Associate professor

phone: 06-72594890
building: PP1


Robert Giovanni Nisticò

Dipartimento di Biologia, Università di Roma “Tor Vergata”, Via della Ricerca Scientifica 1, 00133 Roma (Italia)
Tel:+39 0672594890 Cell:+39 3479030315;

Sesso: Maschio | Data di nascita: 19/12/1974 | Nazionalità: Italiana


From January 2015: Associate Professor of Pharmacology
- Department of Biology, University of Rome “Tor Vergata”, Rome (Italy)
* Teaching activity at the Master's Degree in Pharmacy: General Pharmacology and Toxicology, Neuropsychopharmacology.

From January 2015: Regulatory Affairs Expert
- Malta Medicine Authority, Malta
* Evaluation of Toxicological Reports, RMPs and Assessment Reports (Non Clinical, Clinical, ERA, RMP, Pharmacovigilance, Toxicology)

From June 2015: Principal Investigator
- Neuropharmacology Lab, European Brain Research Institute – Rita-Levi Montalcini Foundation, Rome (Italy)
* Research activities: Synaptic Plasticity, Learning and Memory, Alzheimer’s disease, Multiple Sclerosis, Inflammation, Neurodegeneration

From October 2015: Italian Alternate Member Representative
- European Joint Undertaking Innovative Medicines Initiative (JU IMI)
* Elaboration and implementation of the IMI Strategic Research Agenda, preparation of IMI calls, and communications of IMI-JU with national institutions and public and private research groups

From September 2016: Member of Committee for Orphan Medicinal Products (COMP)
- European Medicines Agency (EMA), United Kingdom
* Scientific and regulatory evaluation of dossiers for orphan drugs.

From December 2016:Erasmus Coordinator of the Master Course in Pharmacy
- Department of Biology, University of Rome "Tor Vergata", Rome (Italy)

From November 2017: Coordinator of the Master Course in Pharmacy
- Department of Biology, University of Rome "Tor Vergata", Rome (Italy)
* Didactic activity: General Pharmacology and Toxicology, Neuropsychopharmacology


From 2001 to 2006: Researcher of Pharmacology
- Faculty of Pharmacy, University of Calabria (Italy)

From 2006 to 2012: Associate Professor of Pharmacology
- Faculty of Pharmacy, University of Calabria (Italy)


From 2012 to 2015: Professor of Pharmacology
- Faculty of Pharmacy and Medicine, Sapienza University of Rome (Italy)

--> 1999: Degree in Medicine and Surgery
- Catholic University of the Sacred Heart, Faculty of Medicine and Surgery, Rome (Italy)
* Vote: 110/110 cum laude

--> 2003: Specialization in Psychiatry and Clinical Psychology
- Catholic University of the Sacred Heart, Faculty of Medicine and Surgery, Rome (Italy)
* Vote: 110/110 cum laude

--> 2013: National Scientific Qualification first level professor
- Scientific Disciplinary Sector BIO /14 Pharmacology


Publications Prof. Nisticò is author or co-author of 129 in extenso papers (PubMed source) in international indexed journals, 8 book chapters and over 200 abstracts of communications at national and international meetings

Citations: Author ID: 6701421675 (Scopus) Orcid: 0000-0003-3433-9232
Documents: 122
Total citations: approx 2600 h-index: 32

Honours and Awards:
* 2002-2003: Marie Curie Intra European Fellowship (EIF) for Life Sciences.
* 2003-2004: Marie Curie Reintegration Grant (ERG) for Life Sciences.
* 2012-2015 Honorary Special Lecturer, School of Pharmacy, University of Nottingham, United Kingdom.
* 2015-2018: Honorary Special Lecturer, School of Pharmacy, University of Nottingham, United Kingdom.

Patents: Prof. Nisticò is inventor or co-inventor of the following patents:
1: Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity. PCT No. PCT/IB2015/051640
2: Formulation for the release of nitric oxide. Filing No. 102015000064118
3: Physical chemical system for the treatment of tinnitus. Filing No. 102016000112285

- American Society for Neuroscience (SFN)
- Italian Society of Pharmacology (SIF)
- European Society for Neuroscience (FENS)


Dr Nisticò is author or co-author of 129 in extenso papers (PubMed source) in international indexed journals, 8 book chapters and over 150 abstracts of communications at national and international meetings.

1. Bagetta G, Corasaniti MT, Paoletti AM, Berliocchi L, Nisticò R, Giammarioli AM, Malorni W, Finazzi-Agrò A. HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2). Biochem Biophys Res Commun. 1998 Mar 27;244(3):819-24.

2. Bagetta G, Corasaniti MT, Berliocchi L, Nisticò R, Giammarioli AM, Malorni W, Aloe L, Finazzi-Agró A. Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat. Neuroscience. 1999;89(4):1051-66.

3. Bagetta G, Rodinò P, Arabia A, Massoud R, Paoletti AM, Nisticò R, Passantino L, Preziosi P. Systemic administration of cocaine, given alone or in combination with sensory stimuli, differentially affects L-arginine-nitric oxide metabolism in discrete regions of the brain of rat. Neurosci Lett. 1999 May 14;266(3):153-6

4. Maccarrone M, Bari M, Corasaniti MT, Nisticò R, Bagetta G, Finazzi-Agrò A. HIV-1 coat glycoprotein gp120 induces apoptosis in rat brain neocortex by deranging the arachidonate cascade in favor of prostanoids. J Neurochem. 2000 Jul;75(1):196-203.

