Phd in PHARMACOLOGY AND TOXICOLOGY

email: patrizia.campolongo@uniroma1.it
phone: 0649912450
building: CU024
room: 3

PATRIZIA CAMPOLONGO


PERSONAL DATA

Name: Patrizia Campolongo, PhD
Born: March 20th, 1977
Nationality: Italian
Marital status: Married, 2 children

Laboratory address: Department of Physiology and Pharmacology,
Sapienza University of Rome
P.le Aldo Moro, 5
Roma 00185, Italy
Tel.: +39 06 49912450
Fax: +39 06 49912480
e-mail: patrizia.campolongo@uniroma1.it

Home address: via I. Giordani, 35
Roma 00159, Italy
Tel.: +39 06 4062690

SUMMARY OF RESEARCH ACTIVITY
Author of 73 papers on peer review journals, editor of 1 international book (Elsevier) and 3 book chapters in international books.
More than 40 invitations as organizer, presenter at symposia and invited speaker within national and International Congresses.
Qualification for full professor SSD BIO/14 Pharmacology and MPSI/01 Psychology (National Agency for Evaluation of University and research) 2014-2020.

1. Total number citations: over 2600
2. Total H-index =26
3. H-index last 10 years (H10) = 24
4. Number publications last 12 years = 62
5. Average Impact factor=
6. Average Impact factor top 10 publications=
7. Average Impact Factor for publication last 12 years;

EDUCATION

March 2006 Ph.D “Pharmacology and Toxicology” Dept. of Physiology and Pharmacology. Sapienza University of Rome
July 2002 Board-Certified Pharmacist. University of Rome “La Sapienza”, Italy.
Nov 2001 Master of Science in Medicinal Chemistry (final marks: 110/110). University of Rome “La Sapienza”, Italy.
Jun 1995 High School Diploma (Classical Studies, final marks: 60/60). Cosenza, Italy.

PROFESSIONAL EXPERIENCE
Jul 2015-present Associate Professor of Pharmacology, University of Rome “La Sapienza”, Italy, School of Pharmacy and Medicine.
Nov 2008- Jul 2015 Assistant Professor with tenure, University of Rome “La Sapienza”, Italy, School of Pharmacy and Medicine.
Jun 2013- Sept 2013 Visiting Professor. Ludwig Maximilians University, Munich, Germany
Dec 2005- Oct 2008 Post-doctoral fellowship. University of Foggia, School of Medicine;
Set 2005- Gen 2006 Junior specialist at the Dept. of Neurobiology and Behavior (McGaugh’s lab). Director: Prof. James L. McGaugh, University of California, Irvine;
Jun 2004- Dec 2004 Junior specialist at the Dept. of Neurobiology and Behavior (McGaugh’s lab). Director: Prof. James L. McGaugh, University of California, Irvine;

Nov 2001-March 2006 Ph.D student. in “Pharmacology and Toxicology” Dept. of Human Physiology and Pharmacology. Course director Prof. Vincenzo Cuomo. School of Pharmacy, University of Rome “La Sapienza”, Italy;
Nov 2002 – Dec 2003 Scientific Guest at the Behavioural Pathophysiology Section of the Laboratorio di Fisiopatologia di Organo e di Sistema. Director: Dr. Enrico Alleva. Istituto Superiore di Sanità, Rome, Italy.


BRIEF SUMMARY OF RESEARCH OVER THE LAST FIVE YEARS
My research focuses on the role of the endocannabinoid system in the control of emotional behavior in rodents. Its clinical application and translational value are represented by the development of novel drugable targets to treat stress-related psychiatric disorders. I found that enhancing endocannabinoid tone results in marked anxiolytic-like and antidepressant-like effects. This finding opened new horizons for clinical intervention, leading to an oncoming clinical trial with drugs able to block anandamide hydrolysis as candidates for the treatment of mood and anxiety disorders. The achieved results clearly demonstrate that endocannabinoids modulate the response to events that cause emotional distress. I have recently expanded this finding, by demonstrating that the cannabinoid system regulates also the memories of emotional events. Overall, my research suggests that the endocannabinoid system might be a key regulator of stress-coping behaviors modulating not only the acute response to emotional challenges but also their higher order cognitive integration. In the last few years my research has been focused to the neural mechanisms underlying the development of stress related disorders in ICU patients. I have discovered that ICU used sedative drugs, such as propofol, may enhance the consolidation of memory for traumatic events. Such discovery opens new horizons leading to new therapeutic approaches for the blockade of posttraumatic memory formation in ICU patients.

