Sebastian Luca D'Addario

PhD Graduate

PhD program:: XXXIV



Thesis title: Early life adversities shape physiological response of VTA dopaminergic neurons to positive and negative stimuli and behavior in adulthood

Exposure to aversive events during sensitive developmental periods can affect the preferential coping strategy adopted by individuals later in life, leading to stress-related psychiatric disorders, such as depression and addiction or, alternatively, increasing resilience to stress effects. We have previously shown that interfering with the development of mother-pups bond by the Repeated Cross Fostering (RCF) protocol induces resilience to depression-like phenotype, and increases susceptibility to cocaine effects in adult C57BL/6J female mice. Here, we used patch-clamp recording in midbrain slice combined with both in vivo and ex vivo pharmacology approaches to test our hypothesis of a link between electrophysiological modifications of dopaminergic neurons in the intermediate Ventral Tegmental Area (VTA) of RCF animals and their behavior. We found reduced hyperpolarization-activated (Ih) cation current amplitude and evoked firing in VTA dopaminergic neurons from both young and adult RCF female mice. In vivo pharmacological manipulation of the VTA neurons Ih current reverted the pro-resilient to depression phenotype and reduced sensitivity to cocaine effects in adult early-stressed mice or mimicked behavioral resilience to depression in adult control animals. However, ih current manipulation in control mice was not able to increase the sensitivity to cocaine effects. This is the first evidence showing how pro-resilience to depression behavior and susceptibility to cocaine induced by early events are linked to a long-lasting reduction of Ih current and excitability in VTA dopaminergic neurons.

