SERENA ROSIGNOLI

PhD Student

PhD program:: XXXVII
email: serena.rosignoli@uniroma1.it
phone: 0649910913
building: CU027
room: T1A




supervisor: Alessandro Paiardini
advisor: Alessandro Paiardini

Research: Development of a protein modeling and drug design platform within the PyMOL molecular visualization environment.

EDUCATION


November 2021

PhD Life Sciences - (XXXVII)
Curriculum: Bioinformatics and Omics, Structure and function of macromolecules, Drug Discovery.


October 2019 – June 2021

Master Degree in Genetics and Molecular Biology (English curriculum, LM-6) - Path of excellence - “Università degli studi di Roma La Sapienza” - 110/110 with honors

Thesis title: Design and Development of a Versatile Graphical User Interface for Assisting Molecular Docking and Drug Discovery.


October 2016 – October 2019

Bachelor’s Degree in Biotechnology (L-2) - “Università degli studi di Roma La Sapienza” - 110/110 with honors

Thesis title: Inibitori di Aurora-A: analisi del contributo della flessibilità dei residui del sito attivo nell’accuratezza del Docking molecolare



TECHNICAL SKILLS AND COMPETENCES

- Object Oriented programming (OOP) in Python (Software and GUI development)

- Advanced usage of ‘in silico’ chemical tools for molecular visualization and manipulation (PyMOL, MarvinSketch, Openbabel, RDKit)

- Detailed theoretical and practical knowledge of Molecular Docking algorithms and related programs

- Bioinformatic analyses on Mass-Spectrometry-derived data.

- Linux, macOS and Windows Operative Systems use and management (software updates, programs installation)

- Good level of knowledge of Bash and R programming languages

- Protein structure prediction (Homology Modeling)

Research products

  • 11573/1661534 - 2022 - Boosting the Full Potential of PyMOL with Structural Biology Plugins (01g Articolo di rassegna (Review))
    SERENA ROSIGNOLI, ALESSANDRO PAIARDINI
  • 11573/1625113 - 2022 - Prediction and modeling of protein–protein interactions using “Spotted” peptides with a template-based approach (01a Articolo in rivista)
    Chiara Gasbarri, SERENA ROSIGNOLI, GIACOMO JANSON, DALILA BOI, ALESSANDRO PAIARDINI
  • 11573/1655650 - 2022 - DockingPie: a consensus docking plugin for PyMOL (01a Articolo in rivista)
    SERENA ROSIGNOLI, ALESSANDRO PAIARDINI
  • 11573/1662673 - 2022 - Severe Bartter syndrome type 1: Prompt postnatal management thanks to antenatal identification of SLC12A1 pathogenic variants (01a Articolo in rivista)
    DANIELA D'ANGELANTONIO, SILVIA MAJORE, TIZIANA DI NETTA, FEDERICA ZOTTA, GIULIA PARISE, EMANUELE SAVINO, SERENA ROSIGNOLI, BIANCA BIZZARRI, Paola GRAMMATICO, IRENE BOTTILLO
  • 11573/1534289 - 2021 - The archaeal elongation factor EF-2 induces the release of aIF6 from 50S ribosomal subunit (01a Articolo in rivista)
    GIADA LO GULLO, ALESSANDRO PAIARDINI, SERENA ROSIGNOLI, Paola LONDEI, DARIO BENELLI
  • 11573/1600685 - 2021 - Design and development of a versatile graphical user interface for assisting consensus docking analyses on therapeutic targets for cancer treatment. (04f Poster)
    SERENA ROSIGNOLI, ALESSANDRO PAIARDINI

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