PhD Student

PhD program:: XXXVIII
email: pietro.scio@uniroma1.it
building: Nuovo Edificio di Chimica Farmaceutica (CU020), piano 2
room: L006

supervisor: Romano Silvestri
advisor: Romano Silvestri

Research: Computer Aided Drug Design and Discovery of Novel Antibacterial and Antineoplastic Agents.

Title of the research project: Computer Aided Drug Design and Discovery of Novel Antibacterial and Antineoplastic Agents.

Thematic area : Medicinal Chemistry.


Education: -18/10/2022. Single Cycle Degree in Pharmaceutical Chemistry and Technology, Sapienza University of Rome, 110/110 cum laude; - 07/2016. Classical diploma, Liceo Classico Statale “Anco Marzio”, 100/100.

Working experience: -11/2022 - in corso. Dottorato di Ricerca in Scienze delle Vita, Sapienza Università di Roma; -02/2022 – 10/2022. Tesi Sperimentale di Laurea in Chimica Farmaceutica, Sapienza Università di Roma, Dipartimento di Chimica e Tecnologia Farmaceutiche; -07/2021 – 02/2022. Farmacista Tirocinante - “Farmacia Benni S.a.s”, Roma.

Brief description of the research project:
The main objective of my research is the discovery and design of novel antibacterial and antineoplatic compounds using chemo-informatics techniques such as molecular docking and molecular dynamics (conventional and enhanced sampling methods). At the moment, the application of these methodologies resulted in the rationalization of the activity of a new class of human carbonic anhydrase and Wnt/β-catenin pathway inhibitors and in the identification of putative molecules endowed with bactericidal properties (ongoing biological testing).

Attendance at schools, meetings, seminars and courses:
- Scuole: 02/06/2023-10/06/2023, International School of Crystallography, Structural Drug Design 2023: Biology, Chemistry and Computers.
- Congressi: 02-04/05/2023, SBDD23 Computational Advances in Drug Discovery.
- Corsi: 02/02/2023-15/02/2023, Fundamentals of Enzyme Kinetics, Roberto Contestabile, Francesco Malatesta & Serena Rinaldo; 04/05/2023, Preparing artwork for scientific papers getting started in scientific illustration, Giorgio Giardina & Stefano Gianni.
- Seminari: 03/03/2023, Cristian Ripoli, Engineering proteins to boost LTP and memory; 09/03/2023, Anna Marabotti, Application of deep learning to the protein structure prediction: the tale of a “gigantic leap”; 17/03/2023, Elena Enzo, Deciphering self-renewal traits in epidermal stem cells; 23/03/2023, Eugenio Barone, Insulin Signaling in Alzheimer’s Disease Brain and Models Thereof; 14/04/2023, Velia Siciliano, Synthetic Biology: what, why and how; 21/04/2023, Simona Giunta, Protecting our genome: mechanisms to maintain DNA repeats stability in human cells; 12/05/2023, Amnon Horowitz, The chaperonin GroEL nano-machine: allostery and function; 19/05/2023, Giampietro Schiavo, The axonal transport machinery and its dysfunctions in neurodegenerative diseases; 01/06/2023, Massimiliano Aschi, Enzymes by the point of view of a computational chemist; 26/09/2023, Jean Quancard, Andra Unzue Lopez, Anita Wegert, Rob Young,Best Practices in hit-to-lead Optimization; 28/11/2023, Sandra Handschuh, Theodor Theis, Real World Use of FEP+ Calculations - Lessons Learned at Boehringer Ingelheim; 30/11/2023, Anna Vulpetti, Chris Phillips, Discovery of IL-1β and DCAF1 Ligands: from Fragment Hits to Cellular Proof of Concept, CryoEM in Industry: Small Proteins, Big Protein complexes, Supramolecular Protein Assemblies. Tales from the AstraZeneca microscope.

Research products

11573/1696179 - 2023 - 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D'ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D'angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 14824-14842 - issn: 1520-4804 - wos: WOS:001096765200001 (0) - scopus: 2-s2.0-85176509722 (0)

Le attività presentate in questa pagina sono finanziate totalmente, o in parte, dai fondi del Piano nazionale di ripresa e resilienza.
L'elenco e le finalità delle attività intraprese dalla Sapienza sono descritte nella pagina dedicata Sapienza per il Pnrr.

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