AWARDS
2011 EBBS (European Brain and Behavior Society) Young investigator award;
2011 Bertè award for the most relevant paper in Pharmacology published in (2009).
2010 Prize “Sapienza Ricerca 2010", for the 6 most promising scientists performing fore-front research within the whole University “La Sapienza”.
2005 Prize for “ the best Pharmacological Research Program” sponsored by the Italian Society of Pharmacology (SIF) for the most promising Italian Researcher younger than 35.
2004 Nunzio Pascale’s award

FELLOWSHIPS
2013 Visiting Professorships in Germany (DAAD 2013)

2006-2008 2-year individual post doc fellowship released by Italian Society of Pharmacology (SIF), Italy for outstanding post doc researchers to complete a post doc period
2004: Travel fellowship released by Italian Society of Pharmacology (SIF), Italy, to spend a period abroad in foreign Neuroscience laboratory
2002-2005 Individual 3-year PhD fellowship (Ministry of Education, Italy)
1996-2001 Fellowships for outstanding master students (Sapienza, University of Rome)
1991-1995 Fellowships for outstanding bachelor students (INPDAP, Italy)

RESEARCH SUPPORTS AS PRINCIPAL INVESTIGATOR
- Italian Ministry of Health. (Ricerca finalizzata 90000€). “Don’t cry over spilt (formula) milk: human fMRI correlates of cognitive impairments due to formula feeding and pre-clinical evidence of maternal milk oligosaccharides supplementation as a potential treatment”. (2018-2021)

- Italian Ministry of Education (MIUR): PRIN 2015 (57200 €), title “Stress in adolescenza: dalle alterazioni cognitive alla suscettibilità per le patologie psichiatriche.” (2015-2018).
- Human Frontier Science Program. Young investigator grant (750,000 USD). Titolo “Neuroscience meets nanotechnology: the key to unlock emotional memories with nanodetectors” (2012-2015).
- Italian Ministry of Education (MIUR): PRIN 2010-2011 (144826 €), title “Emerging role of the endocannabinoid system in neuropsychiatric diseasese” (2012-2015).
- Italian Ministry of Education (MIUR): FIRB, “FUTURO IN RICERCA” (365,000 €), title “Post-traumatic stress disorder at developmental ages: from neurobiology and vulnerability factors to novel nanoparticle-based therapeutics” (2011-2014).
- FARI project, Sapienza Univesrità di Roma (7,000 €), title “Neural underpinnings of emotional memory processing in rats” (2012)
- German-Italian University Centre and Italian Society of Pharmacology. Funding for conference organization. (16,500 €). Title “The emotional brain: from neurobiology to new therapeutic opportunities. 2011. Chair and organizer of the meeting: Patrizia Campolongo
- Sapienza Università di Roma. (15,000 €). Research project title “The endocannabinoid system as a new target for the treatment of Post Traumatic Stress Disorder” (2011-2012).
- VIGONI 2010-2012 German-Italian University Centre (5,000 €). The program aims at developing a bi-national network dedicated to scientific cooperation between Italy and Germany. Title “Neurobiological mechanisms underlying the effects of clinically used sedative drugs on memory consolidation”. Principal investigator (Italy): Patrizia Campolongo. Principal investigator (Germany): Gustav Schelling.
INTERNATIONAL BRAIN RESEARCH ORGANIZATION FUNDING FOR SYMPOSIA ORGANIZATION 2010.
AO-07-CONCORDIA, European Space Agency (ESA) (2009-2012) Consequences of Long term-Confinement and Hypobaric Hypoxia on Immunity in the Antarctic Concordia Environment” (CHOICE Study). This large study (including more than 10 international institutions, such as NASA, eesa etc.) investigates the long-term effects of confinement in the Antarctic environment on physiological parameters and neurobiological systems (among them the study of the functionality of the endocannabinoid system is one major goal). Role: Co-Investigator.
YOUNG INVESTIGATOR RESEARCHER GRANT (2005-2006) Italian Society of Pharmacology (10500 €). Drugs influencing the cannabinoid system: effects on animal models of anxiety .

EDITORIAL ACTIVITIES
- Academic editor of the Journal Plos One (to present)
- Associate Editor of the journal Frontiers in Behavioral Neuroscience (to present)
- Guest editor of the journal Reviews in the Neurosciences (2012)
- Guest Editor of the journal Frontiers in Behavioral Neuroscience (2011)
- Review for international grant proposals (British Council in Israel; Britain-Israel Research and Academic Partnership (BIRAX); Chile National foundation; Agence Nationale de la Recherche, France)
- Review for journals: PNAS, Psychopharmacology, Pharmacology Biochemistry & Behaviour, Neuropharmacology, Neurotoxicity Research, Neurotoxicology & Teratology, Behavioural Brain Research, Behavioural Pharmacology, British Journal of Pharmacology.

