PhD Student

PhD program:: XXXVII
phone: 0649910913
building: CU027
room: T1A

supervisor: Alessandro Paiardini
advisor: Alessandro Paiardini

Research: Development of protein modeling and drug design platforms for assisting structural bioinformatics.


October 2019 – June 2021

Master Degree in Genetics and Molecular Biology (English curriculum, LM-6) - Path of excellence - “Università degli studi di Roma La Sapienza” - 110/110 with honors

October 2016 – October 2019

Bachelor’s Degree in Biotechnology (L-2) - “Università degli studi di Roma La Sapienza” - 110/110 with honors

Curriculum: Bioinformatics and Omics, Structure and function of macromolecules, Drug Discovery.


- Avvio alla Ricerca 2023: A Modular Computational Platform for PPI-Targeted Design and Ab-initio Modeling of D-Peptides binders; Serena Rosignoli; Sapienza; 1.308 €
- Avvio alla Ricerca 2022: A Computational Platform for Allele-specific, Custom-Designed CRISPR/Cas Proteins and its Application in the Treatment of Autosomal Dominant Disorders; Serena Rosignoli; Sapienza; 1.250 €

Poster presentation @EMBO Workshop - Computational structural biology; EMBL Advanced Training Center; Heidelberg (DE); Dec. 2023.
Speaker @ELIXIR 3D-Bioinfo and 3D-SIG Conference in Structural Bioinformatics; Prague (CZ); November 2023.
Lecturer @MedILS Summer School in Bioinformatics; Split (HR); Aug. 2023.
Poster presentation @SBDD-Computational Advances in Drug Discovery; Sestri Levante (IT); May 2023.
Speaker @ELIXIR 3D-Bioinfo Annual Meeting; EMBL-EBI, Hinxton (UK); Nov. 2022.
Lecturer @CIVIS Summer School - Bioinformatics for non-bioinformaticians; Tübingen (DE); Jul. 2022.


- Object Oriented programming (OOP) in Python (Software and GUI development)
- Advanced usage of ‘in silico’ chemical tools for molecular visualization and manipulation (PyMOL, MarvinSketch, Openbabel, RDKit)
- Detailed theoretical and practical knowledge of Molecular Docking algorithms and related programs
- Bioinformatic analyses on Mass-Spectrometry-derived data.
- Linux, macOS and Windows Operative Systems use and management (software updates, programs installation)
- Good level of knowledge of Bash and R programming languages
- Protein structure prediction (Homology Modeling)

Research products

11573/1701072 - 2024 - Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase
Barile, Anna; Graziani, Claudio; Antonelli, Lorenzo; Parroni, Alessia; Fiorillo, Annarita; Di Salvo, Martino Luigi; Ilari, Andrea; Giorgi, Alessandra; Rosignoli, Serena; Paiardini, Alessandro; Contestabile, Roberto; Tramonti, Angela - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL:, INTERNET:, Fax: (212)691-3239) pp. 1-14 - issn: 0961-8368 - wos: WOS:001146773300001 (0) - scopus: 2-s2.0-85182849034 (1)

11573/1707220 - 2024 - Making Use of Averaging Methods in MODELLER for Protein Structure Prediction
Rosignoli, Serena; Lustrino, Elisa; Di Silverio, Iris; Paiardini, Alessandro - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001160493200001 (0) - scopus: 2-s2.0-85184717314 (0)

11573/1691811 - 2023 - PyPCN: protein contact networks in PyMOL
Rosignoli, Serena; Di Paola, Luisa; Paiardini, Alessandro - 01a Articolo in rivista
paper: BIOINFORMATICS ([Oxford] : Oxford University Press) pp. - - issn: 1367-4811 - wos: WOS:001101066800001 (0) - scopus: 2-s2.0-85176804397 (0)

11573/1662673 - 2022 - Severe Bartter syndrome type 1: Prompt postnatal management thanks to antenatal identification of SLC12A1 pathogenic variants
D'angelantonio, D; Majore, S; Di Netta, T; Zotta, F; Parise, G; Savino, E; Rosignoli, S; Bizzarri, B; Signore, F; Grammatico, P; Bottillo, I - 01a Articolo in rivista
paper: ARCHIVES DE PEDIATRIE (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET:, Fax: 011 33 1 71724664) pp. 530-533 - issn: 0929-693X - wos: WOS:000965565600010 (0) - scopus: 2-s2.0-85138547085 (0)

11573/1625113 - 2022 - Prediction and modeling of protein–protein interactions using “Spotted” peptides with a template-based approach
Gasbarri, C.; Rosignoli, S.; Janson, G.; Boi, D.; Paiardini, A. - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. 201- - issn: 2218-273X - wos: WOS:000763712100001 (0) - scopus: 2-s2.0-85123311952 (1)

11573/1655650 - 2022 - DockingPie: a consensus docking plugin for PyMOL
Rosignoli, Serena; Paiardini, Alessandro - 01a Articolo in rivista
paper: BIOINFORMATICS (-Oxford : Oxford University Press, 1998-) pp. 4233-4234 - issn: 1367-4803 - wos: WOS:000824423300001 (8) - scopus: 2-s2.0-85141892299 (7)

11573/1661534 - 2022 - Boosting the full potential of PyMOL with structural biology plugins
Rosignoli, Serena; Paiardini, Alessandro - 01g Articolo di rassegna (Review)
paper: BIOMOLECULES (Basel: MDPI) pp. 1764- - issn: 2218-273X - wos: WOS:000902276900001 (10) - scopus: 2-s2.0-85144708388 (17)

11573/1534289 - 2021 - The archaeal elongation factor EF-2 induces the release of aIF6 from 50S ribosomal subunit
Lo Gullo, Giada; De Santis, Maria Luisa; Paiardini, Alessandro; Rosignoli, Serena; Romagnoli, Alice; La Teana, Anna; Londei, Paola; Benelli, Dario - 01a Articolo in rivista
paper: FRONTIERS IN MICROBIOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 631297- - issn: 1664-302X - wos: WOS:000637212200001 (3) - scopus: 2-s2.0-85103823367 (3)

11573/1600685 - 2021 - Design and development of a versatile graphical user interface for assisting consensus docking analyses on therapeutic targets for cancer treatment.
Rosignoli, Serena; Paiardini, Alessandro - 04f Poster
conference: EMBO Workshop - Systems approaches in cancer (Split; Croatia)
book: Systems approaches in cancer - ()

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