SARA MINOTTI

PhD Student

PhD program:: XLI
email: sara.minotti@uniroma1.it
building: V Clinica Medica (Dip. Medicina Sperimentale)
room: 214




supervisor: Cecilia Battistelli

Research: ncRNAs specific methylation determining tumour cells EVs cargo and immune response

Bachelor's Degree: Biology

For my thesis project, titled "The Role of ncRNAs in the Development of Endometrial Cancer", I explored the main regulatory mechanisms of gene expression through which non-coding RNAs contribute to tumorigenesis, with a particular focus on a ceRNA network in endometrial cancer.

Master's Degree: Medical Biotechnology

For my master's thesis project, “m6A-dependent HOTAIR role in EMT and tumorigenesis,” I investigated the effect of m6A modification on the role of lncRNA HOTAIR, which is capable of regulating the epithelial-mesenchymal transition process at the transcriptional level through the recruitment of the epigenetic modifier EZH2, both during differentiation and tumorigenesis.

Erasmus+ Traineeship
During my internship at CSIC-IIB Institute in Madrid I investigated the role of the gut microbiota and the tumour microenvironment in promoting the proliferative and migratory capabilities of colorectal cancer cells.

Research products

11573/1752344 - 2025 - HOTAIR requires epitranscriptomic modification to exert its pivotal epigenetic role in Epithelial to Mesenchymal Transition
Garbo, Sabrina; Minotti, Sara; Marocco, Francesco; Quattrocchi, Luca; Di Silverio, Iris; Bontempi, Giulio; Strippoli, Raffaele; Tripodi, Marco; Battistelli, Cecilia - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (London: Nature Group-Springer London: Nature Publishing Group, 2001-) pp. - - issn: 2041-4889 - wos: (0) - scopus: (0)

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