Research products

  • 11573/1688011 - 2021 - Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 (01a Articolo in rivista)
    BAI, HUA; BALZAN, ADA ROSA; BARACCA, ANNA MARIA; BELLEUDI, FRANCESCA; BORDI, MANLIO; BREST, PIERRE; BUENO, MICHELE; BUDINI, MAURO; BUTTNER, STEFAN; CARLONI, STEFANO; CARNEVALI, OLIANA; CASTORI, MARCO; CHATTERJEE, SOUPARNO; CHEN, QIAN MATTEO; CHEN, WEI; CHEN, WEI; CHENG, HAO; CHENG, XIYANG; CHUNG, SOMIN; CLEMENTI, ELENA; COCCIA, EMANUELE; COLASANTI, TANIA; COLASUONNO, FRANCESCA; D'ORAZI, GIULIO; DASARI, SAARANYA KUMAR; DAVIS, TOHN; DE NUNZIO, COSIMO; DE SANTI, ANNA MARIA; DI BERNARDO, DIEGO; DI FAZIO, PATRIZIA; DI FONZO, ALESSANDRA; DI NARDO, ANNA MARIA; FACCHIANO, FRANCESCO; FENG, JINGANG; FERRARESI, ADRIANA FRANCESCA; FIMIA, GIAN MARIA; FINESCHI, VITTORIO; FOLLO, FRANCESCA CARMEN; FRANCONI, FRANCESCO; GAO, WIYONG; RUIZ GARCIA, MANUEL ALEJANDRO; GHIGO, ALESSANDRA; GIULIVI, CRISTIAN; GOMEZ, RAPHAELLA DELORES; GRUNE, TILMAN; GUERRI, CARLA; HAIDAR, MAZEN AHMAD; HAN, WEN-BIAO; HARRIS, ROSEMARY JANE; BABILONI, FABIO; RUEDA HERNANDEZ, JORGE ARMANDO; HU, BO; HU, DAVID LITE; HUMBERT, MICHEL; JIANG, LAN; JIN, LIYU; JIN, LIYU; JIN, SANGPIL; KARMAKAR, PURNENDU; KOVACS, ALESSANDRO; KUMAR, DEEPAK; KUMAR, DEEPAK; LEFEBVRE CAPECE MINUTOLO, CARLO; LETELLIER, EMMANUEL; LI, TIANZHAO; LIMANA, FEDERICA; LIN, WEICHENG; LIU, CHANG; LIU, LUCIA; LIU, LUCIA; MA, XIAONAN; MAIANI, ELISA; MAMMADOVA, NUSHABA; MARCUCCI, MARIA FLAVIA; MARDENTE, STEFANIA; MASUELLI, LAURA; MILAN, EDOARDO; MISHRA, ASHISH; MISASI, ROBERTA; MISRA, ANADI; MOLES, ANGELO; MORLEO, ROSANNA MARIA; MUKHERJEE, ADITYA; PANDEY, RAJYASHREE; PANENI, FRANCESCO; PAPALEO, ELEONORA; PERROTTA, CARLOTTA; PICCA, ALESSANDRO; PIERANTONI, GIOVANNA MARIA; PIERDOMINICI, MARIA COSTANZA; QI, YUNING; QIU, YANQI; REN, WEIQING; RENGA, GAIA; ROY, ANANYA; SANTAGUIDA, STEFANO; SARKAR, SUBIR; SARKAR, SUBIR; SCATOZZA, FRANCESCA; SCHMITT, RUEDIGER HANS JOSEF MARIA; SCHNEIDER, ANNA; SCIARRETTA, SEBASTIANO; D'ADDARIO, SEBASTIAN LUCA; SHARMA, KARYANAND MAYANK SHEKHAR; SHEN, MINGMIN; SHEN, ZHIXUN; SINHA, RAJEEV; SPAGNUOLO, PAOLO; RAUCH, STEFAN MICHAL; SU, CHUN LIEN; TAFANI, MARCO; TETTAMANTI, GIORGIA; THOMAS, SOPHIA MAGDALENE; TOMAIPITINCA, LUANA; TRAMONTANO, DANIELE; VARANO, GIANLUCA MARIA; MARTINEZ LUCAS, VICTOR MANUEL; VIDONI, CHIARA; VOLTA, ANDREA MASSIMO; VOMERO, MARTA; WANG, CONG; WANG, CONG; WANG, CONG; WANG, FILIPPO; WANG, FILIPPO; WANG, FILIPPO; WU, CHIEN LIN; WU, MENGRAN; XIAO, HAN; XIE, YUTING; XU, CHENG HAO; XU, JIANWEI; XU, JIANWEI; YANG, LI; YANG, LI; YIN, YANFEI; YING, ZUJIAN; YOSHIDA, KENSUKE; YU, HAU YING; ZHANG, LI; ZHANG, LI; ZHANG, LI; ZHANG, LI; ZHANG, MINGYU; ZHAO, HONGTAO; ZHAO, TIAN; ZHENG, GUIFEN; ZHENG, SHIHENG; ZHENG, YAN; ZHOU, JIAJIA; ZHOU, JIAJIA; ZHOU, JIAJIA; ZHOU, JIAJIA; ZHU, BOWEN; ZHU, HANDONG; ZHU, HANDONG; ZHU, HANDONG; ZOU, ZHENHUAN; ZOU, ZHENHUAN
  • 11573/1291946 - 2019 - Sex-dependent effects of early unstable post-natal environment on response to positive and negative stimuli in adult mice (01a Articolo in rivista)
    DI SEGNI, MATTEO; ANDOLINA, DIEGO; D'ADDARIO, SEBASTIAN LUCA; BABICOLA, LUCY; IELPO, DONALD; PASCUCCI, TIZIANA; LO IACONO, LUISA; VENTURA, ROSSELLA
  • 11573/1307879 - 2019 - MicroRNA-34a regulates the depression-like behavior in mice by modulating the expression of target genes in the Dorsal Raphè (01a Articolo in rivista)
    LO IACONO, LUISA; IELPO, DONALD; ACCOTO, ALESSANDRA; DI SEGNI, MATTEO; BABICOLA, LUCY; D'ADDARIO, SEBASTIAN LUCA; FERLAZZO, FABIO; PASCUCCI, TIZIANA; VENTURA, ROSSELLA; ANDOLINA, DIEGO