INTERNATIONAL COOPERATION
- Center for the Neurobiology of Learning and Memory, Dept. Neurobiology and Behavior, University of California, Irvine, USA (James L McGaugh, PhD)
- Dept. of Neuroscience, Section of Anatomy, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands (Benno Roozendaal, PhD)
- Dept. of Anesthesiology, Ludwig Maximilians University, 81377 Munich, Germany (Gustav Schelling, MD PhD)
- Dept. of Cell Biology & Anatomy/Psychiatry. Hotchkiss Brain Institute. University of Calgary. Canada. (Matthew Hill, PhD)

ORGANIZATION OF SYMPOSIA/MEETINGS

Meetings:

1. 7th International Meeting of Mediterranean Neuroscience Society (MNS). June 2019. Marrakech, Morrocco. Member of the organizing committee.
2. International workshop. European Space Agency. Topical team on Immunity and Stress. Stress related health challenges in space: How can countermeasure research contribute to space exploration and health on Earth? March 2017. Frascati. Local organizer
3. 5th International Meeting of Mediterranean Neuroscience Society (MNS). June 2015. Santa Margherita di Pula. Member of the local organizing committee.
4. International Conference: “The emotional brain”. Chair and president of the conference. Rome, Italy, 5-6 September 2011.
5. International workshop on: Neurological and Psychiatric Disorders: from Neurobiology to Medicine. Rome Italy, Rome, 11March 2010. Member of the Scientific secretariat.
Symposia:
1. Italian Society of Neuroscience (SINS). XVII national Meeting (Ischia, ottobre 2017). Excess memory and excess forgetting: two tails of the same coin? Chairs: Campolongo and Macrì
2. Mediterranean Neuroscience Society (MNS). 6th Conference (Malta, June 2017). Neurological mechanisms of the impact of stress on memory and emotionality in health and disease: Insights from animal and clinical studies. Chairs: Campolongo and Morena
3. International Behavioral Neuroscience Society (IBNS) 25° Annual Meeting (Budapest, June 2016). Diet impact on brain plasticity and cognition. Chairs: Ferreira and Campolongo
4. Italian Society of Pharmacology (SIF) 37th meeting. Old and new drugs in the modulation of reward and emotional behaviour. (Naples, October 2015) Chairs: Campolongo and Ciccocioppo.
5. Mediterranean Neuroscience Society (MNS). 5th Conference (Santa Margherita di Pula, June 2015). Reward sensitivity from adolescence to adulthood. Chairs: Campolongo and Lesscher.
6. Italian Society of Neuroscience (SINS). XV Conference (Rome, October 2013). An emotional perspective on the endocannabinoid system: from health to disease. Chairpersons: Campolongo e Trezza.
7. Mediterranean Neuroscience Society (MNS). 4th Conference (Istanbul, October 2012). Symposium “Endocannabinoids and the control of memory and emotions”. Chairpersons: Campolongo and Fattore.
8. International Behavioral Neuroscience Society (IBNS) 19° Annual Meeting. (Villasimius, June 2010). “Understanding the impact of emotional experiences on brain function: insights from animal and clinical studies”. Sponsored by IBRO. Chairs: Campolongo and Trezza.

PROFESSIONAL MEMBERSHIP
2004-present Member, American Society for Neuroscience (SfN)
2004-present Member, Italian Society of Pharmacology (SIF)
2009-present Member, European Behavioural Pharmacology Society (EBPS)
2011-present Member, European Brain Behaviour Society (EBBS)
2012-present International Cannabinoid Research Society (ICRS)
2012-present Member, Mediterranean Neuroscience Society (MNS)

ACADEMIC ACTIVITIES

2015- present Professor of the Pharmacology course for the Master in “Pharmacy”, Sapienza University of Rome

2010-2015 Professor of the Toxicology course for the Master in “Pharmacy”, Sapienza University of Rome

2009-2010 Professor of the Toxicology course for the Master in “Biotechnology”, Sapienza University of Rome
2002-present Supervisor of undergraduate and graduate students
2008-present Member of the PhD school committee in Pharmacology and Toxicology (School of Pharmacy and Medicine, Sapienza Univ. of Rome).
Other activities:
2012 to present Promoter of the Bilateral Erasmus Agreement for student mobility between Sapienza, University of Rome and Ludwig-Maximilians University of Munich (German Promoter Prof. Gustav Schelling).
2013 Graduate School of Medicine. Pharmacology of anesthetic drugs. Mobility program for Erasmus Teaching Program a.a. 2012-2013.. University of Munich. Germany.


PUBLICATIONS (Peer Reviewed Journals)

1. Strewe C, Thieme D, Dangoisse C, Fiedel B, van den Berg F, Bauer H, Salam AP, Gössmann-Lang P, Campolongo P, Moser D, Quintens R, Moreels M, Baatout S, Kohlberg E, Schelling G, Choukèr A, Feuerecker M. Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. Front Physiol. 2018 Nov 26;9:1647.

2. Siller-Pérez C, Fuentes-Ibañez A, Sotelo-Barrera EL, Serafín N, Prado-Alcalá RA, Campolongo P, Roozendaal B, Quirarte GL. Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory. Psychoneuroendocrinology. 2019;99:97-103.

3. Santangelo V, Cavallina C, Colucci P, Santori A, Macrì S, McGaugh JL, Campolongo P. Enhanced brain activity associated with memory access in highly superior autobiographical memory. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7795-7800.


