ROSA PARADISO

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: Evaluation of the effectiveness of some disinfectants against microbiological contamination and biofilm in hospital water systems

UNIVERSITA’ DEGLI STUDI DI ROMA “LA SAPIENZA” DOTTORATO DI RICERCA SCIENZE FARMACEUTICHE XXIII Ciclo "Evaluation of the effectiveness of some disinfectants against microbiological contamination and biofilm in hospital water systems" Candidate Rosa Paradiso Coordinator Tutor Prof. Gabriele Favero Dr. Enrico Veschetti Dr. Lucia Bonadonna Anno Accademico 2019/2020 Abstract Water quality has a direct link to human-health protection. Safeguarding the quality of drinking water is absolutely essential, especially in particularly critical situations, such as hospitals and other healthcare facilities that represent very vulnerable environments. In these facilities, a contamination of the water may represent a health hazard and a potential risk for exposed people, often characterized by immunosuppression. A water network that is not protected from possible microbiological contaminations, either because not subjected to appropriate disinfection and maintenance operations or because of its structural characteristics, may be responsible for the exposure to water without the necessary quality requirements. In order to prevent water-related microbiological risks, a number of disinfectants has currently been used in these structures; among them monochloramine (NH2Cl) and hydrogen peroxide/silver ion (H2O2-Ag+) have recently acquired more and more importance in the strategy applied to the management of water networks, , especially in the control of Legionella proliferation. A parametric value for this microorganisms has recently been introduced in the recast of the EU Drinking Water Directive taking into account the recommendation published by the WHO in the Guidelines for drinking-water quality. In spite of their potentialities, the use of the two disinfectants is still affected by the lack of detailed information on the optimal conditions to be applied to guarantee the maximum biocidal effect without compromising the chemical quality of the distributed water. With the present doctoral thesis, killing activities of the two disinfectants towards Legionella pneumophila were investigated thouroughly in controlled laboratory conditions taking into account their decomposition kinetics. First-order differential equations were applied to model and compare their biocidal behaviours as initial concentration of the disinfectant, water temperature and contact time varied in the application ranges. Moreover, microbial growth on pipe materials has been examined to understand their role on Legionella proliferation in drinking-water distribution systems. Findings of the batch studies have been used to interprete the results of a monitoring activity made in two different hospitals where hot water treatment with the two disinfectants had been implemented in different periods of time. Corrosion effects of the two chemicals as well as microbiome characterization have been performed by examining coupons exposed to disinfected hot water for different contact times.

Produzione scientifica

11573/1487738 - 2020 - Hepatitis A virus strains circulating in the Campania region (2015-2018) assessed through bivalve biomonitoring and environmental surveillance
La Rosa, G.; Mancini, P.; Bonanno Ferraro, G.; Iaconelli, M.; Veneri, C.; Paradiso, R.; De Medici, D.; Vicenza, T.; Proroga, Y. T. R.; Di Maro, O.; Ciccaglione, A. R.; Bruni, R.; Other Members Of The Nrl For Human Viral, Hepatitis; Della Rotonda, M.; Suffredini, E. - 01a Articolo in rivista
rivista: VIRUSES (Basel: MDPI) pp. - - issn: 1999-4915 - wos: WOS:000610822900001 (14) - scopus: 2-s2.0-85099116324 (15)

11573/1348484 - 2019 - Batteri ambientali e Legionella SPP in acque e biofilm
Bonadonna, L; Bonanno Ferraro, G; Briancesco, R; Coccia, Am; Della Libera, S; Iaconelli, M; La Rosa, G; Mancini, P; Paradiso, R; Veneri, C - 04d Abstract in atti di convegno
congresso: Convegno nazionale legionellosi: una malattia prevenibile con una gestione integrata del rischio ambientale (Bari)
libro: Atti del convegno nazionale legionellosi - ()

11573/1348497 - 2019 - Occurrence of enteric viruses and free-living amoebae in swimming pools and spa, Rome 2015-2018
Bonadonna, L; Briancesco, R; Coccia, Am; Bonanno Ferraro, G; Mancini, P; Veneri, Carolina; Della Libera, S; Iaconelli, M; Paradiso, R; La Rosa, G - 04d Abstract in atti di convegno
congresso: Ottavo international conferenze in swimming pool and spa (Marsiglia)
libro: Atti dell’ottavo international conferenze in swimming pool and spa - ()

11573/1348504 - 2019 - Ecologia delle amebe a vita libera
Bonadonna, L; Briancesco, R; Paradiso, R; Angelici, Mc - 02a Capitolo o Articolo
libro: Rapporti ISTISAN 19/14 - ()

11573/1347465 - 2019 - Inquinanti emergenti
Cerroni, M.; Lucentin, I.; Mattei, D.; Paradiso, R.; Sette, C.; Veschetti, E. - 02a Capitolo o Articolo
libro: Inquinanti emergenti nelle acque ad uso umano. Criteri di monitoraggio, verifica, upgrading e ottimizzazione dei sistemi di approvvigionamento idropotabile per la gestione del rischio - ()

11573/1348468 - 2019 - Study of biofilm formation on different materials used in drinking water distribution systems (DVDS)
Paradiso, R.; Favero, G.; Bonadonna, L.; Lucentini, L.; Veschetti, E. - 04d Abstract in atti di convegno
congresso: BeMM Symposium PhD School Symposium (Roma)
libro: BeMM Symposium PhD School Symposium - ()

11573/1348477 - 2019 - STUDY OF BIOFILM FORMATION ON DIFFERENT MATERIALS USED IN DRINKING WATER DISTRIBUTION SYSTEMS (DWDS)
Paradiso, R.; Favero, G.; Bonadonna, L.; Lucentini, L.; Veschetti, E. - 04d Abstract in atti di convegno
congresso: XXVIII Congress of the Analytical Chemistry Division (Bari)
libro: Atti del XXVIII Congress of the Analytical Chemistry Division - ()

11573/1339300 - 2019 - Occurrence of Pseudomonas aeruginosa in several sources of drinking water
Vitanza, Luca; Rossella, Briancesco; Anna Maria Coccia, ; Paradiso, Rosa; Longhi, Catia - 04f Poster
congresso: 47° Congresso Nazionale della Società Italiana di Microbiologia (Roma, Italia)
libro: Abstract book SIM 2019 - ()

11573/1348506 - 2018 - Determinazione di amebe a vita libera
Bonadonna, L; Briancesco, R; Paradiso, R; Di Cave, D; Berrilli, F; Montalbano Di Filippo, M - 02a Capitolo o Articolo
libro: Rpporti ISTISAN 19/14 - ()

11573/1348500 - 2018 - Pseudomonas reduction in drinking-water and wastewater distridution systems by chlorine disinfection
Favero, G; Lucentini, L; Veschetti, E; Bonadonna, L; Paradiso, R - 04d Abstract in atti di convegno
congresso: XXVII congresso of the analytical chemistry division (Bologna)
libro: Atti del XXVII congresso di chimica analitica - ()

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