5. Corasaniti MT, Strongoli MC, Piccirilli S, Nisticò R, Costa A, Bilotta A, Turano P, Finazzi-Agrò A, Bagetta G. Apoptosis induced by gp120 in the neocortex of rat involves enhanced expression of cyclooxygenase type 2 and is prevented by NMDA receptor antagonists and by the 21-aminosteroid U-74389G. Biochem Biophys Res Commun. 2000 Aug 11;274(3):664-9.

6. Nucci C, Piccirilli S, Rodinò P, Nisticò R, Grandinetti M, Cerulli L, Leist M, Nicotera P, Bagetta G. Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation. Biochem Biophys Res Commun. 2000 Nov 19;278(2):360-7.

7. Corasaniti MT, Turano P, Bilotta A, Malorni W, Stringaro AR, Nisticò R, Finazzi-Agró A, Bagetta G. Evidence that increases of mitochondrial immunoreactive IL-1beta by HIV-1 gp120 implicate in situ cleavage of pro-IL-1beta in the neocortex of rat. J Neurochem. 2001 Aug;78(3):611-8.

8. Corasaniti MT, Piccirilli S, Paoletti A, Nisticò R, Stringaro A, Malorni W, Finazzi-Agrò A, Bagetta G. Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor. Neurosci Lett. 2001 Oct 19;312(2):67-70.

9. Corasaniti MT, Maccarrone M, Nisticò R, Malorni W, Rotiroti D, Bagetta G. Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo. J Neurochem. 2001 Oct;79(1):1-8.

10. Mollace V, Muscoli C, Palma E, Iannone M, Granato T, Nisticò R, Rotiroti D. Central cardiovascular responses induced by interleukin 1 beta and tumor necrosis factor alpha infused into nucleus tractus solitarii, nucleus parabrachialis medialis and third cerebral ventricle of normotensive rats. Neurosci Lett. 2001 Nov 13;314(1-2):53-6.

11. Mollace V, Salvemini D, Riley DP, Muscoli C, Iannone M, Granato T, Masuelli L, Modesti A, Rotiroti D, Nisticò R, Bertoli A, Perno CF, Aquaro S. The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages. J Leukoc Biol. 2002 Jan;71(1):65-72.

12. Bagetta G, Paoletti AM, Leta A, Del Duca C, Nisticò R, Rotiroti D, Corasaniti MT. Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. Biochem Biophys Res Commun. 2002 Feb 22;291(2):255-60.

13. Mollace V, Muscoli C, Iannone M, Palma E, Rotiroti D, Romeo F, Nisticò R, Salvemini D. Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide. J Cardiovasc Pharmacol. 2002 Apr;39(4):544-51.

14. Nucci C, Piccirilli S, Nisticò R, Cerulli L, Bagetta G. Excitotoxic mechanisms of apoptosis in the mammalian visual system following monocular visual deprivation. Pharmacol Toxicol. 2002 Oct;91(4):153-7.

15. Corasaniti MT, Nisticò R, Costa A, Rotiroti D, Bagetta G. The HIV-1 envelope protein, gp120, causes neuronal apoptosis in the neocortex of the adult rat: a useful experimental model to study neuroaids. Funct Neurol. 2001;16(4 Suppl):31-8.

16. Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Rispoli V, Nisticò R, Rotiroti D, Salvemini D. The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic. Neurosci Lett. 2003 Jan 2;335(3):163-6.

17. Nucci C, Morrone L, Rombolà L, Nisticò R, Piccirilli S, Cerulli L. Multifaceted roles of nitric oxide in the lateral geniculate nucleus: from visual signal transduction to neuronal apoptosis. Toxicol Lett. 2003 Apr 4;139(2-3):163-73.

18. Nucci C, Piccirilli S, Nisticò R, Morrone LA, Cerulli L, Bagetta G. Apoptosis in the mechanisms of neuronal plasticity in the developing visual system. Eur J Ophthalmol. 2003 Apr;13 Suppl 3:S36-43.

19. Mollace V, Iannone M, Muscoli C, Palma E, Granato T, Modesti A, Nisticò R, Rotiroti D, Salvemini D. The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils. BMC Pharmacol. 2003 Jun 16;3:8.

20. Lauri SE, Bortolotto ZA, Nisticò R, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL. A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron. 2003 Jul 17;39(2):327-41.

21. More JC*, Nisticò R*, Dolman NP, Clarke VR, Alt AJ, Ogden AM, Buelens FP, Troop HM, Kelland EE, Pilato F, Bleakman D, Bortolotto ZA, Collingridge GL, Jane DE. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 2004 Jul;47(1):46-64.

22. Muscoli C, Sacco I, Alecce W, Palma E, Nisticò R, Costa N, Clementi F, Rotiroti D, Romeo F, Salvemini D, Mehta JL, Mollace V. The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1. J Pharmacol Exp Ther. 2004 Oct;311(1):44-50. Epub 2004 Jun 25.

23. Muscoli C, Visalli V, Colica C, Nisticò R, Palma E, Costa N, Rotiroti D, Nisticò G, Mollace V. The effect of inflammatory stimuli on NMDA-related activation of glutamine synthase in human cultured astroglial cells. Neurosci Lett. 2005 Jan 20;373(3):184-8.

