STEFANO GIANNI

Professore ordinario

email: stefano.gianni@uniroma1.it
telefono: 067886799

Full Professor of Molecular Biology, (1 November 2016-date), Department of Biochemical Sciences, University of Rome “La Sapienza” 
Director of the PhD School in Biochemistry (2017-2023)

Associate Professor, (from 27 December 2012-31 October 2016), Department of Biochemical Sciences, University of Rome “La Sapienza”
Visiting Professor (from 30 May 2013-July 2016), Department of Chemistry, University of Cambridge, UK
Researcher, (from 30 December 2005) Institute of Molecular Biology and Pathology, CNR, Rome, Italy.
Postdoctoral fellow, (1 June 2005 - 28 December 2005) Istituto Pasteur-Fondazione Cenci Bolognetti.
Research Assistant, (1 March 2004 - 31 May 2005), University of Rome “La Sapienza”.
Visiting Scientist, (1 October 2001 – 31 December 2003) Centre for Protein Engineering, Medical Research Council, Cambridge, UK, with Professor Alan Fersht.

Education:
Degree, in Biological Sciences, 110/110 cum laude, 14 December 1999. Sapienza, University of Rome
PhD in Biochemistry, 27 March 2003. Title: Snapshots of Protein folding. The folding pathway of cytochrome c551 from Pseudomonas Aeruginosa. University of Rome “La Sapienza”.

Editorial activities:

Editorial Board Member of Current Opinion in Structural Biology (Elsevier; 2024-date); Biophysical Chemistry (Elsevier; 2015-2020), Scientific Reports (Nature Publishing Group; 2013-date), Protein Engineering Design & Selection (Oxford Journals; 2008-2016), Protein and Peptide Letter (Bentham Science; 2021-date), Int J Mol Sci (MDPI; 2021-date), Life (MDPI; Editor-in-chief; 2021-date); Biology Direct (Springer Nature; 2022-date)

Awards and Prizes:

-May 2009 Accademia Nazionale delle Scienze, detta dei XL, e Accademia Nazionale dei Lincei. “Vincenzo Caglioti" International Prize for Chemistry.
-May 2013 EMBO fellowship
- 2014 - 2018 Elected Member of the Global Young Academy
- 2018 - date Elected Member of the Scientific Board, Pasteur Institute, Italy
- 2019 - date Elected Member of the Academia Europeae (section Molecular Biology)
- September 2020 Accademia Nazionale dei Lincei. “Luigi Tartufari" International Prize for Biological Sciences
- September 2020 Accademia Nazionale delle Scienze, detta dei XL. “Emilia Chiancone Medal" for Biological Chemistry.
- June 2024 Accademia Nazionale dei Lincei. “Antonio Feltrinelli" Prize for Physiology, Biochemistry, Pharmacology and Neurosciences

Invited Talks and seminars:
Prof. Gianni has contributed over 40 talks and seminars in international conferences.

Selected Invited Presentations:

-21 July 2007 Protein Society Conference “Proteins from Birth to Death”, Boston, USA. -14-18 June 2009 VIII European Protein Society Meeting, Zurich, Switzerland
-23-24 September 2010 Conference “Twenty years of Protein Engineering”, Cambridge, UK,
-1-3 December 2010 Conference “Protein Structure and Dynamics”, Accademia dei Lincei Rome, Italy
- 25-30 June 2011 36th FEBS Congress, Turin, Italy.
-25-26 September 2012 Conference “Proteine 2012”, Chieti, Italy
-28-30 May 2018 “Proteine 2018”, Verona, Italy
-23 September 2018 “FISV Conference”, Rome, Italy
-1 August 2023, European Biophysical Society, Stockholm, Sweden
-11 June 2024, EU MORSBI International Conference, Lubjana, Slovenia

FUNDING

Prof. Gianni has been the Beneficiary of several research grants as Principal Investigator, including:

PASTEUR UNDER 40 (2013-2016, 90k Euro)
AIRC MFAG GRANT (2016-2019, 300k Euro)
EU ETN PDZnet (2016-2020, 250k Euro)
EU ETN UBIMOTIF (2020-2024, 250k Euro)
Lazio INNOVA (2021-2023, 100k Euro)
AIRC IG GRANT (2021-2025, 400k Euro)
PNRR – Paternariato Esteso – Age-it Spoke 2 (2023-2026. 300k Euro)
EU ETN IDPro (2023-2027, 250k Euro)

SCIENTIFIC PRODUCTION:

Prof. Gianni is author of about 165 scientific publications in international peer-reviewed scientific journals, with over 4500 citations and an H index of 39.

SCIENTIFIC PUBLICATIONS:

1) Gianni, S., Travaglini-Allocatelli, C., Cutruzzolà, F., Bigotti, M.G. & Brunori, M. (2001). Snapshots of protein folding. A study on the multiple transition state pathway of cytochrome c551 from Pseudomonas aeruginosa. J. Mol. Biol., 309, 1177-87.

2) Gianni, S., Brunori, M. & Travaglini-Allocatelli, C. (2001). Refolding kinetics of cytochrome c551 reveals mechanistic defference between urea and guanidine. Protein Science, 10, 1685-1688

3) Arcovito, A., Gianni, S., Brunori, M., Travaglini-Allocatelli, C. & Bellelli, A. (2001). Fast coordination changes in cytochrome c do not necessarily imply folding. J. Biol. Chem. 276, 41073-41078.

4) Brunori, M., Bigotti, M.G., Cutruzzolà, F., Gianni, S. & Travaglini-Allocatelli, C. (2003) Cytochrome c551 as a model system for protein folding. Biophys. Chem. 100, 409-419.

5) Gianni, S., Travaglini-Allocatelli, C., Cutruzzolà, F., Brunori, M., Ramachandra Shastry, M.C. & Roder, H. (2003) Parallel pathways in cytochrome c551 folding. J. Mol. Biol. 330, 1145-1152 .

6) Travaglini-Allocatelli, C., Gianni, S., Morea, V., Tramontano, A., Soulimane, T. & Brunori, M. (2003) Exploring the cytochrome c folding mechanisms: cyt c552 from Thermus thermophilus folds through an on-pathway intermediate. J. Biol. Chem., 278, 41136-41140 .

7) Gianni, S., Guydosh, N.R., Khan, F., Caldas, T.D., Mayor, U., White, G.W.N., DeMarco, M.L., Daggett, V. & Fersht A.R. (2003) Unifying features in protein folding mechanisms. Proc. Natl. Acad. Sci USA, 100, 13286-13291.

8) Khan, F., Chuang, J.I., Gianni, S. and Fersht, A.R. (2003) The kinetic pathway of folding of barnase. J. Mol. Biol., 333, 169-186.

9) Gianni, S., Mayor, U. and Fersht, A.R. (2003) Structural insights in the folding of single domain proteins. Ital. J. Biochem., 52, 157-161.

10) Jemth, P.*, Gianni S.*, Day, R., Li, B., Johnson, C.M., Daggett, V. and Fersht, A.R. (2004) Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. Proc. Natl. Acad. Sci USA, 101, 6450-6455.

11) Travaglini-Allocatelli, C., Gianni, S. and Brunori, M. (2004) A common folding mechanism in the cytochrome c family. Trends Bioch. Sci., 29, 535-541.

12) White, G.W.N.*, Gianni, S.*, Grossman, J.G., Jemth, P., Fersht, A.R., and Daggett, V. (2005) Simulation and Experiment Conspire to reveal Cryptic Intermediates and the Slide from Framework to Nucleation-Condensation Mechanism in the Folding of the Homeodomain Superfamily. J. Mol. Biol., 350, 757-775.

13) Jemth, P., Day, R., Gianni, S., Khan, F., Allen, M. D., Daggett, V., and Fersht, A. R. (2005) The structure of the major transition state for folding of an FF domain from experiment and simulation. J. Mol. Biol., 350, 363-378

14) Travaglini-Allocatelli, C.*, Gianni, S.*, Dubey, V.K., Borgia, A., Di Matteo, A., Bonivento, D., Cutruzzolà, F., Bren, K.L. and Brunori, M. (2005) An obligatory intermediate in the folding of cytochrome c552 from Hydrogenobacter thermophilus. J. Biol. Chem., 280, 25729-25734

15) Gianni S., Calosci, N., Aelen, J., Vuister, G.W., Brunori, M. and Travaglini-Allocatelli C. (2005) Kinetic folding mechanism of PDZ2 from PTP-BL, Protein Eng. Des. Sel., 18, 389-395.

16) Gianni, S., Engström, A., Larsson, M., Calosci, N., Malatesta, F., Eklund, L., Ngang, C.C., Travaglini-Allocatelli, C., and Jemth P., (2005) The Kinetics Of Pdz Domain – Ligand Interactions And Implications For The Binding Mechanism, J. Biol. Chem., 280, 34805-34812.

17) Chi, C.N, Engstrom, Å, Gianni, S., Larsson, M. and Jemth, P. (2006) Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain. J.Biol. Chem., 281, 36811-36888.

18) Gianni, S., Walma, T., Arcovito, A., Calosci, N., Bellelli, A., Engstrom, Å, Travaglini-Allocatelli, C., Brunori, M., Jemth, P. and Vuister, G.W. (2006) Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering. Structure, 14, 1801-1809.

19) Gianni, S., Geeierhaas, C.D., Calosci, N., Jemth, P., Vuister, G.W., Travaglini-Allocatelli, C., Vendruscolo, M. and Brunori M. (2007) A PDZ domain recapitulates a unifying mechanism for protein folding. Proc. Natl. Acad. Sci USA, 104, 128-133.

20) Federici, L., Masulli, M., Bonivento, D., Di Matteo, A., Gianni, S., Favaloro, B., Di Ilio, C. and Allocati, N., (2007) Role of Ser11 in the stabilization of the structure of Ochrobactrum anthropi glutathione transferase. Biochem J. 2007 403, 267-274

21) Ivarsson, Y., Travaglini-Allocatelli, C., Jemth, P., Malatesta, F., Brunori, M. and Gianni, S.† (2007) An on-pathway intermediate in the folding of a PDZ domain.
J Biol Chem. 282, 8568-8572

22) Chi, C.N*, Gianni, S.*†, Calosci, N., Travaglini-Allocatelli, C. Engstrom, Å, and Jemth, P. (2007) A conserved folding mechanism for PDZ domains. FEBS Letters 2007 581, 1109-1113.

23) Gianni, S.†, Ivarsson, Y., Jemth, P., Brunori, M., Travaglini-Allocatelli, C. (2007) Identification and characterization of protein folding intermediates. Biophys. Chem 128, 105-113.

24) Gianni, S., Brunori, M., Travaglini-Allocatelli, C., (2007) Plasticity of the protein folding landscape: switching between on and off-pathway intermediates Arch. Biochem. Biophys. 466 172-176.

25) Di Matteo, A., Gianni, S., Schininà, M.E., Giorgi, A., Altieri, F., Calosci, N., Brunori, M., Travaglini-Allocatelli, C. (2007) A strategic protein in cytochrome c maturation: 3D structure of CcmH and binding to apocytochrome c. J. Biol. Chem. 282, 27012-27019.

26) Jemth, P., Gianni, S.† (2007) PDZ domains: folding and binding. Biochemistry 46, 8701-8708

27) Gianni, S.†, Ivarsson, Y., Bah, A., Bush-Pelic, L.A., Di Cera, E. (2007) Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics. Biophys. Chem. 131, 111-114.

28) Ivarsson, Y., Travaglini-Allocatelli, C., Morea, V., Brunori, M., Gianni, S.† (2008) The folding pathway of an engineered circularly permuted PDZ domain. Protein Eng. Des. Sel 21 155-160.

29) Ivarsson, Y., Travaglini-Allocatelli, C., Brunori, M., Gianni, S.† (2008) Mechanisms of proten folding. Eur. Biophys. J. 37, 721-728

30) Jemth, P., Johnson, C.M., Gianni, S., Fersht, A.R. (2008) Demonstration by burst phase analysis of a robust folding intermediate in the FF domain Protein Eng. Des. Sel. 21, 207-214.

31) Ivarsson, Y, Travaglini-Allocatelli, C., Brunori, M., Gianni, S.†, (2008) Folding and Misfolding in a naturally circularly permuted PDZ domain. J. Biol. Chem. 283, 8954-8960.

32) Borgia, A., Gianni, S., Brunori, M., Travaglini-Allocatelli, C., (2008) Fast folding kinetics and stabilization of apo-cytochrome c FEBS Letters .582 1003-1007.

33) Parrini, C., Bemporad, F., Baroncelli, A., Gianni, S., Travaglini-Allocatelli, C., Kohn, J.E., Ramazzotti, M., Chiti, F., Taddei, N., (2008) The folding process of acylphosphatase from Escherichia coli is remarkably accelerated by the presence of a disulfide bond. J. Mol. Biol. 379, 1107-1118.

34) Calosci, N., Chi, C.N., Richter, B., Camilloni, C., Engstrom, A, Eklund, L, Travaglini-Allocatelli, C., Gianni, S.†, Vendruscolo, M.†, Jemth, P.†, (2008) Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins Proc. Natl. Acad. Sci. USA, 105, 19241-19246.

35) Sicorello, A., Torrassa, S., Soldi, G., Gianni, S., Travaglini-Allocatelli, C., Taddei, N., Relini, A., Chiti, F., (2009) Agitation and high ionic strength induce amyloidogenesis of a folded PDZ domain in native conditions Biophys. J 96, 2289-2298.

36) Travaglini-Allocatelli, C., Ivarsson, Y., Jemth, P., and Gianni, S.,† (2009) Folding and stability of globular proteins and implications for function. Curr. Opin. Struct. Biol. 19, 3-7.

37) Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M. (2009) Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance. FASEB J. 23, 2360-2365.

38) Federici, L., Masulli, M., Gianni, S., Di Ilio, C., Allocati, N. (2009) A conserved hydrogen-bond network stabilizes the structure of Beta class glutathione S-transferases. Biochem Biophys Res Commun. 382: 525-529.

39) Ivarsson, Y., Travaglini-Allocatelli, C., Brunori, M., Gianni, S., (2009) Engineered symmetric connectivity highlights malleability in protein folding pathways J. Am. Chem. Soc. 131, 11727-11733.

40) Chi, C.N., Bach, A., Engström, A., Wang, H., Strømgaard, K., Gianni, S.†, Jemth, P. † (2009) A sequential binding mechanism in a PDZ domain. Biochemistry. 48, 7089-7097.

41) Savino, C., Montemiglio, L.C., Sciara, G., Miele, A.E., Kendrew, S.G., Jemth, P., Gianni, S.†, Vallone, B., (2009) Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. J. Biol. Chem. 284, 29170-29179.

42) Gianni, S., Brunori, M., Jemth, P., Oliveberg, M., Zhang, M., (2009) Distinguishing between smooth and rough free energy barriers in protein folding. Biochemistry 48, 11825-11830.

43) Giansanti, F., Di Leandro, L., Koutris, I., Pitari, G., Fabbrini, M.S., Lombardi, A., Flavell, D.J., Flavell, S.U., Gianni, S. †, Ippoliti, R. (2010) Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants. Protein Eng. Des, Sel. 23. 61-68.

44) Scaloni, F., Federici, L., Brunori, M., Gianni, S., (2010) Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain. Proc. Natl. Acad. Sci, USA 107, 5447-5452.

45) Haq, S.R., Jurgens, M.C., Chi, C.N., Koh, C.S., Elfstrom, L., Selmer, M., Gianni, S†, Jemth, P (2010) The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain. J Biol Chem. 285, 18051-18059

46) Di Matteo, A., Calosci, N., Gianni ,S., Jemth, P., Brunori, M., Travaglini-Allocatelli, C. (2010) Structural and functional characterization of CcmG from Pseudomonas aeruginosa, a key component of the bacterial cytochrome c maturation apparatus. Proteins. Struct. Funct. Bioinf. 78, 2213-21.

47) Montemiglio, L.C., Gianni, S., Vallone, B., Savino, C. (2010) Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry 49, 9199-9206.

48) Gianni, S., Ivarsson, Y., De Simone, A., Travaglini-Allocatelli, C., Brunori, M., Vendruscolo M., (2010) Characterization of the Structure of a Misfolded Intermediate Populated during the Folding Process of a PDZ domain Nature Struct. Mol Biol. 17, 1431-1437.

49) Morrone, A., McCully, M.E., Bryan, P.N., Brunori, M., Daggett, V., Gianni, S.†, Travaglini-Allocatelli, C., (2011) The denatured state dictates the topology of two proteins with almost identical sequence but different native structure and function. J. Biol., Chem. . 286, 3863-3872.

50) Gianni, S., Haq, S.R., Montemiglio, L.C., Jürgens, M.C., Engström, Å., Chi, C.N., Brunori, M., Jemth, P. (2011) Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity. J. Biol. Chem. 286, 27167-27175.

51) Morrone, A., Giri, R., Toofanny, R.D., Travaglini-Allocatelli, C., Brunori, M., Daggett, V., Gianni, S.†, (2011) GB1 is not a two-state folder: identification and characterization of an on-pathway intermadiate. Biophys. J 101, 2053-2060.

52) Giardina, G., Montioli, R., Gianni, S., Cellini, B., Paiardini, A., Borri-Voltattorni, C., Cutruzzolà, F., (2011) The open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc. Natl. Acad. Sci. USA 108, 20514-20519.

53) Haq SR, Chi CN, Bach A, Dogan J, Engström A, Hultqvist G, Karlsson A, Lundström P, Montemiglio LC, Strømgaard K, Gianni S, Jemth P. (2011) Side chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains. J. Am. Chem. Soc. 134, 599-605

54) Brunori, M., Gianni, S., Giri, R., Morrone, A., Travaglini-Allocatelli, C., (2012) Morphogenesis of a protein: folding pathways and the energy landscape Bioch. Soc. Trans 40(2):429-32.

55) Hultqvist G, Pedersen SW, Chi CN, Strømgaard K, Gianni S, Jemth P. (2012) An expanded view of the protein folding landscape of PDZ domains. Biochem Biophys Res Commun. 421, 550-553.

56) Chi, C.N., Bach, A., Stromgaard, K., Gianni, S., Jemth, P., (2012) Ligand binding by PDZ domains. Biofactors, 38, 338-348.

57) Giri., R., Morrone, A., Travaglini-Allocatelli C., Jemth, P., Brunori, M., Gianni, S.†, (2012) The folding pathways of proteins with increasing degree of sequence identities but different structure and function. Proc. Natl. Acad. Sci. USA. 109, 17772-17776.

58) Morrone, A., Giri, R., Brunori, M., Gianni S. †, (2012) Reassessing the folding of the KIX domain: Evidence for a two-state mechanism Protein Sci. 21, 1775-1779.

59) Gianni, S. †, Morrone, A., Giri, R., Brunori, M. (2012) A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein. Biochem Biophys Res Commun. 428, 205-209

60) Chi CN, Haq SR, Rinaldo S, Dogan J, Cutruzzolà F, Engström A, Gianni S, Lundström P, Jemth P. (2012) Interactions outside the Boundaries of the Canonical Binding Groove of a PDZ Domain Influence Ligand Binding. Biochemistry. 51, 8971-8979

61) Polticelli, F., Caprari, S., Gianni, S., Ascenzi, P., (2012) GA/GB Fold switching may modulate fatty acid transfer from human serum albumin to bacteria. IUBMB Life 64, 885-888.

62) Hultqvist, G., Punekar, A., Morrone, A., Chi, C.N., Engstrom, A, Selmer, M, Gianni, S. †, Jemth, P., (2012) Tolerance of protein folding to a circular permutation in a PDZ domain, PLOS ONE, 7, e50055

63) Chiarella, S., Federici, L., Di Matteo, A., Brunori, M., Gianni, S. †, (2013) The folding pathway of a functionally competent C-terminal domain of nucleophosmin: protein stability and denatured state residual structure. Biochem Biophys Res Commun. 435, 64-68.

64) Ascenzi, P., and Gianni S. †, (2013) On the functional role of reaction intermediates: rediscovering "chronosteric effects" thirty years later. IUBMB Life, 65, 836-844

65) Eildal JN, Hultqvist G, Balle T, Stuhr-Hansen N, Padrah S, Gianni S, Strømgaard K, Jemth P. (2013) Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations J. Am. Chem. Soc. 135, 12998-13007

66) Hultqvist G, Haq SR, Punekar AS, Chi CN, Engström Å, Bach A, Strømgaard K, Selmer M, Gianni, S. †, Jemth P. (2013) Energetic pathway sampling in a protein interaction domain. Structure. 21, 1193-1202.

67) Giri R, Morrone A, Toto A, Brunori M, Gianni, S. † (2013) Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system. Proc Natl Acad Sci U S A. 110, 149422-149427

68) Dogan, J., Gianni, S. †, Jemth, P. (2014) The binding mechanisms of intrinsically disordered proteins Phys. Chem. Chem. Phys. 16, 6323-6331

69) Bonetti D, Toto A, Giri R, Morrone A, Sanfelice D, Pastore A, Temussi P, Gianni, S. †, Brunori M. (2014) The kinetics of folding of frataxin. Phys Chem Chem Phys. 16, 6391-6397.

70) Gianni, S. †, Dogan J, Jemth P. (2014) Distinguishing induced fit from conformational selection. Biophys. Chem. 189, 33-39.

71) Toto A, Giri R, Brunori M, Gianni, S. † (2014) The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb. Protein Sci. 23, 962-969.

72) Di Silvio, E., Bonetti, D., Toto, A., Morrone, A., Gianni, S. † (2014) The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor. Protein Eng. Des. Sel. 27, 249-253

73) Gianni, S. † Jemth, P., (2014) Conserved nucleation sites reinforce the significance of Phi value analysis in protein-folding studies. IUBMB Life 66, 449-452

74) Conti, S., Li, X., Gianni, S., Ghadami, S. A., Buxbaum, J., Cecchi, C., Chiti, F., Bemporad, F., (2014) A complex equilibrium among partially unfolded conformations in monomeric transthyretin. Biochemistry 53, 4381-4392

75) Gianni, S. †, Camilloni, C., Giri, R., Toto, A., Bonetti, D., Morrone, A., Sormanni, P, Brunori, M., Vendruscolo, M. (2014) Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. Proc. Natl. Acad. Sci. USA 111, 14141-14146

76) Dosnon, M., Bonetti, D., Morrone, A., Erales, J., Di Silvio, E., Longhi, S., Gianni, S. † (2015) Demonstration of a Folding after Binding Mechanism in the Recognition between the Measles Virus NTAIL and X Domains. ACS Chem Biol 10, 795-802.

77) Di Silvio, E., Toto, A., Bonetti, D., Morrone, A., Gianni, S. † (2015) Understanding the effect of alternative splicing in the folding and function of the second PDZ from protein tyrosine phosphatase-BL. Sci Rep. 5: 9299.

78) Di Silvio, E., Brunori, M., Gianni, S. † (2015) Frustration Scuplts the early stages of protein folding Angew Chem Int Ed Engl 54, 10867-10869.

79) Gruet A, Dosnon M, Blocquel D, Brunel J, Gerlier D, Das RK, Bonetti D, Gianni, S., Fuxreiter M, Longhi S, Bignon C. (2016) Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions. FEBS J.

80) Gianni, S., Dogan, J., Jemth, P. (2016) Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics? Curr. Opin. Struct. Biol. 38, 18-24.

81) Toto A, Camilloni C, Giri R, Brunori M, Vendruscolo M, Gianni, S. † (2016) Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein Sci. Rep. 6 21994

82) Toto A, Pedersen SW, Karlsson OA, Moran GE, Andersson E, Chi CN, Strømgaard K, Gianni, S. † Jemth P. (2016) Ligand binding to the PDZ domains of postsynaptic density protein 95. Protein Eng. Des. Sel. Mar 2 [epub ahead of print]

83) Gianni, S. †, Jemth, P. (2016) Protein Folding: Vexing debates on a fundamental problem. Biophys. Chem 212, 17-21

84) Bonetti D, Camilloni C, Visconti L, Longhi S, Brunori M, Vendruscolo M, Gianni, S. † (2016) Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X domain. J. Biol. Chem. Mar 21 [epub ahead of print]

85) Camilloni, C., Bonetti, D., Morrone, D., Giri, R., Dobson, C. M., Brunori, M., Gianni, S. † , Vendruscolo, M. (2016) Structural Biology of the hydrophobic effect in protein folding Sci. Rep. Accepted for publication.

86) Toto, A., Gianni, S. † (2016) Mutational Analysis of the Binding-Induced Folding Reaction of the Mixed-Lineage Leukemia Protein to the KIX Domain. Biochemistry. 55, 3957-3962

87) Dogan J, Toto A, Andersson E, Gianni, S. †, Jemth P. (2016) Activation Barrier-Limited Folding and Conformational Sampling of a Dynamic Protein Domain. Biochemistry. 55, 5289-5295.

88) Toto A, Mattei A, Jemth P, Gianni, S. †, (2016) Understanding the role of phosphorylation in the binding mechanism of a PDZ domain. Protein Eng Des Sel. 2016 Oct 19. [Epub ahead of print]

89) Brunori M, Gianni, S. † .(2016) Molecuar Medicine – To be or not to be Biophys Chem. 2016 Jul-Aug;214-215:33-46.

90) Kukic P, Pustovalova Y, Camilloni C, Gianni, S., Korzhnev DM, Vendruscolo M. (2017) Structural Characterization of the Early Events in the Nucleation- Condensation Mechanism in a Protein Folding Process. J Am Chem Soc. 139, 6899- 6910.

91) Troilo F, Bonetti D, Toto A, Visconti L, Brunori M, Longhi S, Gianni, S. † (2017) The folding pathway of the KIX domain ACS Chem. Biol. 12, 1683-1690

92) Longhi S, Bloyet LM, Gianni, S., Gerlier D. (2017) How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication. Cell Mol Life Sci. 74, 3091-3118.

93) Bonetti D, Troilo F, Toto A, Brunori M, Longhi S, Gianni, S. † (2017) Analyzing the Folding and Binding Steps of an Intrinsically Disordered Protein by Protein Engineering. Biochemistry 56, 3780-3786.

94) Caillet-Saguy C, Toto A, Guerois R, Maisonneuve P, di Silvio E, Sawyer K, Gianni, S. † Wolff N. (2017) Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains. Sci Rep. 7, 7875.

95) Toto, A., Bonetti, D., De Simone A., Gianni, S. † (2017) Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2 Oncotarget 8, 82344-82351.

96) Gautier C, Visconti L, Jemth P, Gianni S. † (2017) Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95. Sci Rep. 7, 12593.

97) Gianni S†, Jemth P. (2017) How Fast Is Protein-Ligand Association? Trends Biochem Sci. 42, 847-849.

98) Bignon C, Troilo F, Gianni S, Longhi S. (2017) Partner-Mediated Polymorphism of an Intrinsically Disordered Protein. J Mol Biol. S0022-2836(17)30562-4.

99) Schramm A, Lieutaud P, Gianni S, Longhi S, Bignon C. (2017) InSiDDe: A Server for Designing Artificial Disordered Proteins. Int J Mol Sci. 19: E91.

