmthera.2020.107748. Epub 2020 Nov 24. PMID: 33245993.
4) Po A, Giuliani A, Masiello MG, Cucina A, Catizone A, Ricci G, Chiacchiarini M, Tafani M, Ferretti E, Bizzarri M. Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile. NPJ Microgravity. 2019 Nov 21;5:27. doi: 10.1038/s41526-019-0088-x. PMID: 31799378; PMCID: PMC6872750.
5) Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778. PMID: 25700560; PMCID: PMC4502726.