24. Bortolotto ZA, Nisticò R, More JC, Jane DE, Collingridge GL. Kainate receptors and mossy fiber LTP. Neurotoxicology. 2005 Oct;26(5):769-77. Epub 2005 Jun 6.

25. Dolman NP, Troop HM, More JC, Alt A, Knauss JL, Nisticò R, Jack S, Morley RM, Bortolotto ZA, Roberts PJ, Bleakman D, Collingridge GL, Jane DE. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81.

26. Nisticò R, Piccirilli S, Sebastianelli L, Nisticò G, Bernardi G, Mercuri NB. The blockade of K(+)-ATP channels has neuroprotective effects in an in vitro model of brain ischemia. Int Rev Neurobiol. 2007;82:383-95.

27. Errico F*, Nisticò R*, Palma G, Federici M, Affuso A, Brilli E, Topo E, Centonze D, Bernardi G, Bozzi Y, D'Aniello A, Di Lauro R, Mercuri NB, Usiello A. Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. Mol Cell Neurosci. 2008 Feb;37(2):236-46.

28. Nisticò R, Piccirilli S, Cucchiaroni ML, Armogida M, Guatteo E, Giampà C, Fusco FR, Bernardi G, Nisticò G, Mercuri NB. Neuroprotective effect of hydrogen peroxide on an in vitro model of brain ischaemia. Br J Pharmacol. 2008 Mar;153(5):1022-9.

29. Berretta N*, Nisticò R*, Bernardi G, Mercuri NB. Synaptic plasticity in the basal ganglia: a similar code for physiological and pathological conditions. Prog Neurobiol. 2008 Apr;84(4):343-62.

30. Nisticò R, Lista S, Nappi G, Cereda C, Mercuri NB. Potential therapeutic usefulness of hydrogen peroxide in conditions of brain ischemia. Med Hypotheses. 2008;71(1):162.

31. Giustizieri M, Armogida M, Berretta N, Federici M, Piccirilli S, Mercuri NB, Nisticò R. Differential effect of carbamazepine and oxcarbazepine on excitatory synaptic transmission in rat hippocampus. Synapse. 2008 Oct;62(10):783-9.

32. Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 2009 Jan;56(1):121-30.

33. Federici M, Nisticò R, Giustizieri M, Bernardi G, Mercuri NB. Ethanol enhances GABAB-mediated inhibitory postsynaptic transmission on rat midbrain dopaminergic neurons by facilitating GIRK currents. Eur J Neurosci. 2009 Apr;29(7):1369-77.

34. Amantea D, Marrone MC, Nisticò R, Federici M, Bagetta G, Bernardi G, Mercuri NB. Chapter 25 Oxidative stress in stroke pathophysiology validation of hydrogen peroxide metabolism as a pharmacological target to afford neuroprotection. Int Rev Neurobiol. 2009;85:363-74

35. Nisticò R, Dargan SL, Fitzjohn SM, Lodge D, Jane DE, Collingridge GL, Bortolotto ZA. GLUK1 receptor antagonists and hippocampal mossy fibre function. Int Rev Neurobiol. 2009;85C:13-27

36. Armogida M, Giustizieri M, Zona C, Piccirilli S, Nisticò R, Mercuri NB. N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: an in vitro electrophysiological study. Synapse. 2010 ; 64:161-168.

37. Errico F, Napolitano F, Nisticò R, Centonze D, Usiello A. D-aspartate: an atypical amino acid with neuromodulatory activity in mammals. Rev Neurosci. 2009;20(5-6):429-40.

38. Terrinoni A, Codispoti A, Serra V, Didona B, Bruno E, Nisticò R, Giustizieri M, Alessandrini M, Campione E, Melino G. Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation. Biochem Biophys Res Commun. 2010 Apr 16;394(4):909-14.

39. Middei S, Berretta N, Roberto A, Panico MB, Lista S, Bernardi G, Mercuri NB, Ammassari-Teule M, Nisticò R. Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer’s disease. Learn Mem. 2010 Apr 19;17(5):236-40. IF 2,894

40. Napolitano F, Bonito-Oliva A, Federici M, Carta M, Errico F, Magara S, Martella G, Nisticò R, Centonze D, Pisani A, Gu HH, Mercuri NB, Usiello A. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine. J Neurosci. 2010 Aug 18;30(33):11043-56.

41. Fazi B, Biancolella M, Mehdawy B, Corazzari M, Minella D, Blandini F, Moreno S, Nardacci R, Nisticò R, Sepe S, Novelli G, Piacentini M, Di Sano F. Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain. Neurobiol Dis. 2010 Dec;40(3):634-44.

42. Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R. The γ-Secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J Alzheimers Dis. 2011;24(4):799-816.

43. Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A. Control of PKA stability and signalling by RING ligase praja2. Nat Cell Biol. 2011 Apr;13(4):412-22.

44. Molinaro P, Viggiano D, Nisticò R, Secondo A, Boscia F, Pannaccione A, Scorziello A, Mehdawy B, Sirabella R, Sokolow S, Herchuelz A, Di Renzo GF, Annunziato L. NCX3 knock-out mice display an impairment in hippocampal LTP and spatial learning and memory. J Neurosci. 2011 May 18;31(20):7312-7321.

45. Nisticò R, Mehdawy B, Piccirilli S, Mercuri NB. Paraquat- and rotenone-induced models of Parkinson’s disease. Int J Immunopathol Pharmacol 2011 April-June;24(2):313-322.