100) Saponaro, C., Sergio, S., Coluccia, A., De Luca, M., La Regina, G., Mologni, L., Famiglini, V.,Naccarato, V., Bonetti, D., Gautier, C., Gianni, S., Vergara, D., Salzet, M., Fournier, I., Bucci, C., Silvestri, R., Gambacorti Passerini, C., Maffia, M., Coluccia, A.M.L (2018) β-Catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy Oncogene. 2018 Mar 19.

101) Caflisch, A., Gianni, S.†, (2018) Curr Opin Struct. Biol. 48:iv-vii.

102) Bonetti D, Troilo F, Brunori M, Longhi S, Gianni S†. (2018) How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein? Biophys J.114, 1889-1894.

103) Del Poggetto E, Toto A, Aloise C, Di Piro F, Gori L, Malatesta F, Gianni S, Chiti F, Bemporad F. (2018) Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity. J Biol Chem. 2018 May 14. pii: jbc.RA118.002087.

104) Malgieri G, D'Abrosca G, Pirone L, Toto A, Palmieri M, Russo L, Sciacca MFM, Tatè R, Sivo V, Baglivo I, Majewska R, Coletta M, Pedone PV, Isernia C, De Stefano M, Gianni S, Pedone EM, Milardi D, Fattorusso R. (2018) Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins. Chem Sci. 9: 3290-3298.

105) Bignon C, Troilo F, Gianni S, Longhi S. Modulation of Measles Virus NTAIL Interactions through Fuzziness and Sequence Features of Disordered Binding Sites. (2018) Biomolecules. 2018; 9, E8.

106) Karlsson E, Andersson E, Dogan J, Gianni S, Jemth P, Camilloni C. A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins. (2019) J Biol Chem. 294, 1230-1239

107) Troilo F, Bignon C, Gianni S, Fuxreiter M, Longhi S. (2018) Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral NTAIL Domains With Their Functional Partners. Methods Enzymol. 611:137-192.

108) Gianni S, McCully ME, Malagrinò F, Bonetti D, De Simone A, Brunori M, Daggett V. (2018) A Carboxylate to Amide Substitution That Switches Protein Folds. Angew Chem Int Ed Engl. 2018 57:12795-12798.

109) Troilo F, Bonetti D, Camilloni C, Toto A, Longhi S, Brunori M, Gianni S†. (2018) Folding Mechanism of the SH3 Domain from Grb2. J Phys Chem B. 122(49):11166-11173.

110) Bonetti D, Troilo F, Toto A, Travaglini-Allocatelli C, Brunori M, Gianni S†. (2018) Mechanism of Folding and Binding of the N-Terminal SH2 Domain from SHP2. J Phys Chem B. 122(49):11108-11114.

111) Visconti L, Malagrinò F, Toto A, Gianni S.† (2019) The kinetics of folding of the NSH2 domain from p85. Sci Rep. 9, 4058

112) Troilo F, Bonetti D, Bignon C, Longhi S, Gianni S.†(2019) Understanding Intramolecular Crosstalk in an Intrinsically Disordered Protein. ACS Chem Biol. 14, 337-341.

113) Visconti L, Malagrinò F, Broggini L, De Luca CMG, Moda F, Gianni S†, Ricagno S, Toto A. (2019) Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State. Int J Mol Sci. 20 pii: E396.

114) Coluccia A, La Regina G, Naccarato V, Nalli M, Orlando V, Biagioni S, De Angelis ML, Baiocchi M, Gautier C, Gianni S, Di Pastena F, Di Magno L, Canettieri G, Coluccia AML, Silvestri R. (2019) Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. ACS Med Chem Lett, 10, 499-503

115) Malagrinò F, Troilo F, Bonetti D, Toto A, Gianni, S. † (2019) Mapping the allosteric network within a SH3 domain. Sci Rep. 2019 9:8279.

116) Visconti L, Malagrinò F, Gianni, S. †, Toto A. (2019) Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2. FEBS J. 286(23):4769-4777.

117) Gianni, S. †, Jemth P. (2019) Affinity versus specificity in coupled binding and folding reactions. Protein Eng Des Sel. 32:203.

118) Toto A, Troilo F, Visconti L, Malagrinò F, Bignon C, Longhi S, Gianni, S. †, (2019) Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD. Arch Biochem Biophys. 671:255-261.

119) Petrosino M, Pasquo A, Novak L, Toto A, Gianni S, Mantuano E, Veneziano L, Minicozzi V, Pastore A, Puglisi R, Capriotti E, Chiaraluce R, Consalvi V. (2019) Characterization of human frataxin missense variants in cancer tissues. Hum Mutat. 2019 Sep;40(9):1400-1413.

120) Troilo F, Malagrinò F, Visconti L, Toto A, Gianni S. (2019) The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85. Int J Mol Sci. 2019 Dec 23;21(1). pii: E125.

121) Laursen, L, Karlsson, E., Gianni, S. †, Jemth, P., (2020) Functional interplay between protein domains in a supramodular structure J. Biol. Chem, J Biol Chem. 2020 Feb 14;295(7):1992-2000.

122) Toto A, Malagrinò F, Visconti L, Troilo F, Gianni S. (2020) Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2. Int J Mol Sci. 2020 Jan 10;21(2). pii: E461.

123) Gautier, C., Gianni, S. †, (2020) Unveiling the folding mechanism of PDZ domains Methods Mol. Biol. 2141:661-671

124) Toto, A., Troilo, F., Malagrinò, F., Gianni, S. †, (2020) Understanding binding induced folding by temperature jump Methods Mol. Biol.2141:651-661.

125) Toto A, Malagrinò F, Visconti L, Troilo F, Pagano L, Brunori M, Jemth P, Gianni S†. (2020) Templated folding of intrinsically disordered proteins J Biol Chem. 2020 May 8;295(19):6586-6593.

126) Malagrinò F, Visconti L, Pagano L, Toto A, Troilo F, Gianni S†. (2020) Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls Int J Mol Sci. 2020 May 15;21(10):3484.

127) Visconti L, Toto A, Jarvis JA, Troilo F, Malagrinò F, De Simone A, Gianni S†. (2020) Demonstration of Binding Induced Structural Plasticity in a SH2 Domain Front Mol Biosci. 2020 May 12;7:89.

128) Gautier C, Troilo F, Cordier F, Malagrinò F, Toto A, Visconti L, Zhu Y, Brunori M, Wolff N, Gianni S†. (2020) Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19963-19969.

129) Toto A, Ma S, Malagrinò F, Visconti L, Pagano L, Stromgaard K, Gianni S†. (2020) Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein Protein Sci. 2020 Oct;29(10):2038-2042.

130) Laursen L, Kliche J, Gianni S†, Jemth P. (2020) Supertertiary protein structure affects an allosteric network. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24294-24304.

131) Gianni S†, Jemth P. (2020) Direct Quantification of Protein Dimerization Preference Shed Light on SOD1-associated ALS J Mol Biol. 2020 Nov 20;432(23):6003-6004.

132) Malagrinò F, Coluccia A, Bufano M, Regina G, Puxeddu M, Toto A, Visconti L, Paone A, Magnifico MC, Troilo F, Cutruzzolà F, Silvestri R, Gianni S†. (2020) Targeting the Interaction between the SH3 Domain of Grb2 and Gab2. Cells. 2020 Nov 7;9(11):2435.

133) Pagano L, Toto A, Malagrinò F, Visconti L, Jemth P, Gianni S†. (2021) Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery. Int J Mol Sci. 2021 Jan 15;22(2):828.

134) Visconti L, Malagrinò F, Troilo F, Pagano L, Toto A, Gianni S†. (2021) Folding and Misfolding of a PDZ Tandem Repeat. J Mol Biol. 2021 Apr 2;433(7):166862

135) Gianni S†, Freiberger MI, Jemth P, Ferreiro DU, Wolynes PG, Fuxreiter M. (2021) Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly Acc Chem Res. 2021 Mar 2;54(5):1251-1259.

136) Fusco G, Gianni S†. (2021) Function, Regulation, and Dysfunction of Intrinsically Disordered Proteins Life (Basel) 2021 Feb 12;11(2):140.

137) Nalli M, Puxeddu M, La Regina G, Gianni S, Silvestri R. Emerging Therapeutic Agents for Colorectal Cancer. Molecules. 2021 Dec 9;26(24):7463. doi: 10.3390/molecules26247463.

138) Pagano L, Malagrinò F, Nardella C, Gianni S†, Toto A. Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G. Int J Mol Sci. 2021 Dec 7;22(24):13174.

139) Nardella C, Malagrinò F, Pagano L, Rinaldo S, Gianni S†, Toto A. Determining folding and binding properties of the C-terminal SH2 domain of SHP2. Protein Sci. 2021 Dec;30(12):2385-2395. doi: 10.1002/pro.4201.

140) Nardella C, Visconti L, Malagrinò F, Pagano L, Bufano M, Nalli M, Coluccia A, La Regina G, Silvestri R, Gianni S†, Toto A. Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer. Biol Direct. 2021 Oct 12;16(1):15. doi: 10.1186/s13062-021-00303-9.

141) Laursen L, Gianni S†, Jemth P. Dissecting Inter-domain Cooperativity in the Folding of a Multi Domain Protein. J Mol Biol. 2021 Sep 3;433(18):167148. doi: 10.1016/j.jmb.2021.167148. Epub 2021 Jul 8.

142) Pagano L, Malagrinò F, Visconti L, Troilo F, Pennacchietti V, Nardella C, Toto A, Gianni S. † Probing the Effects of Local Frustration in the Folding of a Multidomain Protein. J Mol Biol. 2021 Jul 23;433(15):167087. doi: 10.1016/j.jmb.2021.167087. Epub 2021 Jun 3.

143) Malagrinò F, Pennacchietti V, Santorelli D, Pagano L, Nardella C, Diop A, Toto A, Gianni S†. On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains Biomolecules. 2022 Jan 26;12(2):209. doi: 10.3390/biom12020209

144) Malagrinò F, Diop A, Pagano L, Nardella C, Toto A, Gianni S†. Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes Curr Opin Struct Biol . 2022 Feb;72:153-160. doi: 10.1016/j.sbi.2021.11.004.

145) Coluccia A, Bufano M, La Regina G, Puxeddu M, Toto A, Paone A, Bouzidi A, Musto G, Badolati N, Orlando V, Biagioni S, Masci D, Cantatore C, Cirilli R, Cutruzzolà F, Gianni S, Stornaiuolo M, Silvestri R. Anticancer Activity of ( S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)- N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1 H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor Cancers (Basel). 2022 Mar 7;14(5):1358. doi: 10.3390/cancers14051358.

146) Toto A, Malagrinò F, Nardella C, Pennacchietti V, Pagano L, Santorelli D, Diop A, Gianni S†. Characterization of early and late transition states of the folding pathway of a SH2 domain Protein Sci. 2022 Jun;31(6):e4332. doi: 10.1002/pro.4332.

147) Brunori M, Gianni S†. An Outlook on the Complexity of Protein Morphogenesis in Health and Disease. Front Mol Biosci. 2022 Jun 13;9:909567. doi: 10.3389/fmolb.2022.909567.

148) Nardella C, Toto A, Santorelli D, Pagano L, Diop A, Pennacchietti V, Pietrangeli P, Marcocci L, Malagrinò F, Gianni S. † (2022) Folding and Binding Mechanisms of the SH2 Domain from Crkl. Biomolecules. 2022 Jul 22;12(8):1014. doi: 10.3390/biom12081014.

149) Malagrinò F, Fusco G, Pennacchietti V, Toto A, Nardella C, Pagano L, de Simone A, Gianni S†. (2022) Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat. Protein Sci. 2022 Sep;31(9):e4396. doi: 10.1002/pro.4396.

150) Gautier C, Gianni S†. A short structural extension dictates the early stages of folding of a PDZ domain. Biochim Biophys Acta Proteins Proteom. 2022 Nov 1;1870(11-12):140852.

151) Pagano L, Pennacchietti V, Diop A, Santorelli D, Pietrangeli P, Marcocci L, Nardella C, Malagrinò F, Toto A, Gianni S. † (2022) Exploring the effect of tethered domains on the folding of Grb2 protein. Arch Biochem Biophys. 2022 Nov 30;731:109444.

152) Hollås H, Ramirez J, Nominé Y, Kostmann C, Toto A, Gianni S, Travé G, Vedeler A. (2022) The cooperative folding of annexin A2 relies on a transient nonnative intermediate. Biophys J. 2022 Dec 6;121(23):4492-4504.

153) Diop A, Santorelli D, Malagrinò F, Nardella C, Pennacchietti V, Pagano L, Marcocci L, Pietrangeli P, Gianni S †, Toto A. SH2 Domains: Folding, Binding and Therapeutical Approaches. Int J Mol Sci. 2022 Dec 15;23(24):15944.

154) Santorelli D, Marcocci L, Pennacchietti V, Nardella C, Diop A, Pietrangeli P, Pagano L, Toto A, Malagrinò F, Gianni S†. (2023) Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains 2023 J Biol Chem. Mar;299(3):102983.

155) Bufano M, Puxeddu M, Nalli M, La Regina G, Toto A, Liberati FR, Paone A, Cutruzzolà F, Masci D, Bigogno C, Dondio G, Silvestri R, Gianni S, Coluccia A. (2023) Targeting the Grb2 cSH3 domain: Design, synthesis and biological evaluation of the first series of modulators. Bioorg Chem. 2023 Sep;138:106607.

156) Diop A, Pietrangeli P, Nardella C, Pennacchietti V, Pagano L, Toto A, Di Felice M, Di Matteo S, Marcocci L, Malagrinò F, Gianni S†. (2023) Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners. Int J Mol Sci. 2023 Jun 14;24(12):10138.

