PIERANDREA MIRINO

Dottore di ricerca

ciclo: XXXV

supervisore: Prof. Cecilia Guariglia

Titolo della tesi: Preclinical pathological aging: predictive markers of the future onset

Background: Detecting the beginning of cognitive decay is crucial to guarantee good management and the possible prevention of dementia progression. The present study arises from observations collected during an educational event to promote mental and physical health in which incidental neuropsychological data gathered on 290 citizens showed the importance of routine neuropsychological examination in detecting early signs of cognitive decay, since many individuals were unaware of the decrease in their cognitive efficiency. Accordingly, the availability of a screening tool that is computerized, portable, selfadministrable, and sensitive to the main neurocognitive changes testifying the progression towards pathological aging is critical. Objective: the main aims of this work were identify the trend over time of the deterioration of cognitive functions, linked to normal aging in the healthy population, in order to create indicators of a preclinical pathological cognitive impairment. Methods: to obtain this result, we proceeded to developing a digital system that will allow to collect large amounts of data from several individuals and from different devices contemporary; developing a battery of neuropsychological test, apt for portable devices, designed to be easily and rapidly self-administered; Calculate normal aging curves to visualize trends in cognitive test performance as age varies, as a reference for identifying pathological brain aging. Results: DiaNe is not just the translation of standard tests into telematics, rather it is a new tool that provides both accuracy and response time measurements, aimed to screen cognitive profile and monitor it over time, being able to detect changes in still normal performances that may be suggestive of an ongoing onset of neurocognitive disorders.

Produzione scientifica

11573/1731516 - 2025 - Explainable machine learning on clinical features to predict and differentiate Alzheimer's progression by sex: Toward a clinician-tailored web interface

D'amore, Fabio Massimo; Moscatelli, Marco; Malvaso, Antonio; D'antonio, Fabrizia; Rodini, Marta; Panigutti, Massimiliano; Mirino, Pierandrea; Carlesimo, Giovanni Augusto; Guariglia, Cecilia; Caligiore, Daniele - 01a Articolo in rivista

rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-20 - issn: 0022-510X - wos: WOS:001394960700001 (1) - scopus: 2-s2.0-85213051635 (1)

11573/1681610 - 2023 - The time squares sequences: a new task for assessing visuospatial working memory

Mirino, Pierandrea; Mercuri, Sara; Pecchinenda, Anna; Boccia, Maddalena; Di Piero, Andrea; Soldani, Marta; Guariglia, Cecilia - 01a Articolo in rivista

rivista: FRONTIERS IN BEHAVIORAL NEUROSCIENCE (Lausanne : Frontiers Research Foundation) pp. 1-6 - issn: 1662-5153 - wos: WOS:001007906000001 (1) - scopus: 2-s2.0-85162048922 (1)

11573/1656168 - 2022 - Objetivos / Objectives Ubicarnos óptimamente en el espacio es fundamental para la vida diaria. Para ello, empleamos dos estrategias de orientación: egocéntrica (utiliza la posición del propio cuerpo como referencia) y alocéntrica (emplea claves del entorno, dependiente del hipocampo). Estas son moduladas por la memoria de trabajo, pero la influencia de la capacidad de percepción temporal y su relación con ellas aún requiere mayor investigación. Por ello, el objetivo de este trabajo es comprobar las diferencias de rendimiento según estrategia espacial (alocéntrica/egocéntrica), mediado por la memoria de trabajo y la percepción temporal simultáneamente. Metodología / Methodology Un total de 20 hombres y 21 mujeres, todos ellos estudiantes de la Universidad de la Sapienza, fueron evaluados empleando dos tareas virtuales de reconocimiento espacial (alocéntrica 3D y egocéntrica 2D). Ambas tareas contaron con dos tiempos de presentación diferentes para la imagen de muestra (3000/1000ms) para verificar su influencia en el rendimiento. También se emplearon otras dos tareas adicionales de memoria de trabajo y percepción temporal. Resultados y Conclusiones / Results & Conclusions Considerando memoria de trabajo y percepción temporal como covariables, en la tarea alocéntrica se encontró que los hombres tienen mejor rendimiento respecto a las mujeres, modulado por el tipo de ensayo (aciertos, falsas alarmas...). Por el contrario, en la tarea egocéntrica, no había diferencias en el rendimiento entre hombres y mujeres, pero sí entre cada tipo de ensayo. En líneas generales, se refleja una modulación diferencial de memoria de trabajo y percepción temporal para cada estrategia espacial. Específicamente, solo se encuentra un patrón conductual sexualmente dimórfico para la estrategia de orientación alocéntrica.