46. Lipski J, Nisticò R, Berretta N, Guatteo E, Bernardi G, Mercuri NB. L-DOPA: a scapegoat for accelerated neurodegeneration in Parkinson's disease? Prog Neurobiol. 2011 Sep 1;94(4):389-407.

47. Armogida M, Spalloni A, Amantea D, Nutini M, Petrelli F, Longone P, Bagetta G, Nisticò R#, Mercuri NB#. On the protective role of catalase against cerebral ischemia in vitro and in vivo. Int J Immunopathol Pharmacol 2011 Jul;24(3):735-747.

48. Errico F*, Nisticò R*, Napolitano F, Florio T, Barbieri F, Bonito Oliva A, Russo C, Mercuri NB, Usiello A. Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay. Neurobiol Aging. 2011 Nov;32(11):2061-74.

49. Errico F*, Nisticò R*, Napolitano F, Astone D, Mazzola C, D’Aniello A, Mercuri NB, Usiello A. Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice. Neurobiol Aging. 2011 Dec;32(12):2229-43.

50. Nisticò R, Dargan SL, Amici M, Collingridge GL, Bortolotto ZA. Synergistic interactions between kainate and mGlu receptors regulate bouton Ca2+ signalling and mossy fibre LTP. Sci Rep. 2011;1:103.

51. Cerreto M, Mehdawy B, Ombrone D, Nisticò R, Ruoppolo M, Usiello A, Daniele A, Pastore L, Salvatore F. Reversal of metabolic and neurological symptoms of phenylketonuric mice treated with a PAH containing helper-dependent adenoviral vector. Curr Gene Ther. 2012 Feb 1;12(1):48-56.

52. Armogida M, Nisticò R, Mercuri NB. Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischemia. Br J Pharmacol. 2012 Feb 21;166:1211–1224.

53. Nisticò R, Cavallucci V, Piccinin S, Macrì S, Pignatelli M, Mehdawy B, Laviola G, Mercuri NB, D’Amelio M. Insulin Receptor haploinsufficiency impairs long-term synaptic plasticity in the hippocampus. Neuromolecular Med. 2012 Jun 3. Doi: 10.1007/s12017-012-8184-z.

54. Nisticò R, Collingridge GL. The synaptic basis of Alzheimer’s disease. Eur J Neurodeg Dis. 2012 Apr; 1(1):21-33.

55. Errico F, Napolitano F, Nisticò R, Usiello A. New insights on the role of D-aspartate in the mammalian brain. Amino Acids. 2012 Nov;43(5):1861-71.

56. Nisticò R, Bolanos JP, De Sarro GB. Editorial: Integrating molecular mechanisms with synaptic plasticity in neurological disease. Mol Neurobiol. 2012 Dec;46(3):545-546.

57. Nisticò R, Pignatelli M, Piccinin S, Mercuri NB, Collingridge G. Targeting synaptic dysfunction in Alzheimer's disease therapy. Mol Neurobiol. 2012 Dec;46(3):572-587.

58. La Rosa LR, Matrone C, Ferraina C, Panico MB, Piccirilli S, Di Certo MG, Strimpakos G, Mercuri NB, Calissano P, D’Amelio M, Nisticò R. Age-related changes of hippocampal synaptic plasticity in AβPP-null mice are restored by NGF through p75NTR. J Alzheimers Dis. 2013 Jan 1;33(1):265-72.

59. Nisticò R, Mango D, Mandolesi G, Piccinin S, Berretta N, Pignatelli M, Feligioni M, Musella A, Gentile A, Mori F, Bernardi G, Nicoletti F, Mercuri NB, Centonze D. Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis. PLoS ONE 2013 Jan 23 8 (1) : e54666

60. Pignatelli M, Vollmayr B, Richter SH, Middei S, Matrisciano F, Molinaro G, Nasca C, Battaglia G, Ammassari-Teule M, Feligioni M, Nisticò R, Nicoletti F, Gass P. Enhanced mGlu5 receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats. Neuropharmacology. 2013 Mar;66:339-47.

61. Rispoli V, Ragusa S, Nisticò R, Marra R, Russo E, Leo A, Felicità V, Rotiroti D. Huperzine A Restores Cortico-Hippocampal Functional Connectivity after Bilateral AMPA Lesion of the Nucleus Basalis of Meynert. J Alzheimers Dis. 2013 Jan 1;35(4):833-46.

62. Tiveron C, Fasulo L, Capsoni S, Malerba F, Marinelli S, Paoletti F, Piccinin S, Scardigli R, Amato G, Brandi R, Capelli P, D'Aguanno S, Florenzano F, La Regina F, Lecci A, Manca A, Meli G, Pistillo L, Berretta N, Nisticò R, Pavone F, Cattaneo A. ProNGF/NGF imbalance triggers neurodegeneration and spontaneous epileptic-like discharges in transgenic mice. Cell Death Differ. 2013 Aug;20(8):1017-30.

63. Cavallucci V, Berretta N, Nobili A, Nisticò R, Mercuri NB, D'Amelio M. Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer's disease. Neuromolecular Med. 2013 Sep;15(3):541-8.

64. Federici M, Latagliata EC, Rizzo FR, Ledonne A, Gu HH, Romigi A, Nisticò R, Puglisi-Allegra S, Mercuri NB. Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation. Neuroscience. 2013 Nov 12;252C:118-124.