157) Nardella C, Pagano L, Pennacchietti V, Felice MD, Matteo SD, Diop A, Malagrinò F, Marcocci L, Pietrangeli P, Gianni S†, Toto A. (2023) An intramolecular energetic network regulates ligand recognition in a SH2 domain. Protein Sci. 2023 Aug;32(8):e4729.

158) Pennacchietti V, Pagano L, Malagrinò F, Diop A, Di Felice M, Di Matteo S, Marcocci L, Pietrangeli P, Toto A, Gianni S. † (2023) Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands. Arch Biochem Biophys. 2023 Sep 1;745:109703.
159) Gianni, S. †, Jemth, P., (2023) Allostery Frustrates the Experimentalist. J Mol Biol. 2023 Feb 28;435(4):167934.

160) Diop A, Pietrangeli P, Pennacchietti V, Pagano L, Toto A, Di Felice M, Di Matteo S, Marcocci L, Malagrinò F, Gianni S†. (2023) Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering. Int J Mol Sci. 2023 Dec 11;24(24):17364

161) Pagano L, Simonetti L, Pennacchietti V, Toto A, Malagrinò F, Ivarsson Y, Gianni S†. (2023) Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD. Biochem Biophys Res Commun. 2024 Apr 9;703:149658.

162) Critical Assessment of Genome Interpretation Consortium. (2024) CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods. Genome Biol. 2024 Feb 22;25(1):53

163) Di Felice M, Pagano L, Pennacchietti V, Diop A, Pietrangeli P, Marcocci L, Di Matteo S, Malagrinò F, Toto A, Gianni S. † (2024) The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain. J Biol Chem. 2024 Apr;300(4):107129.

164) Pietrangeli P, Marcocci L, Pennacchietti V, Diop A, Di Felice M, Pagano L, Malagrinò F, Toto A, Brunori M, Gianni S. † (2024) The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue - Broad Energy Barriers and the General Properties of the Transition State. J Mol Biol. 2024 May 15;436(10):168555.

165) Pagano L, Pennacchietti V, Malagrinò F, Di Felice M, Toso J, Puglisi E, Gianni S†, Toto A. (2024) Folding and Binding Kinetics of the Tandem of SH2 Domains from SHP2. Int J Mol Sci. 2024 Jun 14;25(12):6566.

† Corresponding Author
* Shared First-Author

Produzione scientifica

11573/1706810 - 2024 - The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain

Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: WOS:001345313500001 (3) - scopus: 2-s2.0-85188713900 (3)

11573/1703621 - 2024 - Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods.

Jain, Shantanu; Bakolitsa, Constantina; E Brenner, Steven; Radivojac, Predrag; Moult, John; Repo, Susanna; A Hoskins, Roger; Andreoletti, Gaia; Barsky, Daniel; Chellapan, Ajithavalli; Chu, Hoyin; Dabbiru, Navya; K Kollipara, Naveen; Ly, Melissa; J Neumann, Andrew; R Pal, Lipika; Odell, Eric; Pandey, Gaurav; C Peters-Petrulewicz, Robin; Srinivasan, Rajgopal; F Yee, Stephen; Jyothsna Yeleswarapu, Sri; Zuhl, Maya; Adebali, Ogun; Patra, Ayoti; A Beer, Michael; Hosur, Raghavendra; Peng, Jian; M Bernard, Brady; Berry, Michael; Dong, Shengcheng; P Boyle, Alan; Adhikari, Aashish; Chen, Jingqi; Hu, Zhiqiang; Wang, Robert; Wang, Yaqiong; Miller, Maximilian; Wang, Yanran; Bromberg, Yana; Turina, Paola; Capriotti, Emidio; J Han, James; Ozturk, Kivilcim; Carter, Hannah; Babbi, Giulia; Bovo, Samuele; Di Lena, Pietro; Luigi Martelli, Pier; Savojardo, Castrense; Casadio, Rita; S Cline, Melissa; De Baets, Greet; Bonache, Sandra; Díez, Orland; Gutiérrez-Enríquez, Sara; Fernández, Alejandro; Montalban, Gemma; Ootes, Lars; Özkan, Selen; Padilla, Natàlia; Riera, Casandra; De La Cruz, Xavier; Diekhans, Mark; J Huwe, Peter; Wei, Qiong; Xu, Qifang; L Dunbrack, Roland; Gotea, Valer; Elnitski, Laura; Margolin, Gennady; Fariselli, Piero; V Kulakovskiy, Ivan; J Makeev, Vsevolod; D Penzar, Dmitry; E Vorontsov, Ilya; V Favorov, Alexander; R Forman, Julia; Hasenahuer, Marcia; S Fornasari, Maria; Parisi, Gustavo; Avsec, Ziga; H Çelik, Muhammed; Yen Duong Nguyen, Thi; Gagneur, Julien; Shi, Fang-Yuan; D Edwards, Matthew; Guo, Yuchun; Tian, Kevin; Zeng, Haoyang; K Gifford, David; Göke, Jonathan; Zaucha, Jan; Gough, Julian; S Ritchie, Graham R; Frankish, Adam; M Mudge, Jonathan; Harrow, Jennifer; L Young, Erin; Yu, Yao; D Huff, Chad; Murakami, Katsuhiko; Nagai, Yoko; Imanishi, Tadashi; J Mungall, Christopher; B Jacobsen, Julius O; Kim, Dongsup; Jeong, Chan-Seok; T Jones, David; Jun Li, Mulin; Beleva Guthrie, Violeta; Bhattacharya, Rohit; Chen, Yun-Ching; Douville, Christopher; Fan, Jean; Kim, Dewey; Masica, David; Niknafs, Noushin; Sengupta, Sohini; Tokheim, Collin; N Turner, Tychele; Ting Grace Yeo, Hui; Karchin, Rachel; Shin, Sunyoung; Welch, Rene; Keles, Sunduz; Li, Yue; Kellis, Manolis; Corbi-Verge, Carles; V Strokach, Alexey; M Kim, Philip; E Klein, Teri; Mohan, Rahul; A Sinnott-Armstrong, Nicholas; Wainberg, Michael; Kundaje, Anshul; Gonzaludo, Nina; Y Mak, Angel C; Chhibber, Aparna; K Lam, Hugo Y; Dahary, Dvir; Fishilevich, Simon; Lancet, Doron; Lee, Insuk; Bachman, Benjamin; Katsonis, Panagiotis; C Lua, Rhonald; J Wilson, Stephen; Lichtarge, Olivier; R Bhat, Rajendra; Sundaram, Laksshman; Viswanath, Vivek; Bellazzi, Riccardo; Nicora, Giovanna; Rizzo, Ettore; Limongelli, Ivan; M Mezlini, Aziz; Chang, Ray; Kim, Serra; Lai, Carmen; O'connor, Robert; Topper, Scott; Van Den Akker, Jeroen; Y Zhou, Alicia; D Zimmer, Anjali; Mishne, Gilad; R Bergquist, Timothy; R Breese, Marcus; F Guerrero, Rafael; Jiang, Yuxiang; Kiga, Nikki; Li, Biao; Mort, Matthew; A Pagel, Kymberleigh; Pejaver, Vikas; H Stamboulian, Moses; Thusberg, Janita; D Mooney, Sean; Teerakulkittipong, Nuttinee; Cao, Chen; Kundu, Kunal; Yin, Yizhou; Yu, Chen-Hsin; Kleyman, Michael; Lin, Chiao-Feng; Stackpole, Mary; M Mount, Stephen; Eraslan, Gökcen; S Mueller, Nikola; Naito, Tatsuhiko; R Rao, Aliz; R Azaria, Johnathan; Brodie, Aharon; Ofran, Yanay; Garg, Aditi; Pal, Debnath; Hawkins-Hooker, Alex; Kenlay, Henry; Reid, John; J Mucaki, Eliseos; K Rogan, Peter; M Schwarz, Jana; B Searls, David; Rie Lee, Gyu; Seok, Chaok; Krämer, Andreas; Shah, Sohela; V Huang, Chenglai; F Kirsch, Jack; Shatsky, Maxim; Cao, Yue; Chen, Haoran; Karimi, Mostafa; Moronfoye, Oluwaseyi; Sun, Yuanfei; Shen, Yang; Shigeta, Ron; T Ford, Colby; Nodzak, Conor; Uppal, Aneeta; Shi, Xinghua; Joseph, Thomas; Kotte, Sujatha; Rana, Sadhna; Rao, Aditya; G Saipradeep, V; Sivadasan, Naveen; Sunderam, Uma; Stanke, Mario; Su, Andrew; Adzhubey, Ivan; M Jordan, Daniel; Sunyaev, Shamil; Rousseau, Fr - 01a Articolo in rivista

rivista: GENOME BIOLOGY (BioMed Central) pp. 1-46 - issn: 1474-760X - wos: WOS:001184832400002 (10) - scopus: 2-s2.0-85187866396 (12)

11573/1702558 - 2024 - Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD

Pagano, L.; Simonetti, L.; Pennacchietti, V.; Toto, A.; Malagrinò, F.; Ivarsson, Y.; Gianni, S. - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. 149658- - issn: 0006-291X - wos: WOS:001197686500001 (0) - scopus: 2-s2.0-85186076885 (0)

11573/1711822 - 2024 - Folding and binding kinetics of the tandem of SH2 domains from SHP2

Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001255961100001 (0) - scopus: (0)

11573/1726961 - 2024 - A PDZ tandem repeat folds and unfolds via different pathways

Pennacchietti, Valeria; Di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. 1-14 - issn: 0961-8368 - wos: (0) - scopus: 2-s2.0-85209922425 (0)

11573/1707732 - 2024 - The mechanism of folding of human frataxin in comparison to the yeast homologue – broad energy barriers and the general properties of the transition state

Pietrangeli, Paola; Marcocci, Lucia; Pennacchietti, Valeria; Diop, Awa; Di Felice, Mariana; Pagano, Livia; Malagrinò, Francesca; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: WOS:001223623100001 (0) - scopus: 2-s2.0-85189293931 (0)

11573/1680491 - 2023 - Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators

Bufano, Marianna; Puxeddu, Michela; Nalli, Marianna; La Regina, Giuseppe; Toto, Angelo; Liberati, Francesca Romana; Paone, Alessio; Cutruzzolà, Francesca; Masci, Domiziana; Bigogno, Chiara; Dondio, Giulio; Silvestri, Romano; Gianni, Stefano; Coluccia, Antonio - 01a Articolo in rivista

rivista: BIOORGANIC CHEMISTRY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 106607- - issn: 0045-2068 - wos: WOS:001007153500001 (2) - scopus: 2-s2.0-85159597372 (2)

11573/1683686 - 2023 - Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners

Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 10138- - issn: 1422-0067 - wos: WOS:001017317000001 (2) - scopus: 2-s2.0-85163977385 (2)

11573/1695759 - 2023 - Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering

Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001131010700001 (1) - scopus: 2-s2.0-85180652606 (1)

11573/1670583 - 2023 - Allostery frustrates the experimentalist

Gianni, Stefano; Jemth, Per - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (Elsevier Health Sciences:11830 Westline Industrial Drive:Saint Louis, MO 63146:(800)545-2522, EMAIL: customerservice@elsevier.com, Fax: (314)453-4535) pp. 167934- - issn: 1089-8638 - wos: WOS:000918100900001 (11) - scopus: 2-s2.0-85146015417 (11)

11573/1685968 - 2023 - An intramolecular energetic network regulates ligand recognition in a SH2 domain

Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:001040354200001 (3) - scopus: 2-s2.0-85166371265 (3)

11573/1686025 - 2023 - Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands

Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109703- - issn: 0003-9861 - wos: WOS:001053305400001 (0) - scopus: 2-s2.0-85166633882 (0)

11573/1673852 - 2023 - Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains

Santorelli, Daniele; Marcocci, Lucia; Pennacchietti, Valeria; Nardella, Caterina; Diop, Awa; Pietrangeli, Paola; Pagano, Livia; Toto, Angelo; Malagrino, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 102983- - issn: 0021-9258 - wos: WOS:001009100600001 (4) - scopus: 2-s2.0-85149793931 (4)

11573/1708917 - 2022 - An Outlook on the Complexity of Protein Morphogenesis in Health and Disease

Brunor, Maurizio; Gianni, Stefano - 01g Articolo di rassegna (Review)

rivista: FRONTIERS IN MOLECULAR BIOSCIENCES (Lausanne : Frontiers Media S.A., 2014-) pp. 1-9 - issn: 2296-889X - wos: WOS:000816852000001 (0) - scopus: 2-s2.0-85133548735 (0)

11573/1616528 - 2022 - Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor

Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe La; Puxeddu, Michela; Toto, Angelo; Paone, Alessio; Bouzidi, Amani; Musto, Giorgia; Badolati, Nadia; Orlando, Viviana; Biagioni, Stefano; Masci, Domiziana; Cantatore, Chiara; Cirilli, Roberto; Cutruzzolà, Francesca; Gianni, Stefano; Stornaiuolo, Mariano; Silvestri, Romano - 01a Articolo in rivista

rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000773498900001 (7) - scopus: 2-s2.0-85131007159 (6)

11573/1662469 - 2022 - SH2 Domains: folding, binding and therapeutical approaches

Diop, Awa; Santorelli, Daniele; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 15944- - issn: 1422-0067 - wos: WOS:000902565100001 (18) - scopus: 2-s2.0-85144969444 (22)

11573/1708916 - 2022 - A short structural extension dictates the early stages of folding of a PDZ domain

Gautier, Candice; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (Tokyo ; Oxford ; New York ; London ; Amsterdam ; Shannon ; Paris : Elsevier) pp. 1-6 - issn: 1570-9639 - wos: WOS:000859328300002 (2) - scopus: 2-s2.0-85137114091 (2)