Castillo Escamilla, Joaquín; Mirino, Pierandrea; Del Mar Salvador Viñas, María; María Carmona Lorente, Isabel; Manuel Cimadevilla Redondo, José; Guariglia, Cecilia - 04f Poster

congresso: IV Congreso Internacional de Psicobiologìa (Spagna)

libro: IV International Congress of Psychobiology - ()

11573/1656167 - 2022 - Sexual dimorphism in the estimation of temporal differences in a young population

Del Mar Salvador Viñas, María; Castillo Escamillar, Joaquín; María Carmona Lorente, Isabel; Pepe, Sofia; Mirino, Pierandrea; Manuel Cimadevilla Redondo, José - 04f Poster

congresso: XXXII Internacional conference of the spanish society for comparative psychology (Spagna)

libro: XXXII Internacional conference of the spanish society for comparative psychology - ()

11573/1615368 - 2022 - DiaNe: A New First Level Computerized Tool Assessing Memory, Attention, and Visuospatial Processing to Detect Early Pathological Cognitive Decline

Di Vita, Antonella; Vecchione, Francesca; Boccia, Maddalena; Bocchi, Alessia; Cinelli, Maria Cristina; Mirino, Pierandrea; Teghil, Alice; D'antonio, Fabrizia; De Lena, Carlo; Piccardi, Laura; Giannini, Anna Maria; Guariglia, Cecilia - 01a Articolo in rivista

rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 1-14 - issn: 1387-2877 - wos: WOS:000773411100030 (3) - scopus: 2-s2.0-85128001042 (3)

11573/1652722 - 2022 - A multi-expert ensemble system for predicting Alzheimer transition using clinical features

Merone, M; D'addario, Sl; Mirino, P; Bertino, F; Guariglia, C; Ventura, R; Capirchio, A; Baldassarre, G; Silvetti, M; Caligiore D., A - 01a Articolo in rivista

rivista: BRAIN INFORMATICS (Berlin; Heidelberg: Springer, 2014) pp. 1-11 - issn: 2198-4026 - wos: WOS:001206545600029 (6) - scopus: 2-s2.0-85137599645 (7)

11573/1630483 - 2022 - Cerebellum-Cortical Interaction in Spatial Navigation and Its Alteration in Dementias

Mirino, Pierandrea; Pecchinenda, Anna; Boccia, Maddalena; Capirchio, Adriano; D'antonio, Fabrizia; Guariglia, Cecilia - 01g Articolo di rassegna (Review)

rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. 523- - issn: 2076-3425 - wos: WOS:000804339900001 (9) - scopus: 2-s2.0-85129350134 (9)

11573/1656170 - 2021 - How the cerebellum and prefrontal cortex cooperate during associative learning

Mirino, Pierandrea; Caligiore, Daniele - 04f Poster

congresso: Neuroinformatics Assembly 2021 (Sweden)

libro: Neuroinformatics Assembly 2021 - ()

11573/1600486 - 2021 - Cortico-cerebellar hyper-connections and reduced purkinje cells behind abnormal eyeblink conditioning in a computational model of autism spectrum disorder

Trimarco, Emiliano; Mirino, Pierandrea; Caligiore, Daniele - 01a Articolo in rivista

rivista: FRONTIERS IN SYSTEMS NEUROSCIENCE (Lausanne : Frontiers Research Foundation, 2007-) pp. - - issn: 1662-5137 - wos: WOS:000738526800001 (3) - scopus: 2-s2.0-85122220797 (4)

11573/1433311 - 2020 - How the cerebellum and prefrontal cortex cooperate during trace eyeblinking conditioning

Caligiore, Daniele; Mirino, Pierandrea - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF NEURAL SYSTEMS (World Scientific Publishing Company:PO Box 128, Farrer Road, Singapore 912805 Singapore:011 65 6 4665775, EMAIL: journal@wspc.com.sg, INTERNET: http://www.wspc.com.sg, http://www.worldscinet.com, Fax: 011 65 6 4677667) pp. - - issn: 0129-0657 - wos: WOS:000557917300005 (3) - scopus: 2-s2.0-85088879252 (3)