65. Fuzzati-Armentero MT, Ghezzi C, Nisticò R, Oda A, Blandini F. Single or combined treatment with l-DOPA and quinpirole differentially modulate expression and phosphorylation of key regulatory kinases in neuroblastoma cells. Neurosci Lett. 2013 Sep 27;552C:168-173.

66. Bonito-Oliva A, Pignatelli M, Spigolon G, Yoshitake T, Seiler S, Longo F, Piccinin S, Kehr J, Mercuri NB, Nisticò R, Fisone G. Cognitive impairment and dentate gyrus synaptic dysfunction in experimental parkinsonism. Biol Psychiatry. 2013 Mar 28. doi:pii: S0006-3223(13)00183-2.

67. Mori F*, Nisticò R*, Mandolesi G, Piccinin S, Mango D, Kusayanagi H, Berretta N, Bergami A, Gentile A, Musella A, Nicoletti CG, Nicoletti F, Buttari F, Mercuri NB, Martino G, Furlan R, Centonze D. Interleukin-1beta Promotes Long-Term Potentiation in Patients with Multiple Sclerosis. Neuromolecular Med. 2014 Mar;16(1):38-51.

68. Feligioni M, Nisticò R. SUMO: a (oxidative) stressed protein. Neuromolecular Med. 2013 Dec;15(4):707-19.

69. Iacovelli L, Feligioni M, Nisticò R, Nicoletti F, De Blasi A. Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins. Neuropharmacology. 2013 Oct 19;77C:303-312.

70. D’Amelio M, Nisticò R. Editorial: Targeting synaptic dysfunction and neural connectivity in neurological and psychiatric disorders. Curr Pharm Des. 2013;19(36):6391-2.

71. Pignatelli M, Feligioni M, Piccinin S, Molinaro G, Nicoletti F, Nisticò R. Synaptic plasticity as a therapeutic target in the treatment of autism-related single-gene disorders. Curr Pharm Des. 2013;19(36):6480-90.

72. Feligioni M, Mattson MP, Nisticò R. SUMOylation in Neuroplasticity and Neurological Disorders. Neuromolecular Med. 2013 Dec;15(4):707-19.

73. Novakovic D, Feligioni M, Scaccianoce S, Caruso A, Piccinin S, Schepisi C, Errico F, Mercuri NB, Nicoletti F, Nisticò R. Profile of gantenerumab and its potential in the treatment of Alzheimer’s disease. Drug Des Devel Ther. 2013 Nov 13;7:1359-64.

74. Mori D, Rossi S, Piccinin S, Motta C, Mango D, Kusayanagi H, Bergami A, Studer V, Nicoletti C, Buttari F, Barbieri F, Mercuri NB, Martino G, Furlan R, Nisticò R, Centonze D. Synaptic plasticity and PDGF signaling defects underlie clinical progression in Multiple Sclerosis. J Neurosci. 2013 Dec 4;33(49):19112-9.

75. Nisticò R, Mori F, Feligioni M, Nicoletti F, Centonze D. Synaptic plasticity in multiple sclerosis and in experimental autoimmune encephalomyelitis. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130162.

76. Mango D, Bonito-Oliva A, Ledonne A, Nisticò R, Castelli V, Giorgi M, Sancesario G, Fisone G, Berretta N, Mercuri NB. Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions. Neuropharmacology. 2014 Jan;76 Pt A:127-36.

77. Federici M, Latagliata EC, Ledonne A, Rizzo FR, Feligioni M, Sulzer D, Dunn M, Sames D, Gu H, Nisticò R, Puglisi-Allegra S, Mercuri NB. Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate. J Biol Chem. 2014 Jan 3;289(1):264-74.

78. Hampel H, Lista S, Teipel SJ, Garaci F, Nisticò R, Blennow K, Zetterberg H, Bertram L, Duyckaerts C, Bakardjian H, Drzezga A, Colliot O, Epelbaum S, Broich K, Lehéricy S, Brice A, Khachaturian ZS, Aisen PS, Dubois B. Perspective on Future Role of Biological Markers in Clinical Therapy Trials of Alzheimer's Disease: A Long-Range Point of View Beyond 2020. Biochem Pharmacol. 2014 Apr 15;88(4):426-49.

79. Martella G, Maltese M, Nisticò R, Schirinzi T, Madeo G, Sciamanna G, Ponterio G, Tassone A, Mandolesi G, Vanni V, Pignatelli M, Bonsi P, Pisani A. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia. Neurobiol Dis. 2014 Feb 3;65C:124-132.

80. Nisticò R, Piccinin S, Schepisi C, Ferraina C, Laurenza M, Mango D, Graziani M, Nicoletti F, Mercuri, NB, Feligioni M. Pharmacological modulation of long-term potentiation in animal models of Alzheimer's disease. J Biol Reg Homeost Ag. 2013; 27(2):37-47.

81. Scaccianoce S, Caruso A, Miele J, Nisticò R, Nicoletti F. Potential neurodegenerative effect of anabolic androgenic steroid abuse. J Biol Reg Homeost Ag. 2013; 27(2):107-114.

82. Nisticò R. Long-term potentiation in animal models of Alzheimer’s disease. Eur J Neurodeg Dis. 2013 May-Dec; 2(2-3):133-142.

83. Pignatelli M, Piccinin S, Molinaro G, Di Menna L, Riozzi B, Cannella M, Motolese M, Vetere G, Catania MV, Battaglia G, Nicoletti F, Nisticò R, Bruno V. Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling Angelman Syndrome. J Neurosci. 2014; 34(13):4558-4566.