11573/1659078 - 2022 - The cooperative folding of annexin A2 relies on a transient nonnative intermediate

Hollås, Hanne; Ramirez, Juan; Nominé, Yves; Kostmann, Camille; Toto, Angelo; Gianni, Stefano; Travé, Gilles; Vedeler, Anni - 01a Articolo in rivista

rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. - - issn: 0006-3495 - wos: WOS:000908349700009 (1) - scopus: 2-s2.0-85141976426 (1)

11573/1607647 - 2022 - On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains

Malagrino, F.; Pennacchietti, V.; Santorelli, D.; Pagano, L.; Nardella, C.; Diop, A.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: BIOMOLECULES (Basel: MDPI) pp. 209- - issn: 2218-273X - wos: WOS:000763931100001 (7) - scopus: 2-s2.0-85123285981 (7)

11573/1652072 - 2022 - Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat

Malagrinò, Francesca; Fusco, Giuliana; Pennacchietti, Valeria; Toto, Angelo; Nardella, Caterina; Pagano, Livia; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000840110600001 (3) - scopus: 2-s2.0-85137125864 (5)

11573/1651291 - 2022 - Folding and binding mechanisms of the SH2 domain from Crkl

Nardella, Caterina; Toto, Angelo; Santorelli, Daniele; Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Pietrangeli, Paola; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOMOLECULES (Basel: MDPI) pp. 1014- - issn: 2218-273X - wos: WOS:000846180000001 (5) - scopus: 2-s2.0-85137360513 (5)

11573/1657644 - 2022 - Exploring the effect of tethered domains on the folding of Grb2 protein

Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Santorelli, Daniele; Pietrangeli, Paola; Marcocci, Lucia; Nardella, Caterina; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109444- - issn: 0003-9861 - wos: WOS:000880049100004 (4) - scopus: 2-s2.0-85141826263 (4)

11573/1635685 - 2022 - Characterization of early and late transition states of the folding pathway of a SH2 domain

Toto, Angelo; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Santorelli, Daniele; Diop, Awa; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000798704500001 (4) - scopus: 2-s2.0-85131218830 (4)

11573/1501450 - 2021 - Fuzziness and frustration in the energy landscape of protein folding, function, and assembly

Gianni, Stefano; Inés Freiberger, María; Jemth, Per; Ferreiro, Diego U.; Wolynes, Peter G.; Monika Fuxreiter, And - 01a Articolo in rivista

rivista: ACCOUNTS OF CHEMICAL RESEARCH (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. - - issn: 0001-4842 - wos: WOS:000626269900016 (83) - scopus: 2-s2.0-85101397929 (86)

11573/1593241 - 2021 - Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes

Malagrinò, Francesca; Diop, Awa; Pagano, Livia; Nardella, Caterina; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 160-160 - issn: 0959-440X - wos: WOS:000768730600018 (16) - scopus: 2-s2.0-85120903843 (17)

11573/1604509 - 2021 - Emerging therapeutic agents for colorectal cancer

Nalli, M.; Puxeddu, M.; La Regina, G.; Gianni, S.; Silvestri, R. - 01a Articolo in rivista

rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 7463-7463 - issn: 1420-3049 - wos: WOS:000736380500001 (14) - scopus: 2-s2.0-85121522712 (20)

11573/1577022 - 2021 - Determining folding and binding properties of the C-terminal SH2 domain of SHP2

Nardella, Caterina; Malagrinò, Francesca; Pagano, Livia; Rinaldo, Serena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000705532500001 (6) - scopus: 2-s2.0-85116539527 (6)

11573/1579282 - 2021 - Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

Nardella, Caterina; Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: BIOLOGY DIRECT (London: BioMed Central) pp. - - issn: 1745-6150 - wos: WOS:000706722300001 (13) - scopus: 2-s2.0-85117321017 (14)

11573/1596175 - 2021 - Experimental characterization of the interaction between the n-terminal sh3 domain of crkl and c3g

Pagano, L.; Malagrino, F.; Nardella, C.; Gianni, S.; Toto, A. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 13174- - issn: 1661-6596 - wos: WOS:000738238000001 (1) - scopus: 2-s2.0-85120657305 (1)

11573/1552783 - 2021 - Probing the effects of local frustration in the folding of a multidomain protein

Pagano, Livia; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pennacchietti, Valeria; Nardella, Caterina; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 167087- - issn: 0022-2836 - wos: WOS:000672680300017 (6) - scopus: 2-s2.0-85107967375 (7)

11573/1477086 - 2021 - Double mutant cycles as a tool to address folding, binding, and allostery

Pagano, Livia; Toto, Angelo; Malagrinò, Francesca; Visconti, Lorenzo; Jemth, Per; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 828- - issn: 1422-0067 - wos: WOS:000611298300001 (11) - scopus: 2-s2.0-85099547793 (11)

11573/1495668 - 2021 - Folding and misfolding of a PDZ tandem repeat

Visconti, Lorenzo; Malagrinò, Francesca; Troilo, Francesca; Pagano, Livia; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 166862- - issn: 0022-2836 - wos: WOS:000630007900009 (7) - scopus: 2-s2.0-85100673226 (10)

11573/1435307 - 2020 - Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate

Gautier, Candice; Troilo, Francesca; Cordier, Florence; Malagrinò, Francesca; Toto, Angelo; Visconti, Lorenzo; Zhu, Yanlei; Brunori, Maurizio; Wolff, Nicolas; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 19963-19969-19969 - issn: 0027-8424 - wos: WOS:000567818600007 (16) - scopus: 2-s2.0-85089787733 (17)

11573/1464543 - 2020 - Supertertiary protein structure affects an allosteric network

Laursen, L; Kliche, J; Gianni, S; Jemth, P. - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Editore National Academy of Sciences a Washington, DC) pp. 24294-24304 - issn: 1091-6490 - wos: WOS:000576672700011 (22) - scopus: 2-s2.0-85092281157 (23)

11573/1456152 - 2020 - Targeting the interaction between the SH3 domain of Grb2 and Gab2

Malagrinò, Francesca; Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe; Puxeddu, Michela; Toto, Angelo; Visconti, Lorenzo; Paone, Alessio; Magnifico, Maria Chiara; Troilo, Francesca; Cutruzzolà, Francesca; Silvestri, Romano; Gianni, Stefano - 01a Articolo in rivista

rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 2435- - issn: 2073-4409 - wos: WOS:000592940700001 (7) - scopus: 2-s2.0-85096028884 (7)

11573/1401198 - 2020 - Understanding the binding induced folding of intrinsically disordered proteins by protein engineering: caveats and pitfalls

Malagrinò, Francesca; Visconti, Lorenzo; Pagano, Livia; Toto, Angelo; Troilo, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 3484- - issn: 1422-0067 - wos: WOS:000539312100080 (12) - scopus: 2-s2.0-85084964055 (14)

11573/1359552 - 2020 - Unveiling the molecular basis of the noonan syndrome-causing mutation T42A of SHP2

Toto, A.; Malagrino, F.; Visconti, L.; Troilo, F.; Gianni, S. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 461- - issn: 1661-6596 - wos: WOS:000515380000091 (6) - scopus: 2-s2.0-85077880233 (9)

11573/1445451 - 2020 - Understanding binding-induced folding by temperature jump

Toto, A.; Troilo, F.; Malagrino, F.; Gianni, S. - 02a Capitolo o Articolo

libro: Methods in Molecular Biology - (978-1-0716-0523-3; 978-1-0716-0524-0)

11573/1435303 - 2020 - Comparing the binding properties of peptides mimicking the envelope protein of sars-cov and sars-cov-2 to the pdz domain of the tight junction-associated pals1 protein

Toto, Angelo; Ma, Sana; Malagrinò, Francesca; Visconti, Lorenzo; Pagano, Livia; Stromgaard, Kristian; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000566781500001 (37) - scopus: 2-s2.0-85090470025 (40)

11573/1401188 - 2020 - Templated folding of intrinsically disordered proteins

Toto, Angelo; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pagano, Livia; Brunori, Maurizio; Jemth, Per; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6586-6593 - issn: 0021-9258 - wos: WOS:000537685000027 (48) - scopus: 2-s2.0-85084721842 (47)

11573/1359561 - 2020 - The effect of proline cis‐trans isomerization on the folding of the C‐terminal SH2 domain from p85

Troilo, F.; Malagrino, F.; Visconti, L.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 125- - issn: 1661-6596 - wos: WOS:000515378000125 (4) - scopus: 2-s2.0-85077263439 (5)

11573/1399303 - 2020 - Demonstration of binding induced structural plasticity in a sh2 domain

Visconti, Lorenzo; Toto, Angelo; Jarvis, James A.; Troilo, Francesca; Malagrinò, Francesca; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

rivista: FRONTIERS IN MOLECULAR BIOSCIENCES (Lausanne : Frontiers Media S.A., 2014-) pp. - - issn: 2296-889X - wos: WOS:000537268200001 (6) - scopus: (0)

11573/1223718 - 2019 - Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents

Coluccia, A.; La Regina, G.; Naccarato, V.; Nalli, M.; Orlando, V.; Biagioni, S.; De Angelis, M. L.; Baiocchi, M.; Gautier, C.; Gianni, S.; Di Pastena, F.; Di Magno, L.; Canettieri, G.; Coluccia, A. M. L.; Silvestri, R. - 01a Articolo in rivista

rivista: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 499-503 - issn: 1948-5875 - wos: WOS:000464767700019 (14) - scopus: 2-s2.0-85064264813 (14)

11573/1336097 - 2019 - Seeking allosteric networks in PDZ domains

Gautier, C; Laursen, L; Jemth, P; Gianni, S - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford : Oxford University Press) pp. - - issn: 1741-0134 - wos: WOS:000489553100002 (23) - scopus: 2-s2.0-85065500883 (24)

11573/1336091 - 2019 - A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins

Karlsson, E; Andersson, E; Dogan, J.; Gianni, S.; Jemth, P.; Camilloni, C. - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 1230-1239 - issn: 1067-8816 - wos: WOS:000457879500014 (34) - scopus: 2-s2.0-85060586312 (36)

11573/1338512 - 2019 - Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents

La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Bufano, M.; Nalli, M.; Coluccia, A.; Orlando, V.; Canettieri, G.; Gianni, S.; Silvestri, R. - 04f Poster

congresso: XXVI National Meeting in Medicinal Chemistry - XII Young Medicinal Chemists’ Symposium (Milano)

libro: Abstract Book - ()

11573/1336078 - 2019 - Mapping the allosteric network within a SH3 domain

Malagrinò, F.; Troilo, F.; Bonetti, D.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000470075600028 (16) - scopus: 2-s2.0-85066618062 (18)

11573/1277788 - 2019 - Characterization of human frataxin missense variants in cancer tissues

Petrosino, Maria; Pasquo, Alessandra; Novak, Leonore; Toto, Angelo; Gianni, Stefano; Mantuano, Elide; Veneziano, Liana; Minicozzi, Velia; Pastore, Annalisa; Puglisi, Rita; Capriotti, Emidio; Chiaraluce, Roberta; Consalvi, Valerio - 01a Articolo in rivista

rivista: HUMAN MUTATION (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-14 - issn: 1059-7794 - wos: WOS:000485994200020 (14) - scopus: 2-s2.0-85070717849 (16)

11573/1336088 - 2019 - Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD

Toto, A.; Troilo, F.; Visconti, L.; Malagrinò, F.; Bignon, C.; Longhi, Sonia Rachele Agata; Gianni, S.; S, - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 255-261 - issn: 0003-9861 - wos: WOS:000525438900029 (6) - scopus: 2-s2.0-85069557296 (7)

11573/1336100 - 2019 - Understanding intramolecular crosstalk in an intrinsically disordered protein

Troilo, F.; Bonetti, D; Bignon, C; Longhi, S; Gianni, S - 01a Articolo in rivista

rivista: ACS CHEMICAL BIOLOGY (Washington, D.C. : American Chemical Society, c2006-) pp. - - issn: 1554-8937 - wos: WOS:000461844100004 (15) - scopus: 2-s2.0-85061911824 (15)

11573/1336085 - 2019 - Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2

Visconti, L.; Malagrinò, F.; Gianni, S.; Toto, A. - 01a Articolo in rivista

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 4769-4777 - issn: 1742-4658 - wos: WOS:000499718600012 (7) - scopus: 2-s2.0-85069838702 (8)

11573/1218458 - 2019 - Investigating the molecular basis of the aggregation propensity of the pathological d76n mutant of beta-2 microglobulin: role of the denatured state

Visconti, L; Malagrinò, F; Broggini, L; De Luca, Cmg; Moda, F; Gianni, S; Ricagno, S; Toto, A. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000459746500164 (6) - scopus: 2-s2.0-85060402058 (5)

11573/1253355 - 2019 - The kinetics of folding of the NSH2 domain from p85

Visconti, Lorenzo; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 4058- - issn: 2045-2322 - wos: WOS:000460751700013 (9) - scopus: 2-s2.0-85062766339 (9)

11573/1218454 - 2018 - Modulation of measles virus NTAIL interactions through fuzziness and sequence features of disordered binding sites

Bignon, C; Troilo, F; Gianni, S; Longhi, S. - 01a Articolo in rivista

rivista: BIOMOLECULES (Basel: MDPI) pp. - - issn: 2218-273X - wos: WOS:000458051700008 (9) - scopus: 2-s2.0-85059235938 (12)

11573/1111610 - 2018 - How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein?