  • 11573/1652722 - 2022 - A multi-expert ensemble system for predicting Alzheimer transition using clinical features (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; MIRINO, PIERANDREA; GUARIGLIA, CECILIA; VENTURA, ROSSELLA
  • 11573/1385627 - 2020 - Xlr4 as a new candidate gene underlying vulnerability to cocaine effects (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; BABICOLA, LUCY; IELPO, DONALD; LO IACONO, LUISA; ANDOLINA, DIEGO; VENTURA, ROSSELLA
  • 11573/1688725 - 2023 - A mouse model of the 3-hit effects of stress: Genotype controls the effects of life adversities in females (01a Articolo in rivista)
    BABICOLA, LUCY; RICCELLI, CRISTINA; DI SEGNI, MATTEO; PASSERI, ALICE; MUNICCHI, DIANA; D'ADDARIO, SEBASTIAN LUCA; ANDOLINA, DIEGO; CABIB, SIMONA; VENTURA, ROSSELLA
  • 11573/1385624 - 2020 - RISC RNA sequencing in the Dorsal Raphè reveals microRNAs regulatory activities associated with behavioral and functional adaptations to chronic stress (01a Articolo in rivista)
    BABICOLA, LUCY; IELPO, DONALD; D'ADDARIO, SEBASTIAN LUCA; CABIB, SIMONA; VENTURA, ROSSELLA; FERLAZZO, FABIO; ANDOLINA, DIEGO; LO IACONO, LUISA
  • 11573/1487835 - 2021 - Long term effects of early life stress on HPA circuit in rodent models (01a Articolo in rivista)
    BABICOLA, LUCY; VENTURA, ROSSELLA; D'ADDARIO, SEBASTIAN LUCA; IELPO, DONALD; ANDOLINA, DIEGO; DI SEGNI, MATTEO
  • 11573/1542738 - 2021 - Resilience to anhedonia-passive coping induced by early life experience is linked to a long-lasting reduction of Ih current in VTA dopaminergic neurons: altered Ih current in the VTA of adult resilient-to-depression mice (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; DI SEGNI, MATTEO; LEDONNE, ANNUNZIATA; BABICOLA, LUCY; IELPO, DONALD; ANDOLINA, DIEGO; RAGOZZINO, DAVIDE ANTONIO; RENZI, MASSIMILIANO; VENTURA, ROSSELLA
  • 11573/1542950 - 2021 - MicroRNA-34a regulates 5-HT2C expression in dorsal raphe and contributes to the anti-depressant-like effect of fluoxetine (01a Articolo in rivista)
    LO IACONO, LUISA; IELPO, DONALD; PARISI, CHIARA; ACCOTO, ALESSANDRA; DI SEGNI, MATTEO; BABICOLA, LUCY; D'ADDARIO, SEBASTIAN LUCA; PASCUCCI, TIZIANA; VENTURA, ROSSELLA; ANDOLINA, DIEGO
  • 11573/1671670 - 2023 - Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism (01a Articolo in rivista)
    SABETTA, ANNAMARIA; D'ADDARIO, SEBASTIAN LUCA; VENTURA, ROSSELLA
  • 11573/1574955 - 2021 - Early life adversity affecting the attachment bond alters ventral tegmental area transcriptomic patterning and behavior almost exclusively in female mice (01a Articolo in rivista)
    LO IACONO, LUISA; BABICOLA, LUCY; DI SEGNI, MATTEO; D'ADDARIO, SEBASTIAN LUCA; MUNICCHI, DIANA; IELPO, DONALD; PASCUCCI, TIZIANA; CABIB, SIMONA; FERLAZZO, FABIO; ANDOLINA, DIEGO; VENTURA, ROSSELLA
  • 11573/1659983 - 2022 - The long-lasting effects of early life adversities are sex dependent: The signature of miR-34a (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; MUNICCHI, DIANA; MANCINI, CAMILLA; IELPO, DONALD; BABICOLA, LUCY; DI SEGNI, MATTEO; LO IACONO, LUISA; FERLAZZO, FABIO; ANDOLINA, DIEGO; VENTURA, ROSSELLA
  • 11573/1658988 - 2022 - Morpho-Functional Changes of Nigral Dopamine Neurons in an α-Synuclein Model of Parkinson's Disease (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; VENTURA, ROSSELLA
  • 11573/1596916 - 2021 - Long-term depression of striatal DA release induced by mGluRs via sustained hyperactivity of local cholinergic interneurons (01a Articolo in rivista)
    D'ADDARIO, SEBASTIAN LUCA; VENTURA, ROSSELLA

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