84. Mango D, Barbato G, Piccirilli S, Panico MB, Feligioni M, Schepisi C, Graziani M, Porrini V, Benarese M, Lanzillotta A, Pizzi M, Pieraccini S, Sironi M, Blandini F, Nicoletti F, Mercuri NB, Imbimbo BP, Nisticò R. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: Protection against in vitro ischemia. Pharmacol Res. 2014 Mar 12;81C:83-90.

85. Nisticò R, Ferraina C, Marconi V, Blandini F, Negri L, Egebjerg J, Feligioni M. Age-related changes of protein SUMOylation balance in the APP Tg2576 mouse model of Alzheimer's disease. Front Pharmacol. 2014 Apr 7;5:63.

86. Mori F, Nicoletti CG, Rossi S, Motta C, Kusayanagi H, Bergami A, Studer V, Buttari F, Barbieri F, Weiss S, Nisticò R, Martino G, Furlan R, Centonze D. Growth factors and synaptic plasticity in relapsing-remitting multiple sclerosis. Neuromolecular Med. 2014 Jun;16(2):490-8.

87. Errico F*, Nisticò R*, Di Giorgio A, Squillace M, Vitucci D, Galbusera A, Piccinin S, Mango D, Fazio L, Middei S, Trizio S, Mercuri NB, Teule MA, Centonze D, Gozzi A, Blasi G, Bertolino A, Usiello A. Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals. Transl Psychiatry. 2014 Jul 29;4:e417.

88. Mango D, Bonito-Oliva A, Ledonne A, Cappellacci L, Petrelli R, Nisticò R, Berretta N, Fisone G, Mercuri NB. Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice. Exp Neurol. 2014 Nov;261:733-43.

89. Orlando R, Borro M, Motolese M, Molinaro G, Scaccianoce S, Caruso A, di Nuzzo L, Caraci F, Matrisciano F, Pittaluga A, Mairesse J, Simmaco M, Nisticò R, Monn JA, Nicoletti F. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014 Jul 22;86C:133-144.

90. Graziani M, Nencini P, Nisticò R. Genders and the concurrent use of cocaine and alcohol: pharmacological aspects. Pharmacol Res. 2014 Sep;87:60-70.

91. Hampel H, Schneider LS, Giacobini E, Kivipelto M, Sindi S, Dubois B, Broich K, Nisticò R, Aisen PS, Lista S. Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future. Expert Rev Neurother. 2015 Jan;15(1):83-105.

92. Nisticò R, Florenzano F, Mango D, Ferraina C, Grilli M, Di Prisco S, Nobili A, Saccucci S, D'Amelio M, Morbin M, Marchi M, Mercuri NB, Davis RJ, Pittaluga A, Feligioni M. Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release. Sci Rep. 2015 Mar 12;5:9035.

93. Cristino L, Luongo L, Squillace M, Paolone G, Mango D, Piccinin S, Zianni E, Imperatore R, Iannotta M, Longo F, Errico F, Vescovi AL, Morari M, Maione S, Gardoni F, Nisticò R*, Usiello A*. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain. Neurobiol Aging. 2015 May;36(5):1890-902.

94. Graziani M, Nisticò R. Gender differences in pharmacokinetics and pharmacodynamics of methadone substitution therapy. Front Pharmacol. 2015 Jun 9;6:122.

95. Busceti CL, Pietro PD, Riozzi B, Traficante A, Biagioni F, Nisticò R, Fornai F, Battaglia G, Nicoletti F, Bruno V. 5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacol Res. 2015 Sep;99:258-68.

96. Ghiglieri V, Napolitano F, Pelosi B, Schepisi C, Migliarini S, Di Maio A, Pendolino V, Mancini M, Sciamanna G, Vitucci D, Maddaloni G, Giampà C, Errico F, Nisticò R, Pasqualetti M, Picconi B, Usiello A. Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion. Sci Rep. 2015 Jul 20;5:10933.

97. Severini C, Lattanzi R, Maftei D, Marconi V, Ciotti MT, Petrocchi Passeri P, Florenzano F, Del Duca E, Caioli S, Zona C, Balboni G, Salvadori S, Nisticò R, Negri L. Bv8/prokineticin 2 is involved in Abeta-induced neurotoxicity. Sci Rep. 2015 Oct 19;5:15301.

98. Schepisi C, Pignataro A, Doronzio SS, Piccinin S, Ferraina C, Di Prisco S, Feligioni M, Pittaluga A, Mercuri NB, Ammassari-Teule M, Nisticò R, Nencini P. Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole. Psychopharmacology (Berl). 2015 Nov 17.

99. Nasca C, Zellia D, Bigio B, Piccinin S, Scaccianoce S, Nisticò R, McEwen BS. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity. Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):14960-5.

100. Fazio F, Lionetto L, Curto M, Iacovelli L, Cavallari M, Zappulla C, Ulivieri M, Napoletano F, Capi M, Corigliano V, Scaccianoce S, Caruso A, Miele J, De Fusco A, Di Menna L, Comparelli A, De Carolis A, Gradini R, Nisticò R, De Blasi A, Girardi P, Bruno V, Battaglia G, Nicoletti F, Simmaco M. Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia. Sci Rep. 2015 Dec 8;5:17799.