Bonetti, D; Troilo, F; Brunori, M; Longhi, S; Gianni, S. - 01a Articolo in rivista

rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. 1889-1894 - issn: 0006-3495 - wos: WOS:000432692800013 (33) - scopus: 2-s2.0-85046536598 (34)

11573/1140852 - 2018 - Mechanism of folding and binding of the n-terminal SH2 domain from SHP2

Bonetti, Daniela; Troilo, Francesca; Toto, Angelo; Travaglini-Allocatelli, Carlo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL (American Chemical Society, Washington, D.C.) pp. - - issn: 1520-6106 - wos: WOS:000453488100016 (18) - scopus: 2-s2.0-85050853721 (19)

11573/1111606 - 2018 - Editorial overview: Folding and binding: In silico, in vitro and in cellula

Caflisch, A.; Gianni, S. - 01a Articolo in rivista

rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. - - issn: 0959-440X - wos: WOS:000427218300001 (0) - scopus: 2-s2.0-85042263170 (0)

11573/1159784 - 2018 - Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

Edoardo Del Poggetto‡, ; Toto, Angelo; Chiara, Aloise‡; Francesco Di Piro‡, ; Ludovica, Gori‡; Malatesta, Francesco; Gianni, Stefano; X Fabrizio Chiti‡, ; And, X Francesco Bemporad‡1 - 01a Articolo in rivista

rivista: JOURNAL OF BIOLOGICAL CHEMISTRY (Bethesda, Md. : American Society for Biochemistry and Molecular Biology) pp. 10303-10313 - issn: 1083-351X - wos: WOS:000437096700028 (9) - scopus: 2-s2.0-85049653406 (9)

11573/1159789 - 2018 - A carboxylate to amide substitution that switches protein folds

Gianni, Stefano; Mccully, Michelle E.; Malagrinò, Francesca; Bonetti, Daniela; De Simone, Alfonso; Brunori, Maurizio; And Valerie Daggett, - 01a Articolo in rivista

rivista: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 12795-12798 - issn: 1433-7851 - wos: WOS:000444941600032 (4) - scopus: 2-s2.0-85053053524 (4)

11573/1111524 - 2018 - Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins

Malgieri, G; D'abrosca, G; Pirone, L; Toto, A; Palmieri, M; Russo, L; Sciacca, Mfm; Tatè, R; Sivo, V; Baglivo, I; Majewska, R; Coletta, M; Pedone, Pv; Isernia, C; De Stefano, M; Gianni, S; Pedone, Em; Milardi, D; Fattorusso, R. - 01a Articolo in rivista

rivista: CHEMICAL SCIENCE (Cambridge : Royal Society of Chemistry, 2010-) pp. 3290-3298 - issn: 2041-6520 - wos: WOS:000431113300004 (17) - scopus: 2-s2.0-85044759336 (18)

11573/1071891 - 2018 - β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy

Saponaro, Concetta; Sergio, Sara; Coluccia, Antonio; De Luca, Maria; La Regina, Giuseppe; Mologni, Luca; Famiglini, Valeria; Naccarato, Valentina; Bonetti, Daniela; Gautier, Candice Natacha Anna; Gianni, Stefano; Vergara, Daniele; Salzet, Michel; Fournier, Isabelle; Bucci, Cecilia; Silvestri, Romano; Gambacorti Passerini, Carlo; Maffia, Michele; Maria Luce Coluccia, Addolorata - 01a Articolo in rivista

rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 3301-3316 - issn: 0950-9232 - wos: WOS:000435526600009 (18) - scopus: 2-s2.0-85044095990 (21)

11573/1111615 - 2018 - InSiDDe: A server for designing artificial disordered proteins

Schramm, A; Lieutaud, P.; Gianni, S.; Longhi, ; S., Bignon - 01a Articolo in rivista

11573/1140869 - 2018 - The folding mechanism of the SH3 domain from Grb2

Troilo, Francesca; Bonetti, Daniela; Camilloni, Carlo; Toto, Angelo; Longhi, Sonia; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

11573/1113877 - 2017 - Partner-mediated polymorphism of an intrinsically disordered protein

Bignon, C; Troilo, F; Gianni, S; Longhi, S. - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (Elsevier Health Sciences:11830 Westline Industrial Drive:Saint Louis, MO 63146:(800)545-2522, EMAIL: customerservice@elsevier.com, Fax: (314)453-4535) pp. - - issn: 1089-8638 - wos: WOS:000439402200017 (12) - scopus: 2-s2.0-85039043862 (15)

11573/1014998 - 2017 - Analyzing the folding and binding steps of an intrinsically disordered protein by protein engineering

Bonetti, Daniela; Troilo, Francesca; Toto, Angelo; Brunori, Maurizio; Longhi, Sonia; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 3780-3786 - issn: 0006-2960 - wos: WOS:000406573100011 (25) - scopus: 2-s2.0-85025827155 (25)

11573/1014994 - 2017 - Regulation of the human phosphatase ptpn4 by the inter-domain linker connecting the pdz and the phosphatase domains

Caillet-Saguy, Célia; Toto, Angelo; Guerois, Raphael; Maisonneuve, Pierre; Di Silvio, Eva; Sawyer, Kristi; Gianni, Stefano; Wolff, Nicolas - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000407442500015 (10) - scopus: 2-s2.0-85031675178 (10)

11573/1014992 - 2017 - Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95

Gautier, Candice Natacha Anna; Visconti, Lorenzo; Per, Jemth; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000412138800029 (10) - scopus: 2-s2.0-85030565452 (10)

11573/1014988 - 2017 - How fast is protein– ligand association?

Gianni, Stefano; Jemth, Per - 01a Articolo in rivista

rivista: TRENDS IN BIOCHEMICAL SCIENCES (Elsevier Trends Journals:An Imprint of Elsevier Science Limited, The Boulevard, Langford Lane, Kidlington, Oxford 0X5 1GB United Kingdom:011 44 1865 843000, 011 44 1865 843699, Fax: 011 44 1865 843010) pp. 847-849 - issn: 0968-0004 - wos: WOS:000413441400002 (9) - scopus: 2-s2.0-85029226446 (9)

11573/1014985 - 2017 - Structural characterization of the early events in the nucleation− condensation mechanism in a protein folding process

Kukic, Predrag; Pustovalova, Yulia; Carlo, Camilloni; Gianni, Stefano; Korzhnev, Dmitry M.; Michele, Vendruscolo - 01a Articolo in rivista

rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 6899-6910 - issn: 0002-7863 - wos: WOS:000416406202017 (0) - scopus: 2-s2.0-85019877885 (19)

11573/1014983 - 2017 - How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication

Longhi1, Sonia; • Louis-Marie Bloyet3, 2; Gianni, Stefano; Gerlier, Denis - 01a Articolo in rivista

rivista: CELLULAR AND MOLECULAR LIFE SCIENCES (Basel: Birkhäuser 1997-) pp. - - issn: 1420-9071 - wos: WOS:000406500700003 (28) - scopus: 2-s2.0-85020622279 (31)

11573/1014977 - 2017 - Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2

Toto, Angelo; Bonetti, Daniela; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 82344-82351 - issn: 1949-2553 - wos: WOS:000412683900060 (11) - scopus: 2-s2.0-85030863721 (10)

11573/954031 - 2017 - Understanding the role of phosphorylation in the binding mechanism of a PDZ domain

Toto, Angelo; Mattei, A.; Jemth, P.; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford : Oxford University Press) pp. 1-5 - issn: 1741-0134 - wos: WOS:000397129400001 (11) - scopus: 2-s2.0-85014750887 (11)

11573/956496 - 2017 - The folding pathway of the KIX domain

Troilo, Francesca; Bonetti, Daniela; Toto, Angelo; Visconti, L; Brunori, Maurizio; Longhi, S; Gianni, Stefano - 01a Articolo in rivista

rivista: ACS CHEMICAL BIOLOGY (Washington, D.C. : American Chemical Society, c2006-) pp. 1683-1690 - issn: 1554-8937 - wos: WOS:000403854000030 (6) - scopus: 2-s2.0-85020525210 (6)

11573/866165 - 2016 - Identification and structural characterization of an intermediate in the folding of the measles virus x domain

Bonetti, Daniela; Camilloni, Carlo; Visconti, Lorenzo; Longhi, Sonia; Brunori, Maurizio; Vendruscolo, Michele; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 10886-10892 - issn: 0021-9258 - wos: WOS:000377042600038 (18) - scopus: 2-s2.0-84969179536 (18)

11573/954032 - 2016 - Molecular medicine - to be or not to be

Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 33-46 - issn: 0301-4622 - wos: WOS:000378184800005 (3) - scopus: 2-s2.0-84969132884 (3)

11573/867523 - 2016 - Towards a structural biology of the hydrophobic effect in protein folding

Camilloni, Carlo; Bonetti, Daniela; Morrone, Angela; Giri, Rajanish; Dobson, Christopher M.; Brunori, Maurizio; Gianni, Stefano; Vendruscolo, Michele - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 28285- - issn: 2045-2322 - wos: WOS:000380327800001 (97) - scopus: 2-s2.0-84979738503 (102)

11573/862815 - 2016 - Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?

Gianni, Stefano; Dogan, J.; Jemth, P. - 01a Articolo in rivista

rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 18-24 - issn: 0959-440X - wos: WOS:000372681200005 (67) - scopus: 2-s2.0-84959288285 (69)

11573/931695 - 2016 - Protein folding: vexing debates on a fundamental problem

Gianni, Stefano; Jemth, - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 17-21 - issn: 0301-4622 - wos: WOS:000374625600003 (16) - scopus: 2-s2.0-84961652523 (18)

11573/849898 - 2016 - Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions

Gruet, Antoine; Dosnon, Marion; Blocquel, David; Brunel, Joanna; Gerlier, Denis; Das, Rahul K.; Bonetti, Daniela; Gianni, Stefano; Fuxreiter, Monika; Longhi, Sonia; Bignon, Christophe - 01a Articolo in rivista

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. n/a-n/a - issn: 1742-464X - wos: WOS:000371071900001 (28) - scopus: 2-s2.0-84958945587 (28)

11573/953785 - 2016 - Activation barrier-limited folding and conformational sampling of a dynamic protein domain

Jakob Dogan, *; Toto, Angelo; Eva Andersson, §; Gianni, Stefano; Per Jemth, § - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 5289-5295 - issn: 0006-2960 - wos: WOS:000384038700010 (13) - scopus: 2-s2.0-84988672614 (13)

11573/860590 - 2016 - Molecular recognition by templated folding of an intrinsically disordered protein

Toto, Angelo; Camilloni, Carlo; Giri, Rajanish; Brunori, Maurizio; Vendruscolo, Michele; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 21994- - issn: 2045-2322 - wos: WOS:000370796200001 (81) - scopus: 2-s2.0-84959441550 (83)

11573/931704 - 2016 - Mutational analysis of the binding-induced folding reaction of the mixed-lineage leukemia protein to the KIX domain.

Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 3957-3962 - issn: 0006-2960 - wos: WOS:000380297100011 (18) - scopus: 2-s2.0-84979527196 (18)

11573/931691 - 2016 - Ligand binding to the pdz domains of postsynaptic density protein 95

Toto, Angelo; Pedersen, Sw; Karlsson, Oa; Moran, Ge; Andersson, E; Chi, Cn; Strømgaard, K; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford : Oxford University Press) pp. 169-175 - issn: 1741-0134 - wos: WOS:000376351600002 (11) - scopus: 2-s2.0-84965026277 (11)

11573/782784 - 2015 - Understanding the effect of alternative splicing in the folding and function of the second pdz from protein tyrosine phosphatase-bl

Di Silvio, E; Toto, Angelo; Bonetti, Daniela; Morrone, A; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 9299- - issn: 2045-2322 - wos: WOS:000351277000008 (3) - scopus: 2-s2.0-84925396547 (3)

11573/862814 - 2015 - Frustration sculpts the early stages of protein folding

Di Silvio, Eva; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 10867-10869 - issn: 1433-7851 - wos: WOS:000360628500028 (13) - scopus: 2-s2.0-84940721459 (12)

11573/782780 - 2015 - Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains

Dosnon, M; Bonetti, Daniela; Morrone, A; Erales, J; Di Silvio, E; Longhi, S; Gianni, Stefano - 01a Articolo in rivista

rivista: ACS CHEMICAL BIOLOGY (Washington, D.C. : American Chemical Society, c2006-) pp. 795-802 - issn: 1554-8937 - wos: WOS:000351558700018 (58) - scopus: 2-s2.0-84925346923 (62)

11573/554302 - 2014 - The kinetics of folding of frataxin.

Bonetti, Daniela; Toto, Angelo; Giri, R; Morrone, A; Sanfelice, D; Pastore, A; Temussi, P; Gianni, Stefano; Brunori, Maurizio - 01a Articolo in rivista

rivista: PHYSICAL CHEMISTRY CHEMICAL PHYSICS ([London, England] : Royal Society of Chemistry, 1999-) pp. 6391-6397 - issn: 1463-9084 - wos: WOS:000333119800009 (15) - scopus: 2-s2.0-84896367793 (17)

11573/658611 - 2014 - A complex equilibrium among partially unfolded conformations in monomeric transthyretin.

Conti, S; Li, X; Gianni, Stefano; Ghadami, Sa; Buxbaum, J; Cecchi, C; Chiti, F; Bemporad, F. - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. - - issn: 0006-2960 - wos: WOS:000339226500008 (14) - scopus: 2-s2.0-84904331701 (12)

11573/577793 - 2014 - The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor

Di Silvio, Eva; Bonetti, Daniela; Toto, Angelo; A., Morrone; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. 249-253 - issn: 1741-0126 - wos: WOS:000343042400001 (3) - scopus: 2-s2.0-84906230429 (3)

11573/554301 - 2014 - The binding mechanisms of intrinsically disordered proteins.

