SILVIA PERNA

PhD Student

PhD program:: XL
email: silvia.perna@uniroma1.it
building: V clinica medica, Policlinico Umberto I
room: L07




supervisor: Prof.ssa Claudia Carissimi
advisor: Prof.ssa Laura Stronati

Research: Role of the transcription factor ZNF281 in controlling cancer progression and invasion

WORK EXPERIENCE: 1 November 2024 - Present PhD in Human Biology and Medical Genetics Department of Experimental Medicine, University of Rome ‘La Sapienza’ (RM) 1 June 2024 – 31 October 2024 JUNIOR Scholarship Department of Molecular Medicine, University of Rome ‘La Sapienza’ (RM) JUNIOR Scholarship as part of the FIRB 2011 funded project entitled: ‘Multiomics and machine learning to predict response to drug therapies in paediatric Eosinophilic Oesophagitis’. 1 June 2023 – 31 May 2024 Category B Type I Research Grant – SSD BIO12 Department of Molecular Medicine, University of Rome ‘La Sapienza’ (RM) Research Grant Project: ‘Multiomics and machine learning to predict response to drug therapies in paediatric eosinophilic oesophagitis’. ● Molecular and cellular biology techniques: cell cultures, optical microscopy, RNA interference, Western Blot, PCR, Real Time PCR; ● CRISPR/CAS9 methodology March 2022 – October 2022 Curricular internship I.R.C.C.S. Policlinico San Matteo Foundation, Pavia (PV) Thesis internship aimed at writing a paper entitled: “Development of an alginate and gelatin-based hydrogel suitable for the proliferation of porcine mesenchymal stromal cells”. ● Applied cell biology techniques: isolation, cultivation and expansion of mesenchymal stromal cells and their derivatives; ● Mesenchymal cell-based scaffolds; ● Study of the functional activities of mesenchymal stromal cells and their derivatives (nanoparticles). July 2019 – September 2019 Curricular internship Buonarroti Diagnostic Centre, Civitavecchia (RM) The experience trained me in the various areas of an anatomical pathology laboratory: cytological, histological, immunohistochemical. ● Diagnostics and laboratory analysis: haematology slide staining; microscopic reading of urine samples and their chemical-physical analysis; immunoenzymatic assays for the processing of oropharyngeal/genital swabs; sperm analysis. EDUCATION AND TRAINING: March 2025 Registration in the Register of Biologists of Lazio and Abruzzo March 2024 Qualification to practise as a biologist University of Bari Aldo Moro (BA) December 2022 Master's Degree in Medical Biotechnology, 110 cum laude Faculty of Pharmacy and Medicine, University of Pavia (PV) Thesis: 'Development of an alginate and gelatin-based hydrogel suitable for the proliferation of porcine mesenchymal stromal cells' September 2020 Bachelor's Degree in Biotechnology, 109/110 Department for Innovation in Biological, Agri-Food and Forestry Systems at the University of Tuscia (VT) Thesis: ‘Biotechnological production of molecules of therapeutic interest’ July 2016 Scientific High School Diploma Galileo Galilei Scientific High School, Santa Marinella (RM)

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