4. Ratano P, Petrella C, Forti F, Passeri PP, Morena M, Palmery M, Trezza V, Severini C, Campolongo P. Pharmacological inhibiton of 2-arachidonoilglycerol hydrolysis enhances memory consolidation in rats through CB2 receptor activation and mTOR signaling modulation. Neuropharmacology. 2018; 138: 210-218.

5. Melancia F, Schiavi S, Servadio M, Cartocci V, Campolongo P, Palmery M, Pallottini V, Trezza V. Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling. Br J Pharmacol. 2018 Sep;175(18):3699-3712.


6. Morena M, Berardi A, Colucci P, Palmery M, Trezza V, Hill MN, Campolongo P. Enhancing endocannabinoid neurotransmission augments the efficacy of extinction training and ameliorates traumatic stress-induced behavioral alterations in rats. Neuropsychopharmacology. 2018; 43(6):1284-1296

7. Servadio M, Manduca A, Melancia F, Leboffe L, Schiavi S, Campolongo P, Palmery M, Ascenzi P, di Masi A, Trezza V. Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid. Eur Neuropsychopharmacol. 2018; 28(1):85-96

8. Lissek T et al. Building Bridges through Science. Neuron. 2017; 96(4):730-735.

9. Hill MN, Campolongo P, Yehuda R, Patel S. Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder. Neuropsychopharmacology. 2018; 43(1):80-102

10. Morena M, Berardi A, Peloso A, Valeri D, Palmery M, Trezza V, Schelling G, Campolongo P. Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder. Behav Brain Res. 2017; 329:215-220.

11. Ratano P, Palmery M, Trezza V, Campolongo P. Cannabinoid Modulation of Memory Consolidation in Rats: Beyond the Role of Cannabinoid Receptor Subtype 1. Front Pharmacol, 2017; 8:200.

12. Almenrader N, Colucci P, De Castro V, Valeri D, Palmery M, Trezza V, Campolongo P. Effects of sevoflurane and clonidine on acid base status and long-term emotional and cognitive outcomes in spontaneously breathing rat pups. PLoS One. 2017; 12(3): e0173969.

13. Esposito E, Drechsler M, Mariani P, Carducci F, Servadio M, Melancia F, Ratano P, Campolongo P, Trezza V, Cortesi R, Nastruzzi C. Lipid nanoparticles for administration of poorly water soluble neuroactive drugs. Biomed Microdevices. 2017;19(3):44.
14. Melancia F, Servadio M, Schiavi S, Campolongo P, Giusti-Paiva A, Trezza V. Testing the correlation between experimentally-induced hypothyroidism during pregnancy and autistic-like symptoms in the rat offspring. Behav Brain Res. 2017; 321:113-122.
15. Zamberletti E, Piscitelli F, De Castro V, Murru E, Gabaglio M, Colucci P, Fanali C, Prini P, Bisogno T, Maccarrone M, Campolongo P, Banni S, Rubino T, Parolaro D. Lifelong imbalanced linoleic/alpha-linolenic acid intake impairs emotional and cognitive behavior in adult rats via changes in brain endocannabinoid system. J Lipid Res. 2017; 58(2):301-316.

16. Almenrader N, Colucci P, De Castro V, Valeri D, Palmery M, Trezza V, Campolongo P. Effects of sevoflurane and clonidine on acid base status and long-term emotional and cognitive outcomes in spontaneously breathing rat pups. PLoS One. 2017 20;12(3): e0173969.
17. Manduca A, Lassalle O, Sepers M, Campolongo P, Cuomo V, Marsicano G, Kieffer B, Vanderschuren LJ, Trezza V, Manzoni OJ. Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play. Front Behav Neurosci. 2016; 10:211.
18. Servadio M, Melancia F, Manduca A, di Masi A, Schiavi S, Cartocci V, Pallottini V, Campolongo P, Ascenzi P, Trezza V. Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry. 2016; 6(9): e902.
19. Morena M, Leitl KD, Vecchiarelli HA, Gray JM, Campolongo P, Hill MN. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety. Neuropharmacology. 2016; 111:59-69.
20. Berardi A, Schelling G, Campolongo P. The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings. Pharmacol Res. 2016; 111:668-78.
21. Manduca A, Servadio M, Damsteegt R, Campolongo P, Vanderschuren LJ, Trezza V. Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats. Neuropsychopharmacology. 2016;41(9):2215-23.
22. Morena M, De Castro V, Gray JM, Palmery M, Trezza V, Roozendaal B, Hill MN, Campolongo P. Training-Associated Emotional Arousal Shapes Endocannabinoid Modulation of Spatial Memory Retrieval in Rats. J Neurosci. 2015. 14;35(41):13962-74.
23. Morgese MG, Colaianna M, Mhillaj E, Zotti M, Schiavone S, D'Antonio P, Harkin A, Gigliucci V, Campolongo P, Trezza V, De Stradis A, Tucci P, Cuomo V, Trabace L. Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1. Front Neurosci. 2015. 9:428;
24. Trabace L, Tucci P, Ciuffreda L, Matteo M, Fortunato F, Campolongo P, Trezza V, Cuomo V. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. J Ethnopharmacol. 2015 (15)30113-6.
25. Manduca A, Morena M, Campolongo P, Servadio M, Palmery M, Trabace L, Hill MN, Vanderschuren LJ, Cuomo V, Trezza V. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. Eur Neuropsychopharmacol. 2015 25(8):1362-74.
26. Atsak P, Hauer D, Campolongo P, Schelling G, Fornari RV, Roozendaal B. Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation. Neuropsychopharmacology. 2015. 40(6):1485-94.
27. Esposito E, Ravani L, Drechsler M, Mariani P, Contado C, Ruokolainen J, Ratano P, Campolongo P, Trezza V, Nastruzzi C, Cortesi R. Cannabinoid antagonist in nanostructured lipid carriers (NLCs): Design, characterization and in vivo study. Materials Science and Engineering C, 2015 48:328-336.
28. Morena M, Roozendaal B, Trezza V, Ratano P, Peloso A, Hauer D, Atsak P, Trabace L, Cuomo V, McGaugh JL, Schelling G, Campolongo P. Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training. PNAS 2014, 111(51):18333-8.
29. Esposito E, Ravani L, Drechsler M, Mariani P, Contado C, Ruokolainen J, Ratano P, Campolongo P, Trezza V, Nastruzzi C, Cortesi R. Cannabinoid antagonist in nanostructured lipid carriers (NLCs): Design, characterization and in vivo study. Materials Science and Engineering C , 2015 48:328-336.
30. Berardi A, Trezza V, Palmery M, Trabace L, Cuomo V, Campolongo P. An updated animal model capturing both the cognitive and emotional features of post-traumatic stress disorder (PTSD). Frontiers in behavioral neuroscience. 2014, 8:142.

