Phd in MOLECULAR MEDICINE

email: sonia.coni@uniroma1.it
phone: 0649255155
building: edificio B
room: 215

SHORT CURRICULUM VITAE

PRESENT POSITION: Tenure Track Researcher (RTT) MEDS-26/A
DEPARTMENT: Molecular Medicine

EDUCATION AND CAREER
2024: Tenure Track Researcher (RTT) MEDS-26/A (ex MED/46) at the Molecular Medicine Department, SAPIENZA, University of Rome
2021: National Scientific Qualification (ASN) MEDS-02/A (ex MED/04) SC 06/A2
2020: Research Associate (RtdA) SSD MED/46, at Department of Molecular Medicine Medicine (lab of Molecular Oncology) “Sapienza” University of Rome (Italy)
2020: National Scientific Qualification (ASN) MEDS-26/A (ex MED/46) SC 06/N1
2014: Reaserch Fellow (SSD MED/04) at the Department of Molecular Medicine (lab of Molecular Oncology “Alberto Gulino”) SAPIENZA University of Rome
2011: Post doc Researcher at the CNRS (iBV) Nice, France (Dr Pascal Therond Laboratory)
2010: Research Fellow (SSD MED/04) at the Department of Molecular Medicine “Sapienza” University of Rome (Dr Alberto Gulino lab)
2010: phD in “Molecular Medicine” at the Department of Experimental Medicine SAPIENZA University of Rome
2006: Second Level Degree in Genomic Biotechnology (Magna cum Laude) SAPIENZA – University of Rome
2004: First Level Degree in Genomic Biotechnology (Magna cum Laude) SAPIENZA – University of Rome

MOST RELEVANT RESEARCH LINES
- Study the Epigenetic alterations in the pathogenesis of brain tumors. Studies about the transcriptional control of cell growth in vitro (neuronal cells) and in vivo (mouse models of spontaneous tumorigenesis of Medulloblastoma Hedgehog-dependent).
- Study the Role of polyamine metabolism in colorectal cancer and in muscular diseases, using as models preclinical models of CRC tumorigenesis and Drosophila Melanogaster.
-Characterization of the novel CNBP-ODC-polyamine axis in muscle function and diseases like DM2.
COLLABORATIONS
-Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome;
-Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome
-Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I
-Department of Drug chemistry and Technologies, SAPIENZA University of Rome
-CNRS UMR 7277, Inserm 1091, Institut de Biologie Valrose (iBV), Centre de Biochimie, Universite´ de Nice-Sophia Antipolis, Nice, France

FIVE SELECTED PUBLICATIONS
1) Bordone R, Ivy DM, D'Amico R, Barba M, Gaggianesi M, Di Pastena F, Cesaro B, Bufalieri F,
Balzerano A, De Smaele E, Giannini G, Di Marcotullio L, Fatica A, Stassi G, Di Magno L, Coni S,
Canettieri G. “MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells
through FOXO3a-mediated autophagic adaptation.” Oncogene. 2024 Nov;43(46):3349-3365
2) Coni S*, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, D'Amico R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G*. *co-corresponding “Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.” Cancer Lett. 2023 Apr 10; 559:216120.
3) Coni S, Serrao SM, Yurtsever ZN, Di Magno L, Bordone R, Bertani C, Licursi V, Iannello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G. “Blockade of EIF5A hypusination limits Colorectal Cancer growth by inhibiting MYC elongation” Cell Death and Disease 2020 Dec 10;11(12):1045.
4) Coni S*, Falconio F*, Marzullo M*, Munafò M. Zuliani B, Mosti F, Fatica A, Ianniello Z, Bordone
R, Macone A, Agostinelli E, Perna A, Matkovic T, Sigrist S, Silvestri G, Canettieri G, Ciapponi L.
“Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor
function” E-Life, Elife. 2021 Sep 14.
5) Canettieri G*, Di Marcotullio L*, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P,Giorgi A, Steinkühler C, Vitagliano L, Pedone C, Schininà ME, Screpanti I, Gulino A “Hedgehog signaling is regulated by Histone Deacetylase and Cullin3/RENKCTD11 Ubiquitin Ligase interplay” Nat Cell Biol. 2010 Feb;12(2):132-42.