Dogan, J; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: PHYSICAL CHEMISTRY CHEMICAL PHYSICS ([London, England] : Royal Society of Chemistry, 1999-) pp. 6323-6331 - issn: 1463-9084 - wos: WOS:000333119800002 (112) - scopus: 2-s2.0-84896336036 (118)

11573/675273 - 2014 - Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Gianni, Stefano; Camilloni, C; Giri, R; Toto, Angelo; Bonetti, Daniela; Morrone, A; Sormanni, P; Brunori, Maurizio; Vendruscolo, M. - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. - - issn: 0027-8424 - wos: WOS:000342350200039 (45) - scopus: 2-s2.0-84907573466 (45)

11573/658424 - 2014 - Distinguishing induced fit from conformational selection.

Gianni, Stefano; Dogan, J; Jemth, P. - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0301-4622 - wos: WOS:000336115700005 (122) - scopus: 2-s2.0-84898953700 (131)

11573/675274 - 2014 - Conserved nucleation sites reinforce the significance of Phi value analysis in protein-folding studies.

Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: IUBMB LIFE (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. - - issn: 1521-6543 - wos: WOS:000340575200001 (15) - scopus: 2-s2.0-84906347772 (15)

11573/658425 - 2014 - The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb.

Toto, Angelo; Giri, R; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000337669800012 (34) - scopus: 2-s2.0-84904215986 (33)

11573/554298 - 2013 - Functional role of transient conformations: Rediscovering "chronosteric effects" thirty years later.

Ascenzi, P; Gianni, Stefano - 01a Articolo in rivista

rivista: IUBMB LIFE (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 836-844 - issn: 1521-6543 - wos: WOS:000325027200004 (16) - scopus: 2-s2.0-84884923355 (16)

11573/554291 - 2013 - The folding pathway of a functionally competent C-terminal domain of nucleophosmin: protein stability and denatured state residual structure.

Chiarella, S; Federici, L; Di Matteo, A; Brunori, M; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. 64-68 - issn: 0006-291X - wos: WOS:000320012900011 (6) - scopus: 2-s2.0-84878180768 (7)

11573/554294 - 2013 - Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations.

Eildal, Jn; Hultqvist, G; Balle, T; Stuhr Hansen, N; Padrah, S; Gianni, Stefano; Strømgaard, K; Jemth, P. - 01a Articolo in rivista

rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 12998-13007 - issn: 0002-7863 - wos: WOS:000330163100020 (46) - scopus: 2-s2.0-84883679976 (45)

11573/554296 - 2013 - Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system.

Giri, R; Morrone, A; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 14942-14947 - issn: 0027-8424 - wos: WOS:000324125100038 (89) - scopus: 2-s2.0-84883780190 (92)

11573/554295 - 2013 - Energetic pathway sampling in a protein interaction domain.

Hultqvist, G; Haq, Sr; Punekar, As; Chi, Cn; Engström, Å; Bach, A; Strømgaard, K; Selmer, M; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: STRUCTURE (London: Current Biology.) pp. 1193-1202 - issn: 0969-2126 - wos: WOS:000321681600016 (37) - scopus: 2-s2.0-84879842193 (37)

11573/458690 - 2012 - Morphogenesis of a protein: folding pathways and the energy landscape

Brunori, Maurizio; Gianni, Stefano; Giri, Rajanish; Morrone, Angela; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: BIOCHEMICAL SOCIETY TRANSACTIONS (Portland Press Limited:Commerce Way, Colchester CO2 8HP Essex United Kingdom:011 44 1206 796351, EMAIL: sales@portland-services.com, INTERNET: http://www.portland-services.com, Fax: 011 44 1206 799331) pp. 429-432 - issn: 0300-5127 - wos: WOS:000303624200022 (9) - scopus: 2-s2.0-84859311965 (9)

11573/488091 - 2012 - Interactions outside the Boundaries of the Canonical Binding Groove of a PDZ Domain Influence Ligand Binding

Celestine N., Chi; S., Raza Haq; Rinaldo, Serena; Jakob, Dogan; Cutruzzola', Francesca; Åke, Engstrom; Gianni, Stefano; Patrik, Lundstrom; Per, Jemth - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 8971-8979 - issn: 0006-2960 - wos: WOS:000310664200025 (17) - scopus: 2-s2.0-84868600086 (18)

11573/675050 - 2012 - Ligand binding by PDZ domains.

Chi, Cn; Bach, A; Strømgaard, K; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: BIOFACTORS (primo editore Oxford: IRL Press IOS Press:Nieuwe Hemweg 6B, 1013 BG Amsterdam Netherlands:011 31 20 6883355, EMAIL: r.tosendjojo@iospress.nl, INTERNET: http://www.iospress.nl, Fax: 011 31 20 6203419) pp. - - issn: 0951-6433 - wos: WOS:000310070100004 (60) - scopus: 2-s2.0-84867725616 (58)

11573/675251 - 2012 - A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein.

Gianni, Stefano; Morrone, A; Giri, R; Brunori, Maurizio - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. - - issn: 0006-291X - wos: WOS:000312431900001 (68) - scopus: 2-s2.0-84869218677 (70)

11573/486644 - 2012 - Folding pathways of proteins with increasing degree of sequence identities but different structure and function

Giri, Rajanish; Morrone, Angela; Travaglini Allocatelli, Carlo; Jemth, P; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Editore National Academy of Sciences a Washington, DC) pp. 17772-17776 - issn: 1091-6490 - wos: WOS:000311149900024 (24) - scopus: 2-s2.0-84868122220 (24)

11573/675249 - 2012 - An expanded view of the protein folding landscape of PDZ domains.

Hultqvist, G; Pedersen, Sw; Chi, Cn; Strømgaard, K; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. - - issn: 0006-291X - wos: WOS:000306152000025 (12) - scopus: 2-s2.0-84860674621 (12)

11573/674850 - 2012 - Tolerance of protein folding to a circular permutation in a PDZ domain.

Hultqvist, G; Punekar, As; Morrone, A; Chi, Cn; Engström, A; Selmer, M; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. - - issn: 1932-6203 - wos: WOS:000311821000173 (11) - scopus: 2-s2.0-84869796108 (13)

11573/675049 - 2012 - Reassessing the folding of the KIX domain: evidence for a two-state mechanism.

Morrone, A; Giri, R; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000310032900017 (1) - scopus: 2-s2.0-84867687230 (2)

11573/674852 - 2012 - GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria.

Polticelli, F; Caprari, S; Gianni, Stefano; Ascenzi, P. - 01a Articolo in rivista

11573/427315 - 2011 - Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity.

Gianni, Stefano; S. R., Haq; Montemiglio, Linda Celeste; M. C., Jürgens; Å., Engström; C. N., Chi; Brunori, Maurizio; P., Jemth - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 27167-27175 - issn: 0021-9258 - wos: WOS:000293268700012 (58) - scopus: 2-s2.0-79961006047 (59)

11573/410615 - 2011 - Crystal structure of the apo form of human aromatic L-amino acid decarboxylase: an open conformation unveils novel insights into the mechanism of PLP addition to the apoenzymes of group II decarboxylases

Giardina, Giorgio; Montioli, R.; Gianni, Stefano; Cellini, B.; Paiardini, Alessandro; Voltattorni, Cb; Cutruzzola', Francesca - 04d Abstract in atti di convegno

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 263-263 - issn: 1742-464X - wos: WOS:000292333102058 (0) - scopus: (0)

congresso: 36th FEBS Congress of the Biochemistry for Tomorrows Medicine (Torino, ITALY)

11573/426205 - 2011 - Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases

Giardina, Giorgio; R., Montioli; Gianni, Stefano; B., Cellini; Paiardini, Alessandro; C., Borri Voltattorni; Cutruzzola', Francesca - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 20514-20519 - issn: 0027-8424 - wos: WOS:000298289400055 (88) - scopus: 2-s2.0-84855517335 (86)

11573/408249 - 2011 - Addressing the folding pathway of two proteins with high sequence identity but different structure and function

Giri, Rajanish; Morrone, Angela; Travaglini Allocatelli, Carlo; Gianni, Stefano; Brunori, Maurizio - 04d Abstract in atti di convegno

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 107-107 - issn: 1742-4658 - wos: WOS:000292333101110 (0) - scopus: (0)

11573/675267 - 2011 - Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains

Haq, Sr; Chi, Cn; Bach, A; Dogan, J; Engström, Å; Hultqvist, G; Karlsson, Oa; Lundström, P; Strømgaard, K; Gianni, Stefano; Jemth, P.; Montemiglio, Linda Celeste - 01a Articolo in rivista

rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 599-605 - issn: 0002-7863 - wos: WOS:000301084200096 (41) - scopus: 2-s2.0-84855656923 (41)

11573/468966 - 2011 - Investigating the structural plasticity of a cytochrome P450: 3D structure of EryK and binding to its physiological substrate and inhibitors

Montemiglio, L. C.; Vallone, Beatrice; Gianni, S.; Savino, C. - 04c Atto di convegno in rivista

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 120-120 - issn: 1742-4658 - wos: WOS:000292333101150 (0) - scopus: (0)

congresso: 36th FEBS Congress of the Biochemistry for Tomorrows Medicine (Torino, ITALY)

11573/408262 - 2011 - Detection of an on-pathway intermediate in the folding of the small single-domain protein GB1

Morrone, Angela; Giri, Rajanish; Gianni, Stefano; Travaglini Allocatelli, Carlo; Brunori, Maurizio - 04d Abstract in atti di convegno

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 120-121 - issn: 1742-4658 - wos: WOS:000292333101152 (0) - scopus: (0)

11573/425119 - 2011 - GB1 Is Not a Two-State Folder: Identification and Characterization of an On-Pathway Intermediate

Morrone, Angela; Giri, Rajanish; Rudesh D, Toofanny; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Valerie, Daggett; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. 2053-2060 - issn: 0006-3495 - wos: WOS:000296075800030 (28) - scopus: 2-s2.0-80054705419 (28)

11573/377442 - 2011 - The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function

Morrone, Angela; M. E., Mccully; P. N., Bryan; Brunori, Maurizio; V., Daggett; Gianni, Stefano; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 3863-3872 - issn: 0021-9258 - wos: WOS:000286653200067 (36) - scopus: 2-s2.0-79952805688 (36)

11573/401280 - 2011 - The folding mechanism of c-type cytochromes

Travaglini Allocatelli, Carlo; Gianni, Stefano; Brunori, Maurizio - 02a Capitolo o Articolo

libro: Protein Folding and Metal Ions - (9781439809648)

11573/359035 - 2010 - Structural and functional characterization of CcmG from Pseudomonas aeruginosa, a key component of the bacterial cytochrome c maturation apparatus

Di Matteo, Adele; Calosci, Nicoletta; Gianni, Stefano; Per, Jemth; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: PROTEINS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 2213-2221 - issn: 0887-3585 - wos: WOS:000279387400003 (20) - scopus: 2-s2.0-77955822694 (19)

11573/69778 - 2010 - Azole drugs trap cytochrome P450 EryK in alternative conformational states

Gianni S., Montemiglio Lc; Vallone, Beatrice; Carmelinda, Savino - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 9199-9206 - issn: 0006-2960 - wos: WOS:000283409100009 (17) - scopus: 2-s2.0-78049311396 (19)

11573/377436 - 2010 - Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

Gianni, Stefano; Ivarsson, Y; De Simone, A; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Vendruscolo, M. - 01a Articolo in rivista

rivista: NATURE STRUCTURAL & MOLECULAR BIOLOGY (New York, N.Y. : Nature Pub. Group, [2004]-) pp. 1431-1437 - issn: 1545-9985 - wos: WOS:000284942200006 (46) - scopus: 2-s2.0-78649885501 (47)

11573/338221 - 2010 - Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants.

Giansanti, F; Di Leandro, L; Koutris, I; Pitari, G; Fabbrini, Ms; Lombardi, A; Flavell, Dj; Flavell, Su; Gianni, Stefano; Ippoliti, R. - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. 61-68 - issn: 1741-0126 - wos: WOS:000274286200002 (11) - scopus: 2-s2.0-75649122575 (12)

11573/339026 - 2010 - The plastic energy landscape of protein folding: A triangular folding mechanism with an equilibrium intermediate for a small protein domain.

Haq, Sr; Juergens, Mc; Chi, Cn; Koh, Cs; Elfstrom, L; Selmer, M; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 18051-18059 - issn: 0021-9258 - wos: WOS:000278133400080 (20) - scopus: 2-s2.0-77952913083 (21)

11573/362851 - 2010 - Deciphering the folding transition state structure and denatured state properties of Nucleophosmin C-terminal domain

Scaloni, Flavio; Luca, Federici; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 5447-5452 - issn: 0027-8424 - wos: WOS:000275898300034 (32) - scopus: 2-s2.0-77950375373 (32)

11573/362280 - 2009 - Agitation and High Ionic Strength Induce Amyloidogenesis of a Folded PDZ Domain in Native Conditions

Alessandro, Sicorello; Silvia, Torrassa; Gemma, Soldi; Gianni, Stefano; Travaglini Allocatelli, Carlo; Niccolo, Taddei; Annalisa, Relini; Fabrizio, Chiti - 01a Articolo in rivista

rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. 2289-2298 - issn: 0006-3495 - wos: WOS:000266376700025 (30) - scopus: 2-s2.0-66149144761 (31)

11573/338217 - 2009 - A sequential binding mechanism in a PDZ domain.

Chi, Cn; Bach, A; Engström, A; Wang, H; Strømgaard, K; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 7089-7097 - issn: 0006-2960 - wos: WOS:000268231800002 (41) - scopus: 2-s2.0-68049085520 (41)

11573/338215 - 2009 - A conserved hydrogen-bond network stabilizes the structure of Beta class glutathione S-transferases.