31. Morena M and Campolongo P. The endocannabinoid system: An emotional buffer in the modulation of memory function. Neurobiology of learning and memory. 2014, 112C:30-43. Invited review.

32. Scuderi C, Stecca C, Valenza M, Ratano P, Bronzuoli M, Bartoli S, Steardo L jr, Pompili E, Fumagalli L, Campolongo P, Steardo L. Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer's disease. Cell Death & Disease. 2014, 11;5:e1419.

33. Tucci P, Mhillaj E, Morgese MG, Colaianna M, Zotti M, Schiavone S, Cicerale M, Trezza V, Campolongo P, Cuomo V, Trabace L. Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats. Frontiers in behavioral neuroscience. 2014 19;8:332.

34. Manduca A, Servadio M, Campolongo P, Palmery M, Trabace L, Vanderschuren LJ, Cuomo V, Trezza V. Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats. Eur Neuropsychopharmacol. 2014, 24(8):1337-48

35. Manduca A, Campolongo P, Palmery M, Vanderschuren LJMJ, Cuomo V, Trezza V. Social play behavior, ultrasonic vocalizations and their modulation by morphine and amphetamine in Wistar and Sprague-Dawley rats. Psychopharmacology. 2014, 231(8):1661-73

36. Thieme U, Schelling G, Hauer D, Greif R, Dame T, Laubender RP, Bernhard W, Thieme D, CampolongoP, Theilerb L. Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans. Drug testing and analysis. 2014, 6(1-2):17-23.

37. Hauer D, Kaufmann I, Strewe C, Briegel I, Campolongo P, Schelling G. The Role of Glucocorticoids, Catecholamines and Endocannabinoids in the Development of Traumatic Memories and Posttraumatic Stress Symptoms in Survivors of Critical Illness. Neurobiology of learning and memory. 2014. 112C:68-74.

38. Campolongo P, Ratano P, Ciotti MT, Florenzano F, Lucia Nori S, Marolda R, Palmery M, Rinaldi AM, Zona C, Possenti R, Calissano P, Severini C. Systemic administration of Substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels. Plos One. 2013, 8(11):e78036.

39. Trezza V and Campolongo P. The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder. Frontiers in behavioral neuroscience. 2013, 6:73.

40. Campolongo P, Morena M, Scaccianoce S, Trezza V, Chiarotti F, Schelling G, Cuomo V, Roozendaal B. Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity. Neuropsychopharmacology. 2013, 38(7):1276-86;

41. Hauer D, Schelling G, Gola H, Campolongo P, Morath J, Roozendaal B, Hamuni G, Karabatsiakis A, Atsak P, Vogeser M, Kolassa I. Plasma Concentrations of Endocannabinoids and Related Primary Fatty Acid Amides in Patients with Post-Traumatic Stress Disorder. Plos One. 2013, 7;8(5):e62741.