101. Mori F, Nisticò R, Nicoletti CG, Zagaglia S, Mandolesi G, Piccinin S, Martino G, Finardi A, Rossini PM, Marfia GA, Furlan R, Centonze D. RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis. Mult Scler. 2016 Jan 5. pii: 1352458515621796.

102. Feligioni M, Mango D, Piccinin S, Imbriani P, Iannuzzi F, Caruso A, De Angelis F, Blandini F, Mercuri NB, Pisani A, Nisticò R. Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice. Synapse. 2016 Feb 5. doi: 10.1002/syn.21894.

103. Graziani M, Nisticò R. Gender difference in prescription opioid abuse: A focus on oxycodone and hydrocodone. Pharmacol Res. 2016 Apr 20;108:31-38. doi: 10.1016/j.phrs.2016.04.012

104. Triaca V, Sposato V, Bolasco G, Ciotti MT, Pelicci P, Bruni AC, Cupidi C, Maletta R, Feligioni M, Nisticò R, Canu N, Calissano P. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell. 2016 Aug;15(4):661-72. doi: 10.1111/acel.12473. Epub 2016 Apr 13.

105. Hampel H, O'Bryant SE, Castrillo JI, Ritchie C, Rojkova K, Broich K, Benda N, Nisticò R, Frank RA, Dubois B, Escott-Price V, Lista S. PRECISION MEDICINE – The Golden Gate for Detection, Treatment and Prevention of Alzheimer's Disease. J Prev Alzheimers Dis. 2016 Dec;3(4):243-259. doi: 10.14283/jpad.2016.112.

106. Mango D, Weisz F, Nisticò R. Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus. Front Pharmacol. 2016 Oct 26;7:401. eCollection 2016. PubMed PMID: 27833555

107. Marcelli S, Ficulle E, Iannuzzi F, Kövari E, Nisticò R, Feligioni M. Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2016 Oct 13.

108. Caioli S, Severini C, Ciotti T, Florenzano F, Pimpinella D, Petrocchi Passeri P, Balboni G, Polisca P, Lattanzi R, Nisticò R, Negri L, Zona C. Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer's disease. Neuropharmacology. 2017 Apr;116:82-97. doi: 10.1016/j.neuropharm.2016.12.012. Epub 2016 Dec 15.

109. Mango D, Braksator E, Battaglia G, Marcelli S, Mercuri NB, Feligioni M, Nicoletti F, Bashir ZI, Nisticò R. Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus. Pharmacol Res. 2017 May;119:12-19. doi: 10.1016/j.phrs.2017.01.028. Epub 2017 Jan 27.

110. Weisz F, Piccinin S, Mango D, Ngomba RT, Mercuri NB, Nicoletti F, Nisticò R. The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus. Synapse. 2017 May;71(5). doi: 10.1002/syn.21964.

111. De Jaco A, Mango D, De Angelis F, Favaloro FL, Andolina D, Nisticò R, Fiori E, Colamartino M, Pascucci T. Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism. Int J Mol Sci. 2017 Apr 29;18(5). pii: E941. doi: 10.3390/ijms18050941

112. Marcelli S, Corbo M, Iannuzzi F, Negri L, Blandini F, Nisticò R, Feligioni M. The Involvement of Post- Translational Modifications in Alzheimer's Disease. Curr Alzheimer Res. 2017 May 4. doi: 10.2174/1567205014666170505095109

113. Nisticò R, Salter E, Nicolas C, Feligioni M, Mango D, Bortolotto ZA, Gressens P, Collingridge GL, Peineau S. Synaptoimmunology - roles in health and disease. Mol Brain. 2017 Jun 20;10(1):26. doi: 10.1186/s13041-017-0308-9. Review. PubMed PMID: 28637489; PubMed Central PMCID: PMC5480158

114. D'Amelio M, Nisticò R. Unlocking the secrets of dopamine in Alzheimer's Disease. Pharmacol Res. 2017 Jun 29. pii: S1043-6618(17)30790-9. doi: 10.1016/j.phrs. PMID: 28669711

115. Soligo M, Piccinin S, Protto V, Gelfo F, De Stefano ME, Florenzano F, BerrettaE, Petrosini L, Nisticò R, Manni L. Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats. Sci Rep. 2017 Aug 22;7(1):9077. doi: 10.1038/s41598-017-08556-z. PubMed PMID: 28831054; PubMed Central PMCID: PMC5567336.

116. Lista S, Toschi N, Baldacci F, Zetterberg H, Blennow K, Kilimann I, Teipel SJ,Cavedo E, Dos Santos AM, Epelbaum S, Lamari F, Dubois B, Nisticò R, Floris R, Garaci F, Hampel H; Alzheimer Precision Medicine Initiative (APMI). Cerebrospinal Fluid Neurogranin as a Biomarker of Neurodegenerative Diseases: A Cross-Sectional Study. J Alzheimers Dis. 2017;59(4):1327-1334. doi: 10.3233/JAD-170368. PubMed PMID: 28731449

117. Sancesario GM, Nuccetelli M, Cerri A, Zegeer J, Severini C, Ciotti MT, Pieri M, Martorana A, Caltagirone C, Nistico R, Bernardini S. Bromelain Degrades Aβ1-42 Monomers and Soluble Aggregates: An In Vitro Study in Cerebrospinal Fluid of Alzheimer's Disease Patients. Curr Alzheimer Res. 2018;15(7):628-636. doi: 10.2174/1567205015666180123124851. PubMed PMID: 29359669.