Federici, L; Masulli, M; Gianni, Stefano; Di Ilio, C; Allocati, N. - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. 525-529 - issn: 0006-291X - wos: WOS:000265429200010 (7) - scopus: 2-s2.0-64049098665 (8)

11573/362269 - 2009 - Distinguishing between Smooth and Rough Free Energy Barriers in Protein Folding

Gianni, Stefano; Brunori, Maurizio; Per, Jemth; Mikael, Oliveberg; Mingjie, Zhang - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 11825-11830 - issn: 0006-2960 - wos: WOS:000272394000025 (12) - scopus: 2-s2.0-71549123381 (12)

11573/359076 - 2009 - Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.

Savino, C; Montemiglio, Linda Celeste; Sciara, G; Miele, Adriana Erica; Kendrew, Sg; Jemth, P; Gianni, S.; Vallone, Beatrice - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 29170-29179 - issn: 0021-9258 - wos: WOS:000270678900072 (66) - scopus: 2-s2.0-70350353089 (70)

11573/362859 - 2009 - Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance

Scaloni, Flavio; Gianni, S.; Federici, L.; Falini, B.; Brunori, Maurizio - 01a Articolo in rivista

rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 2360-2365 - issn: 0892-6638 - wos: WOS:000268836700004 (28) - scopus: 2-s2.0-68849105588 (30)

11573/363844 - 2009 - Folding and stability of globular proteins and implications for function

Travaglini Allocatelli, Carlo; Ylva, Ivarsson; Per, Jemth; Gianni, Stefano - 01a Articolo in rivista

rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 3-7 - issn: 0959-440X - wos: WOS:000264282000002 (18) - scopus: 2-s2.0-60649096450 (19)

11573/362282 - 2009 - Engineered Symmetric Connectivity of Secondary Structure Elements Highlights Malleability of Protein Folding Pathways

Ylva, Ivarsson; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 11727-11733 - issn: 0002-7863 - wos: WOS:000269379400033 (23) - scopus: 2-s2.0-69049115135 (23)

11573/364902 - 2008 - Fast folding kinetics and stabilization of apo-cytochrome c

Borgia, Alessandro; Gianni, Stefano; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1003-1007 - issn: 0014-5793 - wos: WOS:000257331400028 (7) - scopus: 2-s2.0-40349108420 (7)

11573/42934 - 2008 - “Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

Calosci, Nicoletta; Chi C., N; Richter, B; Camilloni, C; Engström, A; Eklund, L; Travaglini Allocatelli, Carlo; Gianni, Stefano; Vendruscolo, M; Jemth, P. - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 19240-19245 - issn: 0027-8424 - wos: WOS:000261706600041 (56) - scopus: 2-s2.0-58049200632 (56)

11573/363649 - 2008 - Folding and misfolding in a naturally occuring circularly permuted PDZ domain.

Ivarsson, Y; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 8954-8960 - issn: 0021-9258 - wos: WOS:000254465800024 (25) - scopus: 2-s2.0-44049089395 (25)

11573/366021 - 2008 - Mechanisms of protein folding.

Ivarsson, Y; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 721-728 - issn: 0175-7571 - wos: WOS:000256823000001 (15) - scopus: 2-s2.0-45849102407 (21)

11573/341354 - 2008 - Demonstration by burst phase analysis of a robust folding intermediate in the FF domain

Jemth, P; Johnson, C. M.; Gianni, Stefano; Fersht, A. R. - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. - - issn: 1741-0126 - wos: (0) - scopus: 2-s2.0-40049101670 (10)

11573/42933 - 2008 - The folding process of acylphosphatase from Escherichia coli is remarkably accelerated by the presence of a disulfide bond.

Parrini, C; Bemporad, F; Baroncelli, A; Gianni, Stefano; Travaglini Allocatelli, Carlo; Kohn J., E; Ramazzotti, M; Chiti, F; Taddei, N. - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 1107-1118 - issn: 0022-2836 - wos: WOS:000256815800013 (16) - scopus: 2-s2.0-44349147790 (16)

11573/358132 - 2008 - The folding pathway of an engineered circularly permuted PDZ domain

Y., Ivarsson; Travaglini Allocatelli, Carlo; V., Morea; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. 155-160 - issn: 1741-0126 - wos: WOS:000253831300004 (16) - scopus: 2-s2.0-40049087433 (17)

11573/362837 - 2007 - A conserved folding mechanism for PDZ domains

Celestine N., Chi; Gianni, Stefano; Calosci, Nicoletta; Travaglini Allocatelli, Carlo; K., Engstrom; Per, Jemth - 01a Articolo in rivista

rivista: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1109-1113 - issn: 0014-5793 - wos: WOS:000245370600006 (44) - scopus: 2-s2.0-33847712992 (45)

11573/75154 - 2007 - A strategic protein in cytochrome c maturation: Three-dimensional structure of CcmH and binding to apocytochrome c

Di Matteo, Adele; Gianni, Stefano; Schinina', Maria Eugenia; Giorgi, Alessandra; Altieri, Fabio; Calosci, Nicoletta; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 27012-27019 - issn: 0021-9258 - wos: WOS:000249304900042 (34) - scopus: 2-s2.0-34848835185 (35)

11573/365111 - 2007 - Plasticity of the protein folding landscape: Switching between on- and off-pathway intermediates

Gianni, Stefano; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 172-176 - issn: 0003-9861 - wos: WOS:000250067700003 (4) - scopus: 2-s2.0-34548839354 (5)

11573/361948 - 2007 - A PDZ domain recapitulates a unifying mechanism for protein folding

Gianni, Stefano; C. D., Geierhaas; Calosci, Nicoletta; P., Jemth; G. W., Vuister; Travaglini Allocatelli, Carlo; M., Vendruscolo; Brunori, Maurizio - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 128-133 - issn: 0027-8424 - wos: WOS:000243456300025 (60) - scopus: 2-s2.0-33846115692 (65)

11573/340623 - 2007 - Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics.

Gianni, Stefano; Ivarsson, Y; Bah, A; Bush Pelic, L. A.; Di Cera, E. - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0301-4622 - wos: (0) - scopus: 2-s2.0-35648975465 (26)

11573/362577 - 2007 - Identification and characterization of protein folding intermediates

Gianni, Stefano; Y., Ivarrson; Per, Jemth; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 105-113 - issn: 0301-4622 - wos: WOS:000247582800002 (60) - scopus: 2-s2.0-34249691304 (76)

11573/340622 - 2007 - PDZ domains: folding and binding.

Jemth, P; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. - - issn: 0006-2960 - wos: (0) - scopus: 2-s2.0-34547643210 (147)

11573/362585 - 2007 - An on-pathway intermediate in the folding of a PDZ domain

Y., Ivarsson; Travaglini Allocatelli, Carlo; P., Jemth; Malatesta, Francesco; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 8568-8572 - issn: 0021-9258 - wos: WOS:000245780300002 (39) - scopus: 2-s2.0-34247872879 (44)

11573/340395 - 2006 - Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain.

Chi, C. N.; Engstrom, Å; Gianni, Stefano; Larsson, M; Jemth, P. - 01a Articolo in rivista

11573/358307 - 2006 - Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering

Gianni, Stefano; Tine, Walma; Arcovito, Alessandro; Calosci, Nicoletta; Bellelli, Andrea; Åke, Engstrom; Travaglini Allocatelli, Carlo; Brunori, Maurizio; Per, Jemth; Geerten W., Vuister - 01a Articolo in rivista

rivista: STRUCTURE (London: Current Biology.) pp. 1801-1809 - issn: 0969-2126 - wos: WOS:000242888600008 (98) - scopus: 2-s2.0-33845186553 (98)

11573/361974 - 2005 - The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism

Gianni, Stefano; A., Engstrom; M., Larsson; Calosci, Nicoletta; Malatesta, Francesco; L., Eklund; C. C., Ngang; Travaglini Allocatelli, Carlo; P., Jemth - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 34805-34812 - issn: 0021-9258 - wos: WOS:000232403900052 (80) - scopus: 2-s2.0-27144437020 (83)

11573/363884 - 2005 - Kinetic folding mechanism of PDZ2 from PTP-BL

Gianni, Stefano; Calosci, Nicoletta; J. M. A., Aelen; G. W., Vuister; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. 389-395 - issn: 1741-0126 - wos: WOS:000231362100005 (52) - scopus: 2-s2.0-23944452163 (53)

11573/339832 - 2005 - The structure of the major transition state for folding of an FF domain from experiment and simulation.

Jemth, P; Day, R; Gianni, Stefano; Khan, F; Allen, M. D.; Daggett, V; Fersht, A. R. - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: (0) - scopus: 2-s2.0-20444409471 (67)

11573/362597 - 2005 - An obligatory intermediate in the folding pathway of cyctochrome c552 from Hydrogenobacter thermophilus

Travaglini Allocatelli, Carlo; Gianni, Stefano; Dubey V., K; Borgia, Alessandro; Di Matteo, Adele; Bonivento, Daniele; Cutruzzola', Francesca; Bren K., L; Brunori, Maurizio - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 25729-25734 - issn: 0021-9258 - wos: WOS:000230207900053 (64) - scopus: 2-s2.0-21844453660 (67)

11573/339831 - 2005 - Simulation and Experiment Conspire to reveal Cryptic Intermediates and the Slide from Framework to Nucleation-Condensation Mechanism in the Folding of the Homeodomain Superfamily.

White G. W., N; Gianni, Stefano; Grossman J., G; Jemth, P; Fersht A., R; Daggett, V. - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: (0) - scopus: (0)

11573/339829 - 2004 - Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation.

Jemth, P; Gianni, Stefano; Day, R; Li, B; Johnson C., M; Daggett, V; Fersht, A. R. - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Editore National Academy of Sciences a Washington, DC) pp. - - issn: 1091-6490 - wos: (0) - scopus: 2-s2.0-2342655032 (102)

11573/364606 - 2004 - A common folding mechanism in the cytochrome c family

Travaglini Allocatelli, Carlo; Gianni, Stefano; Brunori, Maurizio - 01a Articolo in rivista

rivista: TRENDS IN BIOCHEMICAL SCIENCES (Elsevier Trends Journals:An Imprint of Elsevier Science Limited, The Boulevard, Langford Lane, Kidlington, Oxford 0X5 1GB United Kingdom:011 44 1865 843000, 011 44 1865 843699, Fax: 011 44 1865 843010) pp. 535-541 - issn: 0968-0004 - wos: WOS:000224580300007 (48) - scopus: 2-s2.0-4644231179 (52)

11573/364932 - 2003 - Cytochrome c551 as a model system for protein folding

Brunori, Maurizio; Bigotti, Maria Giulia; Cutruzzola', Francesca; Gianni, Stefano; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 409-419 - issn: 0301-4622 - wos: WOS:000181883300037 (7) - scopus: 2-s2.0-0037438602 (7)

11573/339590 - 2003 - Unifying features in protein folding mechanisms.

Gianni, Stefano; Guydosh, N. R.; Khan, F; Caldas, T. D.; Mayor, U; White, G. W. N.; Demarco, M. L.; Daggett, V; Fersht, A. R. - 01a Articolo in rivista

11573/339592 - 2003 - Structural insights in the folding of single domain proteins.

Gianni, Stefano; Mayor, U; Fersht, A. R. - 01a Articolo in rivista

rivista: ITALIAN JOURNAL OF BIOCHEMISTRY (Il Pensiero Scientifico) pp. - - issn: 0021-2938 - wos: (0) - scopus: (0)

11573/363340 - 2003 - Parallel pathways in cytochrome c551 folding

Gianni, Stefano; Travaglini Allocatelli, Carlo; Cutruzzola', Francesca; Brunori, Maurizio; Ramachandra Shastry M., C; Roder, H. - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 1145-1152 - issn: 0022-2836 - wos: WOS:000184299000020 (48) - scopus: 2-s2.0-0037675765 (49)

11573/339591 - 2003 - The kinetic pathway of folding of barnase.

Khan, F; Chuang J., I; Gianni, Stefano; Fersht, A. R. - 01a Articolo in rivista

11573/127664 - 2003 - Exploring the cytochrome c folding: cyt c552 from Thermus Thermopilus folds through and on-pathway intermediate

Travaglini Allocatelli, Carlo; Gianni, Stefano; Morea, V.; Tramontano, Anna; Soulimane, T.; Brunori, Maurizio - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 41136-41140 - issn: 0021-9258 - wos: WOS:000185847200089 (40) - scopus: 2-s2.0-0142135083 (40)

11573/364393 - 2001 - Fast coordination changes in cytochrome c do not necessarily imply folding

A., Arcovito; Gianni, Stefano; Brunori, Maurizio; Travaglini Allocatelli, Carlo; Bellelli, Andrea - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 41073-41078 - issn: 0021-9258 - wos: WOS:000171925600094 (27) - scopus: 2-s2.0-0035798650 (30)

11573/42403 - 2001 - Refolding kinetics of cyt c551 from Pseudomonas aeruginosa reveals a mechanistic difference between guanidine and urea.

Gianni, Stefano; Brunori, Maurizio; Travaglini Allocatelli, Carlo - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. 1685-1688 - issn: 0961-8368 - wos: WOS:000169984100022 (25) - scopus: 2-s2.0-0034917762 (25)

11573/393231 - 2001 - Snapshots of protein folding. A study on the multiple transition state pathway of cytochrome c(551) from Pseudomonas aeruginosa.

Gianni, Stefano; Travaglini Allocatelli, Carlo; Cutruzzola', Francesca; Bigotti, Mg; Brunori, Maurizio - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 1177-1187 - issn: 0022-2836 - wos: WOS:000169586000013 (29) - scopus: 2-s2.0-0035933343 (33)