42. Campolongo P, Tomaz C, Gasbarri A. The emotional brain and its relation to psychopathology. Reviews in the Neurosciences. 2012, 23(5-6):445-7; editorial

43. Campolongo P, Trezza V. The endocannabinoid system: a key modulator of emotions and cognition. Frontiers in Behavioral Neuroscience. 2012, 6:73; editorial

44. Berardi A, Trezza V, Campolongo P. Modeling specific phobias and post-traumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features. Reviews in the Neurosciences. 2012, 23(5-6):645-57;

45. Trezza V, Damsteegt R, Manduca A, Petrosino S, Van Kerkhof LWM, Pasterkamp RJ, Zhou Y, Campolongo P, Cuomo V, Di Marzo V, Vanderschuren LJMJ. Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats. The Journal of Neuroscience. 2012, 32(43):14899-908;

46. Manduca A, Campolongo P, Trezza V. Cannabinoid modulation of mother-infant interaction: is it just about milk? Reviews in the Neurosciences. 2012;23(5-6):707-22
47. Hauer D, Weis F, Campolongo P, Schopp M, Beiras-Fernandez A, Strewe C, Giehl M, Toth R, Kilger E, Schelling G. Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression. Reviews in the Neurosciences. 2012, 23(5-6):681-90;
48. Atsak P, Hauer D, Campolongo P, Schelling G, McGaugh JL, Roozendaal B. Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory. PNAS. 2012, 109(9):3504-9. IF: 9.77;
49. Campolongo P, Ratano P, Manduca A, Scattoni ML, Palmery M, Trezza V, Cuomo V. The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness. Frontiers in Behavioral Neuroscience. 2012; 6:11;
50. Atsak P, Roozendaal B, Campolongo P. Role of the endocannabinoid system in regulating glucocorticoid effects on memory for emotional experiences. Neuroscience. 2011, 204:104-16. Invited review
51. Trezza V, Campolongo P, Manduca A, Morena M, Palmery M, Vanderschuren LJMJ, Cuomo V. Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance. Frontiers in Behavioral Neuroscience. 2012, 6:2-20.
52. Trezza V, Campolongo P, Vanderschuren LJMJ. Evaluating the rewarding nature of social interactions in laboratory animals. Developmental Cognitive Neuroscience. 2011, 1(4):444-58.
53. Trapani L, Melli L, Segatto M, Trezza V, Campolongo P, Jozwiak A, Sweiezewska E, Pupillo LP, Moreno S, Fanelli F, Linari M, Pallottini V. Effects of myosin heavy chain (MHC) plasticity induced by HMGCoA-reductase inhibition on skeletal muscle functions. Faseb J. 2011, 25(11):4037-47.
54. Hauer D, Ratano P, Morena M, Briegel I, Scaccianoce S; Palmery M, Cuomo V, Roozendaal B, Schelling G, Campolongo P. Propofol enhances long-term memory formation via an interaction with the endocannabinoid system. Anesthesiology. 2011,114(6):1380-8.
55. Hill M, Patel S, Campolongo P, Tasker J, Wotjak C, Bains J. Functional interactions between stress and the endocannabinoid system: From synaptic signalling to behavioral ouput. J Neurosci. 2010, 30(45):14980-6.
56. Campolongo P, Trezza V, Ratano P, Palmery M, Cuomo V. Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents. Psychopharmacology (Berl). 2011, 214(1):5-15. Invited review
57. Campolongo P, Roozendaal B, Trezza V, Hauer D, Schelling G, McGaugh JL, Cuomo V. Endocannabinoids in the rat basolateral amygdala enhance memory consolidation: involvement of the glucocorticoid system. Proc Natl Acad Sci U S A 2009, 106(12):4888-93.
58. Trezza V, Campolongo P. Toward understanding the neurobiology of social attachment: role of estrogen receptors in the medial amygdala. J Neurosci. 2009; 29(1):1-2.
59. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D. Fat-induced satiety factor OEA enhances memory consolidation. PNAS 2009, 106(19):8027-31.
60. Campolongo P, Trezza V, Palmery M, Trabace L, Cuomo V. Developmental exposure to cannabinoids causes subtle and enduring neurofunctional alterations. Int Rev Neurobiol 2009, 85:117-33. Invited review
61. Kaufmann I, Hauer D, Huge V, Vogeser M, Campolongo P, Chouker A, Thiel M, Schelling G. Enhanced anandamide plasma levels in patients with CRPS following traumatic injury: a preliminary report. Eur Surg Res. 2009 ;43(4):325-329.
62. Kaufmann I, Schelling G, Eisner C, Richter HP, Krauseneck T, Vogeser M, Hauer D, Campolongo P, Chouker A, Beyer A, Thiel M. Anandamide and neutrophil function in patients with fibromyalgia. Psychoneuroendocrinology. 2008, 33(5):676-685;
63. Trezza V*, Campolongo P*, Cassano T, Macheda T, Dipasquale P, Carratù MR, Gaetani S, Cuomo V. Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats. . Psychopharmacology 2008; 198(4): 529-37; * these authors contributed equally to the study;
64. Schwartz GJ; Fu J; Astarita G; Li X; Gaetani S; Campolongo P; Cuomo V; Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Met. 2008; 8(4):281-8.
65. Campolongo P, Trezza V, Cassano T, Gaetani S, Morgese MG, Ubaldi M, Soverchia L, Antonelli T, Ferraro L, Massi M, Ciccocioppo R, Cuomo V. Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats. Addict Biol. 2007; 12(3-4):485-95;
66. Barbaccia ML, Scaccianoce S, Del Bianco P, Campolongo P, Trezza V, Tattoli M, Cuomo V, Steardo L. Cognitive impairment and increased brain neurosteroids in adult rats perinatally exposed to low millimolar alcohol concentrations. Psychoneuroendocrinology, 2007; 32(8-10): 931-42;
67. Economidou D, Mattioli L, Ubaldi M, Lourdusamy A, Soverchia L, Hardiman G, Campolongo P, Cuomo V, Ciccocioppo R. Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol-seeking in adult rats following perinatal exposure to delta-9-tetrahydrocannabinol. Toxicol Appl Pharmacol. 2007; 223(1): 73-85;
68. La Rana G, Russo R, Campolongo P, Bortolato M, Mangieri RA, Cuomo V, Iacono A, Mattace Raso G, Meli R, Piomelli D, Calignano A. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404. J Pharmacol Exp Ther. 2006, 317(3):1365-71;
69. Bortolato M*, Campolongo P*, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404. Neuropsychopharmacology. 2006, 31(12):2652-9; * These authors equally contributed to the present paper;
70. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR, Cuomo V, Piomelli D. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A. 2005; 20;102(51):18620-5;
71. Branchi I, Campolongo P, Alleva E. Scopolamine effects on ultrasonic vocalization emission and behavior in the neonatal mouse. Behav Brain Res. 2004; 151: 9-16;
72. Peluso I, Serafini M, Campolongo P, Palmery M. Effect on rat arterial blood pressure of chemically generated peroxyl radicals and protection by antioxidants. J Nutr Biochem. 2004; 15(6): 323-7;
73. Spano D, Branchi I, Rosica A, Pirro MT, Riccio A, Mithbaokar P, Affuso A, Arra C, Campolongo P, Terracciano C, Macchia V, Bernal J, Alleva E, Di Lauro R. Rhes is involved in striatal function. Mol Cell Biol. 2004; 24(13): 5788-96;
74. Peluso I, Campolongo P, Romanelli L, Valeri P, Palmery M. Intestinal motility disorder induced by free radicals: a new model mimicking oxidative stress in gut. Pharmacol Res. 2002 Dec;46(6):533-8.
BOOK
Campolongo P and Fattore L (Editors). Endocannabinoids and modulation of emotion, memory, and motivation. Springer. 2015, I, 759.