118. Hampel H, Toschi N, Babiloni C, Baldacci F, Black KL, Bokde ALW, Bun RS, Cacciola F, Cavedo E, Chiesa PA, Colliot O, Coman CM, Dubois B, Duggento A, Durrleman S, Ferretti MT, George N, Genthon R, Habert MO, Herholz K, Koronyo Y, Koronyo-Hamaoui M, Lamari F, Langevin T, Lehéricy S, Lorenceau J, Neri C, Nisticò R, Nyasse-Messene F, Ritchie C, Rossi S, Santarnecchi E, Sporns O, Verdooner SR, Vergallo A, Villain N, Younesi E, Garaci F, Lista S; Alzheimer Precision Medicine Initiative (APMI). Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology. J Alzheimers Dis. 2018;64(s1):S47-S105. doi: 10.3233/JAD-179932. PubMed PMID: 29562524; PubMed Central PMCID: PMC6008221.

119. Mango D, Nisticò R, Furlan R, Finardi A, Centonze D, Mori F. PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis. Neurochem Res. 2018 Feb 1. doi: 10.1007/s11064-018-2484-0. [Epub ahead of print] PubMed PMID: 29392518.

120. Nardecchia F, Orlando R, Iacovelli L, Colamartino M, Fiori E, Leuzzi V, Piccinin S, Nistico R, Puglisi-Allegra S, Di Menna L, Battaglia G, Nicoletti F, Pascucci T. Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria. Front Neurosci. 2018 Mar 16;12:154. doi: 10.3389/fnins.2018.00154. eCollection 2018. PubMed PMID: 29615849; PubMed Central PMCID: PMC5864888.

121. Maccarrone M, Totaro A, Leuti A, Giacovazzo G, Scipioni L, Mango D, Coccurello R, Nisticò R, Oddi S. Early alteration of distribution and activity of hippocampal type-1 cannabinoid receptor in Alzheimer's disease-like mice overexpressing the human mutant amyloid precursor protein. Pharmacol Res. 2018 Apr;130:366-373. doi: 10.1016/j.phrs.2018.02.009. Epub 2018 Feb 14. PubMed PMID: 29454025.

122. Ledonne A, Mango D, Latagliata EC, Chiacchierini G, Nobili A, Nisticò R, D'Amelio M, Puglisi-Allegra S, Mercuri NB. Neuregulin 1/ErbB signalling modulates hippocampal mGluRI-dependent LTD and object recognition memory. Pharmacol Res. 2018 Apr;130:12-24. doi: 10.1016/j.phrs.2018.02.003. Epub 2018 Feb 7. PubMed PMID: 29427771.

123. Mango D, Nisticò R. Role of ASIC1a in Aβ-induced synaptic alterations in the hippocampus. Pharmacol Res. 2018 May;131:61-65. doi: 10.1016/j.phrs.2018.03.016. Epub 2018 Mar 21. PubMed PMID: 29574226.

124. Hampel H, Vergallo A, Giorgi FS, Kim SH, Depypere H, Graziani M, Saidi A, Nisticò R, Lista S; Alzheimer Precision Medicine Initiative (APMI). Precision medicine and drug development in Alzheimer's disease: the importance of sexual dimorphism and patient stratification. Front Neuroendocrinol. 2018 Jul;50:31-51. doi: 10.1016/j.yfrne.2018.06.001. Epub 2018 Jun 12. Review. PubMed PMID: 29902481.

125. Vergallo A, Bun RS, Toschi N, Baldacci F, Zetterberg H, Blennow K, Cavedo E, Lamari F, Habert MO, Dubois B, Floris R, Garaci F, Lista S, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI). Association of cerebrospinal fluid α-synuclein with total and phospho-tau(181) protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers. Alzheimers Dement. 2018 Jul 26. pii: S1552-5260(18)33241-2. doi: 10.1016/j.jalz.2018.06.3053. [Epub ahead of print] PubMed PMID: 30055132.

126. Cavedo E, Chiesa PA, Houot M, Ferretti MT, Grothe MJ, Teipel SJ, Lista S, Habert MO, Potier MC, Dubois B, Hampel H; INSIGHT-preAD Study Group; Alzheimer Precision Medicine Initiative (APMI). Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. Alzheimers Dement. 2018 Sep;14(9):1204-1215. doi: 10.1016/j.jalz.2018.05.014. Epub 2018 Jul 7. Review. PubMed PMID: 30201102.

127. Borreca A, Latina V, Corsetti V, Middei S, Piccinin S, Della Valle F, Bussani R, Ammassari-Teule M, Nisticò R, Calissano P, Amadoro G. AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Mol Neurobiol. 2018 Oct;55(10):8124-8153. doi: 10.1007/s12035-018-0974-3. Epub 2018 Mar 5. PubMed PMID: 29508283.

128. Borg JJ, Melchiorri D, Sepodes B, Caramella CM, Tomino C, Micallef B, Nistico R. Optimising bench science to withstand regulatory scrutiny. Pharmacol Res. 2018 Oct 12. pii: S1043-6618(18)31563-9. doi: 10.1016/j.phrs.2018.10.014. [Epub ahead of print] PubMed PMID: 30321599.

129. Nisticò R, Peineau S. Alzheimer's disease: understanding homeostasis deregulation to foster development of effective therapies. Pharmacol Res. 2018 Dec 13;139:467-468. doi: 10.1016/j.phrs.2018.12.011. [Epub ahead of print] PubMed PMID: 30553822.

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