BOOK CHAPTERS
1. Atsak P, Roozendaal B, Campolongo P. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences. In: Popoli, Diamond and Sanacora (eds.) Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders. Springer. 2014, pp 77-98
2. Morena M and Campolongo P. Endocannabinoid modulation of memory for emotionally arousing experiences. In: Fattore and Campolongo (eds.) Endocannabinoids and modulation of emotion, memory, and motivation. Springer. 2014, in press.
3. Campolongo P and Roozendaal B. Stress and glucocorticoid effects on memory. In: Conrad CD (ed). Handbook of Stress: Neuropsychological Effects on the Brain. Malden: Wiley-Blackwell. pp 179-200.

INVITED LECTURES

1. Campolongo P. The modulatory role of the endocannabinoid system on the consolidation and retrieval of memory for stressful experiences in rats. International Behavioral Neuroscience Society (IBNS) 27th Annual Meeting. 27 June – 2 July 2018. Boca Raton Resort. Florida. USA
2. Campolongo P. Arousal and stress effects on cannabinoid modulation of memory for emotionally arousing experiences. Center for Neurobiology of Learning and Memory spring meeting. 18-22 April 2018. Huntington Beach. California. USA
3. Campolongo P. The endocannabinoid system as a potential target for memory consolidation enhancement. 17° National Congress of the Italian Neuroscience Society (SINS). 1-4 October 2017. Ischia (Italy).
4. Campolongo P. Endocannabinoids and the Regulation of Memory for Emotionally Arousing Experiences. Cannabinoid Function in the CNS. Gordon Research Conference. 20-25 August 2017. Waterville (NH) USA.
5. Campolongo P. Perinatal exposure to omega-3 fatty acid imbalance leads to enduring behavioral alterations in rats. International Behavioral Neuroscience Society (IBNS) 25th Annual Meeting. 26-30 June 2016. Budapest. Hungary
6. Campolongo P. Role of the endocannabinoid system in the modulation of memory for traumatic experiences. Colston Research Society Symposium 2015: New developments in PTSD research and treatment. 16-17 November 2015. Bristol. UK
7. Campolongo P. Role of the endocannabinoid system in the modulation of memory for emotional experiences. 37° Meeting of the Italian Society of Pharmacology. 27-30 October 2015. Naples. Italy
8. Campolongo P. Are cannabinoids potential candidates for the treatment of Post-Traumatic Stress Disorder (PTSD)? 37° Meeting of the Italian Society of Pharmacology. 27-30 October 2015. Naples. Italy
9. Campolongo P. Stress and endocannabinoid modulation of emotional memory. Mediterranean Neuroscience Society (MNS) 5th meeting. 12-15 June 2015. Santa Margherita di Pula. Italy.
10. Campolongo P. Neurobiological mechanisms mediating the impact of stress on memory: Which role for the endocannabinoid system? Lecture for the PhD school of the Ecole Polytechnique Federale de Lausanne. 10 June 2015. Lausanne. Switzerland.
11. Campolongo P. Stress and endocannabinoid modulation of aversive memory. Satellite meeting of the 9th fens forum of neuroscience. Milan, 9 July 2014.
12. Campolongo P. Stress and endocannabinoid modulation of memory for emotionally arousing experiences. 26 April 2014. Queretaro. Mexico.
13. Campolongo P. Cannabinoids and memory for emotionally arousing experiences. Symposium on stress and memory. 29-30 March 2014, Basel. Switzerland.
14. Campolongo P. and Cuomo V. Stress and endocannabinoid modulation of aversive memory: potential relevance to the development of psychiatric disorders. International symposium on International Symposium psychoneuroendocrinology: New clinical fruits from old pre-clinical seeds. 5-6 April 2014, Catania. Italy.
15. Campolongo P. Endocannabinoids in the Modulation of Memory for Stressful Experiences: New Players in an Old Game. The 5th Brain and Behavior meeting of the Haifa Forum for Brain and Behavior. 9-11 February 2014. Haifa. Israel.
16. Campolongo P. Stress and endocannabinoid modulation of emotional memory: Potential relevance for psychiatric illnesses. Topical team meeting. 3-4 February 2014, Palermo. Italy.
17. Campolongo P. Endocannabinoids and Emotional Memory Modulation: The Key Role of the Basolateral Complex of the Amygdala. 36° Congresso Nazionale della Società Italiana di Farmacologia. 23-26 October 2013. Torino, Italy.
18. Campolongo P. Stress and endocannabinoid modulation of aversive memory: Potential relevance to the development of psychiatric disorders. 36° Congresso Nazionale della Società Italiana di Farmacologia. 23-26 October 2013. Torino, Italy.
19. Campolongo P. Effects of Clinically Used Sedative/Anesthetic Drugs on Memory for Traumatic Experiences in Rats. University of Munich, Munich, Germany, 9 July 2013.
20. Campolongo P. Role of the endocannabinoid system in the modulation of memory for emotionally arousing experiences. University of Insubria. 19 Apri 2013. Busto Arsizio, Italy.
21. Campolongo P. Endocannabinoid modulation of emotional memory in rodents. Faculty at Fens-IBRO School Synaptic stress and pathogenesis of neuropsychiatric disorders. 24-30 March 2013, Bertinoro, Italy
22. Campolongo P. The endocannabinoid system and the regulation of memory for emotionally arousing experiences. 4th Conference Mediterranean Neuroscience Society. 1-4 October 2012, Istanbul, Turkey.
23. Campolongo P. Endocannabinoids: new players in emotional memory consolidation. 43° meeting European Brain and Behaviour Society (EBBS). 9-11 September 2011, Seville, Spain.
24. Campolongo P, Trezza V, Cuomo V. Endocannabinoid-glucocorticoid interaction and emotional memory in rats. 35° Congresso Nazionale della Società Italiana di Farmacologia. 14- 17 September 2011, Bologna. Italy
25. Campolongo P. Pharmacological interactions in emotional memory consolidation. The Emotional Brain Meeting. 5-6 September 2011, Rome, Italy.
26. Campolongo P. Endocannabinoids: the crucial interplay between memory and emotions. Max Planck Institute of Neuroscience. 9 June 2011, Munich, Germany.
27. Campolongo P. The role of the interaction between the endocannabinoid and glucocorticoid systems in the amygdala in the regulation of emotional memory. 40° annual meeting della Society for Neuroscience (SfN), symposium: “Stress and endocannabinoids, from synapse to behavior”). 13-17 November 2010, San Diego (USA).
28. Campolongo P. The role of endocannabinoids in the amygdala in the regulation of emotional memory. 23° annual meeting dell’European College of Neuropsychopharmacology (ECNP), TEM-symposium: "Neuropsychobiological mechanisms underlying fear memory and extinction: options for new treatment strategies". 30 August- 3 October 2010, Amsterdam, The Netherlands.
29. Campolongo P. Endocannabinoid-glucocorticoid interaction and emotional memory in rats. Symposium on Glucocorticoid-Endocannabinoid Interactions in Traumatic Memory and Posttraumatic Stress Disorder: A Translational Approach. 6-8 June, 2009, Groningen, The Netherlands.
30. Campolongo P. Glucocorticoid – Endocannabinoid Interaction and Emotional Memory in Rats. Workshop: Emotional Memory Regulation by Stress Hormones and Endocannabinoids. University of Munich, 11-12 November 2006, Munich, Germany.